Sarah R. Buzsaki, Savannah M. Mason, Padmanabha V. Kattamuri, Juan M. I. Serviano, Dinora N. Rodriguez, Conner V. Wilson, Drew M. Hood, Jonathan D. Ellefsen, Yen-Chu Lu, Jolie Kan, Julian G. West, Scott J. Miller and Patrick L. Holland

J. Am. Chem. Soc., 2024, 146, 17296
DOI: 10.1021/jacs.4c04047

Nickel-Catalyzed Branched Hydroalkylation of Alkenes with Diazo Compounds

Nikita Kvasovs, Valeriia Iziumchenko, Alistair J. Sterling and Vladimir Gevorgyan

J. Am. Chem. Soc., 2025, 147, 8093
DOI: 10.1021/jacs.4c17586

Practical and Scalable Total Syntheses of (+)-Dysidavarones A–C

Yang Kuang, Le Chang, Bingjian Wang, Jingyi Kang, Chuanke Chong and Zhaoyong Lu

Synlett, 2024, 35, 582
DOI: 10.1055/a-2066-0860

Engaging Alkenes in Metallaphotoredox: A Triple Catalytic, Radical Sorting Approach to Olefin-Alcohol Cross-Coupling

Qinyan Cai, Iona M. McWhinnie, Nathan W. Dow, Amy Y. Chan and David W. C. MacMillan

J. Am. Chem. Soc., 2024, 146, 12300
DOI: 10.1021/jacs.4c02316

Distal Heteroaryl Ipso‐Migration of Unactivated Alkenes via Cobalt/Photoredox‐Catalyzed Hydrogen/Deuterium Atom Transfer

Masaaki Yamashita, Akihiko Suzuki, Tatsuhiko Yoshino, Kosuke Higashida, Masahiro Kojima and Shigeki Matsunaga

Chemistry An Asian Journal, 2025, 20
DOI: 10.1002/asia.202500448

Catalytic hydrofunctionalizations of alkenes via hydrogen atom transfer with 3d transition metal complexes (MHAT): A pragmatic approach to recent contributions

Antonio Torres-Calis and Juventino J. García

Applied Catalysis A: General, 2025, 704, 120379
DOI: 10.1016/j.apcata.2025.120379

Copper‐Catalyzed Markovnikov Hydroboration of Alkenes via Hydrogen Atom Transfer (MHAT)

Antonio Torres‐Calis and Juventino J. García

Adv Synth Catal, 2026, 368
DOI: 10.1002/adsc.70286

Markovnikov-Selective Hydroboration of Unactivated Alkenes via MHAT under Cobalt/Photoredox Dual Catalysis

Yusuke Seino, Shintaro Dozen, Tatsuhiko Yoshino, Kosuke Higashida and Shigeki Matsunaga

Org. Lett., 2026, 28, 2771
DOI: 10.1021/acs.orglett.6c00348

Divergent total synthesis of marine meroterpenoids (+)-dysidavarones A–C

Qunlong Zhang, Yang Kuang, Le Chang, Jingyi Kang, Bingjian Wang, Chuanke Chong and Zhaoyong Lu

Chinese Chemical Letters, 2024, 35, 108338
DOI: 10.1016/j.cclet.2023.108338

Electrocatalytic Access to Azetidines via Intramolecular Allylic Hydroamination: Scrutinizing Key Oxidation Steps through Electrochemical Kinetic Analysis

Steve H. Park, Geunsu Bae, Ahhyeon Choi, Suyeon Shin, Kwangmin Shin, Chang Hyuck Choi and Hyunwoo Kim

J. Am. Chem. Soc., 2023, 145, 15360
DOI: 10.1021/jacs.3c03172

HAT lessons help hydrogen hop, skip, and jump

Sarah R. Buzsaki, Kang-Jie Bian and Julian G. West

Trends in Chemistry, 2022, 4, 1062
DOI: 10.1016/j.trechm.2022.09.001

Total Synthesis of Dactyloquinone A and Spiroetherone A via a Metal‐Hydride Hydrogen Atom Transfer (MHAT) Process and a Quinol–Enedione Rearrangement

