Mitoxantrone-engineered multifunctional nanoplatforms for precision imaging-guided synergistic cancer therapy: recent advances and future perspectives

Juan Yu, Zijun Qiu, Susu Yan, Aishan Lin and Yanan Li

J. Mater. Chem. B, 2026, 14, 70
DOI: 10.1039/D5TB02282G

Docetaxel-conjugated bile acid-derived nanomicelles can inhibit tumour progression with reduced toxicity

Devashish Mehta, Chhavi Dua, Ruchira Chakraborty, Poonam Yadav, Ujjaini Dasgupta and Avinash Bajaj

Nanoscale Adv., 2025, 7, 2003
DOI: 10.1039/D4NA00715H

The biological response of pH-switch-based gold nanoparticle-composite polyamino acid embolic material

Feng Yang, Shiwen Gong, Die Hu, Lihua Chen, Wenyuan Wang, Bo Cheng, Jing Yang, Binbin Li and Xinyu Wang

Nanoscale, 2024, 16, 10448
DOI: 10.1039/D4NR00989D

Polymeric nanoparticle synthesis for biomedical applications: advancing from wet chemistry methods to dry plasma technologies

Elmer S. Austria and Behnam Akhavan

Nanoscale, 2025, 17, 13020
DOI: 10.1039/D5NR00436E

Phage-augmented casein nanocarriers for targeted bioimaging and enhanced combinatorial therapy of triple-negative breast cancer

Sunil Venkanna Pogu, Dokkari Nagalaxmi Yadav, Hima Sree Buddhiraju, Apoorva Basa, Bantal Veeresh and Aravind Kumar Rengan

Nanoscale, 2025, 17, 18948
DOI: 10.1039/D5NR01826A

Rational design of click-assembled chiral dendrimers: anticancer activity and molecular dynamics study

Tamer El Malah and Ahmed A. El-Rashedy

RSC Adv., 2026, 16, 11763
DOI: 10.1039/D6RA00668J

Hyaluronic acid-coated capecitabine nanostructures for CD44 receptor-mediated targeting in breast cancer therapy

Sruthi Laakshmi Mugundhan and Mothilal Mohan

RSC Adv., 2025, 15, 12653
DOI: 10.1039/D5RA01275A

Dual stimuli-responsive biotinylated polymer–drug conjugate for dual drug delivery

Desoshree Ghosh, Afruja Khan, Sagar Bag, Amirul Islam Mallick and Priyadarsi De

J. Mater. Chem. B, 2024, 12, 11826
DOI: 10.1039/D4TB01762E

Revolutionary NIR-activated silicon nanoparticles: precision-controlled release and targeted 3D cancer cell destruction

Vy Anh Tran, Nguyen Huy Hung, Thu Thao Thi Vo, Seong Soo A. An, Sang-Wha Lee, Hun Jeong and Mario A. Tan

RSC Adv., 2025, 15, 4958
DOI: 10.1039/D4RA08889A

Engineering tumor-oxygenated nanomaterials: advancing photodynamic therapy for cancer treatment

Tingting Zuo, Xiaodie Li, Xuan Ma, Ye Zhang, Xueru Li, Xuehai Fan, Mingze Gao, Donglin Xia and Huijun Cheng

Front. Bioeng. Biotechnol., 2024, 12
DOI: 10.3389/fbioe.2024.1383930

Stimuli-responsive mesoporous silica nanoparticles for brain tumor theranostics and drug targeting

Mainuddin, Deepak Tomar, Amulya Jindal, Anshika, Javeria Khan and Anoop Kumar

Drug Development and Industrial Pharmacy, 2026, 52, 627
DOI: 10.1080/03639045.2026.2624601

Nanotechnology Driven Innovations in Modern Pharmaceutics: Therapeutics, Imaging, and Regeneration

Nargish Parvin, Mohammad Aslam, Md Najib Alam and Tapas K. Mandal

Nanomaterials, 2025, 15, 1733
DOI: 10.3390/nano15221733

T-boron-nitride and black phosphorus nanoflakes for anticancer drug delivery application: A computational insight

Md. Hasan Shahria Fahim, Shrabone Rani Biswas, Rashek Dewan Daymond, Afia Abida Mehnaz, Sharmin Akter Shetu, Nihal Siddique, Mohammad Tanvir Ahmed, Abdullah Al Roman and Debashis Roy

Journal of Molecular Liquids, 2025, 438, 128799
DOI: 10.1016/j.molliq.2025.128799

A Peptoid-Chelator Selective to Cu2+ That Can Extract Copper from Metallothionein-2 and Lead to the Production of ROS

Anastasia Esther Behar and Galia Maayan

Antioxidants, 2023, 12, 2031
DOI: 10.3390/antiox12122031

Hallmarks of cancer resistance

Muhammad Tufail, Jia-Ju Hu, Jie Liang, Cai-Yun He, Wen-Dong Wan, Yu-Qi Huang, Can-Hua Jiang, Hong Wu and Ning Li

iScience, 2024, 27, 109979
DOI: 10.1016/j.isci.2024.109979

ABCG2 Expression as a Potential Survival Predictor in Human Gliomas

Marina Raguž, Marko Tarle, Danko Müller, Čedna Tomasović-Lončarić, Hana Chudy, Tonko Marinović and Darko Chudy

