Identification, screening and molecular mechanisms of natural stable angiotensin-converting enzyme (ACE) inhibitory peptides from foxtail millet protein hydrolysates: a combined in silico and in vitro study

Yiqing Zhu, Changyu Chen, Zijian Dai, Han Wang, Yiyun Zhang, Qingyu Zhao, Yong Xue and Qun Shen

Food Funct., 2024, 15, 7782
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Characterization, mechanisms, structure–activity relationships, and antihypertensive effects of ACE inhibitory peptides: rapid screening from sufu hydrolysate

Jianfei Li, Haohan Hu, Feng Chen, Chenying Yang, Wanzhou Yang, Yuexin Pan, Xiaodong Yu and Qiyi He

Food Funct., 2024, 15, 9224
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Sourcing, Use of Biopeptides, and Active Protein Hydrolysates as a Positive Response to Green Politics in the World—Current State and Challenges: A Review

Hana Gedif and Joanna Tkaczewska

Food Bioprocess Technol, 2024, 17, 4450
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Enhancement of Spirulina platensis bioactivity by probiotic fermentation and encapsulation by spray‐drying

Esmeray Kuley, Leyla Uslu, Mustafa Durmus, Yetkin Sakarya and Gulsun Özyurt

Int J of Food Sci Tech, 2023, 58, 6015
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Discovery of a novel nanomolar angiotensin-I converting enzyme inhibitory peptide with unusual binding mechanisms derived from Chlorella pyrenoidosa

Qishan Suo, Jing Wang, Ning Wu, Lihua Geng, Quanbin Zhang and Yang Yue

International Journal of Biological Macromolecules, 2024, 280, 135873
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Natural antihypertensive agents: innovative extraction techniques: Bioactive profiling and mechanistic pathways for therapeutic development

Raji Ramachandran, Ratna Surya Alwi, Maulida Mazaya, Pradisha Prem, Chinnaperumal Kamaraj, Silviyah Maytasya and Maratu Soleha

South African Journal of Botany, 2026, 188, 494
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Exploring the Nutritional and Medicinal potential of Spirulina

Khushboo Gaur, Ankita Wal, Preeti Sharma, Amana Parveen, Prerna Singh, Prashant Mishra, Pranay Wal and N T Pramathesh Mishra

NRFHH, 2024, 4, 277
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Microalgal proteins: Extraction, interfacial properties, bioactivities, and future perspectives – A review

Junwen Wang, Jiangfei Li, Wenchen Yu, Ge Wang, Alejandro Cifuentes, Elena Ibañez and Weihong Lu

Food Chemistry, 2025, 486, 144680
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A novel ACE inhibitory peptide from Gadus morhua skin: Isolation, characterization and antihypertensive mechanisms

Shuai Li, Jie Huai, Bingfu Yang, Cunxi Lu, Junjie Qiu, Yi Ding, Renjie Zhou and Shan Wang

Journal of Functional Foods, 2026, 136, 107133
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Response surface optimization of preparation parameters and evaluation of the antioxidant and antihypertensive activities of Spirulina protein hydrolysates

Qishan Suo, Zhenzhen Deng, Yang Yue, Jing Wang, Ning Wu, Lihua Geng and Quanbin Zhang

J. Ocean. Limnol., 2025, 43, 196
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Discovery and mechanistic insights into ACE inhibitory peptides from the gastrointestinal digest of royal jelly proteins: peptidomics, bioactivity profiling, in silico screening, and in vitro validation

Wanyu Yang, Xiaodi Hu, Tianrong Zhang, Ming Zhao, Qiongmin Li, Mengnan Sang, Jinling Fan, Yuan Zhao and Bin Zhang

Food Research International, 2026, 229, 118476
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Comprehensive characterization of bioactive peptides in rice bran protein hydrolysates: A multi‐platform approach for metabolomic profiling, identification, and molecular docking analysis

Ajay Kumar, Narpinder Singh and Robin Joshi

Cereal Chem, 2024, 101, 1000
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Plant protein-derived anti-breast cancer peptides: sources, therapeutic approaches, mechanisms, and nanoparticle design

Deju Zhang, Ying Yuan, Qingdong Zeng, Juan Xiong, Yiming Gan, Kai Jiang and Ni Xie

Front. Pharmacol., 2025, 15
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A novel ACE inhibitory peptide from Douchi hydrolysate: Stability, inhibition mechanism, and antihypertensive potential in spontaneously hypertensive rats

Jianfei Li, Haohan Hu, Xiya Chen, Haiting Zhu, Wenhao Zhang, Zhiyuan Tai, Xiaodong Yu and Qiyi He

