Extraction technologies for hemp seed oil: a comparative study of yield, bioactive compound extractability, and oxidative stability

Aymane Allay, Rafika El Ati, Youssef Rbah, Marie-Laure Fauconnier, Hana Serghini Caid, Ahmed Elamrani and Farid Mansouri

Sustainable Food Technol., 2026, 4, 709
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A Comprehensive Exploration of the Fatty Acids Profile, Cholesterol, and Tocopherols Levels in Liver from Laying Hens Fed Diets Containing Nonindustrial Hemp Seed

Youssef Rbah, Yassine Taaifi, Aymane Allay, Kamal Belhaj, Reda Melhaoui, Nadia Houmy, Abdessamad Ben Moumen, Embarek Azeroual, Mohamed Addi, Farid Mansouri, Hana Serghini-Caid, Ahmed Elamrani and Luis T. Ortiz

Scientifica, 2024, 2024, 1
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Correlation between Chemical Fertilization Practices, Phytochemical Response, and Biological Activities of Cannabis sativa L.

Marianela Simonutti, Gisela Seimandi, Geraldina Richard, Juan M. Zabala and Marcos Derita

CCHTS, 2025, 28, 2369
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Laboratory-Scale Optimization of Hemp Seed Roasting Temperature and Time for Producing a High-Quality Pressed Oil

Farid Mansouri, Aymane Allay, Abdessamad Ben Moumen, Chaymae Benkirane, Yassine Taaifi, Kamal Belhaj, Mohamed Addi, Christophe Hano, Marie-Laure Fauconnier, Hana Serghini Caid, Ahmed Elamrani and Alam Zeb

Journal of Food Processing and Preservation, 2023, 2023, 1
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Evaluation of Commercially Available Products of Cannabis sativa L. Inflorescences to Identify Their Contents of Elemental and Phenolic Compounds

Katarzyna Wozniczka, Agnieszka Viapiana, Anna Roszkowska, Alina Plenis, Tomasz Baczek and Pawel Konieczynski

Foods, 2025, 14, 1208
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Comprehensive review on cannabis seed phenolic compounds from extraction to functional applications

Chaymae Benkirane, Rafika El Ati, Malika Abid, Jacques Nkengurutse, Hana Serghini-Caid, Ahmed Elamrani and Farid Mansouri

J Cannabis Res, 2026, 8
DOI: 10.1186/s42238-026-00401-3

Chemical Analysis of the Antihyperglycemic, and Pancreatic α-Amylase, Lipase, and Intestinal α-Glucosidase Inhibitory Activities of Cannabis sativa L. Seed Extracts

Salima Haddou, Amal Elrherabi, El Hassania Loukili, Rhizlan Abdnim, Asmae Hbika, Mohamed Bouhrim, Omkulthom Al Kamaly, Asmaa Saleh, Abdelaaty A. Shahat, Mohamed Bnouham, Belkheir Hammouti and Abdelkrim Chahine

Molecules, 2023, 29, 93
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Nutrients and Bioactive Compounds from Cannabis sativa Seeds: A Review Focused on Omics-Based Investigations

Tiziana M. Sirangelo, Gianfranco Diretto, Alessia Fiore, Simona Felletti, Tatiana Chenet, Martina Catani and Natasha Damiana Spadafora

IJMS, 2025, 26, 5219
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Hemp seed as an emerging source of nutritious functional ingredients

Laila Hossain, Kristin Whitney and Senay Simsek

Critical Reviews in Food Science and Nutrition, 2026, 66, 933
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Hemp Seeds (Cannabis sativa L.) as a Valuable Source of Natural Ingredients for Functional Foods—A Review

Virginia Tănase Apetroaei, Eugenia Mihaela Pricop, Daniela Ionela Istrati and Camelia Vizireanu

Molecules, 2024, 29, 2097
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Exploring of biological activity and diverse metabolites in hemp (Cannabis sativa) seed oil by GC/MS, GC–FID, and LC–HRMS chromatographies

İlhami Gulcin, Eda Mehtap Ozden, Muzaffer Mutlu, Ziba Mirzaee, Zeynebe Bingol, Ekrem Köksal, Saleh Alwasel and Ahmet C. Goren

Futur J Pharm Sci, 2024, 10
DOI: 10.1186/s43094-024-00705-2

Extraction of Active Compounds from Mixtures of Hemp (Cannabis sativa) with Plants of the Zingiberaceae Family

