Kushal Dhake, Kyla J. Woelk, Liam D. N. Krueckl, Faith Alberts, James Mutter, Matthew O. Pohl, Gilian T. Thomas, Muskan Sharma, Jaelyn Bjornerud-Brown, Nahiane Pipaón Fernández, Nathan D. Schley and David C. Leitch

Chem. Commun., 2024, 60, 13008
DOI: 10.1039/D4CC04730C

Diastereoselective 1,3-nitrooxygenation of bicyclo[1.1.0]butanes

Anirban Maity, Kuruva Balanna, Constantin G. Daniliuc and Armido Studer

Chem. Sci., 2025, 16, 7264
DOI: 10.1039/D4SC08753D

Theoretical investigation of a chiral Brønsted acid (CBA)-catalyzed isomerization reaction of BCB: mechanism and origin of stereoselectivity

Yu-Nuo Wang and Yang Wang

New J. Chem., 2024, 48, 11360
DOI: 10.1039/D4NJ01986E

Photochemical α-selective radical ring-opening reactions of 1,3-disubstituted acyl bicyclobutanes with alkyl halides: modular access to functionalized cyclobutenes

Yuanjiu Xiao, Tong-Tong Xu, Jin-Lan Zhou, Feng Wu, Lei Tang, Ruo-Yi Liu, Wen-Biao Wu and Jian-Jun Feng

Chem. Sci., 2023, 14, 13060
DOI: 10.1039/D3SC04457B

Synthesis of polysubstituted cyclobutanes through a photoredox strain-release/[3,3]-rearrangement cascade

Fangqing Zhang, Chun Xu, Zichun Zhang, Zhuang Yang, Tao Peng, Wen Shao, Xiaoming Feng and Yangbin Liu

Chem. Sci., 2025, 16, 11508
DOI: 10.1039/D5SC01431J

Oxidative sulfonylarylation of strained C–C σ-bonds for the synthesis of 3-spirocyclic oxindoles initiated by insertion of sulfur dioxide

Jian-Hong Fan, Jing Yuan, Long-Jin Zhong, Yu Liu and Ke-Wen Tang

Org. Chem. Front., 2024, 11, 1982
DOI: 10.1039/D4QO00062E

Lewis acid-catalyzed (3 + 2) annulation of bicyclobutanes with ynamides: access to 2-amino-bicyclo[2.1.1]hexenes

Deeptanu Sarkar, Shiksha Deswal, Rohan Chandra Das and Akkattu T. Biju

Chem. Sci., 2024, 15, 16243
DOI: 10.1039/D4SC03893B

Photocatalytic α-Selective σ-Bond Hydroboration of Bicyclo[1.1.0]butanes

Mingjun Yi, Xiaoyu Wu, Jianwei Wu, Yan Lu and Zhaoguo Zhang

Org. Lett., 2026, 28, 1851
DOI: 10.1021/acs.orglett.5c05405

Strain-Release-Driven Alder–Ene Reaction of Bicyclo[1.1.0]butanes with β-Fluoroalkyl-α,β-Unsaturated Ketones

Wenjie Xu, Zhiyi Zhang, Hao Wu and Dachang Bai

J. Org. Chem., 2025, 90, 7003
DOI: 10.1021/acs.joc.5c00455

Synthesis of Cyclobutanes and Cyclobutenes by Strain-Release-Driven Ring-Opening of Bicyclo[1.1.0]butanes

Xuan Zhan, Heng-Xian He, Quanxin Peng and Jian-Jun Feng

Synthesis, 2024, 56, 3829
DOI: 10.1055/a-2402-6920

Regiodivergent hydrophosphination of Bicyclo[1.1.0]-Butanes under catalyst control

Zhuo Huang, Huiwen Tan, Ranran Cui, Yudong Hu, Siyu Zhang, Jinming Jia, Xinglong Zhang and Qing-Wei Zhang

Nat Commun, 2025, 16
DOI: 10.1038/s41467-025-61415-8

Visible-Light-Mediated Strain-Release Radical Spirocyclizations: Access to Functionalized Spirocyclobutanes