IJMS, 2024, 25, 3116
DOI: 10.3390/ijms25063116

Elucidating Ras protein as a dual therapeutic target for inflammation and cancer: a review

Parmar Keshri Nandan and Jayanthi Sivaraman

Discov Onc, 2025, 16
DOI: 10.1007/s12672-025-02783-x

Mannose-modified ZnO particles for controlled Zn2+ release as potential drug carriers

Anna Piasek, Halyna Kominko, Michał Zielina, Marcin Banach and Jolanta Pulit-Prociak

Chem. Pap., 2025, 79, 3007
DOI: 10.1007/s11696-025-03984-y

Exploring the therapeutic efficacy of crocetin in oncology: an evidence-based review

Wojciech Koch, Anna Wawruszak, Wirginia Kukula-Koch, Magdalena Zdziebło, Paweł Helon, Zainab M. Almarhoon, Basem Al-Omari, Daniela Calina and Javad Sharifi-Rad

Naunyn-Schmiedeberg's Arch Pharmacol, 2024, 397, 1455
DOI: 10.1007/s00210-023-02714-z

Recent Advances in Smart Stimulus-Responsive Hydrogels for Precision Drug Delivery in Tumours

Huiling Zuo, Yuhang Jiao, Jiaxin Chen, Sen Tong, Yan Li and Wei Zhao

Gels, 2026, 12, 98
DOI: 10.3390/gels12020098

Emerging trends in NanoTheranostics: Integrating imaging and therapy for precision health care

Heba M. Fahmy, Laila Bayoumi, Nada F. Helal, Naglaa R.A. Mohamed, Yassmin Emarh and Asmaa M. Ahmed

International Journal of Pharmaceutics, 2025, 683, 126057
DOI: 10.1016/j.ijpharm.2025.126057

RNA-binding proteins as therapeutic targets in cancer

Jennifer Jungfleisch and Fátima Gebauer

RNA Biology, 2025, 22, 1
DOI: 10.1080/15476286.2025.2470511

Revolutionizing Retinal Therapy: The Role of Nanoparticle Drug Carriers in Managing Vascular Retinal Disorders

Huihui Lu, Na He, Lina Zhang, Yayan You and Zhigang Lv

OPTH, 2025, Volume 19, 1565
DOI: 10.2147/OPTH.S503273

Development and characterization of Fe2O3 nanoparticles coated with chitosan and folic acid for biomedical applications

Ravi Kant Kushwaha, Uzma Noor Shah, Vishal Sandhwar, Sakshi Pandey, Indumathi Thangavelu, AbdulAziz A. AlGhamdi and Srinivas Tadepalli

Journal of the Indian Chemical Society, 2025, 102, 101909
DOI: 10.1016/j.jics.2025.101909

Nanoparticle-Enabled Photothermal Therapy Integrated with Gene Delivery, Immunotherapy, and Chemotherapy: A Comprehensive Review

Juyoung Hwang, Nuri Oh, Moon Sung Kang, Chung-Yul Yoo, Ji-Ho Park, Dong-Wook Han and Minseok Kwak

IJN, 2026, Volume 21, 1
DOI: 10.2147/IJN.S573093

Transforming Healthcare with Nanomedicine: A SWOT Analysis of Drug Delivery Innovation

Hao Zhang, Suping Li and Xingming Ma

DDDT, 2024, Volume 18, 3499
DOI: 10.2147/DDDT.S470210

Nanoparticle-enabled herbal therapeutics for wound healing: bridging traditional medicine and modern nanotechnology

Shrihari B. Patil, Priyanka P. Patil, Sourav D. Gore, Shashidhar C. Patil and Rahul Koli

Nano Trends, 2026, 13, 100170
DOI: 10.1016/j.nwnano.2025.100170

Theranostic Nanoparticles in Prostate Cancer: Disrupting Hypoxia‐Induced Glycolysis by Targeting Hypoxia‐Inducible Factor‐1 Alpha and Downstream Metabolites

Daniel Ejim Uti, Wilson Achu Omang, Esther Ugo Alum, Inalegwu Bawa, Okechukwu Paul‐Chima Ugwu, Ayodeji Oluwafemi Idowu, Item Justin Atangwho and Godwin Eneji Egbung

Cancer Medicine, 2026, 15
DOI: 10.1002/cam4.71519

Silica Nanoparticles: A Promising Vehicle for Anti-Cancer Drugs Delivery

T. Naga Aparna, Rohit Kumar, Shah Raj Ali, Dhaval J. Patel, Kazi Julekha, Touseef Begum, Jyoti Bala and Pawan Kumar

AAPS PharmSciTech, 2025, 26
DOI: 10.1208/s12249-024-02982-9

Preparation of spleen aminopeptide-loaded pH-responsive oral hydrogel microspheres for improving recurrent respiratory infection in children

Aqin Wang, Zhengbing Zhou, Zhou Hang, Zhengbing Lyu, Jingchun Yang, Lu Zhang, Meng Wang, Wei Liu, Liqiang Zou and Jun Yu

Sci Rep, 2026, 16
DOI: 10.1038/s41598-025-34890-8

Developments & Potential of Nanotechnology for the Detection and Treatment of Pancreatic Cancer

Danielle O'Meara and Clare Hoskins

IJN, 2026, Volume 21, 1
DOI: 10.2147/IJN.S559038

Nanomedicine-enabled epigenetic therapy for glioblastoma: Overcome the blood-brain barrier and therapeutic resistance