Vesna Postružnik, Taja Žitek Makoter, Darko Goričanec, Petra Kotnik, Željko Knez and Maša Knez Marevci

Molecules, 2023, 28, 7826
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Microwave‐Assisted Extraction of Hemp Seed Oil: Process Optimization for Enhancing Oil Yield and Bioactive Compound Extractability

Aymane Allay, Chaymae Benkirane, Abdessamad Ben Moumen, Youssef Rbah, Marie-Laure Fauconnier, Hana Serghini Caid, Ahmed Elamrani, Farid Mansouri and Severino Matias de Alencar

International Journal of Food Science, 2025, 2025
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Hemp Seed (Cannabis sativa L.) Varieties: Lipids Profile and Antioxidant Capacity for Monogastric Nutrition

Elena Rosso, Rosangela Armone, Annalisa Costale, Giorgia Meineri and Biagina Chiofalo

Animals, 2024, 14, 2699
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Recent HPLC-UV Approaches for Cannabinoid Analysis: From Extraction to Method Validation and Quantification Compliance

Eduarda M. P. Silva, Antonella Vitiello, Agnese Miro and Carlos J. A. Ribeiro

Pharmaceuticals, 2025, 18, 786
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Combined experimental design based-PROMETHEE approach to evaluate antimicrobial activity and optimization of polyphenol content of Prunus spinosa L. fruit

Gulsum Ucak Ozkaya

Food Measure, 2025, 19, 2844
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Investigating the Influence of Drying Methods on the Quality and Bioactive Properties of Hemp (Cannabis sativa L.) Seed Oil

Oumayma Boussetta, Amal Elrherabi, Fahd A. Nasr, El Hassania Loukili, Meryem Idrissi Yahyaoui, Nouhaila Amrani, Mohamed Chebaibi, Abdeslam Asehraou, Mohamed Bouhrim, Mohammed Al‐zharani, Ashraf Ahmed Qurtam and Mohammed Ramdani

Food Science & Nutrition, 2025, 13
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Protein Mass Fingerprinting and Antioxidant Power of Hemp Seeds in Relation to Plant Cultivar and Environment

Chiara Cattaneo, Annalisa Givonetti and Maria Cavaletto

Plants, 2023, 12, 782
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Aqueous Extracts from Hemp Seeds as a New Weapon against Staphylococcus epidermidis Biofilms

Angela Casillo, Caterina D’Angelo, Paola Imbimbo, Daria Maria Monti, Ermenegilda Parrilli, Rosa Lanzetta, Giovanna Gomez d’Ayala, Salvatore Mallardo, Maria Michela Corsaro and Donatella Duraccio

IJMS, 2023, 24, 16026
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A comparative study on phytochemical analysis and biological properties of three varieties of cannabis sativa L. seeds

Rafik El-Mernissi, Naoual El Menyiy, Aziz Zouhri, Yahya El-Mernissi, Amira Metouekel, Farhan Siddique, Mohammed H. AL Mughram, Denekew Temesgen, Abdullah R. Alanzi, Mohammad Khalid, Hassan Amhamdi, Oualid Abboussi and Lhoussain Hajji

Open Life Sciences, 2026, 21
DOI: 10.1515/biol-2025-1211

Phenolic profiles of non‐industrial hemp (Cannabis sativa L.) seed varieties collected from four different Moroccan regions

Chaymae Benkirane, Farid Mansouri, Abdessamad Ben Moumen, Yassine Taaifi, Reda Melhaoui, Hana Serghini Caid, Marie‐Laure Fauconnier, Ahmed Elamrani and Malika Abid

Int J of Food Sci Tech, 2023, 58, 1367
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Population structure and genetic diversity of Moroccan cannabis (Cannabis sativa L.) germplasm through simple sequence repeat (SSR) analysis

Chaymae Benkirane, Majida Charif, Christina M. Müller, Yassine Taaifi, Farid Mansouri, Mohamed Addi, Mohammed Bellaoui, Hana Serghini-Caid, Ahmed Elamrani and Malika Abid

Genet Resour Crop Evol, 2024, 71, 2037
DOI: 10.1007/s10722-023-01754-x

Plant-Derived Compounds in Hemp Seeds (Cannabis sativa L.): Extraction, Identification and Bioactivity—A Review

Virginia Tanase Apetroaei, Daniela Ionela Istrati and Camelia Vizireanu

Molecules, 2024, 30, 124
DOI: 10.3390/molecules30010124

Characterization of different hempseed fractions after dehulling and defatting: chemical composition and functional properties