Tushar Singha and Durga Prasad Hari

Synlett, 2025, 36, 445
DOI: 10.1055/a-2442-1796

Stereoselective Radical Acylfluoroalkylation of Bicyclobutanes via N‐Heterocyclic Carbene Catalysis

Chuyu Xiao, Jing‐Ran Shan, Wen‐Deng Liu, Xingyuan Gao, Jingwei Dai, Zuwei Wang, Wentao Wang, K. N. Houk and Jiannan Zhao

Angewandte Chemie, 2025, 137
DOI: 10.1002/ange.202416781

Synthesis of 1,3‐Oxazole‐Substituted 2‐Naphthols and Phenols From Their Corresponding Ethers via Claisen Rearrangement

Sujeet Kumar and Chintakunta Ramesh

Adv Synth Catal, 2026, 368
DOI: 10.1002/adsc.70295

Lewis Acid-Catalyzed Ring-Opening Reaction of Bicyclobutanes (BCBs) for the Highly Selective Synthesis of 1,1,3-Trisubstituted Cyclobutanes

Mengcheng Zhang, Yuying Chen, Jiayu Liu, Shangyuan Li, Wenjia Xu, Jiaojiao Qi and Xiantao Ma

Org. Lett., 2025, 27, 9471
DOI: 10.1021/acs.orglett.5c02896

Three-Component Reaction through Rh(III)-Catalyzed Strain Release of Bicyclo[1.1.0]butanes

Shubham K. Dhal, Saista Afreen, Sikun Pradhan and Ponneri C. Ravikumar

Org. Lett., 2025, 27, 10739
DOI: 10.1021/acs.orglett.5c03345

Stereoselective Alder-Ene Reactions of Bicyclo[1.1.0]butanes: Facile Synthesis of Cyclopropyl- and Aryl-Substituted Cyclobutenes

Ayan Dasgupta, Subrata Bhattacharjee, Zixuan Tong, Avishek Guin, Ryan E. McNamee, Kirsten E. Christensen, Akkattu T. Biju and Edward A. Anderson

J. Am. Chem. Soc., 2024, 146, 1196
DOI: 10.1021/jacs.3c13080

Oxidative Alkylarylation of N‐Aryl Bicyclobutyl Amides with C(sp3)–H Feedstocks via C(sp3)–H/C(sp2)–H Functionalization

Jing Yuan, Jiao Zhou, Peng‐Fei Xia, Yu Liu, Ke‐Wen Tang and Jian‐Hong Fan

Chin. J. Chem., 2024, 42, 3399
DOI: 10.1002/cjoc.202400748

Photoredox-Catalyzed Alkylarylation of N-Aryl Bicyclobutyl Amides with α-Carbonyl Alkyl Bromides: Access to 3-Spirocyclobutyl Oxindoles

Jian-Hong Fan, Jing Yuan, Peng-Fei Xia, Jiao Zhou, Long-Jin Zhong, Peng-Fei Huang, Yu Liu, Ke-Wen Tang and Jin-Heng Li

Org. Lett., 2024, 26, 2073
DOI: 10.1021/acs.orglett.4c00333

Reductive Olefin Bicyclo[1.1.0]butane Coupling Enabled by Iron Hydride Hydrogen Atom Transfer

Guang Chen, Dayu Tian, Xiaocheng Wang and Hai-Jun Zhang

ACS Catal., 2024, 14, 14928
DOI: 10.1021/acscatal.4c04837

Sc(OTf)3‐Catalyzed Ring‐Opening Reactions of Donor‐Acceptor Cyclopropanes/Bicyclo[1.1.0]butanes: Access to 3‐Substituted Chromenones, Cyclopenta[b]chromenones and 2‐Aminobicyclo[2.1.1]hexanes

