Ethylene oxide graft copolymers reduce the immunogenicity of lipid nanoparticles

Yalin Qi, Hesong Han, Albert Liu, Sheng Zhao, Atip Lawanprasert, Josefine Eilsø Nielsen, Hema Choudhary, Dengpan Liang, Annelise E. Barron and Niren Murthy

RSC Adv., 2024, 14, 30071
DOI: 10.1039/D4RA05007J

Gold nanoparticle transport across tumour-associated biological barriers: in vitro models, imaging, and quantification

Christina Christodoulou, Alexander J. MacRobert, Marilena Loizidou, Bala Ramesh, Kate Ricketts, Christopher Thrasivoulou, Gavin Jell and Hirak K. Patra

Nanoscale, 2026, 18, 110
DOI: 10.1039/D5NR02045J

Asymmetrical branched PEG-modified liposomes evade anti-PEG antibody recognition to abolish accelerated blood clearance and amplify tumor drug accumulation

Kunfeng Zhang, Mingze Li, Dezhi Sui, Jingyi Zhao, Zhennan She, Kaihe Ding, Xiaoqiu Shang, Zhouchunxiao Du, Ning Wang, Yuanyuan Lu, Yanzhi Song and Yihui Deng

Nanoscale, 2025, 17, 21693
DOI: 10.1039/D5NR01680K

mRNA-LNP vaccines: rational design, delivery optimization, and clinical translation

Sangni Jiang and Zhihui Lu

J. Mater. Chem. B, 2025, 13, 15447
DOI: 10.1039/D5TB01972A

Anti-PEG antibodies: Current situation and countermeasures

Jiaru Fu, Ercan Wu, Guanghui Li, Bin Wang and Changyou Zhan

Nano Today, 2024, 55, 102163
DOI: 10.1016/j.nantod.2024.102163

Enhanced Hydrophilicity and Antifouling Performance of PEG with Sulfoxide-Containing Side Chains for Nanomedicine Applications

Yuhao Zhang, Mingdi Hu, Ruijing Xin, Xin Xu, Ze Zhang, Hui Peng, Rong Cai, Chunying Chen, Andrew K. Whittaker and Changkui Fu

Polymer Science & Technology, 2025, 1, 640
DOI: 10.1021/polymscitech.5c00084

RETRACTED ARTICLE: Investigating the Effects of Melittin-Loaded Pectin as Novel Anti Breast Cancer Drug to Increase the Apoptosis Rate

Esmaeil Alibeigi, Arsham Azari Dehkordi, Milad Asadian, Abbas Doosti and Tohid Piri-Gharaghie

Int J Pept Res Ther, 2024, 30
DOI: 10.1007/s10989-024-10593-y

Polyethylene Glycol‐Functionalized Graphene Oxide Nanocomposites: Advances in Biomedical Applications

Oluwasegun Chijioke Adekoya, Gbolahan Joseph Adekoya, Williams Kehinde Kupolati, Yskandar Hamam and Rotimi Emmanuel Sadiku

Nano Select, 2025, 6
DOI: 10.1002/nano.70051

POx-Lipids as an Alternative to PEG-Lipids? Multimethod Assessment of Chemistry and Structure

Ekaterina Tsarenko, Ilya Anufriev, Caroline T. Holick, Tobias Klein, Stephanie Schubert, Nicole Fritz, Stephanie Hoeppener, Ulrich S. Schubert and Ivo Nischang

Anal. Chem., 2026, 98, 8277
DOI: 10.1021/acs.analchem.5c07351

Polyphosphocholination of liposomic vehicles extends blood circulation, enhances cellular uptake, and lowers immunogenicity relative to PEGylation

Monika Kluzek, Maryana Hamad, Weifeng Lin, Evgenia Mitsou, Ziv Porat, Yuri Kuznetsov, Yaara Oppenheimer-Shaanan and Jacob Klein

