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Fan Zhang, Di Zhao, Yuzhu Wu and Lei Li

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Synthetic-bioinformatic natural product-inspired peptides

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Production of subtilosin A in E. coli: insights into the head-to-tail macrocyclization

Yifei Jia, Yuanjun Han, Wenning Wang and Qi Zhang

Org. Biomol. Chem., 2025, 23, 6694
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Iterative acylation on mature lasso peptides by widespread acetyltransferases

Jiang Xiong, Shanquan Wu, Zi-Qi Liang, Shuo Fang, Fen-Yu Tao, Xiao-Tong Gong, Xing Wu, Qingfeng Wu, Jiao-Jiao Cui, Kun Gao, Kin Kuan Hoi, Yong Peng, Shangwen Luo, Dongsheng Lei and Shi-Hui Dong

Nat Chem Biol, 2026
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Amphibian skin bacteria contain a wide repertoire of genes linked to their antifungal capacities

Francisco González-Serrano, Yordan J. Romero-Contreras, Alberto H. Orta, M. Delia Basanta, Hugo Morales, Gabriela Sandoval García, Elena Bello-López, A. S. Escobedo-Muñoz, Víctor H. Bustamante, Víctor Ávila-Akerberg, Miguel Ángel Cevallos, Mario Serrano and Eria A. Rebollar

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Discovery and Heterologous Expression of Trilenodin, an Antimicrobial Lasso Peptide with a Unique Tri‐Isoleucine Motif

Conor Pulliam, Dan Xue, Andrew Campbell, Ethan Older and Jie Li

ChemBioChem, 2024, 25
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Gymnopeptides C and D, Highly N-Methylated Fungal Cyclopeptides

Márton Weber, Miklós Dékány, Andrea Nedves Nagyné, Csenge Anna Felegyi-Tóth, Suratno Suratno, Balázs Krámos, Enikő Bodó, Zoltán Béni and Attila Ványolós

J. Nat. Prod., 2025, 88, 644
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Targeted Peptide Modification Using an Engineered Bacterial N-Glycosyltransferase

Ayoola B. Smith and Jonathan R. Chekan

ACS Catal., 2024, 14, 12875
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Advancing Africa’s bioeconomy and biosolutions through microbial natural product discovery: unlocking indigenous microbe potential for sustainability

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Microbiol Mol Biol Rev, 2026, 90
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Leader-Independent C-Terminal Modification by a Radical S-Adenosyl-l-methionine Maturase Enables Macrocyclic GLP-1-Like Peptides

Jacob K. Pedigo, Karsten A. S. Eastman and Vahe Bandarian

ACS Bio Med Chem Au, 2025, 5, 1007
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Biosynthesis of Antimicrobial Ornithine-Containing Lacticin 481 Analogues by Use of a Combinatorial Biosynthetic Pathway in Escherichia coli

Yanli Xu, Roos Reuvekamp and Oscar P. Kuipers

ACS Synth. Biol., 2024, 13, 4209
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Engineering RiPP pathways: strategies for generating complex bioactive peptides

Ayoola B. Smith, Renee C. Ejindu and Jonathan R. Chekan

Trends in Biochemical Sciences, 2025, 50, 495
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A broad-spectrum lasso peptide antibiotic targeting the bacterial ribosome

Manoj Jangra, Dmitrii Y. Travin, Elena V. Aleksandrova, Manpreet Kaur, Lena Darwish, Kalinka Koteva, Dorota Klepacki, Wenliang Wang, Maya Tiffany, Akosiererem Sokaribo, Xuefei Chen, Zixin Deng, Meifeng Tao, Brian K. Coombes, Nora Vázquez-Laslop, Yury S. Polikanov, Alexander S. Mankin and Gerard D. Wright

Nature, 2025, 640, 1022
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Systematic characterization of horizontally transferred biosynthetic gene clusters in the human gut microbiota using HTBGC‐Finder

Jiacheng Wu, Xiao Yang, Lanlan Zhao, Ziyun Li, Guoping Zhao and Lei Zhang

iMetaOmics, 2025, 2
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Strategies Used for the Discovery of New Microbial Metabolites with Antibiotic Activity

Pablo Dasí-Delgado, Cecilia Andreu and Marcel·lí del Olmo

Molecules, 2025, 30, 2868
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Bacterial Cytochrome P450 Catalyzed Macrocyclization of Ribosomal Peptides

Jing Liu, Runze Liu, Bei-Bei He, Xiaoqian Lin, Longcheng Guo, Gengfan Wu and Yong-Xin Li

ACS Bio Med Chem Au, 2024, 4, 268
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Overview of Peptides and Their Potential Roles in Skin Health and Beauty

