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Total synthesis of cyclopropane-containing natural products: recent progress (2016–2024)

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Terpenoids of plants from Chloranthaceae family: chemistry, bioactivity, and synthesis

Bin Zhou and Jian-Min Yue

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Holotrichones A and B, potent anti-leukemic lindenane-type sesquiterpene trimers with unprecedented complex carbon skeletons from a rare Chloranthus species

Xue-Jiao Wang, Jun-Li Xin, Hong Xiang, Ze-Yu Zhao, Yu-Hang He, Haibo Wang, Guangyao Mei, Yi-Cheng Mao, Juan Xiong and Jin-Feng Hu

Chinese Chemical Letters, 2024, 35, 109682
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Neuroprotective lindenane sesquiterpenoids from the roots of Lindera aggregata (Sims) Kosterm

Lie-Feng Ma, Shan-Rong Luo, Qian-Qing Liu, Rui-Si Tang, Ning-Yu Chen, Di Luo, Lu Guo, Jia Li, Rui Wu and Zha-Jun Zhan

Phytochemistry, 2025, 235, 114452
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Chlorjaponoids A and B, Two Lindenane–Guaiane Sesquiterpenoid Dimers with a Cage-like Tetracyclo[8.5.0.02,7.03,13]pentadecane Scaffold from Chloranthus japonicus

Lu Gan, Xin-Yi Hu, Rong Huang, Li-Fen Ma, Dean Guo and Wei Li

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The total biosynthesis route of rosmarinic acid in Sarcandra glabra based on transcriptome sequencing

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Plant Physiology and Biochemistry, 2024, 215, 109016
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Trishizukaol A alleviates chronic kidney disease by restraining P2X7/PSME3-driven 20S proteasome hyperactivation

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Journal of Ethnopharmacology, 2026, 362, 121357
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Trisarcglaboids A and B, two cytotoxic lindenane sesquiterpenoid trimers with a unique polymerization mode isolated from Sarcandra glabra

Danyang Zhang, Zhiqi Xiao, Nan Wang, An Huang, Jie Wen, Lingyi Kong and Jun Luo

Bioorganic Chemistry, 2024, 146, 107259
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Linaggrenoids A−I, structurally diverse lindenane sesquiterpenoids with anti-hepatic fibrosis effects from Lindera aggregata

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Phytochemistry, 2025, 235, 114477
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Lindenane-Based Sesquiterpenoid Hetero-Oligomers with Diverse Skeletons and Extracellular Regulated Protein Kinases Inhibitory Activity from Sarcandra glabra

Danyang Zhang, Zhiqi Xiao, An Huang, Pengfei Tang, Houli Jiang, Mengmeng Yu, Ze Zheng, Lingyi Kong and Jun Luo

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UPLC-PDA-MS guided isolation of lindenane sesquiterpene oligomers with anti-neuroinflammatory activity from two rare Chloranthus species

Jun-Li Xin, Ke-Xin Li, Zhi-Xuan Wang, Xian-Neng Lu, Xue-Jiao Wang, Yi-Cheng Mao, Jin-Feng Hu and Juan Xiong

Phytochemistry, 2026, 246, 114831
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Anti-inflammatory lindenane sesquiterpenoid dimers from the roots of Chloranthus holostegius var. trichoneurus

Xiaoli Wang, Zhenyu Zan, Jun Chi, An Huang, Danyang Zhang, Houli Jiang, Yi Li and Jun Luo

J Nat Med, 2024, 78, 995
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Recent advances in crosslinking strategies for designing self-healing hydrogels in biomedical applications: a review

Jingrui Chang, Xinyu Wang, Yunhan Huang, Wu Gu, Xuejiao Ma and Bo Lu

Front. Mater. Sci., 2025, 19
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Diverse anti-inflammatory lindenane sesquiterpenoid hetero- or homo-dimers from Chloranthus holostegius var. shimianensis

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Bioorganic Chemistry, 2025, 158, 108327
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Highly Fused Lindenane Sesquiterpenoid Dimers with Apoptosis-Inducing Properties from Chloranthus holostegius var. shimianensis

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J. Org. Chem., 2025, 90, 4062
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Tetrasargltones A and B, Fully Helically Polymerized Lindenane Sesquiterpenoid Tetramers from Sarcandra glabra

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Org. Lett., 2026, 28, 3885
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Sarcglabates A/B, Aromatized Pentanor Lindenane Sesquiterpenoid Dimers from Sarcandra glabra

Danyang Zhang, Pengfei Tang, Yi Zhu, Ze Zheng, Jun Luo and Lingyi Kong

Org. Lett., 2025, 27, 11969
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Unmatched-Electron-Demand Diels–Alder Reaction of Lindenane-Based Electron-Deficient Trienes

Fengxia Yuan, Zhengsong Huang, Yan Hao, Zhen Wang, Yitao Pu, Shaomin Fu, Song Qin and Bo Liu