Poonam Rani and Sampak Samanta

Adv Synth Catal, 2025, 367
DOI: 10.1002/adsc.202500132

Bridge Cross-Coupling of Bicyclo[1.1.0]butanes

Ryan E. McNamee, Ayan Dasgupta, Kirsten E. Christensen and Edward A. Anderson

Org. Lett., 2024, 26, 360
DOI: 10.1021/acs.orglett.3c04030

Conditions-Controlled Divergent Annulation of Bicyclo[1.1.0]butanes and Dioxopyrrolidines through Lewis Acid Catalysis

Jun-Long Li, Chuan Xie, Rong Zeng, Wen-Chao Yuan, Yuan-Yuan Lei, Ting Qi, Hai-Jun Leng and Qing-Zhu Li

ACS Catal., 2025, 15, 6025
DOI: 10.1021/acscatal.4c07205

HFIP-Mediated Ring Opening of Bicyclo[1.1.0]butanes with Hydroperoxides for Diastereoselective Access to Peroxycyclobutanes

Priyanshu Gupta, Palash Roy and Akkattu T. Biju

Org. Lett., 2025, 27, 10477
DOI: 10.1021/acs.orglett.5c03346

Palladium-catalyzed selective alkoxycarbonylation of different alcohols toward the direct synthesis of cyclobutanecarboxylates

Yu-Kun Liu, Xing-Wei Gu, Yan-Hua Zhao and Xiao-Feng Wu

Journal of Catalysis, 2025, 443, 115956
DOI: 10.1016/j.jcat.2025.115956

Stereoselective Radical Acylfluoroalkylation of Bicyclobutanes via N‐Heterocyclic Carbene Catalysis

Chuyu Xiao, Jing‐Ran Shan, Wen‐Deng Liu, Xingyuan Gao, Jingwei Dai, Zuwei Wang, Wentao Wang, K. N. Houk and Jiannan Zhao

Angew Chem Int Ed, 2025, 64
DOI: 10.1002/anie.202416781

Lewis Acid-Catalyzed 1,3-Dipolar Cycloaddition of Bicyclobutanes with Isatogens: Access to Tetracyclic 2-Oxa-3-azabicyclo[3.1.1]heptanes

Shiksha Deswal, Rohan Chandra Das, Deeptanu Sarkar and Akkattu T. Biju

JACS Au, 2025, 5, 136
DOI: 10.1021/jacsau.4c00839

Strain-release transformations of bicyclo[1.1.0]butanes and [1.1.1]propellanes

Qian-Qian Hu, Jie Chen, Yang Yang, Hui Yang and Ling Zhou

Tetrahedron Chem, 2024, 9, 100070
DOI: 10.1016/j.tchem.2024.100070

Silver-catalyzed formal [2π+2σ] cycloaddition of bicyclobutanes with naphthols as surrogates for arynes

Lei Tang, Kun-Ju Wang, Lei Wang, Fujian Yang, Quanxin Peng, Guoqiang Wang and Jian-Jun Feng

Sci. China Chem., 2026, 69, 239
DOI: 10.1007/s11426-025-2698-2

Double Strain‐Release (3+3)‐Cycloaddition: Lewis Acid Catalyzed Reaction of Bicyclobutane Carboxylates and Aziridines

Malini George, Jasper Mindner, Silas Wittmer, Daniil A. Knyazev and Daniel B. Werz

Chemistry A European J, 2025, 31
DOI: 10.1002/chem.202404099

Access to Quaternary‐Substituted Cyclobutylsilanes by Ring Opening of Arylbicyclobutanes with Silyllithium Reagents

Zachary P. Sercel and Ilan Marek

Angewandte Chemie, 2025, 137
DOI: 10.1002/ange.202421235

Copper-Catalyzed Radical-Triggered Annulation–Halocyanomethylation Reaction of Alkynyl-Bearing Bicyclo[1.1.0]butanes (BCBs) Leading to Spirocyclobutyl Quinolinones

Xiao Zou, Zheng-Ren Jia, Yu-Ting Wang, Peng-Cheng Xu, Jian-Wu Liu, Shan-Shan Zhu and Hang-Dong Zuo

Org. Lett., 2025, 27, 13027
DOI: 10.1021/acs.orglett.5c04128

Merging Aldehydic C–H Activation with Strain Release C–C Bond Cleavage of Bicyclo[1.1.0]butanes under Rh(III) Catalysis

