Strategies to improve the performance of polyetheretherketone (PEEK) as orthopedic implants: from surface modification to addition of bioactive materials

Huagui Huang, Xin Liu, Jinzuo Wang, Moran Suo, Jing Zhang, Tianze Sun, Honghua Wang, Chengde Liu and Zhonghai Li

J. Mater. Chem. B, 2024, 12, 4533
DOI: 10.1039/D3TB02740F

PEEK implants for cranioplasty: a mapping review of 3D printing, surface functionalisation, and clinical performance gaps

Zoltán Márk Horváth, Roman Viter, Oskars Radziņš, Andreas Thor, Tetiana Kolisnyk and Valentyn Mohylyuk

Mater. Adv., 2026
DOI: 10.1039/D5MA01194A

Surface Integrity of NiTi Alloy by Femtosecond Laser Shock Peening

Qibiao Yang, Yuanlin Jiang, Qingdong Zeng, Jian Cheng, Lie Chen, Deyuan Lou, Qianliang Li and Dun Liu

Physica Status Solidi (a), 2025, 222
DOI: 10.1002/pssa.202400950

Oriented microstructures and HA/PSP modulation of PEEK implants synergistically promote muscle integration via Myogenesis, immunomodulation and angiogenesis

Yang Su, Yu Chen, Zhengrui Li, Zhaocheng Pan, Lai Jiang, Xiaofeng Xu, Chengshuai Yang, Jinyang Wu, Yong Zhang, Kaili Lin and Shilei Zhang

Chemical Engineering Journal, 2026, 529, 172915
DOI: 10.1016/j.cej.2026.172915

Osteoinductive sandwich-structured HA/PEEK implant for rapid critical-size skull repair

Mei-li Qi, Kunshan Yuan, Enhui Song, Xiangyi Feng, Tianheng Lu, Lin Zhao, Haihong Guo and Haijun Zhang

Colloids and Surfaces B: Biointerfaces, 2026, 261, 115428
DOI: 10.1016/j.colsurfb.2026.115428

Controllable ultrafast laser hybrid fabrication of biomimetic omniphobic polyetheretherketone surfaces for sustainable food processing

Jiayi Xu, Bingxu Guo, Yan Shi, Shuye Zhang, Taoshuai Zhou, Senyu Tu, Yao Du, Qixiao Xu, Rui Pan and Shujun Chen

Optics & Laser Technology, 2026, 200, 115093
DOI: 10.1016/j.optlastec.2026.115093

Enhanced osteogenic and antibacterial properties of polyetheretherketone by ultraviolet‐initiated grafting polymerization of a gelatin methacryloyl/epsilon‐poly‐L‐lysine/laponite hydrogel coating

Yuhong Chen, Yiyi Chen, Tianlei Han, Zhe Xie, Yuchen Yang, Siyuan Chen and Chen Wang

J Biomedical Materials Res, 2023, 111, 1808
DOI: 10.1002/jbm.a.37589

Enhancing antibacterial properties of PEEK surfaces: Laser-induced and machine-learning assessed

WeiXuan Zhang, Kun Gao, Xiaohong Li, Huijuan Li, Jihan Liao, Sensen Xuan and Guoqiang Li

Applied Physics Letters, 2024, 125
DOI: 10.1063/5.0219141

Effects of combined modification of sulfonation, oxygen plasma and silane on the bond strength of PEEK to resin

Tongtong Ma, Jiajia Zhang, Xueye Liu, Shuoyao Sun and Junling Wu

Dental Materials, 2024, 40, e1
DOI: 10.1016/j.dental.2024.02.001

Polyetheretherketone biomaterials and their current progress, modification-based biomedical applications and future challenges

Zuge Yang, Weiwei Guo, Wenhao Yang, Jianye Song, Wenhui Hu and Kun Wang

Materials & Design, 2025, 252, 113716
DOI: 10.1016/j.matdes.2025.113716

Leveraging 3D Printing-Induced Spherulitic Topographical and Biochemical Cues on Polyether Ether Ketone/Hydroxyapatite/Magnesium Orthosilicate Composites for Orthopedic Applications

Praveen Jeyachandran, Lionel Yan Jin Lee, Si Jian Hui, Balamurugan Vellayappan, Jerry Ying Hsi Fuh, James Thomas Patrick Decourcy Hallinan, A. Senthil Kumar and Naresh Kumar

ACS Appl. Mater. Interfaces, 2026, 18, 9411
DOI: 10.1021/acsami.5c22456

Diameter-dependent effects of nanopillar arrays on PEEK bioactivity and soft tissue integration