Simon Okomo Aloo, SeonJu Park, Ye-Jin Jeong, Tuaumelsan Shumye Gebre and Deog-Hwan Oh

Food Measure, 2024, 18, 7868
DOI: 10.1007/s11694-024-02771-9

Optimizing Phenolic Compounds Extraction from Jatobá Fruit Husk Using a Mixture Design Approach

Felipe Tecchio Borsoi, Glaucia Maria Pastore and Henrique Silvano Arruda

Processes, 2026, 14, 1129
DOI: 10.3390/pr14071129

Comparative evaluation of hemp seed oil yield and physicochemical properties using supercritical CO2, accelerated hexane, and screw press extraction techniques

Rattana Muangrat and Apisada Kaikonjanat

Journal of Agriculture and Food Research, 2025, 19, 101618
DOI: 10.1016/j.jafr.2024.101618

Characterization of phenolic compounds and evaluation of anti-diabetic potential in Cannabis sativa L. seeds: In vivo, in vitro, and in silico studies

Rafik El-Mernissi, Naoual El Menyiy, Amira Metouekel, Aziz Zouhri, Yahya El-Mernissi, Farhan Siddique, Sumaira Nadeem, Hassan Amhamdi, Oualid Abboussi, Abdulaziz Abdullah Alsahli, Mohammed Bourhia, Musaab Dauelbait, Gamal A. Shazly and Lhoussain Hajji

Open Life Sciences, 2024, 19
DOI: 10.1515/biol-2022-1024

Biochemical Changes Induced by the Administration of Cannabis sativa Seeds in Diabetic Wistar Rats

Camelia Munteanu, Mihaela Mihai, Francisc Dulf, Andreea Ona, Leon Muntean, Floricuța Ranga, Camelia Urdă, Daria Pop, Tania Mihaiescu, Sorin Marian Mârza and Ionel Papuc

Nutrients, 2023, 15, 2944
DOI: 10.3390/nu15132944

Experimental optimization of a short-path distillation of alcoholic extracts from hemp

Oscar Y. Buitrago-Suescún, Carlos Martínez-Riascos and Alvaro Orjuela

Chemical Engineering and Processing - Process Intensification, 2026, 220, 110658
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Exploring the phytochemical and toxicological profile of Moroccan Cannabis sativa L. leaves extract: Behavioral, histological, and oxidative stress assessments

Hafida El Ghachi, Mjid Oukhrib, Faissal Aziz, Karima Benrazzouk, Halima Gamrani, Rachid Soulimani and Loubna Boukhzar

Journal of Ethnopharmacology, 2025, 350, 120058
DOI: 10.1016/j.jep.2025.120058

Detection and quantification of free amino compounds in selected agricultural by-products with derivatization followed by liquid chromatography-tandem mass spectrometry analysis

Larissa Silva Maciel, Dunja Malenica, Koit Herodes, Marko Kass and Rajeev Bhat

Food Chemistry Advances, 2024, 4, 100629
DOI: 10.1016/j.focha.2024.100629

Inhibitory effects of phenylpropionamides from the hemp seed husk on tyrosinase

Jang Hoon Kim, Kyung-Sook Han, Eun-Song Lee, Yong-Goo Kim, Yong-Il Kim, Jae-Young Cheon, Hyun-Ju Jung, Ki Mo Kim and Ik Soo Lee

International Journal of Biological Macromolecules, 2024, 282, 136939
DOI: 10.1016/j.ijbiomac.2024.136939

Optimization of UAE-NADES green extraction of bioactive compounds from chickpea (Cicer arietinum L.) sprouts using simplex lattice mixture design methodology

Waseem Khalid, Hyrije Koraqi, Imed E Benmebarek, Andrés Moreno, Tawfiq Alsulami, Robert Mugabi and Gulzar Ahmad Nayik

Ultrasonics Sonochemistry, 2025, 112, 107186
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Development of Clean-Label Protein- and Fiber-Enriched Dry Pretzels Using Hemp Seed By-Products

Tatiana Capcanari and Eugenia Covaliov

Foods, 2025, 14, 3925
DOI: 10.3390/foods14223925

Optimization of Hemp Seed (Cannabis sativa L.) Protein Extraction and Glycation Conditions by Response Surface Methodology: Physicochemical, Functional, and Thermal Characteristics