Qingxin Yang, Yuan Zhong, Shaoyu Cai, Zenghua Sheng, Da Sun, Peixing Chen, Yuanyuan Zhang, Jianshu Li, Wei Wu and Maolan Zhang

Nano Research, 2026, 19, 94908472
DOI: 10.26599/NR.2026.94908472

Zinc phthalocyanine loaded- antibody functionalized nanoparticles enhance photodynamic therapy in monolayer (2-D) and multicellular tumour spheroid (3-D) cell cultures

Nokuphila Winifred Nompumelelo Simelane and Heidi Abrahamse

Front. Mol. Biosci., 2024, 10
DOI: 10.3389/fmolb.2023.1340212

Enhanced Tumor Therapy Utilizing Lipid-Based Drug Delivery Systems

Yihyeon Kim, Chaeseon Kim, Hyun-Ouk Kim and Kwang Suk Lim

KSBB, 2025, 40, 1
DOI: 10.7841/ksbbj.2025.40.1.1

The potential of luteolin-conjugated mesoporous silica nanoparticles functionalized with folic acid in targeted cancer therapy in an in vitro model

Maryam Hosseini, Masoud Homayouni Tabrizi, Bita Behboodian and Mozhgan Soltani

Discov Onc, 2025, 16
DOI: 10.1007/s12672-025-03815-2

The phospholipid composition of artificial lipid droplets enhances their deliverability and facilitates a broad Biodistribution in vivo and in vitro

Z Telikani, I Amarasinghe, V Impicciche, A Nalbantlar, J Whan, K Caracciolo, JI Phillips, JL Dutton, LA Wallace, A Jamal, TA Gibson Hughes, KS Okuda, A Mechler, EA Monson and KJ Helbig

Acta Biomaterialia, 2025, 200, 520
DOI: 10.1016/j.actbio.2025.05.002

Hybrid Systems of Gels and Nanoparticles for Cancer Therapy: Advances in Multifunctional Therapeutic Platforms

Kibeom Kim

Gels, 2025, 11, 170
DOI: 10.3390/gels11030170

Synthesis of pH-responsive hollow molecularly imprinted polymers for enhanced doxorubicin delivery in cancer therapy

Hossein Hosseinzadeh, Arash Vahdatkhah, Siamak Javanbakht and Reza Mohammadi

Journal of Pharmaceutical Sciences, 2025, 114, 103993
DOI: 10.1016/j.xphs.2025.103993

Upconversion Nanoparticles with Mesoporous Silica Coatings for Doxorubicin Targeted Delivery to Melanoma Cells

Párástu Oskoei, Rúben Afonso, Verónica Bastos, João Nogueira, Lisa-Marie Keller, Elina Andresen, Maysoon I. Saleh, Bastian Rühle, Ute Resch-Genger, Ana L. Daniel-da-Silva and Helena Oliveira

Molecules, 2025, 31, 74
DOI: 10.3390/molecules31010074

Solid-Lipid Nanoparticle (SLN) Based Approaches for Enhancing the Therapeutic Efficacy of Anticancer Drugs in Targeting Gastrointestinal Malignancies

Milan Gaurav R and Ashwini Prabhu

J Pharm Innov, 2026, 21
DOI: 10.1007/s12247-025-10138-w

Artesunate loaded core-shell nanoplatform for the chemo-chemodynamic-photothermal synergistic cancer therapy

Zhaoyang Gan, Chang Liu, Shaopeng Li, Chengda Ju, Sixuan Huo, Jing Wang and Yulong Lin

Colloids and Surfaces B: Biointerfaces, 2025, 254, 114810
DOI: 10.1016/j.colsurfb.2025.114810

Exosome-Enhanced Sonodynamic Therapy in Cancer: Emerging Synergies and Modulation of the Tumor Microenvironment

Giulia Chiabotto, Marzia Conte and Valentina Cauda

Cancers, 2025, 18, 118
DOI: 10.3390/cancers18010118

Revisiting gold nanoshells as multifunctional biomedical nanotools

Antonio Topete, Alejandro Varela, Mariana Navarro-Real, Ramón Rial, Alberto Pardo and Pablo Taboada

Coordination Chemistry Reviews, 2025, 523, 216250
DOI: 10.1016/j.ccr.2024.216250

PLGA and cancer: a comprehensive patent-based review on the present state of art

Venessa Nath, Mohini Singh, Bani Kumar Jana, Tumpa Sarkar, Niva Rani Gogoi and Bhaskar Mazumder

Pharmaceutical Patent Analyst, 2024, 13, 201
DOI: 10.1080/20468954.2025.2470103

Nanocarriers as drug delivery system for chemotherapeutic agents: from inception to clinical implementation

Talha Zubair, Sheikh Arefin Rashid, Nishat Laila Bristy, Somnath Banik, Shanjida Sultana, Tanjum Jahan Mojumder, Rafsana Binte Ashraf and Abdullah-Al Masum

Drug Development and Industrial Pharmacy, 2025, 51, 1699
DOI: 10.1080/03639045.2025.2569572

A narrative review on the use of Green synthesized metallic nanoparticles for targeted cancer therapy

Prashant Kumar, Sumel Ashique, Himanshu Sharma, Sabina Yasmin, Anas Islam, Subhajit Mandal, B.H. Jaswanth Gowda, Mohammad Khalid, Mohammad Yousuf Ansari, Mansi Singh, Iman Ehsan, Tahreen Taj and Farzad Taghizadeh-Hesary