Journal of Controlled Release, 2025, 388, 114306
DOI: 10.1016/j.jconrel.2025.114306

Overcoming PEG Antigenicity: Statistical PEG Isomers Reduce Antibody Binding

Mareike Deuker, Dominik Schulz, Kaloian Koynov, Svenja Morsbach, Holger Frey and Katharina Landfester

Advanced Science, 2026, 13
DOI: 10.1002/advs.202521061

Recent advances and future prospects of wearable sensors based on nanomaterial sensing mechanisms for biosafety monitoring

Xiaoyu Yu, Hui Li, Junwen Wang, Xin Zhang, Rui Jiao, Yuwei Ren, Danfeng Zhang, Na Ling and Yingwang Ye

Chemical Engineering Journal, 2025, 512, 162695
DOI: 10.1016/j.cej.2025.162695

Microparticle and nanoparticle-based influenza vaccines

Luis Ontiveros-Padilla, Eric M. Bachelder and Kristy M. Ainslie

Journal of Controlled Release, 2024, 376, 880
DOI: 10.1016/j.jconrel.2024.10.031

A Non‐Antigenic Randomized Polyethylene Glycol/Poly(2‐Phenyl‐2‐Oxazine)‐Based Drug Delivery Platform

Julian Schmidt, Anna‐Lena Ziegler, Florian T. Kaps, Laura J. Rosenberger, Matthias Bros, Holger Frey and Robert Luxenhofer

Macromol. Rapid Commun., 2025
DOI: 10.1002/marc.202500781

Polyethylene glycol and immunology: aspects of allergic reactions and their mechanisms, as well as ways to prevent them in clinical practice

Maria Zofia Lisiecka

Immunol Res, 2024, 72, 675
DOI: 10.1007/s12026-024-09473-w

Advancing influenza virus treatment: in vitro and ex vivo studies of PI3K inhibitor-loaded lipid nanoparticles

Josefine Schroeder, Jana Ismail, Caroline T. Holick, Johannes Jungwirth, Laura Klement, Stephanie Hoeppener, Christian Kosan, Michaela Schmidtke, Bettina Löffler, Christine Weber, Ulrich S. Schubert, Carsten Hoffmann, Stephanie Schubert and Christina Ehrhardt

Materials Today Bio, 2025, 35, 102587
DOI: 10.1016/j.mtbio.2025.102587

Recombinant Trichosanthin-Loaded Nanoparticles with Tumor-Targeting and Cell-Penetrating Capabilities for Activatable Antitumor Therapy

Lian-Hua Fu, Minghuan Zhang, Zeyao Zhu, Kaifang Wang, Ning-Ning Nie, Feng Gao, Xia Wang, Wanqiu Li, Jing Lin, Peng Huang and Ou Sha

ACS Appl. Mater. Interfaces, 2025, 17, 54423
DOI: 10.1021/acsami.5c09291

Cell membrane-coated nanoparticles: A new frontier in atherosclerosis therapy

Nasrullah Jan, Rania M. Yehia, Mahir Mohammed, Mazin B. Ahmed, Hajeltom G. Seedahmed, Hassan Shah, Syed Faisal Badshah and Guixiu Shi

Chemical Engineering Journal, 2025, 524, 169183
DOI: 10.1016/j.cej.2025.169183

Engineering mesoporous silica nanoparticles for cancer immunotherapy: mechanistic insights, therapeutic synergies, and translational roadmap

Adel Mahmoudi Gharehbaba, Fatemeh Soltanmohammadi, Morteza Eskandani and Khosro Adibkia

Materials & Design, 2026, 262, 115452
DOI: 10.1016/j.matdes.2026.115452

Overcoming resistance: targeted nanomedicine solutions for cancer therapy

Bhaveshkumar Patel, Ankur Vashi, Akhilesh Kumar Kuril, Praveen Kumar Subbappa and Ramakrishna Borra