Org. Lett., 2025, 27, 5485
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Chloranthalactone B covalently binds to the NACHT domain of NLRP3 to attenuate NLRP3-driven inflammation

Pengfei Tang, Shuai Zhao, Xiaoli Wang, Siyuan Wang, Yongyue Wang, Lingyi Kong and Jun Luo

Biochemical Pharmacology, 2024, 226, 116360
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Recent advances of sesquiterpenoid dimers from Compositae: distribution, chemistry and biological activities

FanCheng Meng, Zhe Wang, SiJie Peng, GangGang Zhou, Ammara Khalid, JingXin Mao, GuoWei Wang, ZhiHua Liao and Min Chen

Phytochem Rev, 2024, 23, 625
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Four-Step Synthesis of (±)-Nanolobatolide via Site-Selective Functionalization

Ashutosh Panigrahi and Kiran Kumar Pulukuri

Org. Lett., 2025, 27, 12758
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Research progress on new techniques and methods for identifying active ingredients in traditional Chinese medicine

Jiaxin Zhang, Xinhao Zhu, Chaofeng Zhang, Wangning Zhang and Jiangwei Tian

Chinese Journal of Natural Medicines, 2025, 23, 1153
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Lindenane Sesquiterpenoid Hetero‐ or Homo‐Dimers From Sarcandra glabra and Their Anti‐Neuroinflammatory Activities

Jin‐Yu Li, Yuan‐Yuan Liu, Dong‐Yu Wang, Han‐Fei Liu, Chao Chen and Ni Zhang

Chemistry & Biodiversity, 2026, 23
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Base‐Mediated [4+1] Annulation Strategy for Modular Assembly of Alkynyl/Carboxylated Dihydrobenzofurans

Yangzilin Kong, Yinsong Wu, Yanan Liu, Binbin Fei, Mengdi Wu, Ni Gu, Qiang Tang and Xinwei He

Eur J Org Chem, 2025, 28
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Chlorajaponins A—Q, Lindenane‐Related Sesquiterpenoid Dimers from Chloranthus japonicus and Their Biological Activities

Wei‐Jiao Feng, Yue Gu, Pei‐Zhi Huang, Hong‐Ying Yang, Rui Zhang, Yi‐Lin He, Ting‐Hong Lv, Ya Li and Kun Gao

Chin. J. Chem., 2024, 42, 1247
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Terpenoids from the whole plants of Chloranthus holostegius

Huan Yan, Yong-Sheng Zhou, Long-Gao Xiao, Wei Ni, Yupeng Geng and Hai-Yang Liu

Fitoterapia, 2026, 189, 107065
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Structurally diverse sesquiterpenoids from Sarcandra glabra and their anti-inflammatory activities

An Huang, Mengmeng Yu, Houli Jiang, Danyang Zhang, Zhenyu Zan, Jun Luo and Yi Li

Phytochemistry, 2025, 233, 114381
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Structurally diverse sesquiterpenoids from the roots of Lindera aggregata and their anti-necroptosis activities

Lun Wang, Dong-Mei Fang, Yan Jiang, Xi-Lan Jiang, Ming-Kui Wang and Xiao-Fei Shen

Phytochemistry, 2026, 247, 114881
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Lindenane sesquiterpenoid dimers from Chloranthus japonicus improve LDL uptake by regulating PCSK9 and LDLR

Pengju Guo, Tong Chen, Xianggang Hu, Yelin Duan, Liu Zheng, Gaoxiang Du, Qing Wang, Aoxue Ding, Guoqing Qin, Yihan Chen, Wenqiong Wang, Qing Mu and Lijiang Xuan

Bioorganic Chemistry, 2024, 142, 106958
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Lindenane sesquiterpenoid dimers with NLRP3 inflammasome inhibitory activities from Chloranthus holostegius var. shimianensis

Longgao Xiao, Huan Yan, Songxue Yang, Hui Liu, Yanxi Li, Xin Fang, Wei Ni, Xingjie Zhang, Weilie Xiao and Haiyang Liu

Biomedicine & Pharmacotherapy, 2024, 177, 117087
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Sesquiterpene dimers with a rare skeleton from Chloranthus holostegius exhibiting multidrug resistance reversal activity in vitro and in vivo

Sibei Wang, Jiantong Hou, Haojing Jiang, Dongho Lee, Jing Xu and Yuanqiang Guo

Fitoterapia, 2024, 177, 106125
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Sarcanoids A and B, two new lindenane-type sesquiterpenoid dimers from the aerial parts of Sarcandra glabra

Ju Liu, Qian-ying Chen, Lu Jin, Chong Feng, En-yao Ma, Xin-jun Xu, De-po Yang and Zhi-min Zhao

Natural Product Research, 2025, 39, 6061
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