Bioorganic Chemistry, 2025, 157, 108305
DOI: 10.1016/j.bioorg.2025.108305

Nanocarrier-mediated cancer therapy with cisplatin: A meta-analysis with a promising new paradigm

Ranmali Ranasinghe, Michael Mathai, Mohammed Abdullah Alshawsh and Anthony Zulli

Heliyon, 2024, 10, e28171
DOI: 10.1016/j.heliyon.2024.e28171

Advancing pancreatic cancer therapy by mesothelin-specific nanobody conjugation

Soyeon Yi, Kyunghee Noh, Hyeran Kim, Eunkyeong Jung, Suhyeon Kim, Jieun Lee, Kyeonghye Guk, Jinsol Choi, Eun-Kyung Lim, Seokho Kim, Hwangseo Park, Jung Hwa Lim, Cho-Rok Jung, Taejoon Kang and Juyeon Jung

Mol Cancer, 2025, 24
DOI: 10.1186/s12943-025-02325-7

Bio-Functional Nanomaterials for Enhanced Lung Cancer Therapy: The Synergistic Roles of Vitamins D and K

Andreea Crintea, Camelia Munteanu, Tamás Ilyés, Ciprian N. Silaghi and Alexandra M. Crăciun

JFB, 2025, 16, 352
DOI: 10.3390/jfb16090352

An overview of advanced nanocarrier systems for Ibrutinib delivery: overcoming pharmacokinetic barriers and enabling targeted cancer therapy

Akshay Shetty, Mahesha Keerikkadu, Pragathi Devanand Bangera, Vamshi Krishna Tippavajhala and Mahalaxmi Rathnanand

International Journal of Pharmaceutics: X, 2025, 10, 100417
DOI: 10.1016/j.ijpx.2025.100417

Genetic-bioengineering of nanotechnology in cell-specific pharmaceutical targeting: Biological, pharmacological, and biochemical impact of nanomaterials-based breast cancer therapies

Javad Mohammadi, Sina Ebrahimi, Maryam Ghodousi, Mohammadreza Mahmoodi, Ali Hheidari, Esmail Pishbin, Zelal Kharaba, Abbas Rahdar and Luiz Fernando Romanholo Ferreira

Journal of Drug Delivery Science and Technology, 2024, 101, 106249
DOI: 10.1016/j.jddst.2024.106249

Advances in research on flavonoids in tumor immunotherapy (Review)

Chaoguang Yan and Guangchun Wang

Mol Med Rep, 2025, 31, 1
DOI: 10.3892/mmr.2025.13515

Nanoparticles in agriculture: balancing food security and environmental sustainability

Saburi Abimbola Atanda, Rafiu Olarewaju Shaibu and Foluso Oyedotun Agunbiade

Discov Agric, 2025, 3
DOI: 10.1007/s44279-025-00159-x

Lab-on-a-Chip and Microfluidics Technologies for Nano Drug Delivery

Bochun Guo, Yuchao Zhao and Xunli Zhang

Bioengineering, 2026, 13, 363
DOI: 10.3390/bioengineering13030363

Nanomedicines: Emerging Platforms in Smart Chemotherapy Treatment—A Recent Review

Mosab Arafat, Molham Sakkal, Rami Beiram and Salahdein AbuRuz

Pharmaceuticals, 2024, 17, 315
DOI: 10.3390/ph17030315

Recent trends on polycaprolactone as sustainable polymer-based drug delivery system in the treatment of cancer: Biomedical applications and nanomedicine

Mohammad Adnan Raza, Mukesh Kumar Sharma, Kushagra Nagori, Parag Jain, Vijayalakshmi Ghosh, Umesh Gupta and Ajazuddin

International Journal of Pharmaceutics, 2024, 666, 124734
DOI: 10.1016/j.ijpharm.2024.124734

DFT and Molecular Docking Study of HA-Conjugated SWCNTs for CD44-Targeted Delivery of Platinum-Based Chemotherapeutics

Muhammad Uzair Khan, Ishrat Jabeen, Abdulhamid Althagafi, Muhammad Umar Farooq, Moussab Harb and Bassim Arkook

Pharmaceuticals, 2025, 18, 805
DOI: 10.3390/ph18060805

Redefining Chemoresistance: Natural Bioactives as Molecular Modulators at the Cancer–Tumor Microenvironment Interface

Claudia Reytor-González, Emilia Jiménez-Flores, Natalí González and Daniel Simancas-Racines

IJMS, 2025, 26, 8037
DOI: 10.3390/ijms26168037

Green synthesis of copper nanoparticles: a promising solution for drug resistance and cancer therapy challenges

Anand G. Krishna, S. Sahana, H. Venkatesan and Vettrivel Arul

J Egypt Natl Canc Inst, 2024, 36
DOI: 10.1186/s43046-024-00254-y

Histotripsy: A Promising Modality for Cancer Treatment

Ashish Kumar Parashar, Lalit Kumar Tyagi and Vandana Arora

CCTR, 2025, 21, 1030
DOI: 10.2174/0115733947330950240906075443

Ferroptosis in liver fibrosis and its potential intervention strategy

Wanchun Zhu, Lihong Fu, Yu Cui, Yiwen Tang, Kun Liu, Lei Shi, Yueqiu Gao, Man Li and Lingying Huang

