Combined bioderivatization and engineering approach to improve the efficiency of geraniol production

Xun Wang, Longjie Xiao, Xinyi Zhang, Jia Zhang, Yu Zhang, Fei Wang and Xun Li

Green Chem., 2022, 24, 864
DOI: 10.1039/D1GC03419G

Reprogramming the metabolism of oleaginous yeast for sustainably biosynthesizing the anticarcinogen precursor germacrene A

Qi Liu, Ge Zhang, Liqiu Su, Pi Liu, Shiru Jia, Qinhong Wang and Zongjie Dai

Green Chem., 2023, 25, 7988
DOI: 10.1039/D3GC01661G

Purification of artemisinin precursor amorphadiene from microbial metabolites containing isomeride farnesene: Solid-Pd chemocatalysis of farnesene to squalene with high boiling point

Cuicui Wu, Pan Feng, Xuan Guo and Yunming Fang

Catalysis Communications, 2023, 183, 106770
DOI: 10.1016/j.catcom.2023.106770

Genome analysis of a halophilic Virgibacillus halodenitrificans ASH15 revealed salt adaptation, plant growth promotion, and isoprenoid biosynthetic machinery

Anjney Sharma, Ram Nageena Singh, Xiu-Peng Song, Rajesh Kumar Singh, Dao-Jun Guo, Pratiksha Singh, Krishan K. Verma and Yang-Rui Li

Front. Microbiol., 2023, 14
DOI: 10.3389/fmicb.2023.1229955

A Novel Lycopene β-Cyclase from Crocus Sativus with Comparable Activity in Carotenoid Biosynthesis

Chaogang Wang, Cheng Yang, Zeyu Hong, Sulin Lou, Yan Wu and Danqiong Huang

J. Agric. Food Chem., 2026, 74, 1135
DOI: 10.1021/acs.jafc.5c10734

Decoding Catalysis by Terpene Synthases

Joshua N. Whitehead, Nicole G. H. Leferink, Linus O. Johannissen, Sam Hay and Nigel S. Scrutton

ACS Catal., 2023, 13, 12774
DOI: 10.1021/acscatal.3c03047

PID Controller Design for an E. coli Fed-Batch Fermentation Process System Using Chaotic Electromagnetic Field Optimization

Olympia Roeva, Tsonyo Slavov and Jordan Kralev

Processes, 2024, 12, 1795
DOI: 10.3390/pr12091795

Unlocking the potential of microbes: Concomitant production of polyhydroxyalkanoates and carotenoids

Tejas Jagannath Naik and Bhakti Balkrishna Salgaonkar

International Journal of Biological Macromolecules, 2025, 303, 140654
DOI: 10.1016/j.ijbiomac.2025.140654

Engineering phototrophic cyanobacteria as a robust platform for production of plant-derived bioactive terpenoids

Hui-Cheng Feng, Chun-Lin Tan, Xiang-Mei Zheng, Xin Yu, Jonathan Gershenzon, Sheng-Hong Li and Yan Liu

Chemical Engineering Journal, 2026, 529, 172487
DOI: 10.1016/j.cej.2025.172487

Metabolic Engineering of Rhodotorula toruloides for the Production of Linalool

Xiaochun Zheng, Yajun Li, Chong Che, Qidou Gao, Xue Wang, Rodrigo Ledesma-Amaro, Zi Wei Luo, Xin Lü, Yanan Wang and Xiaobing Yang

J. Agric. Food Chem., 2025, 73, 5395
DOI: 10.1021/acs.jafc.4c12081

Metabolic engineering of Escherichia coli for efficient production of linalool from biodiesel-derived glycerol by targeting cofactors regeneration and reducing acetate accumulation

Xun Wang, Xinyi Zhang, Jia Zhang, Longjie Xiao, Yujunjie Zhou, Fei Wang and Xun Li

Industrial Crops and Products, 2023, 203, 117152
DOI: 10.1016/j.indcrop.2023.117152

Molecular Determinants of Carbocation Cyclisation in Bacterial Monoterpene Synthases

Nicole G. H. Leferink, Andrés M. Escorcia, Bodi R. Ouwersloot, Linus O. Johanissen, Sam Hay, Marc W. van der Kamp and Nigel S. Scrutton

ChemBioChem, 2022, 23
DOI: 10.1002/cbic.202100688

Metabolic engineering for improved heterologous pinene production in the chloroplast of Phaeodactylum tricornutum

