Design, synthesis, and biological evaluation of novel thiazole derivatives as PI3K/mTOR dual inhibitors

Samar I. Faggal, Yara El-Dash, Amr Sonousi, Amr M. Abdou and Rasha A. Hassan

RSC Med. Chem., 2024, 15, 4111
DOI: 10.1039/D4MD00462K

An overview of pyrazolo[3,4-d]pyrimidine heterocycles: recent synthetic approaches and biological activities

Ahmed S. Abdelkhalek, Ahmed Abdulrahman, Mansour E. Abokull, Samy M. Ibrahim, Mostafa K. Soltan, Mokhtar A. Abdul-Malik and Shaban A.A. Abdel-Raheem

Journal of the Indian Chemical Society, 2025, 102, 101763
DOI: 10.1016/j.jics.2025.101763

Recent Advances in Nanocatalyzed One-Pot Sustainable Synthesis of Bioactive N, N-Heterocycles with Anticancer Activities: An Outlook of Medicinal Chemistry

Sasadhar Majhi

CTMC, 2025, 25, 63
DOI: 10.2174/0115680266311149240822111827

Design, synthesis, and anticancer evaluation of new pyrazolo[3,4-d]pyrimidine-based derivatives: CDK2 inhibition, apoptosis-inducing activity, molecular modelling studies

Rasha A. Hassan, Hanan H. Kadry, Radwa G. Sayed, Amr M. Abdou and Rana H. Refaey

Bioorganic & Medicinal Chemistry, 2025, 128, 118286
DOI: 10.1016/j.bmc.2025.118286

New S‐substituted‐3‐phenyltetrahydrobenzo[4,5]thieno[2,3‐d]pyrimidin‐4(3H)‐one scaffold with promising anticancer activity profile through the regulation and inhibition of mutated B‐RAF signaling pathway

Safaa E. Seif, Wagnat W. Wardakhan, Rasha A. Hassan, Amr M. Abdou and Zeinab Mahmoud

Drug Development Research, 2024, 85
DOI: 10.1002/ddr.70007

Design, synthesis, in silico, and biological evaluation of novel pyrazolopyrimidinone-based estrogen receptor inhibitors

Sara A. Hesham, Mai I. Shahin, Laila Ziko, Rabah A. T. Serya, Nahla A. Farag, Khaled Abouzid and Samar Mowafy

Future Medicinal Chemistry, 2026, 1
DOI: 10.1080/17568919.2026.2642673

Design, synthesis, and anticancer evaluation of new Phenylpyrazolone derivatives: Dual JAK1/ JAK2 inhibition, apoptosis-inducing activity, and molecular modelling studies

Samar I. Faggal, Rasha A. Hassan, Kholoud I. Eissa, Mohamed R. Elnagar, Mohamed M. Tawfik, Amr M. Abdou and Akram Hifny Abd El-Haleem

Bioorganic Chemistry, 2025, 167, 109268
DOI: 10.1016/j.bioorg.2025.109268

Thiazolation of phenylthiosemicarbazone to access new thiazoles: anticancer activity and molecular docking

Walid E Elgammal, Safaa S Shaban, Essam M Eliwa, Ahmed H Halawa, Shimaa M Abd El-Gilil, Rasha A Hassan, Amr M Abdou, Gameel AM Elhagali and MAM Abdel Reheim

Future Medicinal Chemistry, 2024, 16, 1219
DOI: 10.1080/17568919.2024.2342668

Pyrazolopyrimidines: A Promising Frontier in Cancer Treatment‐Reviewing Their Potential as Inhibitors of Serine/Threonine Kinases

Ahmed M. Abdelhamed, Amira A. Helwa, Hanan H. Kadry and Rasha A. Hassan

Chemistry & Biodiversity, 2025, 22
DOI: 10.1002/cbdv.202403071

Novel Dorsomorphin Derivatives: Molecular Modeling, Synthesis, and Bioactivity Evaluation

Evangelia N. Tzanetou, Sandra Liekens, Konstantinos M. Kasiotis, Nikolas Fokialakis, Nikolaos Tsafantakis, Raul SanMartin, Haralampos Tzoupis, Konstantinos D. Papavasileiou, Antreas Afantitis and Serkos A. Haroutounian

Biomolecules, 2026, 16, 145
DOI: 10.3390/biom16010145

Molecular Docking, Dynamics, and Cytotoxicity Assessment of Pyrazolo[1,5‐a]pyrimidine Derivatives Against Breast Cancer

Gaurav Patel, Rizwan Ghumara, Sagarkumar Patel, Pranaykumar Shah, Niyati Patel, Nitin Lunagariya, Purvi Shah, Suraj Mali, Mehul Patel and Umang Shah

Chemistry & Biodiversity, 2025, 22
DOI: 10.1002/cbdv.202501510

Pyrazole and Pyrimidine Scaffolds as Promising Anticancer Agents

Vaishnavi Chaudhari, Kalyani R. Thombre, Krishna Radheshyam Gupta, Sushil Burle and Milind Janrao Umekar

COC, 2026, 30, 426
DOI: 10.2174/0113852728402678250728094527

Design, Synthesis, Biological Evaluation, and In Silico Studies of Novel Furo[2,3‐d]pyrimidine Derivatives as EGFR Inhibitors With Potential Antitumor Activity

Samar I. Faggal, Walid E. Elgammal, Amr Sonousi, Amr M. Abdou, Soha O. Hassanin and Rasha A. Hassan

Archiv der Pharmazie, 2025, 358
DOI: 10.1002/ardp.70146

Synthesis and structural proof of novel oxazolo[5,4-d]pyrimidine derivatives as potential VEGFR2 inhibitors. In vitro study of their anticancer activity

Aleksandra Sochacka-Ćwikła, Andrzej Regiec, Żaneta Czyżnikowska, Urszula Śliwińska-Hill, Anna Kwiecień, Benita Wiatrak, Agnieszka Rusak, Klaudia Krawczyńska, Monika Mrozowska, Sylwia Borska, Katarzyna Ratajczak, Anna Pyra and Marcin Mączyński

Bioorganic Chemistry, 2024, 153, 107958
DOI: 10.1016/j.bioorg.2024.107958

Design, synthesis, and anticancer evaluation of new Quinazoline hybrids: DNA intercalation, topoisomerase IIα inhibition, and in silico studies

Rasha A. Hassan, Zeinab Mahmoud, Ayman Abo Elmaaty, Mohamed R. Elnagar, Amr M. Abdou, Akram Hifny Abd El-Haleem and Mohammed I.A. Hamed

Bioorganic Chemistry, 2025, 164, 108921
DOI: 10.1016/j.bioorg.2025.108921

Bioactive Fused Pyrazoles Inspired by the Adaptability of 5-Aminopyrazole Derivatives: Recent Review

Dana M. Odeh, Mohanad M. Odeh, Taghrid S. Hafez and Ashraf S. Hassan

Molecules, 2025, 30, 366
DOI: 10.3390/molecules30020366

Design and synthesis of new Thieno[2,3-d]pyrimidine-based derivatives as anti-breast cancer: Biological evaluation, PIM-1 kinase inhibition, and in silico studies

Menna Tallah M. Sayed, Zeinab Mahmoud, Makarem M. Said, Amr M. Abdou and Rasha A. Hassan

Bioorganic Chemistry, 2025, 165, 109003
DOI: 10.1016/j.bioorg.2025.109003