Journal of Biomaterials Science, Polymer Edition, 2025, 1
DOI: 10.1080/09205063.2025.2545089

T Cell and Natural Killer Cell Membrane-Camouflaged Nanoparticles for Cancer and Viral Therapies

Fatma Ozsoy, Mahir Mohammed, Nasrullah Jan, Elif Lulek and Yavuz Nuri Ertas

ACS Appl. Bio Mater., 2024, 7, 2637
DOI: 10.1021/acsabm.4c00074

Introducing Sulfur Ylides as Charge-Neutral Termini for Mitigating Poly(ethylene glycol) Antigenicity in Nanomedicine

Dulce M. Sánchez-Cerrillo, Kouichi Shiraishi, Lucía Mallen-Huertas, Remi Peters, Daniela A. Wilson and Kevin Neumann

JACS Au, 2025, 5, 4378
DOI: 10.1021/jacsau.5c00748

Harmonizing immunogenicity for AAV and LNP/mRNA modalities: best-practice panels for binding, neutralizing, and cellular assays with pre-existing immunity controls

Ahmad Z. Al Meslamani, Anan S. Jarab and Eman Merghani Ali Mohammed

Bioanalysis, 2026, 18, 199
DOI: 10.1080/17576180.2026.2638522

Isomerization of Poly(ethylene glycol): A Strategy for the Evasion of Anti-PEG Antibody Recognition

Philip Dreier, Rebecca Matthes, Fabian Fuß, Julian Schmidt, Dominik Schulz, Gregor M. Linden, Ramona D. Barent, Sandra Schüttner, Barry W. Neun, Edward Cedrone, Marina A. Dobrovolskaia, Matthias Bros and Holger Frey

J. Am. Chem. Soc., 2025, 147, 21538
DOI: 10.1021/jacs.5c02716

Extrahepatic Gene Editing In Vivo Using Organic Solvent‐Free Lipid Nanoparticles

Michael Streiber, Na Liu, Laurianne Simon, Franziska Adermann, Vivien Bachmann, Lucas Gath, Stephanie Hoeppener, Stephanie Schubert, Oliver Werz, Vincent Lapinte, Marie Morille, Michael Bauer, Adrian T. Press, Ulrich S. Schubert and Anja Traeger

Small, 2026
DOI: 10.1002/smll.202511489

From RNA to DNA: How Cargo Identity Reprograms Lipid Nanoparticle Architecture and Function

Erica Quagliarini, Daniela Pozzi and Giulio Caracciolo

Adv Healthcare Materials, 2026
DOI: 10.1002/adhm.202505261

Balancing stealth and targeting to improve nanomedicine efficacy

Yi Ju and Stephen John Kent

Nat. Nanotechnol., 2025, 20, 576
DOI: 10.1038/s41565-025-01926-z

Poly(Oligo(Ethylene Glycol) Methacrylate)-Based Polymers in Biomedical Applications: Preparation and Applications

Andrew Singh, Nate Dowdall and Todd Hoare

Biomacromolecules, 2025, 26, 3929
DOI: 10.1021/acs.biomac.5c00145

Polyethylene glycol immunogenicity in nanomedicine

Yunching Chen, Yu-Cheng Su and Steve R. Roffler

Nat Rev Bioeng, 2025, 3, 742
DOI: 10.1038/s44222-025-00321-6

Interaction of nanodrug delivery systems via fibroblasts in colorectal cancer

Wenpeng Wang, Mingrui Li, Ying Liu and Benno Weigmann

Expert Opinion on Drug Delivery, 2026, 23, 169
DOI: 10.1080/17425247.2025.2593979

Nanoscintillator Coating: A Key Parameter That Strongly Impacts Internalization, Biocompatibility, and Therapeutic Efficacy in Pancreatic Cancer Models

