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N-2,2,2-Trifluoroethylisatin ketimine as a 1,2-dipolarophile for [3 + 2]-addition to access optically pure spirothiazolidine oxindoles

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DBU-catalyzed diastereoselective 1,3-dipolar [3+2] cycloaddition of trifluoroethyl amine-derived isatin ketimines with chalcones: synthesis of 5′-CF3-substituted 3,2′-pyrrolidinyl spirooxindoles

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Organocatalytic enantioselective assembly of dispiro-bisoxindoles with vicinal stereocenters

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Metal catalyzed asymmetric 1,3-dipolar cycloaddition of azomethine ylides: structural diversity at the dipole partner

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Synthesis of benzofuranyl indolinones and benzonaphthoxazepinones via reaction of sulfonyl phthalide with nitroisatylidenes

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Asymmetric synthesis of spiro[benzofuran-pyrrolidine]-indolinedione via bifunctional urea catalyzed [3 + 2]-annulation

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Recent Advances in Diazophosphonate Chemistry: Reactions and Transformations

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Construction and Antifungal Activity Study of Trifluoroacetyl Substituted Spiro Indolinone-Hexahydropyrrolizine Derivatives

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Chinese Journal of Organic Chemistry, 2025, 45, 3378
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Defluorinative Hydroxylation Promoted by Silica to Access Optically Pure Hexahydrofuranocarbazole via [4+2] Addition Reaction

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Integrating Catalysis and Analysis: Accelerated Asymmetric Reaction Development With a Multitasking Reactivity Umpolung/Chiroptical Reporter Auxiliary

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Photochemical Direct Mono/Di/Trifluoro‐Functionalization of Quinoxalin‐2(1H)‐ones

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Design, synthesis, crystal structure analysis, Hirshfeld surface scrutiny, and DFT-calculations of fused 4H-pyrans and spirooxindole-embedded fused pyran

Naveena S. Veeranagaiah, Biplob Borah, Raghavaiah Pallepogu and L. Raju Chowhan

Journal of Molecular Structure, 2025, 1347, 143249
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Recent advances in palladium-catalyzed cyclizations for the synthesis of spirooxindoles

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DMAP‐Catalyzed Efficient Diastereo‐ and Regioselective Synthesis of Isoxazolone‐Based Bisspiroheterocyclic Oxindoles

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Eur J Org Chem, 2024, 27
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Green Synthesis of Spiroindole Derivatives: Biological Evaluation and in Silico Studies

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Asymmetric Cycloaddition of N-2,2,2-Trifluoroethylisatin Ketimines and Unsymmetrical Dicarbonyl-Activated Alkenes: Construction of 5′-Trifluoromethylated 3,2′-Pyrrolidinyl Spirooxindoles with Three Carbonyl Groups

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J. Org. Chem., 2024, 89, 12924
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Dinuclear Zinc Catalyzed [3+2] Annulation of Benzylideneindolinones Access to CF3‐Containing 2,3‐Pyrrolidinyl Dispirooxindoles

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Engaging Isatins and Amino Acids in Multicomponent One-Pot 1,3-Dipolar Cycloaddition Reactions—Easy Access to Structural Diversity

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Aminocatalytic, Stereoselective Synthesis of Tetrahydrocarbazole Spiropyrazolones via Remote [4 + 2] Annulation of Indole Tethered Enal With Olefinic Pyrazolones

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ChemistrySelect, 2025, 10
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Base-mediated [3 + 2] cyclization/rearrangement of N-2,2,2-trifluoroethylisatin ketimines with diethyl azodicarboxylate for construction of spirooxindoles containing trifluoromethyl-1,2,4-triazoles

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Journal of Fluorine Chemistry, 2025, 285-286, 110452
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Michael Addition/Hemiketalization Cascade Reaction Between β-Dicarbonyl Compounds and Isatin-Derived α,β-Unsaturated Ketones to Construct 3,4'-Pyran-spirooxindoles

Mingmei Zhang, Feng Sha and Xin-Yan Wu

Chinese Journal of Organic Chemistry, 2025, 45, 1369
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P53: A key player in diverse cellular processes including nuclear stress and ribosome biogenesis, highlighting potential therapeutic compounds

Gazmend Temaj, Silvia Chichiarelli, Pelin Telkoparan-Akillilar, Sarmistha Saha, Nexhibe Nuhii, Rifat Hadziselimovic and Luciano Saso

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Highly Diastereoselective Hydroxy-Aza-Prins Cyclization: Rapid Access to 4′-Hydroxy Six-Membered Spiro Azacyclic Oxindoles

Hoe Young Choi, Chan Su Jang, Jaehwan Kim and Haye Min Ko

J. Org. Chem., 2025, 90, 18033
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Lewis Base-Mediated [3 + 3] Cycloaddition of N-2,2,2-Trifluoroethylisatin Ketimines with Diazo Esters: Synthesis of Trifluoromethyl-1,2,4-triazine-spirooxindoles

Liangjun Chen, Fei Xu, Xiaopeng Qiu, Yan Fu, Wenhe Shi, Yuwei Zheng, Yiran Wang, Lei Wang, Ruijuan Xing, Jianmin Gu and Ran Guo

J. Org. Chem., 2026, 91, 4377
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Ag‐Catalyzed Asymmetric 1,3‐Dipolar Cycloaddition of N‐2,2,2‐Trifluoroethylisatin Ketimines with Conjugated Exocyclic Double Bonds: Access to Pyrrolidines with Four Consecutive Stereocenters Including Two Adjacent Spiro‐Quaternary Centers

Ji‐Hong Liu, Yan‐Ping Zhang, Zhen‐Hua Wang, Ji‐Hong Lu, Lei Yang, Yong You, Jian‐Qiang Zhao, Ming‐Qiang Zhou and Wei‐Cheng Yuan

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C3-Spirooxindoles: Divergent chemical synthesis and bioactivities (2018–2023)

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Bioorganic Chemistry, 2024, 143, 107091
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Photochemical Multicomponent Synthesis of Six‐Membered Heterocycles

Biplob Borah, Mihir Patat and L. Raju Chowhan

Eur J Org Chem, 2025, 28
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Copper-Catalyzed Asymmetric [3 + 2] Cycloaddition of N-2,2,2-Trifluoroethylisatin Ketimines to Access Three Classes of Polyfunctionalized Spiro-Pyrrolidine–Oxindole Motifs

Wen-Feng Xu, Ren-Xu Xiao, Shuo Lv, Xing-Yue Li, Ming-Xing Lan, Xue-Qing Mou, Yun Zhang, Yong-Zheng Chen and Bao-Dong Cui

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