Nicola Trevisan, John van der Oost, Maria Barbosa and Sarah D’Adamo

Microb Cell Fact, 2026, 25
DOI: 10.1186/s12934-026-02933-y

CRISPR-Enhanced β-Carotene Biosynthesis: Droplet Microfluidics-Driven Pathway Optimization and High-Yield Terpenoid Strain Screening

Shuilian Guo, Zhengjiao Liang, Shangfeng Liao, Haixin Chen, Chuang Xue, Zhen Yue, Yunjiang Jiang and Xiaodong Fang

J. Agric. Food Chem., 2026, 74, 8497
DOI: 10.1021/acs.jafc.5c10513

Engineering Streptomyces for Efficient Terpenoid Production

Xiaoxu Lin, Xingwang Xu, Dongxu Zhang, Shungen Chen, Xingming Pan, Zengyuan Wang, Hui-Min Xu and Liao-Bin Dong

J. Agric. Food Chem., 2025, 73, 22039
DOI: 10.1021/acs.jafc.5c08127

Chemoenzymatic Synthesis of the Cyclopiane Family of Diterpenoid Natural Products

Tao Wang, Jiasheng Zou, Kaibiao Wang, Yuanning Liu, Shouqi Zhang, Yao Kong and Zhengren Xu

Angew Chem Int Ed, 2025, 64
DOI: 10.1002/anie.202419092

Microbial upcycling of agricultural cabbage waste into novel dietary carotenoid, phytoene: Advancing circular economy from waste to natural products

Sun-Wook Jeong, Jung Eun Yang, Ahrah Jeong, Ji Hyeon Lee, Jeoungjin Ryu, Seunghyun Kang and Yong Jun Choi

Energy & Environment, 2025
DOI: 10.1177/0958305X251315809

Rab geranylgeranyl transferase activity is required for proper sterol biosynthesis in Arabidopsis thaliana

Małgorzata Gutkowska, Marta Zajbt-Łuczniewska, Daniel Buszewicz, Anna Anielska-Mazur, Agata Lipko, Cezary Pączkowski, Grzegorz Spólnik, Maciej Sojka, Radosław Jaźwiec, Emilia Samborowska, Ewa Swiezewska and Marta Hoffman

Plant and Cell Physiology, 2025
DOI: 10.1093/pcp/pcaf166

Enhancing D-pantothenate production in Escherichia coli through multiplex combinatorial strategies

Lianggang Huang, Landuo Sui, Yuan Yao, Yixuan Ma, Junping Zhou, Bo Zhang, Zhiqiang Liu and Yuguo Zheng

Bioprocess Biosyst Eng, 2025, 48, 247
DOI: 10.1007/s00449-024-03105-1

Rational engineering of Escherichia coli strain for stable and enhanced biosynthesis of pinene

Muhammad Hammad Hussain, Lu Han, Yanlong Wei, Muhammad Javid, Kamran Ashraf, Maria Martuscelli, Waleed Aldahmash, Meijin Guo, Ali Mohsin and Zhanxia Li

Front. Microbiol., 2025, 15
DOI: 10.3389/fmicb.2024.1527113

Characterization of the Cubamyces Menziesii Terpenome

Létitia Leydet, Julie Couillaud, Agnès Amouric, Elise Courvoisier‐Dezord, Carole Avesque, Thierry Giardina, Mireille Attolini, Pierre Rousselot‐Pailley, Katia Duquesne, Marie‐Noelle Rosso and Gilles Iacazio

ChemBioChem, 2025, 26
DOI: 10.1002/cbic.202401083

A new sesquiterpene synthase catalyzing the formation of (R)-β-bisabolene from medicinal plant Colquhounia coccinea var. mollis and its anti-adipogenic and antibacterial activities

De-Sen Li, Lin-Lin Shi, Kai Guo, Shi-Hong Luo, Yan-Chun Liu, Yue-Gui Chen, Yan Liu and Sheng-Hong Li

Phytochemistry, 2023, 211, 113681
DOI: 10.1016/j.phytochem.2023.113681

Limonene’s Bacteriostatic Activity against Ralstonia solanacearum by Compromised Membrane Integrity: A Transcriptomic and Metabolomic Analysis