Tanmay Barman, Om Prakash Dash, Jatin Patra and Chandra M. R. Volla

Org. Lett., 2025, 27, 14168
DOI: 10.1021/acs.orglett.5c04093

Electrochemical Selenized Reaction of N-Arylbicyclo[1.1.0]butane-1-carboxamides: Access to 3-(Arylselanyl)spiro[cyclobutane-1,3′-indolin]-2′-one Derivatives

Jiyao Liu, Yuliang Qian, Haicheng Zhao, Yun Liu, Zhenglong Qin, Zifeng Zhang and Liangce Rong

J. Org. Chem., 2024, 89, 15914
DOI: 10.1021/acs.joc.4c02085

Catalytic Intermolecular Asymmetric [2π + 2σ] Cycloadditions of Bicyclo[1.1.0]butanes: Practical Synthesis of Enantioenriched Highly Substituted Bicyclo[2.1.1]hexanes

Ying-Jie Li, Zhi-Long Wu, Qiang-Shuai Gu, Tingting Fan, Ming-Hao Duan, Lihong Wu, Yu-Tao Wang, Ji-Peng Wu, Fang-Lei Fu, Fan Sang, Ai-Ting Peng, Yuyang Jiang, Xin-Yuan Liu and Jin-Shun Lin

J. Am. Chem. Soc., 2024, 146, 34427
DOI: 10.1021/jacs.4c10968

Simultaneous Activation of Bicyclobutanes and Indolyl Alcohols with HFIP: Access to Indole‐Fused Bicyclo[3.1.1]Heptanes

Shiksha Deswal, Rohan Chandra Das, Deeptanu Sarkar and Akkattu T. Biju

Angewandte Chemie, 2025, 137
DOI: 10.1002/ange.202501655

Oxidative Difunctionalization of N-Aryl Bicyclobutyl Amides with Aldehydes: Divergent Synthesis of Acylated and Alkylated 3-Spirocyclobutyl Oxindoles

Peng-Fei Xia, Jiao Zhou, Jing Yuan, Rui Zeng, Yu Liu, Ke-Wen Tang and Jian-Hong Fan

Org. Lett., 2024, 26, 6486
DOI: 10.1021/acs.orglett.4c02325

Photoredox-Catalyzed Strain-Release-Driven Synthesis of Functionalized Spirocyclobutyl Oxindoles

Tushar Singha, Nakul Abhay Bapat, Subrat Kumar Mishra and Durga Prasad Hari

Org. Lett., 2024, 26, 6396
DOI: 10.1021/acs.orglett.4c02177

Annulation of Hydroxyarenes and Derivatives with Bicyclo[1.1.0]butanes by Synergistic Combination of Metal Lewis Acid and Organic Acid

Qihang Guo, Dongshun Ni and Li Deng

JACS Au, 2025, 5, 5059
DOI: 10.1021/jacsau.5c00956

Lewis Acid‐Catalyzed Unusual (4+3) Annulation of para‐Quinone Methides with Bicyclobutanes: Access to Oxabicyclo[4.1.1]Octanes

Shiksha Deswal, Avishek Guin and Akkattu T. Biju

Angew Chem Int Ed, 2024, 63
DOI: 10.1002/anie.202408610

Simultaneous Activation of Bicyclobutanes and Indolyl Alcohols with HFIP: Access to Indole‐Fused Bicyclo[3.1.1]Heptanes

Shiksha Deswal, Rohan Chandra Das, Deeptanu Sarkar and Akkattu T. Biju

Angew Chem Int Ed, 2025, 64
DOI: 10.1002/anie.202501655

Pyridine-boryl radical-catalyzed [3π + 2σ] cycloaddition for the synthesis of pyridine isosteres

Yuan Liu, Shuang Lin, Zhengwei Ding, Yin Li, Ya-Jie Tang, Jiang-Hao Xue, Qingjiang Li, Pengfei Li and Honggen Wang