Guillaume Schoenn, Cyrille Kouklovsky, Régis Guillot, Thomas Magauer and Guillaume Vincent

Angew Chem Int Ed, 2025, 64
DOI: 10.1002/anie.202505270

C–H Functionalization-Enabled 11-Step Semisynthesis of (−)-Veragranine A and Characterization of Synthetic Analogs in Osteoarthritis-related Pain Treatment

Donghui Ma, Paz Duran, Reem Al-Ahmad, Sara Hestehave, Margarita Joa, Omar Alsbiei, Erick J. Rodríguez-Palma, Yanrong Li, Shilin Wang, Rajesh Khanna and Mingji Dai

J. Am. Chem. Soc., 2024, 146, 16698
DOI: 10.1021/jacs.4c04025

Synthesis of Polysubstituted Enamides by Hydrogen Atom Transfer Alkene Isomerization Using Dual Cobalt/Photoredox Catalysis

Yusuke Seino, Yuto Yamaguchi, Akihiko Suzuki, Masaaki Yamashita, Yuji Kamei, Futa Kamiyama, Tatsuhiko Yoshino, Masahiro Kojima and Shigeki Matsunaga

Chemistry A European J, 2023, 29
DOI: 10.1002/chem.202300804

Divergent Total Syntheses of Elisapterane and Relevant Diterpenoids Assisted by In Silico Structure Reassignment

Chun-Hui Liu, Han Gong, Yidian Sheng, Wentao Wang, Qidong Xia and Hanfeng Ding

J. Am. Chem. Soc., 2025, 147, 33136
DOI: 10.1021/jacs.5c11010

Isocyanides as Acceptor Groups in MHAT Reactions with Unactivated Alkenes

Jordi Puig, Josep Bonjoch and Ben Bradshaw

Org. Lett., 2023, 25, 6539
DOI: 10.1021/acs.orglett.3c02358

Cobalt-catalyzed HAT reaction for asymmetric hydrofunctionalization of alkenes and nucleophiles

Ge Zhang and Qian Zhang

Chem Catalysis, 2023, 3, 100526
DOI: 10.1016/j.checat.2023.100526

Diastereoselective Ring Expansion of Cyclic Ketones Enabled by HAT-Initiated Radical Cascade

Wenxue Wang, Shouyang Feng, Yansheng Wei, Hongyu Wang and Yun Li

Org. Lett., 2023, 25, 8022
DOI: 10.1021/acs.orglett.3c03236

Total Synthesis of (−)-Retigeranic Acid A: A Reductive Skeletal Rearrangement Strategy

Dongyu Sun, Ruyi Chen, Dongmin Tang, Qidong Xia, Yifan Zhao, Chun-Hui Liu and Hanfeng Ding

J. Am. Chem. Soc., 2023, 145, 11927
DOI: 10.1021/jacs.3c03178

Asymmetric Reduction of Unactivated Alkenes

Nico D. Fessner, Sebastian Roth, Richard Niese and Michael Müller

Chemistry A European J, 2026
DOI: 10.1002/chem.70826

Strategy Evolution in a Skeletal Remodeling and C–H Functionalization-Based Synthesis of the Longiborneol Sesquiterpenoids

Robert F. Lusi, Goh Sennari and Richmond Sarpong

J. Am. Chem. Soc., 2022, 144, 17277
DOI: 10.1021/jacs.2c08136

Concise Enantioselective Total Syntheses of Rearranged ent‐Trachylobane Diterpenoids (–)‐Wallichanols A and B

Dattatraya H. Dethe, Nitin Sharma and Sakshi Juyal

Angew Chem Int Ed, 2025, 64
DOI: 10.1002/anie.202505766

Total Synthesis of Euphane Triterpenoids Using Metal‐Catalyzed Hydrogen Atom Transfer

Chengying Zhou, Weitian Qin, Canhui Tu, Yunxuan Chen, Shaomin Fu and Bo Liu

Angewandte Chemie, 2025, 137
DOI: 10.1002/ange.202503943

Formation of TEMPO Adducts with Hydrogen Atom Transfer: An Alternative Pathway to Versatile Hydrofunctionalizations of Olefins