Ruya Zhang, Honghao Zhang, Linfeng Li, Yuchen Feng, Lin Yang, Jiaxin Liu, Senfeng Gao, Zihao Zhou, Yong Yang, Haibo Xiang, Mei Li and Yanyan Li

JACEN, 2024, 13, 312
DOI: 10.4236/jacen.2024.133021

Natural Food Pigments: From Biosynthesis to Application

Zhan Shi, Yue Zhao, Jie Meng, Yaping Bo, Qi Zhao, Guoqi Zhang, Luyao Zhang, Yike Wang, Wei Yuan, Juan Wang, Lanping Guo and Wenyuan Gao

J. Agric. Food Chem., 2026
DOI: 10.1021/acs.jafc.5c05093

Metabolic flux balancing and enhanced expression of engineered Paeonia lactiflora pinene synthase for high-yield α-pinene production in Serratia marcescens HBQA7

Ping Zhang, Linbo Gou, Di Liu, Shengfang Wu, Xiuwen Zhou, Tai-Ping Fan, Long Wang and Yujie Cai

Bioresource Technology, 2026, 442, 133712
DOI: 10.1016/j.biortech.2025.133712

Strategies for Metabolic Engineering of Escherichia coli for β-Carotene Biosynthesis

Jiali Liu, Yilin Shi, Daxin Zhao, Minghao Lin, Ping Wang, Ying Zhou and Xiaohui Yan

Molecules, 2026, 31, 611
DOI: 10.3390/molecules31040611

Transcriptional Tuning of Mevalonate Pathway Enzymes to Identify the Impact on Limonene Production in Escherichia coli

Jonghyeon Shin, Eric J. South and Mary J. Dunlop

ACS Omega, 2022, 7, 18331
DOI: 10.1021/acsomega.2c00483

Production of geraniol by a solvent-tolerant Serratia marcescens without the formation of geraniol derivatives

Yongai Ma, Di Liu, Long Wang, Yao Lu, Taiping Fan, Huaxiang Deng and Yujie Cai

Biocatalysis and Agricultural Biotechnology, 2025, 65, 103567
DOI: 10.1016/j.bcab.2025.103567

Recent advances in genetic engineering and chemical production in yeast species

Sangdo Yook and Hal S Alper

FEMS Yeast Research, 2025, 25
DOI: 10.1093/femsyr/foaf009

Metabolic engineering of endogenous MEP pathway for enhanced lycopene production in Escherichia coli

Xian Xu, Hongyu Xing, Hui Zhi, Chen Qin, Yuyue Deng, Wanqi Wei and Chunyan Huang

Synthetic and Systems Biotechnology, 2026, 13, 109
DOI: 10.1016/j.synbio.2026.01.014

Multi-Population Genetic Algorithm and Cuckoo Search Hybrid Technique for Parameter Identification of Fermentation Process Models

Maria Angelova, Olympia Roeva, Peter Vassilev and Tania Pencheva

Processes, 2023, 11, 427
DOI: 10.3390/pr11020427

Development of isopentenyl phosphate kinases and their application in terpenoid biosynthesis

Xinyi Zhang, Xun Wang, Yu Zhang, Fei Wang, Congqiang Zhang and Xun Li

Biotechnology Advances, 2023, 64, 108124
DOI: 10.1016/j.biotechadv.2023.108124

Engineered microbial production of carotenoids and their cleavage products: Recent advances and prospects

Ping Lin, Guocheng Du, Jian Chen, Juan Zhang and Zheng Peng

Biotechnology Advances, 2025, 85, 108708
DOI: 10.1016/j.biotechadv.2025.108708

Mevalonate production by electro-fermentation in Escherichia coli via Mtr-based electron transfer system

Takuya Matsumoto, Kazuki Higuma, Ryosuke Yamada and Hiroyasu Ogino

Biochemical Engineering Journal, 2023, 191, 108772
DOI: 10.1016/j.bej.2022.108772

Enhanced isoprenoid production in Escherichia coli cells harboring the archaeal mevalonate pathway

Takuya Takahashi, Takuya Saito, Irori Dohgami, Tomokazu Ito and Hisashi Hemmi

Biochemistry and Biophysics Reports, 2025, 44, 102307
DOI: 10.1016/j.bbrep.2025.102307

Membrane Permeant Analogs for Independent Cellular Introduction of the Terpene Precursors Isopentenyl‐ and Dimethylallyl‐Pyrophosphate