Food Chemistry, 2024, 460, 140734
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Structure characterization and mechanism of angiotensin I-converting enzyme (ACE) inhibitory peptides modified by plastein reaction derived from tiger nut (Cyperus esculentus)

Junhua Shi, Zhuo Yang, Ming Xu, Guogang Zhao, Yawen Gao, Hongyan Zheng and Ji Feng

Front. Sustain. Food Syst., 2025, 8
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Microalgae-Derived Peptides Targeting Lifestyle-Related Diseases: Discovery, Mechanisms, Structure–Activity Relationships, and Structural Modifications

Mohammed S. Qoms, Sok Kuan Wong, Norsyahida Mohd Fauzi, Khairana Husain, Suzana Makpol and Jen Kit Tan

Antioxidants, 2025, 14, 1170
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The Role of Chlorella and Spirulina as Adjuvants of Cardiovascular Risk Factor Control: A Systematic Review and Meta-Analysis of Randomised Controlled Trials

Mariana Pinto-Leite, Diana Martins, António Carlos Ferreira, Cláudia Silva, Fábio Trindade, Francisca Saraiva, Rui Vitorino, Raquel Barros, Pedro A. Lima, Adelino Leite-Moreira, João Pedro Ferreira, António S. Barros and Isabel M. Miranda

Nutrients, 2025, 17, 943
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Exploration and molecular mechanism of novel ACE inhibitory peptides from goat milk protein: A combined in silico and in vitro study

Ruikai Zhu, Hong Zhang, Yulong Wu, Huanhuan Li, Honggang Tang, Xianrong Xu and Ke Zhao

International Dairy Journal, 2025, 167, 106265
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Separation, characterization, AI screening, and bioactivities of marine bioactive peptides: A review

Yi Cui, Xiaorui Li, Yiran Sun, Yinyin Liu, Weiye Zhang, Yifan Jiang, Yunxiang Zhou, Jinshan Liu, Bangyu Gong, Yuzhen Wu, Shengfu Li, Linwu Zhuang, Wei Cong and Junjie Zhang

Food Chemistry, 2025, 495, 146312
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Marine proteins and peptides: Production, biological activities, and potential applications

Ilekuttige Priyan Shanura Fernando, Thilina U. Jayawardena and Jianping Wu

FIA, 2023, 2, 69
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Beneficial Effects of Spirulina Supplementation in the Management of Cardiovascular Diseases

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Nutrients, 2024, 16, 642
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From Multi-Species Screening to Targeted Investigation: Discovery of ACE Inhibitory Peptides in Gigantidas platifrons via Peptidomics, Virtual Screening, and Molecular Dynamics Simulations

Haorui Zhang, Yuhong Ouyang, Qishan Suo, Hao Chen, Jie Cui and Yang Yue

Molecules, 2026, 31, 757
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Spirulina/Arthrospira/Limnospira—Three Names of the Single Organism

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Foods, 2024, 13, 2762
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Algae and Algal Protein in Human Nutrition: A Narrative Review of Health Outcomes from Clinical Studies

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Nutrients, 2026, 18, 277
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Alcalase for Food-Protein-Derived Bioactive Peptides: Trends, Gaps, and Translational Opportunities

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Macromol, 2026, 6, 16
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Study on material basis and anti-hypertensive metabolomics of different extraction methods of the Uncaria rhynchophylla Scrophularia Formula

Haichao Li, Lihua Wang, Ling Zhang, Jinlei Liu, Hao Zhang, Danyang Wang and Wenqing Yang

Journal of Pharmaceutical and Biomedical Analysis, 2023, 233, 115464
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Cashew nut oligopeptide inhibits mast cell degranulation by suppressing activation of the NF-Κb signalling pathway

Di Chen, Xin Zhou, Yan Zhang and Jian Chen

Food Chemistry: X, 2025, 29, 102839
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From Sea to Lab: Angiotensin I-Converting Enzyme Inhibition by Marine Peptides—Mechanisms and Applications

Du-Min Jo, Fazlurrahman Khan, Seul-Ki Park, Seok-Chun Ko, Kyung Woo Kim, Dongwoo Yang, Ji-Yul Kim, Gun-Woo Oh, Grace Choi, Dae-Sung Lee and Young-Mog Kim

Marine Drugs, 2024, 22, 449
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Testosterone-promoting effects of Trichosanthes kirilowii-derived peptides on TM3 cells

Zhilin He, Dong Peng, Jieyu Zeng, Wanying Liang, Xinqi Li, Junyi Chen, Pan Li, Bing Du and Hua Li

Food Bioscience, 2024, 61, 104890
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The Therapeutic Importance of Oxy+: An Overview

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Hippocratic Journal of Unani Medicine, 2024, 19, 6
DOI: 10.4103/hjum.hjum_53_25