An asymmetric and theoretical approach to the Morita–Baylis–Hillman reaction using vinyl-1,2,4-oxadiazoles as nucleophiles

Thaynan A. B. Chagas, Bruno A. Piscelli, Hugo Santos, Sâmia R. Lima, Rodrigo A. Cormanich, Fábio S. Fernandes and Fernando Coelho

Org. Biomol. Chem., 2025, 23, 5872
DOI: 10.1039/D5OB00540J

I2-catalyzed tandem sp3C–H oxidation and annulation of aryl methyl ketones with amidoximes for the synthesis of 5-aroyl-1,2,4-oxadiazoles

Shiva Kumar Punna, Mariyaraj Arockiaraj and Venkatachalam Rajeshkumar

Org. Biomol. Chem., 2024, 22, 7478
DOI: 10.1039/D4OB01221F

Unveiling the therapeutic potential of 1,2,4-oxadiazole derivatives: An updated review

Hussam Elddin Nabeih Khasawneh, Ali Abdulrazzaq Abdulhussein Alrikabi, Amran M. AL-Erjan, Mustafa Jawad Kadham, Raed Fanoukh Aboqader Al-Aouadi, Natrayan Lakshmaiya, Roziyeva Muhayyo, Stefan Bräse and Hadeer M. Farhan

Results in Chemistry, 2025, 15, 102271
DOI: 10.1016/j.rechem.2025.102271

Design, Synthesis, Molecular Docking, and Biological Evaluation of Novel 1,2,4-Oxadiazole-Based Derivatives as Inhibitors of Trypsin, ALDH2, and iNOS

Mohammed Salah Ayoup, Rabia E. Alashhab, Hamida Abdel-Hamid, Doaa A. Ghareeb, Aliaa Masoud, Amr Sonousi, Asmaa E. Kassab and Mohamed N. Abd Al Moaty

Russ J Bioorg Chem, 2025, 51, 1171
DOI: 10.1134/S1068162024606128

Novel palladium(II) complexes of dipodal bis(1,3,4-oxadiazole-5-thione) ligands: Syntheses, characterization, in vitro antiproliferative activity, DNA binding interactions, and theoretical insights

Somayeh Karami, Mitra Ghassemzadeh, Mahboube Eslami Moghadam and Farshid Mohsenzadeh

Journal of Molecular Structure, 2025, 1337, 142160
DOI: 10.1016/j.molstruc.2025.142160

Novel 1,3,4‐Oxadiazole Acetamide Derivatives as Potential Antimicrobial Agents: Design, Synthesis, Biological Evaluation, and Molecular Modelling Studies

Khouloud Rouzi, Imane El Houssni, Njabulo J. Gumede, Ali Alsalme, Afaf Oulmidi, Miloud El Karbane, Mustapha Bouatia and Khalid Karrouchi

ChemistrySelect, 2025, 10
DOI: 10.1002/slct.202500076

Current pharmacophore based approaches for the development of new anti-Alzheimer’s agents

Prachi Sharma, Sunil Sharma, Yogesh Yadav, Paritosh Shukla and Ram Sagar

Bioorganic & Medicinal Chemistry, 2024, 113, 117926
DOI: 10.1016/j.bmc.2024.117926

Rational drug design and synthesis of novel bioactive molecules with oxygen heterocycles, including AChE and BChE inhibitory properties and SAR studies

Rajarshi Nath, Sumel Ashique, Bhupender Nehra, Ishita Debnath, Suman Ghosh, Pooja A Chawla, Fatimah M. Al-Salem, Sabina Yasmin, Md Sadique Hussain, Lakshminarayan Das, Arka Chakraborty, Aganta Chakraborty, Sathvik Belagodu Sridhar, Joy Das, Biplab Debnath and Md Yousuf Ansari

Mol Divers, 2026
DOI: 10.1007/s11030-026-11499-1

Deprotonated 5-acetylmethyl-1,2,4-oxadiazoles as bidentate chelating ligands for the synthesis of palladium(II) and copper(II) complexes

Jacob U. Abulkhaev, Artem V. Semenov, Daniil M. Ivanov, Irina I. Fedorova, Eugene V. Ignatov, Ekaterina A. Radiush, Sergey V. Baykov and Nadezhda A. Bokach

Inorganica Chimica Acta, 2025, 587, 122817
DOI: 10.1016/j.ica.2025.122817

A comprehensive overview of the recent development of privileged 1, 3, 4-oxadiazole derivatives and their biological activities

Nahid Shajari and Parvin Eskandari

Journal of Molecular Structure, 2026, 1349, 143639
DOI: 10.1016/j.molstruc.2025.143639

Exploring N-acetyl-1,3,4-oxadiazoline derivatives against Alzheimer's disease: ADMET, molecular docking, and DFT analysis

Preeti Shrivastava, Jaydip D. Bhaliya, Mitesh Solanki, Lokesh Bontha Venkata Subramanya, Gautam Patel and Soundarajan Krishnan

Letters in Drug Design & Discovery, 2025, 22, 100102
DOI: 10.1016/j.lddd.2025.100102

WITHDRAWN: Biomarker Detection and Therapy of Parkinson's and Alzheimer's disease using upconversion based approach: A Comprehensive Review

Kabirdas B. Ghorpade, Shivanshu Agrawal and Ujwal Havelikar

Ageing Research Reviews, 2025, 102656
DOI: 10.1016/j.arr.2025.102656

Oxadiazoles as multi-target therapeutic agents in Alzheimer’s Disease: A review of cholinesterase, MAO, β-Secretase, and Aβ aggregation inhibition

Moksh Shah, Chanchal Singh, Mange Ram Yadav and Afzal Nagani

J. Saudi Chem. Soc., 2025, 29
DOI: 10.1007/s44442-025-00036-8

1,2,4-Oxadiazoles in medicinal chemistry: trends of the last years

Anastasia Cherkasova, Roberta Astolfi, Maxim Nawrozkij, Boris Gladkikh, Eleonora Proia, Lidia Giuliani, Dante Rotili, Rino Ragno and Roman Ivanov

European Journal of Medicinal Chemistry, 2025, 297, 117935
DOI: 10.1016/j.ejmech.2025.117935