Francis M. Rossi, Dillon P. McBee, Thomas N. Trybala, Zackary N. Hulsey, Camila Gonzalez Curbelo, William Mazur and Joshua A. Baccile

ChemBioChem, 2023, 24
DOI: 10.1002/cbic.202200512

Synthetic biology development of microbial strains for liquid biofuel production

Kun Li, Jinsong Xuan and Yingang Feng

Biotechnology Advances, 2026, 90, 108891
DOI: 10.1016/j.biotechadv.2026.108891

Artificial seawater-assisted fractionation of wheat straw and its subsequent usage for the production of branched fatty acids and squalene-enriched lipid and trehalose

Chetna Grover, Lohith Kumar DH and Bijan Choudhury

Biomass Conv. Bioref., 2025, 15, 21455
DOI: 10.1007/s13399-025-06705-3

Role of terpenes and terpenoids in cross-talk between adipocyte browning and gut microbiome in obesity

Devinya Pillay, Umah Rani Kuppusamy and Bavani Arumugam

Fitoterapia, 2026, 190, 107113
DOI: 10.1016/j.fitote.2026.107113

De novo synthesis of (+)-nootkatone in Escherichia coli using stress-response dynamic regulatory system

Xilong He, Xiaolong Kong, Jie Huang, Jia Zhang, Xun Wang, Fei Wang and Xun Li

Food Bioscience, 2025, 74, 108047
DOI: 10.1016/j.fbio.2025.108047

Production of Gibberellins via a Non-Natural Pathway Using Steviol as a Substrate

Yu Lin, Meng Liang, Hao Pang, Zilong Wang, Hai Bi, Yutuo Wei and Liqin Du

J. Agric. Food Chem., 2024, 72, 540
DOI: 10.1021/acs.jafc.3c06932

Semi-continuous biomanufacturing for maximizing the production of complex chemicals and fuels: a case study of amorpha-4,11-diene

Carlos Castillo-Saldarriaga, Stephen Sarria, Christine N.S. Santos, Parayil K. Ajikumar and Ralf Takors

Trends in Biotechnology, 2024, 42, 1777
DOI: 10.1016/j.tibtech.2024.08.010

Bioactivities and biosynthesis of monoterpene-based biopesticides: current state and perspectives

Ruiqi Chen, Weilin Liu, Daoguang Tian, Shengli Wang, Jianjun Qiao, Weiguo Li and Qinggele Caiyin

Microb Cell Fact, 2026, 25
DOI: 10.1186/s12934-026-02973-4

The Aroma Volatile in ‘Nanguo’ Pear: A Review

Zhuoran Zhang and Zepeng Yin

Horticulturae, 2023, 9, 339
DOI: 10.3390/horticulturae9030339

Biosynthesis of monoterpenoid and sesquiterpenoid as natural flavors and fragrances

Hui Jiang and Xi Wang

Biotechnology Advances, 2023, 65, 108151
DOI: 10.1016/j.biotechadv.2023.108151

Bioproduction of Linalool From Paper Mill Waste

Mauro A. Rinaldi, Shirley Tait, Helen S. Toogood and Nigel S. Scrutton

Front. Bioeng. Biotechnol., 2022, 10
DOI: 10.3389/fbioe.2022.892896

Engineering an Extremely Monoterpene-Tolerant Serratia marcescens for High-Yield Geraniol Production via a Rationally Modified Insect Phosphatase

Di Liu, Long Wang, Linbo Gou, Yongai Ma, Yao Lu, Songsong Yao, Tai-Ping Fan, Huaxiang Deng and Yujie Cai

ACS Sustainable Chem. Eng., 2025, 13, 6197
DOI: 10.1021/acssuschemeng.4c10765

Optimization of microbial cell factories for astaxanthin production: Biosynthesis and regulations, engineering strategies and fermentation optimization strategies

Mostafa Basiony, Liming Ouyang, Danni Wang, Jiaming Yu, Liming Zhou, Mohan Zhu, Xuyuan Wang, Jie Feng, Jing Dai, Yijie Shen, Chengguo Zhang, Qiang Hua, Xiuliang Yang and Lixin Zhang

Synthetic and Systems Biotechnology, 2022, 7, 689
DOI: 10.1016/j.synbio.2022.01.002

Unleashing the potential of microbial biosynthesis of monoterpenes via enzyme and metabolic engineering