Cell Biol Toxicol, 2025, 41
DOI: 10.1007/s10565-025-10111-w

Cathepsin B-Responsive Nanocarriers: Silica and Liposomes for Precision Cancer Therapy

Sumiya Iqbal, Niklas Schlensog, Valerie Tan Shu Li, Shaista Ilyas and Sanjay Mathur

ACS Appl. Bio Mater., 2026
DOI: 10.1021/acsabm.5c02219

Molecular Gold Nanoclusters for Advanced NIR-II Bioimaging and Therapy

Ani Baghdasaryan and Hongjie Dai

Chem. Rev., 2025, 125, 5195
DOI: 10.1021/acs.chemrev.4c00835

Targeted drug delivery strategies for oral cancer: the role of liposomes in drug delivery systems

Elham Saberian, Faezeh Amiri, Parizad Ghanbarikondori, Ali Heidari, Hadi Zare-Zardini, Mahyar Khanlari goodarzi, Tahere Mokhtari, Amir Mohammad Karimi Forood and Meysam Ebrahimi far

BioMed Eng OnLine, 2026, 25
DOI: 10.1186/s12938-026-01531-8

KCNN4 as a genomic determinant of cytosolic delivery by the attenuated cationic lytic peptide L17E

Masashi Kuriyama, Hisaaki Hirose, Yoshimasa Kawaguchi, Junya Michibata, Masashi Maekawa and Shiroh Futaki

Molecular Therapy, 2025, 33, 595
DOI: 10.1016/j.ymthe.2024.12.050

Stimuli-responsive smart materials: Bridging the gap between biotechnology and regenerative medicine

Karthik K. Karunakar, Binoy Varghese Cheriyan, Ragavendran Anandakumar, Akshaya Murugathirumal, Abinaya Senthilkumar, J. Nandhini, Kunal Kataria and Lincy Yabase

Bioprinting, 2025, 48, e00415
DOI: 10.1016/j.bprint.2025.e00415

Recent Advances in the Use of Vitamin D Organic Nanocarriers for Drug Delivery

Ioanna Aggeletopoulou, Maria Kalafateli, Georgios Geramoutsos and Christos Triantos

Biomolecules, 2024, 14, 1090
DOI: 10.3390/biom14091090

Nanotechnology-Based Strategies for Safe and Effective Immunotherapy

Seeun Hong, Juwon Park, Yoojeong Oh, Hanhee Cho and Kwangmeyung Kim

Molecules, 2024, 29, 5855
DOI: 10.3390/molecules29245855

Bioinformatics-Driven Engineering of ROS-Responsive Dextran-block-Poly(propylene sulfide) Nanoparticles Functionalized with Folic Acid for Targeted Prostate Cancer Therapy

Yixun Zhang, Zhenguo Liang, Zeheng Tan, Jundong Lin, Xinqing Jiang, Xin Zhou, Yangjia Zhuo, Fen Zou, Ronghua Yang, Weide Zhong and Huikang Yang

ACS Omega, 2025, 10, 24601
DOI: 10.1021/acsomega.5c01372

Biobased Nanomaterials in Drug Delivery System: Current Trends and Future Prospectives

Alebachew Molla

NANO, 2025, 13, 35
DOI: 10.11648/j.nano.20251302.12

Progress in Nanocarriers‐Based Approaches for the Delivery of Tyrosine Kinase Inhibitors in Bone Cancer: Trends and Prospects

Dexin Xu, Wenbin Zhang, Yinping Pan, Wenhai Wang, Dongna Wang and Jian Ding

IUBMB Life, 2025, 77
DOI: 10.1002/iub.70052

Studying the wound healing property of biologically and chemically synthesized gold nanoparticles through scratch assay and neural network modeling

Anjana S. Desai, Aparna Ashok, Shivali A. Wagle, Neeru Bhagat, Zhadyra Ashirova, Zhanna T. Abdrassulova, Nurshat Abdolla, Zhazira Mukazhanova, Alibek Ydyrys and Ainur Seilkhan

Adv Compos Hybrid Mater, 2025, 8
DOI: 10.1007/s42114-024-01133-9

Alantolactone as a Bioactive Sesquiterpene Lactone: Molecular Mechanisms and Anticancer Potential for Pharmaceutical Development

Alice Njolke Mafe, Lipana Dorcas Bappa, Javad Sharifi‐Rad, William N. Setzer and Daniela Calina

Archiv der Pharmazie, 2025, 358
DOI: 10.1002/ardp.70170

PEGylated dendrimers for precision cancer therapy: Advances in tumor targeting, drug delivery, and clinical translation

Prashant Kesharwani, Vivek Puri, Taha Alqahtani, Humood Al Shmrany, Garima Gupta, Khang Wen Goh and Amirhossein Sahebkar

Biomaterials Advances, 2026, 179, 214493
DOI: 10.1016/j.bioadv.2025.214493

From Pioneering Discoveries to Innovative Therapies: A Journey Through the History and Advancements of Nanoparticles in Breast Cancer Treatment

Fatemah Basingab, Omniah Alshahrani, Ibtehal Alansari, Nada Almarghalani, Nada Alshelali, Abeer Alsaiary, Najwa Alharbi and Kawther Zaher