Chengbo Yao, Muinat A. Aliyu, Yanjun Wan and Jack R. Norton

Chemistry A European J, 2025, 31
DOI: 10.1002/chem.202403899

Asymmetric Total Synthesis of Naphthospironone A

Jia‐Xuan Liu, Shi‐Peng Zhang, Feng‐Sen Sun, Hui Li, Ya‐Ling Gong, Shi‐Chao Lu and Shu Xu

Angewandte Chemie, 2023, 135
DOI: 10.1002/ange.202303229

Role of Steric Effects on Rates of Hydrogen Atom Transfer Reactions

Yi Sun, Fengjiao Liu, Jacob N. Sanders and K. N. Houk

J. Org. Chem., 2023, 88, 12668
DOI: 10.1021/acs.joc.3c01361

Remote Steric and Electronic Effects of N-Heterocyclic Carbene Ligands on Alkene Reactivity and Regioselectivity toward Hydrocupration Reactions: The Role of Expanded-Ring N-Heterocyclic Carbenes

Aqeel A. Hussein and Azhar Ariffin

J. Org. Chem., 2023, 88, 13009
DOI: 10.1021/acs.joc.3c01121

A Quadruple Catalysis Enabling Intermolecular Branch‐Selective Hydroacylation of Styrenes

Yunosuke Takekawa, Masanari Nakagawa, Kazunori Nagao and Hirohisa Ohmiya

Chemistry A European J, 2023, 29
DOI: 10.1002/chem.202301484

Synthesis of 1,2‐N/O‐Heterocycles via Metal Hydride Hydrogen Atom Transfer Radical Cyclization on Vinylogous N‐Alkoxycarbamates

Santosh J. Gharpure, Simran R. Narang, Rupali S. Chavan and Gajain V. Dessai

Adv Synth Catal, 2026, 368
DOI: 10.1002/adsc.70320

Iron-Mediated Segment Coupling of Alkenols with Acceptors via C–C Radical Translocation and Remote Oxidative 1,5/6-Hydrogen Atom Transfer

Santosh J. Gharpure, Rupali S. Chavan and Dipak J. Fartade

Org. Lett., 2024, 26, 9920
DOI: 10.1021/acs.orglett.4c03749

Total Synthesis of Euphane Triterpenoids Using Metal‐Catalyzed Hydrogen Atom Transfer

Chengying Zhou, Weitian Qin, Canhui Tu, Yunxuan Chen, Shaomin Fu and Bo Liu

Angew Chem Int Ed, 2025, 64
DOI: 10.1002/anie.202503943

Intercepting Hydrogen Evolution with Hydrogen-Atom Transfer: Electron-Initiated Hydrofunctionalization of Alkenes

Xiangyu Wu, Cara N. Gannett, Jinjian Liu, Rui Zeng, Luiz F. T. Novaes, Hongsen Wang, Héctor D. Abruña and Song Lin

J. Am. Chem. Soc., 2022, 144, 17783
DOI: 10.1021/jacs.2c08278

Total Synthesis of Dactyloquinone A and Spiroetherone A via a Metal‐Hydride Hydrogen Atom Transfer (MHAT) Process and a Quinol–Enedione Rearrangement

Guillaume Schoenn, Cyrille Kouklovsky, Régis Guillot, Thomas Magauer and Guillaume Vincent

Angewandte Chemie, 2025, 137
DOI: 10.1002/ange.202505270

Manganese/Enzyme Sequential Catalytic Pathway for the Production of Optically Active γ-Functionalized Alcohols

Meng Deng, Jiaqi Yang, Zhiyi Kong, Yaning Li, Quanpeng Wang, Huan Liu, Shu-Zhen Deng and Nan Li

J. Org. Chem., 2024, 89, 9103
DOI: 10.1021/acs.joc.4c00776

Divergent Total Syntheses of Rearranged Steroids Swinhoeisterols A–C

Ganlin Huang, Xinliang Zhang, Yu-Cheng Gu and Jinghan Gui

J. Am. Chem. Soc., 2025, 147, 20239
DOI: 10.1021/jacs.5c07053

Asymmetric Total Synthesis of Naphthospironone A

Jia‐Xuan Liu, Shi‐Peng Zhang, Feng‐Sen Sun, Hui Li, Ya‐Ling Gong, Shi‐Chao Lu and Shu Xu