Dianqi Yang, Hong Liang, Xuxu Li, Chenyu Zhang, Zewei Lu and Xiaoqiang Ma

Biotechnology Advances, 2025, 79, 108525
DOI: 10.1016/j.biotechadv.2025.108525

Predictive Engineering of Class I Terpene Synthases Using Experimental and Computational Approaches

Nicole G. H. Leferink and Nigel S. Scrutton

ChemBioChem, 2022, 23
DOI: 10.1002/cbic.202100484

Immobilization of Lathyrus cicera Amine Oxidase on Magnetic Microparticles for Biocatalytic Applications

Elisa Di Fabio, Antonia Iazzetti, Alessio Incocciati, Valentina Caseli, Giancarlo Fabrizi, Alberto Boffi, Alessandra Bonamore and Alberto Macone

IJMS, 2022, 23, 6529
DOI: 10.3390/ijms23126529

Systems biology approach for enhancing limonene yield by re-engineering Escherichia coli

Jasmeet Kaur Khanijou, Yan Ting Hee, Clement P. M. Scipion, Xixian Chen and Kumar Selvarajoo

npj Syst Biol Appl, 2024, 10
DOI: 10.1038/s41540-024-00440-7

Engineering Plant Terpene Synthase PtPS30 for Enhanced Biopesticide Precursor Synthesis: Synergistic Optimization via Homologous Sequence Alignment and Structure-Guided Engineering

Tao Li, YuJunjie Zhou, Xiaolong Kong, Xun Wang, Fei Wang and Xun Li

J. Agric. Food Chem., 2026, 74, 6919
DOI: 10.1021/acs.jafc.5c08449

Functional mining of novel terpene synthases from metagenomes

Suryang Kwak, Nathan Crook, Aki Yoneda, Naomi Ahn, Jie Ning, Jiye Cheng and Gautam Dantas

Biotechnol Biofuels, 2022, 15
DOI: 10.1186/s13068-022-02189-9

Efficient production of the β-ionone aroma compound from organic waste hydrolysates using an engineered Yarrowia lipolytica strain

Shuyi Chen, Yanping Lu, Wen Wang, Yunzi Hu, Jufang Wang, Shixing Tang, Carol Sze Ki Lin and Xiaofeng Yang

Front. Microbiol., 2022, 13
DOI: 10.3389/fmicb.2022.960558

Identification and Functional Analysis of Two Novel Genes—Geranylgeranyl Pyrophosphate Synthase Gene (AlGGPPS) and Isopentenyl Pyrophosphate Isomerase Gene (AlIDI)—from Aurantiochytrium limacinum Significantly Enhance De Novo β-Carotene Biosynthesis in Escherichia coli

Shitao Shi, Yi Chang, Jinhui Yu, Hui Chen, Qiang Wang and Yuping Bi

Marine Drugs, 2023, 21, 249
DOI: 10.3390/md21040249

De novo production of prenylnaringenin compounds by a metabolically engineered Escherichia coli

Daniela Gomes, Joana L. Rodrigues, Nigel S. Scrutton and Ligia R. Rodrigues

Journal of Biotechnology, 2025, 405, 215
DOI: 10.1016/j.jbiotec.2025.05.017

Stable Isotopic Labeling of Dimethylallyl Pyrophosphate (DMAPP) Reveals Compartmentalization of Isoprenoid Biosynthesis during Sporulation in Bacillus subtilis

Dillon P. McBee, Zackary N. Hulsey, Makayla R. Hedges and Joshua A. Baccile

J. Am. Chem. Soc., 2025, 147, 19777
DOI: 10.1021/jacs.5c03639

Enhanced Production of (+)-Limonene through Targeted Engineering of Citrus sinensis Limonene Synthase

Clement P. M. Scipion, Jérémy Esque, Shreyash Borkar, Jing Sen Ong, Cristalle Seah, Leonard Ong, Pnelope Ng, Yoganathan Kanagasundaram, Magali Remaud-Simeon, Sophie Bozonnet, Bo Xue, Wen Shan Yew, Isabelle André and Xixian Chen

ACS Synth. Biol., 2025, 14, 2151
DOI: 10.1021/acssynbio.5c00078

Exploring linker's sequence diversity to fuse carotene cyclase and hydroxylase for zeaxanthin biosynthesis