Xi Liu, Yuqi Zhao, Hui Liu, Haochen Wang, Xiaocheng Li, Yixuan Gong, Jie Zheng, Haohan Yu, Chang Su and Wen Song

J Nanobiotechnol, 2026
DOI: 10.1186/s12951-026-04254-z

Effect of sulfonation time on physicochemical, osteogenic, antibacterial properties and biocompatibility of carbon fiber reinforced polyether ether ketone

Jingjing Su, Qingshi Wu, Xiaojie Xing, Dexiong Li, Yanjing Ou, Kaixun He, Hanyu Lin, Yubei Qiu, Xiaohui Rausch-Fan and Jiang Chen

Journal of the Mechanical Behavior of Biomedical Materials, 2023, 145, 105979
DOI: 10.1016/j.jmbbm.2023.105979

Surface Modification of Polyetheretherketone (PEEK) via Femtosecond Laser Microprocessing for Enhanced Bioactivity: A Preliminary Study

Liliya Angelova, Emil Filipov, Georgi Avdeev and Albena Daskalova

Bioengineering, 2025, 12, 1285
DOI: 10.3390/bioengineering12121285

Current treatment methods to improve the bioactivity and bonding strength of PEEK for dental application: A systematic review

Tongtong Ma, Jiajia Zhang, Shuoyao Sun, Wenqing Meng, Yan Zhang and Junling Wu

European Polymer Journal, 2023, 183, 111757
DOI: 10.1016/j.eurpolymj.2022.111757

Efficient Osteogenic Activity of PEEK Surfaces Achieved by Femtosecond Laser–Hydroxylation

Fengxiong Luo, Dongxuan Li, Yawen Huang, Ruiqi Mao, Ling Wang, Jian Lu, Xiang Ge, Yujiang Fan, Xingdong Zhang, Yafang Chen and Kefeng Wang

ACS Appl. Mater. Interfaces, 2023, 15, 37232
DOI: 10.1021/acsami.3c06430

Effects of surface treatments on the adhesion strengths between polyether ether ketone and both composite resins and poly(methyl methacrylate)

Yongcheng Ge, Ting Zhao, Sizheng Fan, Pengyuan Liu and Xiaoqiu Liu

BMC Oral Health, 2025, 25
DOI: 10.1186/s12903-025-06305-7

Dual surface modification of medical-grade PEEK: Nanosecond laser pre-treatment and hydrothermal hydroxyapatite coating

Weixuan Zhang, Kun Gao, Xiaohong Li, Jihan Liao and Guoqiang Li

Optics & Laser Technology, 2025, 191, 113307
DOI: 10.1016/j.optlastec.2025.113307

Poly-Ether-Ether-Ketone (PEEK) Biomaterials and Composites: Challenges, Progress, and Opportunities

Jesús Molinar-Díaz, Andrew J. Parsons, Ifty Ahmed, Nicholas A. Warrior and Lee T. Harper

Polymer Reviews, 2025, 65, 527
DOI: 10.1080/15583724.2024.2406965

Surface modifications of polyetheretherketone using tantalum pentoxide layer attached with UV-induced sulfonate groups for the boosting of antibacterial and osteointegration activities

Ngi-Chiong Lau and Kong-Wei Cheng

Journal of the Taiwan Institute of Chemical Engineers, 2026, 180, 106478
DOI: 10.1016/j.jtice.2025.106478

Improving tribological performance of 3D-printed PEEK and CFR-PEEK composites by combining optimized deposition strategies and post-processing conditions

Zhongcheng Cui, Wurikaixi Aiyiti, Ayiguli Kasimu, Lanlan Dong, Ru Jia and Cijun Shuai

Wear, 2025, 572-573, 206079
DOI: 10.1016/j.wear.2025.206079

Liver‐Inspired Polyetherketoneketone Scaffolds Simulate Regenerative Signals and Mobilize Anti‐Inflammatory Reserves to Reprogram Macrophage Metabolism for Boosted Osteoporotic Osseointegration

Hao Gu, Yuhui Zhu, Jiawei Yang, Ruixue Jiang, Yuwei Deng, Anshuo Li, Yingjing Fang, Qianju Wu, Honghuan Tu, Haishuang Chang, Jin Wen and Xinquan Jiang

Advanced Science, 2023, 10
DOI: 10.1002/advs.202302136

Laser Melt Infiltration of UHMWPE into the Binary Coatings of Strontium Apatite and Colloidal Silica

Akira Furukawa and Yasuhito Tanaka

Coatings, 2023, 13, 580
DOI: 10.3390/coatings13030580