Chem, 2024, 10, 3699
DOI: 10.1016/j.chempr.2024.08.010

Regio- and Diastereoselective Cascade Reactions of Bicyclo[1.1.0]butanes: Access to gem-Difluorinated Carbocyclic Rings

Zhiyi Zhang, Hao Wu, Wenjie Xu and Dachang Bai

Org. Lett., 2025, 27, 4378
DOI: 10.1021/acs.orglett.5c01132

Lewis Acid Catalyzed Divergent Reaction of Bicyclo[1.1.0]Butanes With Quinones for the Synthesis of Diverse Polycyclic Molecules

Qian‐Qian Hu, Ze‐Xiang Geng, Xue Bai, Jie Chen and Ling Zhou

Angewandte Chemie, 2025, 137
DOI: 10.1002/ange.202506228

B(C6F5)3-Catalyzed Dearomative [2π+2σ] Cycloaddition of 1-Naphthols with Bicyclo[1.1.0]butanes

Lin Li, Lei Xiao, Zhongyu Yi, Yufen Zhao, Douglas W. Stephan and Jing Guo

Org. Lett., 2025, 27, 13968
DOI: 10.1021/acs.orglett.5c04557

Transition-Metal Catalyzed Carbene Transformations via Ring Strain-Release Processes

Fukuan Zhang, Hui Wen and Yaojia Jiang

ACS Catal., 2026, 16, 3013
DOI: 10.1021/acscatal.5c09031

Access to Quaternary‐Substituted Cyclobutylsilanes by Ring Opening of Arylbicyclobutanes with Silyllithium Reagents

Zachary P. Sercel and Ilan Marek

Angew Chem Int Ed, 2025, 64
DOI: 10.1002/anie.202421235

Controllable divergent transformations of bicyclo[1.1.0]butanes

Heng-Xian He, Xue-Chun Yang, Yuanjiu Xiao, Lei Tang, Wen-Li Xu and Jian-Jun Feng

Sci. China Chem., 2026, 69, 1120
DOI: 10.1007/s11426-025-2941-2

Palladium-catalyzed allylic amination of vinyl bicyclo[1.1.0]butanes: A strain release approach toward alkylidenecyclobutanes

Huan Zhang, Wen-Jie Liang, Jun-An Xiao, Wei Wang, Ru-Fang Meng, Kai Chen, Lan Zheng, Chenxiang Lin, Wei Su and Hua Yang

Green Synthesis and Catalysis, 2024
DOI: 10.1016/j.gresc.2024.11.004

Silver‐Catalyzed Dearomative [2π+2σ] Cycloadditions of Indoles with Bicyclobutanes: Access to Indoline Fused Bicyclo[2.1.1]hexanes**

Lei Tang, Yuanjiu Xiao, Feng Wu, Jin‐Lan Zhou, Tong‐Tong Xu and Jian‐Jun Feng

Angewandte Chemie, 2023, 135
DOI: 10.1002/ange.202310066

A General Approach for Strained Ring Functionalization via Nucleophilic Catalysis

Ping Wang, Cheng Deng, Zihao Luo, Ding Chen, Alex Yida Li, Yuanqiang Li, Lin Huang and Peng Yu

JACS Au, 2025, 5, 5404
DOI: 10.1021/jacsau.5c00849

Lewis Acid Catalyzed Divergent Reaction of Bicyclo[1.1.0]Butanes With Quinones for the Synthesis of Diverse Polycyclic Molecules

Qian‐Qian Hu, Ze‐Xiang Geng, Xue Bai, Jie Chen and Ling Zhou

Angew Chem Int Ed, 2025, 64
DOI: 10.1002/anie.202506228

HFIP-Mediated Spiro-annulation of Bicyclo[1.1.0]butanes with α-Halo Hydroxamates: Access to Functionalized Spirocyclobutenes

Safa Shajahan, Shiksha Deswal, Malini George, Mumtaz Ahmad, Kishor Mohanan, Daniel B. Werz and Akkattu T. Biju