BCTT, 2025, Volume 17, 27
DOI: 10.2147/BCTT.S501448

Synergistic effect of DR5-targeted capsules loaded with doxorubicin in drug-resistant 3D tumour spheroids

Daria Trushina, Anastasia Gileva, Anne Yagolovich, Marine Gasparian, Leyli Kurbanova, Sergey Burov, Tatiana Bukreeva, Tatiana Pallaeva, Vladimir Artemov, Vladimir Oleinikov and Elena Markvicheva

Journal of Microencapsulation, 2025, 42, 736
DOI: 10.1080/02652048.2025.2570651

Overview of drug-loaded lactoferrin nanoparticles in lung cancer therapy

Zainab Sabri Abbas, Zaizafoon N. Nasif and Amer T. Tawfeeq

Next Nanotechnology, 2025, 8, 100302
DOI: 10.1016/j.nxnano.2025.100302

Moving beyond traditional therapies: the role of nanomedicines in lung cancer

Jingjing Zhang, Yanzhi Li, Sa Guo, Weifen Zhang, Bing Fang and Shaohui Wang

Front. Pharmacol., 2024, 15
DOI: 10.3389/fphar.2024.1363346

Scorpion Venom Neurotoxins: Molecular Diversity, Mechanisms, and Drug Scaffolds

Yun Huang, Peter Muiruri Kamau, Jiamin Wang, Mingyue Gao and Bowen Li

Toxins, 2026, 18, 25
DOI: 10.3390/toxins18010025

Comprehensive Analysis of CD44 in Colorectal Cancer: Molecular Mechanisms, Isoform Interactions, and Targeted Treatments to Address Tumorigenesis and Chemoresistance

Megha Jha, Sankha Bhattacharya, Girdhari Lal Gupta, Bhupendra Prajapati and Devesh U. Kapoor

Cancer Biotherapy and Radiopharmaceuticals, 2025
DOI: 10.1177/10849785251381993

Magnetically Controlled Nanocarriers for Site-Specific Drug Delivery and Theranostics in Cancer Precision Medicine

Loushambam Samananda Singh, Chabungbam Satyananda Singh and Thounaojam Premlata

Mol Imaging Biol, 2026
DOI: 10.1007/s11307-026-02097-6

Antarctic marine sediment as a source of filamentous fungi-derived antimicrobial and antitumor compounds of pharmaceutical interest

Karine Fernandes Camacho, Layssa de Melo Carlos, Suzan Prado Fernandes Bernal, Valéria M. de Oliveira, Jorge Luiz Maria Ruiz, Júlia Ronzella Ottoni, Rosemary Vieira, Arthur Neto, Luiz Henrique Rosa and Michel Rodrigo Zambrano Passarini

Extremophiles, 2024, 28
DOI: 10.1007/s00792-024-01339-1

Recent advances in polymer-based nanoparticles: current strategies and translational challenges in cancer therapy

Kumar Janakiraman, Vaidevi Sethuraman, Venkateshwaran Krishnaswami and Geethanjali Sampath

Journal of Chemotherapy, 2025, 1
DOI: 10.1080/1120009X.2025.2573516

Multiscale physics-based in silico modelling of nanocarrier-assisted intravascular drug delivery

Nicolae-Viorel Buchete, Iwona Cicha, Sutapa Dutta and Panagiotis Neofytou

Front. Drug Deliv., 2024, 4
DOI: 10.3389/fddev.2024.1362660

Functionalized Polymeric Micelles for Targeted Cancer Therapy: Steps from Conceptualization to Clinical Trials

Ana Serras, Célia Faustino and Lídia Pinheiro

Pharmaceutics, 2024, 16, 1047
DOI: 10.3390/pharmaceutics16081047

Combining ultrasound technology with targeted fucoidan/arginine-gelatin nanoparticles loaded with doxorubicin to enhance therapeutic efficacy and modulate bioeffects in drug-resistant triple-negative breast cancer

Chi-Huang Hsiao, Hau-Lun Huang, Hao-Li Liu, Chieh-Cheng Huang, Jung-Chen Su, Yi-Hsuan Chen and Yu-Hsin Lin

International Journal of Biological Macromolecules, 2024, 283, 137764
DOI: 10.1016/j.ijbiomac.2024.137764

Transforming cancer detection and treatment with nanoflowers

Bhupendra G. Prajapati, Kanika Verma, Swapnil Sharma and Devesh U. Kapoor

Med Oncol, 2024, 41
DOI: 10.1007/s12032-024-02530-2

From Nature to Nanomedicine: Enhancing the Antitumor Efficacy of Rhein, Curcumin, and Resveratrol

Ana-Maria Trofin, Dragoș Viorel Scripcariu, Silviu-Iulian Filipiuc, Anca-Narcisa Neagu, Leontina-Elena Filipiuc, Bogdan-Ionel Tamba, Madalina Maria Palaghia and Cristina Mariana Uritu

Medicina, 2025, 61, 981
DOI: 10.3390/medicina61060981

Nanotechnology-enhanced delivery of α- and β-mangostins for cancer therapy: mechanistic insights and clinical perspectives

Lutfun Nahar, Rawiwan Charoensup, Kulyash Kaliyeva, Daijie Wang, Emran Habibi, Thidarat Duangyod, Chuanchom Khuniad, Wallapa Choeibuakaew, Namfa Sermkaew, Nuttapon Songnaka, Jibo Ren, Xuelin Wang, Rajat Nath, Anupam D. Talukdar, Shaden A. M. Khalifa, Hesham R. El-Seedi, Mingquan Guo and Satyajit D. Sarker

