Exploration of the VEGFR-2 inhibition activity of phthalazine derivatives: design, synthesis, cytotoxicity, ADMET, molecular docking and dynamic simulation

Hatem Hussein Bayoumi, Mohamed-Kamal Ibrahim, Mohammed A. Dahab, Fathalla Khedr and Khaled El-Adl

RSC Adv., 2024, 14, 21668
DOI: 10.1039/D4RA03459G

Anticancer evaluations of iodoquinazoline substituted with allyl and/or benzyl as dual inhibitors of EGFRWT and EGFRT790M: design, synthesis, ADMET and molecular docking

Ahmed K. B. Aljohani, Khaled El-Adl, Basmah Almohaywi, Omar M. Alatawi, Marwa Alsulaimany, Ahmed El-morsy, Sara A. Almadani, Hussam Y. Alharbi, Majed S. Aljohani, Felemban Athary Abdulhaleem M, Hanan E. M. Osman and Samy Mohamady

RSC Adv., 2024, 14, 7964
DOI: 10.1039/D4RA00502C

Rationale, in silico docking, ADMET profile, design, synthesis and cytotoxicity evaluations of phthalazine derivatives as VEGFR-2 inhibitors and apoptosis inducers

Hatem Hussein Bayoumi, Mohamed-Kamal Ibrahim, Mohammed A. Dahab, Fathalla Khedr and Khaled El-Adl

RSC Adv., 2024, 14, 27110
DOI: 10.1039/D4RA04956J

Green synthesis of new chiral amino acid urea derivatives and evaluation of their anti-inflammatory activity

Sirine Mehrez, Sarah Absi, Assia Hamdi, Sylvain Marque, Abderrahman Bouraoui, Yakdhane Kacem and Jamil Kraiem

RSC Adv., 2025, 15, 36219
DOI: 10.1039/D5RA04473A

Cerbera odollam fruit extracts enhance anti-cancer activity of sorafenib in HCT116 and HepG2 cells

Supawadee Parhira, Orakot Simanurak, Khemmachat Pansooksan, Julintorn Somran, Apirath Wangteeraprasert, Zhihong Jiang, Liping Bai, Pranee Nangngam, Dumrongsak Pekthong and Piyarat Srisawang

Chinese Herbal Medicines, 2025, 17, 108
DOI: 10.1016/j.chmed.2024.11.007

Synthesis, Anticancer Activity, and Computational Studies of Novel Imidazo[1′,2′:1,5]pyrazolo[3,4‐b]pyridine Derivatives

Adel A. ‐H. Abdel‐Rahman, Farag A. El‐Essawy, Norah M. Almaneai, Mohamed N. El‐Bayaa, Nader M. Boshta, Sabri Messaoudi and Wael A. El‐Sayed

ChemistrySelect, 2025, 10
DOI: 10.1002/slct.202502934

Synthesis, anticancer activity and computational studies of new benzimidazole-triazole-pyridine glycoside conjugates

Mohamed N. El-Bayaa, Aladdin M. Srour, Asmaa L. Alanzy, Sabri Messaoudi, Ahmed A. Abd-Rabou, Asmaa Saleh, Mahmoud G. A. Saleh and Wael A. El-Sayed

Future Medicinal Chemistry, 2025, 17, 2927
DOI: 10.1080/17568919.2025.2587567

Rational design, docking, syntheses, ADMET and cytotoxicity assessments of iodoquinazoline derivatives as inhibitors of EGFRT790M and VEGFR-2

Ahmed K.B. Aljohani, Marwa Alsulaimany, Omar M. Alatawi, Hussam Y. Alharbi, Majed S. Aljohani, Basmah Almohaywi, Sara A. Almadani, Read Alghamdi, Jumana Alnezari, Dana Alsaedi, Raghad Abdulrazaq and Khaled El‐Adl

Journal of Molecular Structure, 2025, 1331, 141634
DOI: 10.1016/j.molstruc.2025.141634

Benzimidazole-derived VEGFR-2 inhibitors: Docking, ADMET, anticancer evaluations, design and synthesis

Ibrahim Mohammed Hepishy, Helmy Sakr, Fathalla Khedr, Khaled El‐Adl and Mo’men Salem

Journal of Molecular Structure, 2026, 1360, 145575
DOI: 10.1016/j.molstruc.2026.145575

Exploration of cytotoxicity of iodoquinazoline derivatives as inhibitors of both VEGFR‐2 and EGFRT790M: Molecular docking, ADMET, design, and syntheses

Marwa Alsulaimany, Sanadelaslam S. A. El‐Hddad, Zuhir S. M. Akrim, Ahmed K. B. Aljohani, Basmah Almohaywi, Omar M. Alatawi, Sara A. Almadani, Hussam Y. Alharbi, Majed S. Aljohani, Samar F. Miski, Read Alghamdi and Khaled El‐Adl

Archiv der Pharmazie, 2024, 357
DOI: 10.1002/ardp.202400389

Enhancement of apoptosis in HCT116 and HepG2 cells by Coix lacryma-jobi var. lacryma-jobi seed extract in combination with sorafenib

Supawadee Parhira, Guoyuan Zhu, Apirath Wangteeraprasert, Suphunwadee Sawong, Pennapha Suknoppakit, Julintorn Somran, Naphat Kaewpaeng, Khemmachat Pansooksan, Dumrongsak Pekthong and Piyarat Srisawang

Chinese Herbal Medicines, 2025, 17, 322
DOI: 10.1016/j.chmed.2025.02.005