Clémentine Aubrun Fulbert, Frédéric Chaput, Sarah Stelse‐Masson, Maxime Henry, Benoit Chovelon, Sylvain Bohic, Dennis Brueckner, Jan Garrevoet, Christine Moriscot, Benoit Gallet, Julien Vollaire, Olivier Nicoud, Frédéric Lerouge, Sandrine Denis‐Quanquin, Xavier Jaurand, Thibault Jacquet, Anthony Nomezine, Véronique Josserand, Jean‐Luc Coll, Jean‐Luc Ravanat, Hélène Elleaume and Anne‐Laure Bulin

Small Science, 2024, 4
DOI: 10.1002/smsc.202400041

Advancements in Nanotags for Enhanced Mass Spectrometric Biosensors: Toward Next Generation Bioassay and Cytometry

Yi Wu, Rui Liu, Jianyu Hu, Zili Huang, Yi Lv and Xinrong Zhang

Chem. Rev., 2025, 125, 11083
DOI: 10.1021/acs.chemrev.5c00514

Site-specific PEGylation of proteins: Insights into structural and functional changes

Ming Ma, Jinwei Di, Chengcai Wang, Yanwei Xie, Fengqian Cui, Yanan Zhai, Shanwei Zhu and Jing Gao

Acta Pharmaceutica Sinica B, 2025, 15, 6253
DOI: 10.1016/j.apsb.2025.10.014

Degraders on Demand: Engineering Smart Nanocarriers for PROTAC Delivery

Antalin Casmie Amalraj and Vijaya Parthasarathy

Mol. Pharmaceutics, 2026, 23, 622
DOI: 10.1021/acs.molpharmaceut.5c01070

Impact of Pre-existing Anti-polyethylene Glycol Antibodies on the Pharmacokinetics and Efficacy of a COVID-19 mRNA Vaccine (Comirnaty) In Vivo

Yen-Ling Liu, Tzu-Yi Liao, Kai-Wen Ho, En-Shuo Liu, Bo-Cheng Huang, Shih-Ting Hong, Yuan-Chin Hsieh, Mu-Shen Chang, Bing-Tsung Wu, Fang-Ming Chen, Steve R. Roffler, Chiao-Yun Chen, Yuan-Chieh Yang and Tian-Lu Cheng

Biomater Res, 2024, 28
DOI: 10.34133/bmr.0112

Detection of PEG-specific antibodies in SARS-CoV-2 positive and negative sera with implications for autoimmune reactivity

Aristo Vojdani and Elroy Vojdani

Sci Rep, 2025, 15
DOI: 10.1038/s41598-025-17777-6

Polyoxazolines with Cholesterol Lipid Anchor for Fast Intracellular Delivery

Laurianne Simon, Liên Sabrina Reichel, Belkacem Tarek Benkhaled, Jean‐Marie Devoisselle, Sylvain Catrouillet, Juliane Eberhardt, Stephanie Hoeppener, Ulrich S. Schubert, Johannes Christopher Brendel, Marie Morille, Vincent Lapinte and Anja Traeger

Macromolecular Bioscience, 2024, 24
DOI: 10.1002/mabi.202400148

Strategies for extending the half-life of biotherapeutics: successes and complications

Uli Binder and Arne Skerra

Expert Opinion on Biological Therapy, 2025, 25, 93
DOI: 10.1080/14712598.2024.2436094

Pre-programming the protein corona: From avoidance to endogenous targeting

Nalla Usha Kumari, Sri Pada Datta Chigurupati, Naveen Rajana, Ravindra Vasave, Sumedh Bahadure and Neelesh Kumar Mehra

Journal of Controlled Release, 2026, 389, 114447
DOI: 10.1016/j.jconrel.2025.114447

Biocompatibility and immunomodulation of MXenes for targeted delivery of bioactive agents and drugs

Marzieh Ramezani Farani, Danial Mirzaee, Afrooz Hatami, Krishan Kumar, Seyed Majid Ghoreishian and Yun Suk Huh