Elvan Yüzer, Naciye Kutlu, Mustafa Onur Yüzer and El Hassan Sakar

Journal of Food Biochemistry, 2025, 2025
DOI: 10.1155/jfbc/5493335

Dietary hempseed and cardiovascular health: nutritional composition, mechanisms and comparison with other seeds

Ömer Furkan Kaçar, Tugba Kose and Hüsna Kaya Kaçar

Front. Nutr., 2025, 12
DOI: 10.3389/fnut.2025.1669375

Hemp seed extract exerts cytostatic effects through metabolic stress and autophagy modulation in malignant cells

Stefania Moccia, Maria Russo, Carmen Cervellera, Giuseppina Crescente, Carmela Spagnuolo and Gian Luigi Russo

Sci Rep, 2026, 16
DOI: 10.1038/s41598-026-37119-4

HPLC-DAD Profiling of Phenolic Components and Comparative Assessment of Antioxidant Potency in Opuntia robusta, Opuntia dillenii, and Opuntia ficus-indica Cladodes at Diverse Stages of Ripening

Ahmed Marhri, Youssef Rbah, Aymane Allay, Mehdi Boumediene, Aziz Tikent, Abdessamad Benmoumen, Reda Melhaoui, Ahmed Elamrani, Malika Abid and Mohamed Addi

J. Oleo Sci., 2024, 73, 1529
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Effect of screw pressing temperature on yield, bioactive compounds, and quality of hemp (Cannabis sativa L.) seed oil

Aymane Allay, Abdessamad Ben Moumen, Youssef Rbah, Marie-Laure Fauconnier, Jacques Nkengurutse, Hana Serghini Caid, Ahmed Elamrani and Farid Mansouri

J Cannabis Res, 2025, 7
DOI: 10.1186/s42238-025-00296-6

Chemical and functional characterization of the main bioactive molecules contained in hulled Cannabis sativa L. seeds for use as functional ingredients

S. Frazzini, M.C. Torresani, G. Roda, M. Dell’Anno, G. Ruffo and L. Rossi

Journal of Agriculture and Food Research, 2024, 16, 101084
DOI: 10.1016/j.jafr.2024.101084

Inhibitory activity of lignanamides isolated from hemp seed hulls(Cannabis sativa L.) against soluble epoxide hydrolase

Jang Hoon Kim, Yun-Chan Huh, Mok Hur, Woo Tae Park, Youn-Ho Moon, Tae IL. Kim, Seon Mi Kim and Sung-Cheol Koo

Heliyon, 2023, 9, e19772
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Biopeptide-rich fermented hemp seeds: Boosting anti-inflammatory and immune responses through Lactiplantibacillus plantarum probiotic fermentation

LingYue Shan, SeonJu Park, Kaliayn Barathikannan, Ramachandran Chelliah, Dong-Gyu Kim, Zhen Yang and Deog Hwan Oh

International Journal of Biological Macromolecules, 2025, 290, 138782
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Optimizing ethanol-modified supercritical CO₂ extraction for enhanced bioactive compound recovery in hemp seed oil

Aymane Allay, Chaymae Benkirane, Abdessamad Ben Moumen, Marie-Laure Fauconnier, Hamza Bouakline, Jacques Nkengurutse, Hana Serghini Caid, Ahmed Elamrani and Farid Mansouri

Sci Rep, 2025, 15
DOI: 10.1038/s41598-025-91441-x

Valorisation of pomegranate waste: A sustainable approach to harnessing natural antioxidants

Nadia Shahbazi, Ali Azizi, Mohammad Sayyari, Forouh Sadat Seyedi and Seyyed Hossein Pourhosseini

Bioresource Technology Reports, 2025, 31, 102178
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Hemp seed ( Cannabis sativa L.) cake as sustainable dietary additive in slow-growing broilers: effects on performance, meat quality, oxidative stability and gut health

Vincenzo Tufarelli, Caterina Losacco, Luigi Tedone, Letizia Passantino, Simona Tarricone, Vito Laudadio and Maria Antonietta Colonna

Veterinary Quarterly, 2023, 43, 1
DOI: 10.1080/01652176.2023.2260448

Hemp Seed Cake Flour as a Source of Proteins, Minerals and Polyphenols and Its Impact on the Nutritional, Sensorial and Technological Quality of Bread

Tatiana Capcanari, Eugenia Covaliov, Cătălina Negoița, Rodica Siminiuc, Aurica Chirsanova, Vladislav Reșitca and Dinu Țurcanu