Phytochem Rev, 2025
DOI: 10.1007/s11101-025-10130-9

Recent advances in nanotechnology-based diagnosis and treatment of bladder cancer: an updated review

Keyao Hu, Yanfang Cui, Ning Li, Peng Li, Xiaofei Wang and Jianfeng Chu

International Journal of Smart and Nano Materials, 2025, 16, 309
DOI: 10.1080/19475411.2025.2493656

Breakthroughs in nanoparticle-based strategies for pancreatic cancer therapy

Sara Escalera-Anzola, Maria Rosado, Yuchen Yang, Daniel Parra-Sanchez, Carolina San Pedro-Liberal and Pilar Acedo

Biochemical Pharmacology, 2025, 232, 116685
DOI: 10.1016/j.bcp.2024.116685

Fabrication of targeted PDA-Hemin-Dox-FA nanoplatform for enhanced chemodynamic therapy synergized with chemo/photothermal therapy

Yue Wang, Nannan Zheng, Zhaolei Zhang, Hongchao Ma and Yanhui Wei

Colloids and Surfaces A: Physicochemical and Engineering Aspects, 2023, 679, 132620
DOI: 10.1016/j.colsurfa.2023.132620

Synergistic Cytotoxicity of Nano-titanium Dioxide and Phthalocyanine on HepG2 Cells via Sonophotodynamic Therapy

Adem Yavaş, Ömer Kesmez, Feride Demir and Mehran Aksel

Biol Trace Elem Res, 2025, 204, 25
DOI: 10.1007/s12011-025-04660-8

Hairpin DNA-functionalized gold nanoparticles for diagnostic imaging and overcoming doxorubicin resistance: Enhanced drug loading and cytotoxicity based on thermodynamic guidance

Jie Liu, Xiangtai Wang, Lixia Yuan, Yanna Zhao, Yongfang Zhang, Yushu Wu and Min Liu

Journal of Molecular Structure, 2025, 1337, 142264
DOI: 10.1016/j.molstruc.2025.142264

Biosurfactant Nanomicelles and Peptide Integration: Novel Approaches to Targeted Gene Delivery in Colon Cancer Treatment

Sankha Bhattacharya, Devendra Kumar, Bhuphendra G. Prajapati and Md Meraj Anjum

CMC, 2025, 32, 5493
DOI: 10.2174/0109298673312968240803104252

Enhancing stability, bioavailability and nutritional intervention effect of procyanidins using bio-based delivery systems: A review

Shanshan Tie, Mengmeng Xue, Yannan Chen, Ying Wu, Shaobin Gu and Mingqian Tan

International Journal of Biological Macromolecules, 2025, 287, 138517
DOI: 10.1016/j.ijbiomac.2024.138517

Cytotoxicity of Nanocarrier-Based Drug Delivery in Oral Cancer Therapy: A Systematic Review and Meta-Analysis

Mohammad A. Saghiri, Ravinder S. Saini and Artak Heboyan

Cancer Control, 2025, 32
DOI: 10.1177/10732748241310936

Immunomodulatory nanoplatforms with multiple mechanisms of action in cancer treatment

Rodolfo Villa, Ya-Ping Shiau, Sohaib Mahri, Kelsey Jane Racacho, Menghuan Tang, Qiufang Zong, Donovan Ruiz, Judy Kim and Yuanpei Li

Nanomedicine, 2025, 20, 1321
DOI: 10.1080/17435889.2025.2500906

Nanobubbles: An emerging therapeutic paradigm for targeted cancer therapy

Soumya Sarkar, Joy Das, Biplab Debnath, Mohhammad Ramzan, Sumel Ashique and Farzad Taghizadeh-Hesary

Bioorganic Chemistry, 2025, 164, 108927
DOI: 10.1016/j.bioorg.2025.108927

Imaging cells and nanoparticles using modulated optically computed phase microscopy

Xuan Liu, Rupak Bhakta, Emily Kryvorutsky and Yuanwei Zhang

Sci Rep, 2025, 15
DOI: 10.1038/s41598-025-86377-1

Tangeretin, a natural flavonoid with promising anticancer effects: A comprehensive review

Olalekan Bukunmi Ogunro, Oladimeji Taiwo Babatunde and Olufemi Samuel Araoyinbo

Pharmacological Research - Natural Products, 2025, 8, 100287
DOI: 10.1016/j.prenap.2025.100287

New dual-targeted PEI-coated core-shell nanocapsules for simultaneous delivery of doxorubicin and metformin as therapeutic and cardioprotective agents for hepatocellular carcinoma treatment

Ellen Youssef, Amira Mansour and Ibrahim M. El-Sherbiny

Journal of Drug Delivery Science and Technology, 2026, 115, 107653
DOI: 10.1016/j.jddst.2025.107653

Coordination-driven design of molecularly imprinted polymer (MIP) architectures integrated with metal–organic frameworks (MOFs) for cancer therapy

Tahereh Nasiriani, Arash Fattah-alhosseini, Payam Veisi, Murad M. Abualrejal, Burak Dikici and Mosab Kaseem

Coordination Chemistry Reviews, 2026, 557, 217744
DOI: 10.1016/j.ccr.2026.217744

Tryptophan-Conjugated Carbon Dots with Enhanced Cellular Uptake as a Potential Drug Delivery System for Melanoma