Aurélie Bouin, Congqiang Zhang, Nic D. Lindley, Gilles Truan and Thomas Lautier

Metabolic Engineering Communications, 2023, 16, e00222
DOI: 10.1016/j.mec.2023.e00222

Yeast metabolism adaptation for efficient terpenoids synthesis via isopentenol utilization

Guangjian Li, Hui Liang, Ruichen Gao, Ling Qin, Pei Xu, Mingtao Huang, Min-Hua Zong, Yufei Cao and Wen-Yong Lou

Nat Commun, 2024, 15
DOI: 10.1038/s41467-024-54298-8

Efficient production of clerodane and ent-kaurane diterpenes through truncated artificial pathways in Escherichia coli

Fang-Ru Li, Xiaoxu Lin, Qian Yang, Ning-Hua Tan and Liao-Bin Dong

Beilstein J. Org. Chem., 2022, 18, 881
DOI: 10.3762/bjoc.18.89

A Programmable CRISPR/Cas9 Toolkit Improves Lycopene Production in Bacillus subtilis

Yang Liu, Haijiao Cheng, Haoni Li, Yingzhe Zhang, Meng Wang and Arpita Bose

Appl Environ Microbiol, 2023, 89
DOI: 10.1128/aem.00230-23

Biosynthesis of Edible Terpenoids: Hosts and Applications

Mengyu Wang, Zhengyi Zhang, Xinyu Liu, Zhixuan Liu and Ruirui Liu

Foods, 2025, 14, 673
DOI: 10.3390/foods14040673

Substitute Yeast Extract While Maintaining Performance: Showcase Amorpha‐4,11‐Diene Production

Carlos Castillo‐Saldarriaga, Christine N. S. Santos, Stephen Sarria, Parayil K. Ajikumar and Ralf Takors

Microbial Biotechnology, 2024, 17
DOI: 10.1111/1751-7915.70056

Advance toward function, production, and delivery of natural astaxanthin: A promising candidate for food ingredients with future perspectives

Jing Zhang, Meizhen Liu, Tiantian Han, Lu Luo, Ying Zhang, Gaofeng Yuan, Xubo Fang, Fangrui Han, Xiaoe Chen and Yuhua Wang

Food Chemistry, 2025, 463, 141428
DOI: 10.1016/j.foodchem.2024.141428

Metabolic Engineering of Terpenoid Biosynthesis in Medicinal Plants: From Genomic Insights to Biotechnological Applications

Changfeng Guo, Si Xu and Xiaoyun Guo

CIMB, 2025, 47, 723
DOI: 10.3390/cimb47090723

Advances in the sustainable biosynthesis of valuable terpenoid flavor compounds and precursors in micro-organisms

Qian Li, Yibo Ning, Deyu Liu, Jie Ren, Changtong Lu, Zhifei Chen and Guanglu Wang

Biotechnol. Biofuels Bioprod., 2025, 18
DOI: 10.1186/s13068-025-02699-2

Production of the terpenoid-based biofuel α-bisabolene by metabolically engineered Corynebacterium glutamicum

Basak Atas Erden, Jan Seeger, Fatma Gizem Avci, Volker F. Wendisch and Berna Sariyar Akbulut

World J Microbiol Biotechnol, 2025, 41
DOI: 10.1007/s11274-025-04588-0

An Update on Microbial Biosynthesis of β-Caryophyllene, a Sesquiterpene with Multi-Pharmacological Properties

Lidia Tsigoriyna, Chakarvati Sango and Daniela Batovska

Fermentation, 2024, 10, 60
DOI: 10.3390/fermentation10010060

Expanding the Terpene Universe: Synthetic Biology and Non-Natural Chemistry in Engineered Microorganisms

Yueli Hu, Ziyan Yuan, Qian Wang, Ziyan Wang, Jianan Cao, Jiaxin Wu and Xinkun Ren

Molecules, 2025, 30, 4065
DOI: 10.3390/molecules30204065

Applications of cytochrome P450 monooxygenases in the biosynthesis of active pharmaceutical ingredients

Yuben Qiao, Xiaodong Zhang, Qianqian Xu, Ikuro Abe and Aitao Li

Green Synthesis and Catalysis, 2025
DOI: 10.1016/j.gresc.2025.05.005

Green Biosynthesis of Terpenoid-Derived Flavor and Fragrance Compounds: Advances and Strategic Perspectives