Angew Chem Int Ed, 2023, 62
DOI: 10.1002/anie.202303229

Concise Syntheses of Harziane Diterpenoids by Merging Local Desymmetrization and Radical Retrosynthesis

Jiang Wu, Jiajing Bao, Jiachen Deng, Hailong Tian and Jinghan Gui

J. Am. Chem. Soc., 2025, 147, 30599
DOI: 10.1021/jacs.5c09579

cis‐Aziridines From Terminal Alkenes via Diastereoselective Intramolecular Electrocatalytic Hydroamination

Ahhyeon Choi, Hyeonseo Kim, Daniel Yim, Hyungjun Kim and Hyunwoo Kim

Angewandte Chemie, 2026
DOI: 10.1002/ange.4116549

Total Synthesis of Ganoderma Meroterpenoids Cochlearol B and Its Congeners Driven by Structural Similarity and Biological Homology

Qin Zhou, Xia Ma, Jin‐Bao Qiao, Wen‐Jing He, Ming‐Rui Jiang, Hui Shao and Yu‐Ming Zhao

Chemistry A European J, 2024, 30
DOI: 10.1002/chem.202400084

Enantioselective Synthesis of (+)-Auriculatol A

Jordan K. Thompson, Kala C. Youngblood, Yun Hao Shawn Teh, Conner M. Farley, Zhehao Zhang, Scott C. Virgil and Sarah E. Reisman

J. Am. Chem. Soc., 2025
DOI: 10.1021/jacs.5c17269

Four‐Step Synthesis of (−)‐4‐epi‐Presilphiperfolan‐8α‐ol by Intramolecular Iron Hydride Atom Transfer‐Mediated Ketone‐Alkene Coupling and Studies to Access trans‐Hydrindanols with a Botryane Scaffold

Mar Saladrigas, Enrique Gómez‐Bengoa, Josep Bonjoch and Ben Bradshaw

Chemistry A European J, 2023, 29
DOI: 10.1002/chem.202203286

Recent advances in the application of [2 + 2] cycloaddition in the chemical synthesis of cyclobutane-containing natural products

Song-Yu Hou, Bing-Chao Yan, Han-Dong Sun and Pema-Tenzin Puno

Nat. Prod. Bioprospect., 2024, 14
DOI: 10.1007/s13659-024-00457-9

Multiple Deuterium Atom Transfer Perdeuteration of Unactivated Alkenes under Base‐Assisted Cobalt/Photoredox Dual Catalysis

Akihiko Suzuki, Kosuke Higashida, Tatsuhiko Yoshino and Shigeki Matsunaga

Angewandte Chemie, 2025, 137
DOI: 10.1002/ange.202500233

Total Synthesis of Natural Terpenoids Enabled by Cobalt Catalysis

Shu Xiao, Likun Ai, Qichang Liu, Baihui Yang, Jian Huang, Wei Xue and Yang Chen

Front. Chem., 2022, 10
DOI: 10.3389/fchem.2022.941184

Geometry-Controlled Synthesis of Pyrido/Pyrrolo-isoindolones via MHAT Radical Cyclization of Carbethoxy Methylene Isoindolone

Santosh J. Gharpure, Rupali S. Chavan, Kaushik C. Pansuriya and Anusha Khandelwal

Org. Lett., 2025, 27, 14017
DOI: 10.1021/acs.orglett.5c04595

Enantioselective Divergent Total Syntheses of Cycloaurenones and Dysiherbols

Yu‐Hao Huang, Qing‐Xiu Gu, Qing‐Cen Chao, Han‐Zhi Xiao and Hai‐Hua Lu

Angewandte Chemie, 2025, 137
DOI: 10.1002/ange.202507638

Electrochemical Transition Metal Hydride Catalysis

Xinyi Wang, Depeng Duan, Lu Song and Niankai Fu

ChemCatChem, 2025, 17
DOI: 10.1002/cctc.202500348

A Dual Photoredox/Cobalt Catalytic System Enables Markovnikov-Selective Hydroaminoalkylation of Alkenes