Org. Lett., 2025, 27, 8137
DOI: 10.1021/acs.orglett.5c02493

Photocatalytic Oxidative Activation of Bicyclo[1.1.0]butanes for Formal [2σ+2π] Cycloadditions

Maxim Golfmann, Marius Reinhold, Jorn D. Steen, Malte S. Deike, Behrend Rodemann, Christopher Golz, Stefano Crespi and Johannes C. L. Walker

ACS Catal., 2024, 14, 13987
DOI: 10.1021/acscatal.4c05067

Lewis Acid‐Catalyzed Unusual (4+3) Annulation of para‐Quinone Methides with Bicyclobutanes: Access to Oxabicyclo[4.1.1]Octanes

Shiksha Deswal, Avishek Guin and Akkattu T. Biju

Angewandte Chemie, 2024, 136
DOI: 10.1002/ange.202408610

Ruthenium‐Catalyzed Isomerization of Oxabicyclic Alkenes to 1,2‐Naphthalene Oxides: A Density Functional Theory Study

Austin Pounder, Noah King and William Tam

Eur J Org Chem, 2025, 28
DOI: 10.1002/ejoc.202500192

Harnessing Strain-Release via Photocatalysis to Construct Functionalized Spirocyclobutyl Oxindoles

Vinjamuri Srinivasu, Ajmeera Balaraju, Pratap Mondal and Devarajulu Sureshkumar

J. Org. Chem., 2025, 90, 17594
DOI: 10.1021/acs.joc.5c02434

Enantioselective Synthesis of Chiral Cyclobutenes Enabled by Brønsted Acid-Catalyzed Isomerization of BCBs

Si-Li Lin, Ye-Hui Chen, Huan-Huan Liu, Shao-Hua Xiang and Bin Tan

J. Am. Chem. Soc., 2023, 145, 21152
DOI: 10.1021/jacs.3c06525

Copper-Catalyzed Cross-Coupling of Bicyclobutanes with Triftosylhydrazone Leading to Skipped Dienes

Xiaolong Zhang, Tian Tian, Peiqiu Liao, Zhaohong Liu, Karunanidhi Murali and Xihe Bi

Org. Lett., 2025, 27, 2300
DOI: 10.1021/acs.orglett.4c04519

Silver‐Catalyzed Dearomative [2π+2σ] Cycloadditions of Indoles with Bicyclobutanes: Access to Indoline Fused Bicyclo[2.1.1]hexanes**

Lei Tang, Yuanjiu Xiao, Feng Wu, Jin‐Lan Zhou, Tong‐Tong Xu and Jian‐Jun Feng

Angew Chem Int Ed, 2023, 62
DOI: 10.1002/anie.202310066

Rhodium(II)-Catalyzed Strain-Enabled Stereoselective Synthesis of Skipped Dienes

Ganesh Arjun Kadam, Tushar Singha, Sapna Rawat and Durga Prasad Hari

ACS Catal., 2024, 14, 12225
DOI: 10.1021/acscatal.4c03569

Lewis Acid-Assisted Formal C═S Insertion of Thioindolinones to Bicyclobutanes: Diastereoselective Access to Trisubstituted Cyclobutanethiols

Palash Roy, Shiksha Deswal and Akkattu T. Biju

Org. Lett., 2025, 27, 10916
DOI: 10.1021/acs.orglett.5c03564

Lewis Acid‐Catalyzed Tandem Annulation of Propargylic Alcohols with 2‐Allylphenols and Their Anti‐tumor Activities

Xiang Li, Ning‐Yu Guo, Qing‐Hui Liu, Ya‐Ping Han, Hong‐Yu Zhang and Li‐Zeng Peng

Asian J Org Chem, 2024, 13
DOI: 10.1002/ajoc.202400265

Diastereoselective synthesis of multi-substituted cyclobutanes via catalyst-controlled regiodivergent hydrophosphination of acyl bicyclobutanes

Heng-Xian He, Feng Wu, Kun-Ju Wang, Lei Wang and Jian-Jun Feng

Nat Commun, 2025, 16
DOI: 10.1038/s41467-025-61726-w