Yuanyuan Zheng, Huaxia Cao, Jiacen Bi and Feng Xue

J. Agric. Food Chem., 2026, 74, 6569
DOI: 10.1021/acs.jafc.5c08719

Characterization of novel mevalonate kinases from the tardigrade Ramazzottius varieornatus and the psychrophilic archaeon Methanococcoides burtonii

Lygie Esquirol, Janet Newman, Tom Nebl, Colin Scott, Claudia Vickers, Frank Sainsbury and Thomas S. Peat

Acta Crystallogr D Struct Biol, 2024, 80, 203
DOI: 10.1107/S2059798324001360

Chemoenzymatic Synthesis of the Cyclopiane Family of Diterpenoid Natural Products

Tao Wang, Jiasheng Zou, Kaibiao Wang, Yuanning Liu, Shouqi Zhang, Yao Kong and Zhengren Xu

Angewandte Chemie, 2025, 137
DOI: 10.1002/ange.202419092

Metabolic Engineering of Model Microorganisms for the Production of Xanthophyll

Nan Wang, Huakang Peng, Caifeng Yang, Wenfang Guo, Mengqi Wang, Gangqiang Li and Dehu Liu

Microorganisms, 2023, 11, 1252
DOI: 10.3390/microorganisms11051252

Identification of the adhesive domain of AtaA from Acinetobacter sp. Tol 5 and its application in immobilizing Escherichia coli

Shogo Yoshimoto, Sota Aoki, Yuki Ohara, Masahito Ishikawa, Atsuo Suzuki, Dirk Linke, Andrei N. Lupas and Katsutoshi Hori

Front. Bioeng. Biotechnol., 2023, 10
DOI: 10.3389/fbioe.2022.1095057

Pyruvic Acid Production from Sucrose by Escherichia coli Pyruvate Dehydrogenase Variants

W. Chris Moxley and Mark A. Eiteman

Fermentation, 2023, 9, 478
DOI: 10.3390/fermentation9050478

Biotechnology of isopentenols production from microbial cell factories

Suresh Chandra Phulara, Pratima Gupta, Nikita Bhadri and Ashish Runthala

Bioresource Technology, 2026, 441, 133574
DOI: 10.1016/j.biortech.2025.133574

An Isopentenol Utilization Pathway-Based “Deuterium-Scanning” Method for Mechanistic Investigations of Terpene Cyclases

Shouqi Zhang, Kaibiao Wang, Yuanning Liu, Tao Wang, Yao Kong, Pengcheng Zhang, Bo Zhang, Min Yin, Guohui Pan and Zhengren Xu

ACS Catal., 2024, 14, 17598
DOI: 10.1021/acscatal.4c05811

Engineering a complete mevalonate pathway in Chlamydomonas reinhardtii for enhanced isoprenoid production

Jingkai Wang, Muhammad Anwar, Jiancheng Li, Lin Dan, Bin Jia and Zhangli Hu

Algal Research, 2025, 88, 103987
DOI: 10.1016/j.algal.2025.103987

De Novo Production of Xanthohumol by a Metabolically Engineered Escherichia coli

Daniela Gomes, Joana Santos, Armando Venâncio, Joana L. Rodrigues, Nigel S. Scrutton and Ligia R. Rodrigues

ACS Synth. Biol., 2025, 14, 3913
DOI: 10.1021/acssynbio.5c00221

Effects of producing high levels of hyperthermophile-specific C25,C25-archaeal membrane lipids in Escherichia coli

Ryo Yoshida, Kento Motoyama, Tomokazu Ito and Hisashi Hemmi

Biochemical and Biophysical Research Communications, 2024, 729, 150349
DOI: 10.1016/j.bbrc.2024.150349

Advances in the Discovery and Engineering of Gene Targets for Carotenoid Biosynthesis in Recombinant Strains

Buli Su, Ming-Rong Deng and Honghui Zhu

Biomolecules, 2023, 13, 1747
DOI: 10.3390/biom13121747

Chemical profile and analysis of biosynthetic pathways and genes of volatile terpenes in Pityopsis ruthii, a rare and endangered flowering plant

Xinlu Chen, Marcin Nowicki, Phillip A. Wadl, Chi Zhang, Tobias G. Köllner, Miriam Payá‐Milans, Matthew L. Huff, Margaret E. Staton, Feng Chen, Robert N. Trigiano and Waqas Khan Kayani

