Exploring the latest trends in chemistry, structure, coordination, and diverse applications of 1-acyl-3-substituted thioureas: a comprehensive review

Sayyed Aqib Ullah, Aamer Saeed, Muhammad Azeem, Mian Bilal Haider and Mauricio F. Erben

RSC Adv., 2024, 14, 18011
DOI: 10.1039/D4RA02567A

New coumarin–chalcone–triazole hybrids as promising anti-diabetic agents: from molecular design to in vivo validation

Fariba Peytam, Maryam Norouzbahari, Mahsa Akbari, Hayrettin Ozan Gülcan, Mahfam Moradi, Somayeh Mojtabavi, Mohammad Ali Faramarzi, Fahimeh Ghasemi, Mohammadreza Torabi, Maliheh Barazandeh Tehrani, Vahid Sheibani, Loghman Firoozpour and Alireza Foroumadi

RSC Adv., 2025, 15, 51136
DOI: 10.1039/D5RA07254A

Genetics and humoral responses of the immune system to Aspergillus fumigatus

Daniel Ruben Akiola Sanya, Krish Jayachandran and Djamila Onésime

Molecular Immunology, 2025, 184, 164
DOI: 10.1016/j.molimm.2025.06.007

Novel heterocyclic organic compounds as DPP-4, α-amylase, and α-glucosidase inhibitors: Design, synthesis, and docking studies

Nazenin Akın, Serap Demir, Mehmet Çadır, İlhan Özer İlhan and Ayşe Ogan

Biochemical and Biophysical Research Communications, 2025, 778, 152354
DOI: 10.1016/j.bbrc.2025.152354

Evaluation of Ternary Thiazole-Coumarin-Azomethine Derivatives as Multi-Target Inhibitors: α-Amylase, Urease, Free Radical Scavenging and Antibacterial Activities with Molecular Docking Studies

Mian Bilal Haider, Aamer Saeed, Qurat ul Ain, Hammad Ismail, Muhammad Umar Ijaz, Hummera Rafique, R. Huzaifa Sharafat and Madiha Irfan

Chemistry Africa, 2025, 8, 201
DOI: 10.1007/s42250-024-01155-2

Synthesis of Some Novel Chalcone and 3,5‐Disubstituted Pyrazoline Derivatives: Evaluation of Their α‐Amylase and α‐Glucosidase Inhibitory Activities In Vitro and In Silico

Fatma Erbay, Melike Yildirim Akatin, Fatma Demir, Nuran Kahriman, Ahmet Colak, Nagihan Saglam Ertunga and Murat Küçük

Archiv der Pharmazie, 2026, 359
DOI: 10.1002/ardp.70222

Decoding Urease Inhibition: A Comprehensive Review of Inhibitor Scaffolds

Nuno Martinho and Natália Aniceto

ChemMedChem, 2026, 21
DOI: 10.1002/cmdc.202500423

Fluoro-substituted benzoylthiourea derivatives: Synthesis, structural characterization, and evaluation of antioxidant and antimicrobial activities

Tasneem Joha, Ummuhan Solmaz, Aylin Dogen and Hakan Arslan

Journal of Molecular Structure, 2026, 1356, 145070
DOI: 10.1016/j.molstruc.2025.145070

Synthesis, in vitro activity, and computational evaluation of novel Thiadiazole derivatives as potent urease inhibitors

Naseer Ahmed, Kamran Mehdi, Obaid-ur-Rehman Abid, Saqib Khan, Adi T. Zikri and Is Helianti

Results in Chemistry, 2025, 16, 102482
DOI: 10.1016/j.rechem.2025.102482

Synthesis, Structural Characterization, Biological and Computational Evaluation of Oxazolidin‐2‐one‐Based Carbonylsulfamates as Urease Inhibitors

Dounia Beldjezzia, Aϊcha Amira, Houria Bentoumi, Sofiane Bouacida, Taha Khaldi, Latifa Khattabi, Rayene Sayad, Nour‐Eddine Aouf and Hacène K'tir

ChemistrySelect, 2025, 10
DOI: 10.1002/slct.202504979

Diastereoselective synthesis of novel (S)-lactic pyrazoline derivatives and investigation of antibacterial capabilities

Maryam Gholami, Gholamhassan Imanzadeh, Farhad Kabiri Esfahani, Morteza Karami-Zarandi and Amir Nasser Shamkhali

Sci Rep, 2025, 16
DOI: 10.1038/s41598-025-32881-3

Putting forward novel sulfonamide-thiazole-pyrazoline hybrids as potential central core structure for the development of non-specific b-TNAP and c-IAP inhibitors

Mian Bilal Haider, Aamer Saeed, Muhammad Azeem, Sayyed Aqib Ullah, Syeda Abida Ejaz and Hafiz Muhammad Attaullah