Bioactive Materials, 2026, 55, 546
DOI: 10.1016/j.bioactmat.2025.09.038

Mass‐Spectrometric Identification of Proteins and Pathways Responsible for Fouling on Poly(ethylene glycol) Methacrylate Polymer Brushes

Zuzana Riedelová, Andres de los Santos Pereira, Diego Fernando Dorado Daza, Pavel Májek, Filip Dyčka and Tomáš Riedel

Macromolecular Bioscience, 2024, 24
DOI: 10.1002/mabi.202300558

Short-chain dense brush PEGylation on rigid nanocarriers overcomes anti-PEG antibody recognition for immune-stealth drug delivery

Ting-Yu Chen, Chi-Yuan Chang, Li Xu, Ting-Chun Wen, Yu-Han Lin, Cheng-Liang Peng, Yi-Qi Yeh, Chueh-Hsuan Chen, I-Lin Tsai, Kuo-Hsiang Chuang and Si-Han Wu

Biomaterials, 2026, 328, 123854
DOI: 10.1016/j.biomaterials.2025.123854

Evaluating the Antiviral Efficacy of Encapsulated PKC Inhibitor BIM‐I against influenza A Virus Infection

Laura Klement, Jana Ismail, Josefine Schroeder, Amod Godbole, Johanna Schreiber, Christine Weber, Zoltan Cseresnyes, Marc T. Figge, Bettina Löffler, Ulrich S. Schubert, Stephanie Schubert, Christina Ehrhardt and Carsten Hoffmann

Adv Healthcare Materials, 2026, 15
DOI: 10.1002/adhm.202504060

Tuning the Functional Properties of Nanocarriers Using Tunable Nano‐Biointerfaces

Alessia Pancaro, Volker Mailänder, Katharina Landfester and Anitha Ethirajan

Adv Funct Materials, 2026, 36
DOI: 10.1002/adfm.202508121

Surface engineering of nanoparticles for precision medicine

Jiaxi Zheng, Yuji Sun, Youqing Shen and Zhuxian Zhou

Precision Medicine and Engineering, 2025, 2, 100037
DOI: 10.1016/j.preme.2025.100037

Exploring Residue-Level Interactions between the Biofilm-Driving R2ab Protein and Polystyrene Nanoparticles

Radha P. Somarathne, Sandeep K. Misra, Chathuri S. Kariyawasam, Jacques J. Kessl, Joshua S. Sharp and Nicholas C. Fitzkee

Langmuir, 2024, 40, 1213
DOI: 10.1021/acs.langmuir.3c02609

Optimized Enzyme-Linked Immunosorbent Assay for Anti-PEG Antibody Detection in Healthy Donors and Patients Treated with PEGylated Liposomal Doxorubicin

Yue Li, Utibeabasi Ettah, Sarah Jacques, Hanmant Gaikwad, Andrew Monte, Layne Dylla, Saketh Guntupalli, S. Moein Moghimi and Dmitri Simberg

Mol. Pharmaceutics, 2024, 21, 3053
DOI: 10.1021/acs.molpharmaceut.4c00278

Advances in biodistribution of gold nanoparticles: the influence of size, surface charge, and route of administration

Bashiru K Sodipo and Zainab Kasim Mohammed

Biomed. Mater., 2024, 19, 042010
DOI: 10.1088/1748-605X/ad5484

Poly(2‐ethyl‐2‐oxazoline) (POx) as Poly(ethylene glycol) (PEG)‐Lipid Substitute for Lipid Nanoparticle Formulations

Caroline T. Holick, Tobias Klein, Charlotte Mehnert, Franziska Adermann, Ilya Anufriev, Michael Streiber, Lukas Harder, Anja Traeger, Stephanie Hoeppener, Christian Franke, Ivo Nischang, Stephanie Schubert and Ulrich S. Schubert

Small, 2025, 21
DOI: 10.1002/smll.202411354