Foods, 2023, 12, 4327
DOI: 10.3390/foods12234327

Waste from hemp essential oil production: How distillation methods shape the byproducts value

Eleonora Spinozzi, Luca Boldrini, Marta Ferrati, Erica Betti, Massimo Ricciutelli, Valtcho D. Zheljazkov, Stefano Dall’Acqua, Stefania Sut, Marco Cespi, Riccardo Petrelli and Filippo Maggi

Industrial Crops and Products, 2025, 230, 121094
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Microwave-Assisted Subcritical Water Extraction of Hemp Seeds for the Simultaneous Recovery of Proteins and Phenolic Compounds

Aziadé Chemat, Salah Chaji, Christian Cravotto, Giorgio Capaldi, Luisa Boffa, Giorgio Grillo, Anne-Sylvie Fabiano-Tixier and Giancarlo Cravotto

Foods, 2025, 14, 4201
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Solvent Selection for Polyphenol Extraction from Yerba Mate (Ilex paraguariensis) Leaf Residue: A Mixture Design and Exhaustive Extraction Approach

Emiliano R. Neis, Mónica M. Covinich, Ana E. Thea, Griselda P. Scipioni and Miguel E. Schmalko

Food Anal. Methods, 2026, 19
DOI: 10.1007/s12161-026-03099-4

Enhancement of ultrasonic-assisted extraction and antioxidant potential of phenolic compounds from Moroccan Cannabis sativa: A green intelligent approach integrating optimal mixture process design and artificial neural networks

Mouhcine Fadil, Sara Lebrazi, Abderrazak Aboulghazi, Aafaf El Baakili, Nour Eddine Es-safi, Chaimae Rais, Chaimae Slimani and Abdellah Farah

Sustainable Chemistry and Pharmacy, 2024, 37, 101359
DOI: 10.1016/j.scp.2023.101359

Comparative Analysis of Antioxidant Potency and Phenolic Compounds in Fruit Peel of Opuntia robusta, Opuntia dillenii, and Opuntia ficus-indica Using HPLC‐DAD Profiling

Ahmed Marhri, Youssef Rbah, Aymane Allay, Mehdi Boumediene, Aziz Tikent, Abdessamad Benmoumen, Reda Melhaoui, Ahmed Elamrani, Malika Abid, Mohamed Addi and Maria Concetta Strano

Journal of Food Quality, 2024, 2024
DOI: 10.1155/2024/2742606

Enhancing bioactive compound extractability and antioxidant properties in hemp seed oil using a ternary mixture approach of polar and non-polar solvents

Aymane Allay, Chaymae Benkirane, Abdessamad Ben Moumen, Youssef Rbah, Marie-Laure Fauconnier, Hana Serghini Caid, Ahmed Elamrani and Farid Mansouri

Industrial Crops and Products, 2024, 219, 119090
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Lignanamides: A comprehensive review of chemical constituents, biological activities, extraction methods and synthetic pathway

Jing Sun, Li-Tao Tong, Peng-Fei Tu, Lin-Lin Chen, Xin Xu, Ya Song, Xin-Xin Yang, Zi-Bin Guo, Xiang Zou, Chen-Xin Sun, Yan Mi, Bei Fan and Feng-Zhong Wang

Food Chemistry, 2024, 460, 140459
DOI: 10.1016/j.foodchem.2024.140459

Optimization of extraction condition to improve blackthorn (Prunus spinosa L.) polyphenols, anthocyanins and antioxidant activity by natural deep eutectic solvent (NADES) using the simplex lattice mixture design method

Hyrije Koraqi, Alev Yüksel Aydar, Ravi Pandiselvam, Bujar Qazimi, Waseem Khalid, Anka Trajkovska Petkoska, Cengiz Çesko, Seema Ramniwas, Syed Mohammed Basheeruddin Asdaq and Sarvesh Rustagi

Microchemical Journal, 2024, 200, 110497
DOI: 10.1016/j.microc.2024.110497

Cosmetic potential of phenolic-rich extracts from Cannabis sativa L. seeds: Inhibition of enzymes involved in skin aging, inflammation and hyperpigmentation

Chaymae Benkirane, Rafika El Ati, Omayma El Maabiche, Marie-Laure Fauconnier, Malika Abid, Larbi Rhazi, Alicia Ayerdi Gotor, Hana Serghini-Caid, Ahmed Elamrani and Farid Mansouri

Scientific African, 2026, 32, e03332
DOI: 10.1016/j.sciaf.2026.e03332