International Journal of Biological Macromolecules, 2024, 283, 137699
DOI: 10.1016/j.ijbiomac.2024.137699

Discovery of bis -chalcones and bis -pyrimidines as potential urease inhibitors: from synthesis to computational insights

Nafeesa Naeem, Sumera Zaib, Ehsan Ullah Mughal, Gehan Ahmed Othman, Amina Sadiq and Nehal Rana

Future Medicinal Chemistry, 2025, 17, 929
DOI: 10.1080/17568919.2025.2485870

Lignan-rich extract from Cinnamomum camphora leaf attenuates metabolic syndrome by modulating glycolipid metabolism and gut microbiota in T2DM mice

Wei Huang, Guan-peng Huang, Lan-xiong Zhang, En da Yu, Wang-ke Yang, Min Ye, Shuang-quan Zou, Lin Ni and Hua-Qin He

Phytomedicine, 2024, 135, 156118
DOI: 10.1016/j.phymed.2024.156118

Spectroscopic and Theoretical Elucidation of Acylthiourea Derivatives with Antioxidant and Low-Toxicity Profiles

Adriana Castro Pinheiro, Ana Paula Bonato Wille, Ianka Jacondino Nunes, Wesley Vieira Ferreira, Alecia Ferreira da Silva, Ravi Kumar Kapavarapu, Renieidy Flávia Clemente Dias, Rául Ramos Cairo, Ana María Plutín Stevens, Jenifer Saffi, Vanessa Macedo Esteves da Rocha and Ethel Antunes Wilhelm

Journal of Molecular Structure, 2026, 1351, 144242
DOI: 10.1016/j.molstruc.2025.144242

Synthesis and Molecular Docking of Curcumin‐Derived Pyrazole‐Thiazole Hybrids as Potent α‐Glucosidase Inhibitors

Jehan Y. Al‐Humaidi, Lamia A. Albedair, Deepika Maliwal, Magdi E. A. Zaki, Sami A. Al‐Hussain, Raghuvir Pissurlenkar, Yousef E. Mukhrish, Tariq Z. Abolibda and Sobhi M. Gomha

Chemistry & Biodiversity, 2025, 22
DOI: 10.1002/cbdv.202401766

Unveiling the cyclopropyl appended acyl thiourea derivatives as antimicrobial, α-amylase and proteinase K inhibitors: Design, synthesis, biological evaluation, molecular docking, DFT and ADMET studies

Hina Zaman, Aamer Saeed, Hammad Ismail and Muhammad Rashid

Archives of Biochemistry and Biophysics, 2025, 765, 110304
DOI: 10.1016/j.abb.2025.110304

Design, synthesis, and antimicrobial activity of new thiourea-uracil derivatives: Anti-biofilm, ROS, DHFR, computational and SAR studies

Farid M. Sroor, Ahmed F. El-Sayed and Mohamed Abdelraof

Bioorganic Chemistry, 2025, 163, 108719
DOI: 10.1016/j.bioorg.2025.108719

Design, synthesis, and combined computational and experimental evaluation of novel 1,2,4-triazole Schiff base hybrids as potent dual inhibitors of urease and α-glucosidase

Ergün Gültekin, Abdurrahman Atalay and Yakup Şirin

Future Medicinal Chemistry, 2026, 18, 291
DOI: 10.1080/17568919.2026.2617604

Exploration of morpholine-thiophene hybrid thiosemicarbazones for the treatment of ureolytic bacterial infections via targeting urease enzyme: Synthesis, biochemical screening and computational analysis

Rubina Munir, Sumera Zaib, Muhammad Zia-ur-Rehman, Hira Javed, Ayesha Roohi, Muhammad Zaheer, Nabiha Fatima, Mashooq Ahmad Bhat and Imtiaz Khan

Front. Chem., 2024, 12
DOI: 10.3389/fchem.2024.1403127

Synthesis, crystal structures and urease inhibition of nickel(II), copper(II), zinc(II) and molybdenum(VI) complexes derived from N,n’ -bis(4-bromosalicylidene)-1,3-propanediamine

Hai-Ying Chen, Rundong Lu, Jinkai Lei, Jiacheng Liu, Chi Liu, Liuxiu Chen and Wu Chen

Journal of Coordination Chemistry, 2024, 77, 1103
DOI: 10.1080/00958972.2024.2357722

Exploring 2-Pyrazoline derivatives as potent antidiabetic agents and cholinesterase inhibitors: Their synthesis and molecular docking studies

Zefine Uğraş, Fatih Tok, Cansel Çakir, Kübra Tuna, Gizem Tatar-Yilmaz, Doğukan Mutlu, Yusuf Sicak, Şevki Arslan, Mehmet Öztürk and Bedia Koçyіğіt-Kaymakçioğlu

Journal of Molecular Structure, 2024, 1315, 138978
DOI: 10.1016/j.molstruc.2024.138978