Nasrin Imumkachi, Pornpattra Rattanaseth, Sawinee Ngernpimai, Janpen Thonghlueng, Piyaporn Matulakul, Pakawat Toomjeen, Theerapong Puangmali, Raynoo Thanan, Tawut Rudtanatip, Natthida Weerapreeyakul and Chadamas Sakonsinsiri

ACS Appl. Bio Mater., 2025, 8, 11047
DOI: 10.1021/acsabm.5c01730

Stimuli-responsive liposomes and niosomes in leukemia therapy: targeted delivery and clinical translation

Anil Pareek, Ali M. Alaseem, Glowi Alasiri, Devesh U. Kapoor and Bhupendra G. Prajapati

International Journal of Pharmaceutics, 2025, 684, 126169
DOI: 10.1016/j.ijpharm.2025.126169

Advanced Nanomaterials for Cancer Therapy: Gold, Silver, and Iron Oxide Nanoparticles in Oncological Applications

Priyanka Singh, Santosh Pandit, Sri Renukadevi Balusamy, Mukil Madhusudanan, Hina Singh, H. Mohamed Amsath Haseef and Ivan Mijakovic

Adv Healthcare Materials, 2025, 14
DOI: 10.1002/adhm.202403059

Impact of lactate on immune cell function in the tumor microenvironment: mechanisms and therapeutic perspectives

Xuan-Yu Gu, Jia-Li Yang, Rui Lai, Zheng-Jun Zhou, Dan Tang, Long Hu and Li-Jin Zhao

Front. Immunol., 2025, 16
DOI: 10.3389/fimmu.2025.1563303

Surface engineering of nanoparticles for precision medicine

Jiaxi Zheng, Yuji Sun, Youqing Shen and Zhuxian Zhou

Precision Medicine and Engineering, 2025, 2, 100037
DOI: 10.1016/j.preme.2025.100037

Multifunctional chitosan–doxorubicin nanocarriers: advancing targeted breast cancer chemotherapy

Gaurav Mishra, Muskan Leharwani, Taha Alqahtani, Humood Al Shmrany, Garima Gupta, Amirhossein Sahebkar, Umesh Kumar Patil and Prashant Kesharwani

Mol Cancer, 2026
DOI: 10.1186/s12943-026-02639-0

Overcoming Cancer Drug Resistance with Nanoparticle Strategies for Key Protein Inhibition

Hyeonji Yoo, Yeonjin Kim, Jinseong Kim, Hanhee Cho and Kwangmeyung Kim

Molecules, 2024, 29, 3994
DOI: 10.3390/molecules29173994

Recent Advances in Supramolecular Systems for Precision Medicine: Structural Design, Functional Integration, and Clinical Translation Challenges

Xiaomin Ma, Yazhe Xiao, Shuyu Li, Jianghai Du, Junjie Wang and Xingzhou Peng

Pharmaceutics, 2025, 17, 1192
DOI: 10.3390/pharmaceutics17091192

Nanostructured lipid carriers in cancer therapy: Advances in passive and active targeting strategies

Dana Alkhamach, Saeed Ahmad Khan, Khaled Greish, Hatem A.F.M. Hassan and Mohamed Haider

International Journal of Pharmaceutics, 2025, 678, 125736
DOI: 10.1016/j.ijpharm.2025.125736

Advancing Breast Cancer Therapeutics: Targeted Gene Delivery Systems Unveiling the Potential of Estrogen Receptor-Targeting Ligands

Jung Ro Lee, Young-Min Kim, Eun-Ji Kim, Mi-Kyeong Jang and Seong-Cheol Park

Biomater Res, 2024, 28
DOI: 10.34133/bmr.0087

Polyethylene Glycol–Based Polymer-Drug Conjugates: Novel Design and Synthesis Strategies for Enhanced Therapeutic Efficacy and Targeted Drug Delivery

Vinay Sagar Verma, Aakansha Pandey, Arvind Kumar Jha, Hemant Kumar Ramchandra Badwaik, Amit Alexander and Ajazuddin

Appl Biochem Biotechnol, 2024, 196, 7325
DOI: 10.1007/s12010-024-04895-6

Current status and prospects for improved targeted delivery approaches for cancer

Sofiene Mansouri, Yousef Alharbi and Abdulrahman Alqahtani

Pathology - Research and Practice, 2024, 253, 154993
DOI: 10.1016/j.prp.2023.154993

Synthesis, characterisation, and anti-tumour activity of nano-immuno-conjugates for enhanced photodynamic therapy of oesophageal cancer stem cells

Onyisi Christiana Didamson, Rahul Chandran and Heidi Abrahamse

Biomedicine & Pharmacotherapy, 2024, 181, 117693
DOI: 10.1016/j.biopha.2024.117693

Biobased Organic Nanoparticles: A Promising Versatile Green Tool for Novel Antimicrobial Agents for Improved Safety

Edith Dube, Grace Emily Okuthe and Swarup Roy

International Journal of Food Science, 2025, 2025
DOI: 10.1155/ijfo/7955106

An analytical review of the therapeutic application of recent trends in MIL-based delivery systems in cancer therapy

Mohammad Beiranvand and Gholamreza Dehghan

Microchim Acta, 2025, 192
DOI: 10.1007/s00604-024-06944-7