Structure activity relationship (SAR) and anticancer activity of pyrrolidine derivatives: Recent developments and future prospects (A review)

Aeyaz Ahmad Bhat, Iqubal Singh, Nitin Tandon and Runjhun Tandon

European Journal of Medicinal Chemistry, 2023, 246, 114954
DOI: 10.1016/j.ejmech.2022.114954

Experimental and computational study of Ni(II) and Zn(II) complexes of isatin-3-thiosemicarbazone: Structure, biological activity and ct-DNA binding study

Qurat Ul Ain, Iqubal Singh, Kamaldeep Paul, Ray J. Butcher and Rekha Sharma

Journal of Molecular Structure, 2025, 1335, 141846
DOI: 10.1016/j.molstruc.2025.141846

Synthesis and biological evaluation of 1-phenyl-4,6-dihydrobenzo[b]pyrazolo[3,4-d]azepin-5(1H)-one/thiones as anticancer agents

Ramulu Parupalli, Ravikumar Akunuri, Akella Spandana, Regur Phanindranath, Suneela Pyreddy, Mohd Rabi Bazaz, Manasa Vadakattu, Swanand Vinayak Joshi, Sushmitha Bujji, Balakishan Gorre, Venkata Madhavi Yaddanapudi, Manoj P. Dandekar, Velma Ganga Reddy, Narayana Nagesh and Srinivas Nanduri

Bioorganic Chemistry, 2023, 135, 106478
DOI: 10.1016/j.bioorg.2023.106478

Investigating the Antibacterial Efficiency and Mechanism of Indole- and Naphthalimide-Mediated Benzimidazoles: Membrane Damage, Metabolic Inactivation, and Oxidative Stress against Bacillus subtilis

Rohini Gupta, Vijay Luxami and Kamaldeep Paul

ACS Appl. Mater. Interfaces, 2025, 17, 24830
DOI: 10.1021/acsami.4c21661

Exploring the interplay between structure-activity relationship and anticancer potential of pyridine derivatives

Aeyaz Ahmad Bhat and Iqubal Singh

Future Medicinal Chemistry, 2026, 18, 675
DOI: 10.1080/17568919.2026.2620359

Synthesis, characterization and anti-tubercular activities of copper(II) complexes of substituted 2,3-isatin bisthiosemicarbazones: An experimental and theoretical approach

Qurat Ul Ain, Amandeep Singh, Iqubal Singh, Raanan Carmieli and Rekha Sharma

Results in Chemistry, 2023, 6, 101171
DOI: 10.1016/j.rechem.2023.101171

Design, Synthesis, and Biological Evaluation of a Class of TEMPOmodified Naphthalimide Derivatives with Good Selectivity for Tumor Cells

Qingqing Hao, Yujiao Zhang and Xuliang Jiang

LDDD, 2024, 21, 790
DOI: 10.2174/1570180820666230112165606

Integrated insulin-iron nanoparticles: a multi-modal approach for receptor-specific bioimaging, reactive oxygen species scavenging, and wound healing

Komal Attri, Bhupendra Chudasama, Roop L. Mahajan and Diptiman Choudhury

Discover Nano, 2024, 19
DOI: 10.1186/s11671-024-04024-6

New benzothiazole-indole-1,2,3-triazole-N-phenylacetamide derivatives as cytotoxic agents: Design, synthesis, and in vitro cytotoxic evaluations

Amir Mohammad Taherkhani, Mohammad Hosein Sayahi, Bahareh Hassani, Navid Dastyafteh, Maryam Mohammadi-Khanaposhtani, Elahe Rafiei, Maryam Meshkani, Sajedeh Safapoor, Mohammadreza Mohajeri Tehrani, Bagher Larijani, Mohammad Mahdavi and Omidreza Firuzi

Journal of Molecular Structure, 2025, 1336, 142089
DOI: 10.1016/j.molstruc.2025.142089

Recent Developments in the Synthesis of Benzothiazoles and their Anti-cancer Mechanistic Discoveries

Wafaa A. Zaghary, Galal H. Elgemeie, Rasha A. Azzam, Safa A. Aljuhr and Tamer M. Sakr

CPD, 2025, 31, 2559
DOI: 10.2174/0113816128355783250212043621

Crystal structure, bioactivity and in silico binding simulations of NiII and ZnII Thiosemicarbazone complexes

Qurat Ul Ain, Charanjit Kaur, Pooja, Ray J. Butcher and Rekha Sharma

Inorganica Chimica Acta, 2026, 589, 122934
DOI: 10.1016/j.ica.2025.122934

The Synthesis and Biological Evaluation of 2-(1H-Indol-3-yl)quinazolin-4(3H)-One Derivatives

Elena Y. Mendogralo, Larisa Y. Nesterova, Ekaterina R. Nasibullina, Roman O. Shcherbakov, Alexander G. Tkachenko, Roman Y. Sidorov, Maxim A. Sukonnikov, Dmitry A. Skvortsov and Maxim G. Uchuskin

Molecules, 2023, 28, 5348
DOI: 10.3390/molecules28145348

The anti‐breast cancer potential of indole/isatin hybrids

Ruo Wang, Renhong Huang, Yaofeng Yuan, Zheng Wang and Kunwei Shen

Archiv der Pharmazie, 2023, 356
DOI: 10.1002/ardp.202300402

Indole-thiazole hybrids with anticancer potential

Lianlian Chen, Danchen Zhao, Kesong Zhu, Donghong Wang, Yu Li, Mengnan Qu and Yafei Zhuang

Future Medicinal Chemistry, 2026, 18, 713
DOI: 10.1080/17568919.2026.2620365

Synthesis and Biological Importance of 2-(thio)ureabenzothiazoles

Martha Cecilia Rosales-Hernández, Jessica E. Mendieta-Wejebe, Itzia I. Padilla-Martínez, Efrén V. García-Báez and Alejandro Cruz

Molecules, 2022, 27, 6104
DOI: 10.3390/molecules27186104

Benzothiazole‐based apoptosis inducers: A comprehensive overview and future prospective

Payal Kamboj, Anjali Mahore, Asif Husain and Mohammad Amir

Archiv der Pharmazie, 2024, 357
DOI: 10.1002/ardp.202300493

Development of indole hybrids for potential lung cancer treatment - part II

Shanshan Huang, Zhi Xu and Yafei Zhuang

Future Medicinal Chemistry, 2025, 17, 961
DOI: 10.1080/17568919.2025.2485867

Synthesis, SAR, and in Silico ADME Screening Studies of Some 9-Amino-3-Phenylacridone Derivatives as Topoisomerase II Inhibitors

Abiodun S. Oyedele, Toluwase H. Fatoki, Esha Dalvie, Neil Osheroff and Cosmas O. Okoro

OJMC, 2023, 13, 15
DOI: 10.4236/ojmc.2023.132002