PLoS ONE, 2023, 18, e0287524
DOI: 10.1371/journal.pone.0287524

MICROBIAL isoprene production: an overview

Jasmine Isar, Dharmendra Jain, Harshvardhan Joshi, Shrikant Dhoot and Vidhya Rangaswamy

World J Microbiol Biotechnol, 2022, 38
DOI: 10.1007/s11274-022-03306-4

Optimization of Germacrene A Synthase for Efficient Production of β-Elemene in Escherichia coli

Yihua Lu, Xinyi Zhang, Fei Wang, Yu Zhang and Xun Li

ACS Sustainable Chem. Eng., 2024, 12, 9018
DOI: 10.1021/acssuschemeng.3c07658

Engineering for life in toxicity: Key to industrializing microbial synthesis of high energy density fuels

Lijuan Liu, Wenzhi Bao, Xiao Men and Haibo Zhang

Engineering Microbiology, 2022, 2, 100013
DOI: 10.1016/j.engmic.2022.100013

Designing artificial pathways for improving chemical production

Zaigao Tan, Jian Li, Jin Hou and Ramon Gonzalez

Biotechnology Advances, 2023, 64, 108119
DOI: 10.1016/j.biotechadv.2023.108119

Multiplex Expression Cassette Assembly: A flexible and versatile method for building complex genetic circuits in conventional vectors

Xun Jiang, Zhuoxiang Zhang, Xiuming Wu, Changmei Li, Xuan Sun, Yiting Li, Aixia Chang, Aiguo Yang and Changqing Yang

Plant Biotechnology Journal, 2024, 22, 3361
DOI: 10.1111/pbi.14454

Enhancing limonene production by probing the metabolic network through time-series metabolomics data

Jasmeet Kaur Khanijou, Clement P. M. Scipion, Shreyash Borkar, Xixian Chen and Wee Chew

Metabolomics, 2025, 21
DOI: 10.1007/s11306-025-02254-y

Engineering a robust and versatile terpenoid production platform in Serratia marcescens HBQA7

Long Wang, Linbo Gou, Di Liu, Shengfang Wu, Xiuwen Zhou, Tian Yang, Tai-Ping Fan and Yujie Cai

Chemical Engineering Journal, 2025, 524, 169601
DOI: 10.1016/j.cej.2025.169601

A growth-coupling strategy for improving the stability of terpenoid bioproduction in Escherichia coli

Jing Chong Tan, Qitiao Hu and Nigel S. Scrutton

Microb Cell Fact, 2024, 23
DOI: 10.1186/s12934-024-02548-1

Bioengineering of the Optimized Biosynthesis of Commercially Vital Carotenoids- Techno-Advanced Applications

Ishrat Perveen, Naaz Abbas, Bakhtawar Bukhari, Yasar Saleem, Sania Mazhar, Shaista Nawaz, Quratulain Syed, Syed Hussain Imam Abidi, Sana Riaz and Fatima Akram

PBMJ, 2023, 19
DOI: 10.54393/pbmj.v6i12.995

Hybrid Methylotrophic Pathway in Serratia marcescens for Sustainable Terpenoid Biosynthesis

Di Liu, Long Wang, Linbo Gou, Yao Lu, Yongai Ma, Songsong Yao, Tai-Ping Fan, Huaxiang Deng and Yujie Cai

ACS Synth. Biol., 2025, 14, 1766
DOI: 10.1021/acssynbio.5c00116

A Comprehensive Analysis of Transcriptomics and Metabolomics Revealed LcMYC4 Regulating LcDXS3 to Promote Terpenoid Biosynthesis in Litsea cubeba

Jiahui Yang, Feifei Ni, Yicun Chen, Ming Gao, Yunxiao Zhao and Yangdong Wang

Physiologia Plantarum, 2025, 177
DOI: 10.1111/ppl.70518

Advances in integrating microbial metabolism with catalytic systems

Stefania Gianolio, Arpita Mrigwani and Francesca Paradisi

Nat Chem Biol, 2025, 21, 1654
DOI: 10.1038/s41589-025-02048-2

Integration of pathway balance and protein fusion enables de novo biosynthesis of (+)-bicyclogermacrene in Escherichia coli

Chen-Yi Sun, Wen-Liang Xie, Zheng-Yu Huang, Chun-Xiu Li and Jian-He Xu

Bioresour. Bioprocess., 2026, 13
DOI: 10.1186/s40643-026-01017-4