Yunosuke Takekawa, Lilian Geniller, Kazunori Nagao and Hirohisa Ohmiya

Precision Chemistry, 2026
DOI: 10.1021/prechem.5c00388

Concise Total Synthesis of Salimabromide

Hai-Hua Lu, Kang-Ji Gan, Fu-Qiang Ni, Zhihan Zhang and Yao Zhu

J. Am. Chem. Soc., 2022, 144, 18778
DOI: 10.1021/jacs.2c08337

Collective total synthesis of fusicoccane diterpenoids via Yu [5+2+1] cycloaddition and oxidative Nazarov cyclization

Sujun Xie, Yuye Chen, Yan Zhang, Zhiting Zhang, Xinyue Hu, Chongyuan Yan and Jing Xu

Cell Reports Physical Science, 2024, 5, 101855
DOI: 10.1016/j.xcrp.2024.101855

Intramolecular Hydrogen Atom Transfer Hydroarylation of Alkenes toward δ-Lactams Using Cobalt-Photoredox Dual Catalysis

Yuto Yamaguchi, Yusuke Seino, Akihiko Suzuki, Yuji Kamei, Tatsuhiko Yoshino, Masahiro Kojima and Shigeki Matsunaga

Org. Lett., 2022, 24, 2441
DOI: 10.1021/acs.orglett.2c00700

Shuttle HAT for mild alkene transfer hydrofunctionalization

Tanner C. Jankins, Philip M. Blank, Andrea Brugnetti, Philip Boehm, Françoise A. Aouane and Bill Morandi

Nat Commun, 2024, 15
DOI: 10.1038/s41467-024-53281-7

Cobalt-catalysed alkene hydronitration enabled by anomeric nitroamide

Yu Wang, Marcell M. Bogner, Jake B. Bailey, Lauren N. Grant, Milan Gembicky, Paul F. Richardson and Phil S. Baran

Nat Catal, 2025, 8, 457
DOI: 10.1038/s41929-025-01336-3

Repurposing haemoproteins for asymmetric metal-catalysed H atom transfer

Xiang Zhang, Dongping Chen, María Álvarez and Thomas R. Ward

Nature, 2025, 644, 381
DOI: 10.1038/s41586-025-09308-0

Diastereoselectivity Switch During Alkene Reductions: Diastereodivergent Syntheses of Molecular Fossils via MHAT or Homogeneous Catalytic Hydrogenation Reactions

Christian R. S. Maior, Paulo C. S. Costa, Carolina B. P. Ligiéro, Lygia S. de Moraes, Gustavo R. Sousa, Sidney G. Lima, Pierre M. Esteves and Paulo C. M. L. Miranda

Chemistry A European J, 2023, 29
DOI: 10.1002/chem.202203731

Development of Multiple Local Computational Models in Retrosynthetic Analysis: Total Synthesis of (−)-Deoxylimonin

Leanna M. Gharbaoui, Jungmin Eun, Yizhou Zhao and Timothy R. Newhouse

J. Am. Chem. Soc., 2026, 148, 4886
DOI: 10.1021/jacs.5c21055

Total Synthesis of Sculponin U through a Photoinduced Radical Cascade Cyclization

Wei Cao, Zhen Wang, Yan Hao, Tianli Wang, Shaomin Fu and Bo Liu

Angew Chem Int Ed, 2023, 62
DOI: 10.1002/anie.202305516

Photocatalytic phosphine-mediated water activation for radical hydrogenation

Jingjing Zhang, Christian Mück-Lichtenfeld and Armido Studer

Nature, 2023, 619, 506
DOI: 10.1038/s41586-023-06141-1

Asymmetric Total Syntheses of Hetidine-Type C20-Diterpenoid Alkaloids: Spirasines V and VI, Spiradine D, and the Proposed Structures of Spirafines II and III

Fengjie Yao, Yufei Wu, Yidian Sheng, Kuan Yu, Peirong Rao, Jun Xuan and Hanfeng Ding