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Recent Advances in Synthetic Isoquinoline-Based Derivatives in Drug Design

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AlkaPlorer: A database‐driven explorer for natural alkaloids and derivatives

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Multi-targeted antimicrobial action of Juglone against Proteus mirabilis biofilm and virulence

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Modular Chemoenzymatic Cascade for Highly Diastereo- and Enantioselective Synthesis of 1,3-Disubstituted Tetrahydroisoquinolines

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One-Step Biomimetic Synthesis of the Alkaloids Karachine, Valachine, and Sinometumine E

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Synthesis, structure characterization and antimicrobial activity of novel (1H-pyrazol-4-yl)(1,2,4-triazol-3-yl)methanone derivatives bearing isoquinoline moiety

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Advances in Synthesis Methods of Quinoline and Isoquinoline Derivatives

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Chinese Journal of Organic Chemistry, 2025, 45, 3255
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Metal‐Free [3 + 3] and [4 + 2] Cascade Cyclization of Dihydroisoquinolines and Ene‐Yne‐Oxazolones: Synthesis of Indenoisoquinolinoquinolinamides

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Chemistry A European J, 2025, 31
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Rh(III)-catalyzed chemodivergent synthesis of isocoumarins and isoquinolones from N-methoxybenzamides and cyclic α-diazo-1,3-diketones

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Chemistry Letters, 2026, 55
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An updated review of isoquinoline alkaloids: Biological activity and mode of action, structural modifications, and agricultural applications

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Bioactivities and Phytochemical Profiling of Trigynaea axilliflora from Brazil

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ACS Omega, 2025, 10, 57630
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Novel aminophosphoryl hybridization of natural berberine and heterocyclic azoles with large potential to combat global increasing bacterial resistance

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A multi-dimensional multi-mode multi-column preparative chromatography strategy for systematic purification of alkaloids

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Fumaria officinalis: Phytochemical complexity and its medicinal significance

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N-Doped π-Extended Coumarins: Synthesis and Photophysical Properties of Isoquinoline and Pyrimidine-Fused Coumarins

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I2-Induced Selenation/Annulation Reaction of N-(2-Vinyl)phenylindoles to Assemble Seleno-Indolo[1,2-a]indole Derivatives

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A Modular Chemoenzymatic Cascade Simplifies Divergent Synthesis of Natural and Unnatural Benzylisoquinoline Alkaloids

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Advanced Science, 2026, 13
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Flavin-Catalyzed Aerobic α-Functionalization of 1,2,3,4-Tetrahydro-isoquinolines: Application to C=O and C–O Bond Formation

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Photodriven Enantioselective 6-endo Hydroaminative Cyclization to Chiral 4-Substituted 3,4-Dihydroisoquinolones

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A Novel Solid-Phase Extraction Approach Based on π-Conjugated Polymer-Functionalized Mesoporous Silica Nanoparticles for Isoquinoline Alkaloid Purification from Cinnamomum camphora Seed Kernels

Yujing Yang, Ping Yu, Zheling Zeng, Xiansi Gao, Yifang Gao, Ding Cheng, Cheng Zeng, Xuefang Wen, Deming Gong and Xianghui Yan

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Rh(III)‐Catalyzed Dual C─H Annulation of Isoquinolones and 1,6‐Diynes: Access to Naphtho‐Fused Polycyclic Derivatives

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Metal-free radical cascade trifluoromethylation/cyclization of N-allylbenzamide for direct construction of trifluoromethyl dihydroisoquinolones

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HPLC–UV-Guided Discovery of Eurotamines A–F: Six Pairs of Isoquinoline Derivative Enantiomers from Marine-Derived Fungus Eurotium sp. SCSIO F452

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Integrated Metabolomics and Transcriptomics Analysis Reveals the Biosynthetic Mechanism of Isoquinoline Alkaloids in Different Tissues of Hypecoum erectum L.

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A comprehensive review of anti‐colorectal cancer alkaloids from traditional Chinese medicine: Sources, chemical structures, mechanisms and therapeutic applications

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British J Pharmacology, 2026
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Organic Peroxides in Transition-Metal-Free Cyclization and Coupling Reactions (C–C) via Oxidative Transformation

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ACS Omega, 2025, 10, 15852
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Design, Synthesis, and Preclinical Evaluation of Inhibitor-Based Radiotracers for Potential Application in Monitoring CDK4/6 Expression

Yuan Pan, Xiaoli Zhang, Bo Zhou, Yuze Ma, Jie Hu, Junhui He, Xue Shang, Chao Zhang, Ting Liang and Feng Gao

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Effect of magnetization on antibacterial, lipid-lowering and antioxidant activities of isoquinoline alkaloids

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Naphthalene-containing octreotide radioligand elevates selectivity and radionuclide therapy for somatostatin receptor 2-positive tumor

Juan Sun, Jiangtao Yang, Jiakun Guo, Bin Xu, Lei Tao, Xingyu Zhao, Guanglin Wang, Fenghua Meng and Zhiyuan Zhong

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Leptocaramine from Hypecoum erectum inhibits inflammatory responses via CSF2-NF-κB signaling pathway

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Synthesis and Preclinical Evaluation of 68Ga-Labeled Radiotracers for Monitoring PD-L1 Expression in Tumors

Bo Zhou, Xiaoli Zhang, Kexia Fang, Yuan Pan, Xue Shang, Min Li, Yinlong Zhao and Feng Gao

J. Med. Chem., 2026
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Synergistic Antibacterial Strategy of AIEgens Photosensitizer CPTQ for Photodynamic Therapy and Ferroptosis-like Bacterial Death to Prevent Dental Caries

Yixue Li, Ting Pan, Kaiqi Peng, Yiyi Huang, Weichang Li, Feng-shou Liu and Yan Zhou

ACS Appl. Mater. Interfaces, 2025, 17, 49165
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Flexible perovskite solar cells: advancements in materials, fabrication techniques, and future prospects

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A Cu(NTf2)2-Catalyzed Tandem Mannich-Cyclization Process of N-Boc-1,2,3,4-tetrahydroisoquinolin-1-ols with α-Aryl α-Diazo Ketones for the Construction of Substituted α-2-Furanyl Tetrahydro-1-isoquinolinemethanols

Xin Li, Nai-Xuan Liu, Jian-Ting Sun, Ya-Nan Li, Jing-Bo Zhou and Bang-Guo Wei

Org. Lett., 2026
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Computational metabolomics reveals overlooked chemodiversity of alkaloid scaffolds in Piper fimbriulatum

Tito Damiani, Joshua Smith, Téo Hebra, Milana Perković, Marijo Čičak, Alžběta Kadlecová, Vlastimil Rybka, Martin Dračínský and Tomáš Pluskal

The Plant Journal, 2025, 121
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