Leyang Wang, Zhijing Wu, Xinyu Wang, Xiaoli Wang, Jingzhuo Mao, Yan Yan, Lu Zhang and Zhuzhen Zhang

Journal of Peptide Science, 2025, 31
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Methyltransferases from RiPP pathways: shaping the landscape of natural product chemistry

Maria-Paula Schröder, Isabel P-M Pfeiffer and Silja Mordhorst

Beilstein J. Org. Chem., 2024, 20, 1652
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Whole-genome analysis of Lysinibacillus boronitolerans MSR1: A dairy-isolated multidrug-resistant and non-pathogenic strain

Md. Shahedur Rahman, Md. Tofidul Islam, Mahadi Hasan, Md. Tariquzzaman, Nure Sharaf Nower Samia, Md. Mahfuzur Rahman, Mustafizur Rahman and Rajesh Singh Rathore

PLoS One, 2025, 20, e0333844
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Fungal RiPPs Side Chain Macrocyclization Catalyzed by Copper-Dependent DUF3328 Enzyme

Chen-Yu Chiang, Masao Ohashi and Yi Tang

J. Am. Chem. Soc., 2025, 147, 8113
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Balgacyclamide A: Structural Revision of the First Reported Total Synthesis and Evaluation of Oxazoline Synthesis via β‐Hydroxy Amides Dehydrative Cyclization Conditions

Arnaldo X. Torres‐Hernandez, Prathibha Desman and Ryan J. Rafferty

Chemistry A European J, 2025
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Elucidating Leader Peptide–Enzyme Dynamics in Lactazole Biosynthesis Using mRNA Display

EuTchen Ang, Jun Shi Chang, Wei-En Huang, Sven Ullrich, Alexander A. Vinogradov and Hiroaki Suga

J. Am. Chem. Soc., 2026, 148, 2890
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Copper-Dependent Oxidase Catalyzes Aryl Cross-Coupling in the Biosynthesis of a Minimal Ribosomally Derived Natural Product

Chen-Yu Chiang, Masao Ohashi and Yi Tang

J. Am. Chem. Soc., 2025, 147, 48311
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A multi-iron enzyme installs copper-binding oxazolone/thioamide pairs on a nontypeable Haemophilus influenzae virulence factor

Olivia M. Manley, Tucker J. Shriver, Tian Xu, Isaac A. Melendrez, Philip Palacios, Scott A. Robson, Yisong Guo, Neil L. Kelleher, Joshua J. Ziarek and Amy C. Rosenzweig

Proc. Natl. Acad. Sci. U.S.A., 2024, 121
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Anticancer Ribosomally Synthesized and Post-Translationally Modified Peptides from Plants: Structures, Therapeutic Potential, and Future Directions

Hyeon-Jeong Hwang, Youngsang Nam, Chanhee Jang, Eun La Kim, Eun Seo Jang, Yeo Jin Lee and Seoung Rak Lee

CIMB, 2024, 47, 6
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Dokdothiocin, an Anti-Neuroinflammatory Thiopeptide from Streptomyces sp. 20A130

Jihun Park, Son Hung Tran, Keunwan Park, Jin-Hyub Paik, Woong Lee, Jin-Suk Youn, Gwi Ja Hwang, Taehoon Oh, Sung-Kyun Ko, Hiyoung Kim, Young-Soo Hong, Kyungsu Kang, Jun-Pil Jang and Jae-Hyuk Jang

Org. Lett., 2026, 28, 3117
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Peptide Prenylation Follows Divergent Substrate Engagement Rules

Mujeeb A. Wakeel, Andrew C. McShan and Vinayak Agarwal

J. Am. Chem. Soc., 2025, 147, 45855
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Discovery of methylated pyrroloindoline fungal RiPPs with anti-parkinsonian activity

Jun-Jie Gu, Yang Zhao, Ting-Ting Wang, Bin Zhu, Xue-Ming Wu, Hui-Ming Ge, Ren Xiang Tan and Zhi-Wu Tong

Chinese Chemical Letters, 2026, 112399
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The radical SAM enzyme EpeE exhibits distinct site reactivity during the biosynthesis of the RiPP natural product epipeptide

William G. Walls, Hao Yang, Madeline B. Ho, William E. Broderick, Brian M. Hoffman and Joan B. Broderick

Proc. Natl. Acad. Sci. U.S.A., 2026, 123
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Advancements in the Application of Ribosomally Synthesized and Post-Translationally Modified Peptides (RiPPs)

Sang-Woo Han and Hyung-Sik Won

Biomolecules, 2024, 14, 479
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