Ethnopharmacology, phytochemistry, pharmacology and product application of Platycodon grandiflorum: A review

Lanying Zhang, Xinrui Wang, Jingze Zhang, Dailin Liu and Gang Bai

Chinese Herbal Medicines, 2024, 16, 327
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Platycodon grandiflorum: A promising medicinal and food homologous plant for cigarette smoke-induced chronic bronchitis

Jianwen Sun, Xinrui Wang, Xiangwei Chang, Yuzhe Huang, Liangping Zha, Nannan Zhi, Jutao Wang, Daiyin Peng, Qijun Xia, Jingjing Hu, Xingyuan Pang, Xiao Liang, Cheng Jin and Shuangying Gui

Journal of Ethnopharmacology, 2025, 353, 120381
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Probiotic-fermented traditional Chinese herbal medicine, a promising approach to maintaining the intestinal microecology

Jie Ma, Junrui Wang, Yujun Wan, Shihua Wang and Changqing Jiang

Journal of Ethnopharmacology, 2025, 337, 118815
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Probiotic‐fermented edible herbs as functional foods: A review of current status, challenges, and strategies

Rui Cui, Cong Zhang, Zhen‐Hui Pan, Teng‐Gen Hu and Hong Wu

Comp Rev Food Sci Food Safe, 2024, 23
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Jiegeng Gancao Decoction Ameliorates Ulcerative Colitis: An Integrative Approach Combining Network Pharmacology and Proteomics via in silico and in vivo studies

Ruipeng Shi, Sio I Chan, Haochun Jin, Wei Li, Lili Zhang, Jinglin Yang, Ruichen Wang, Xiaoting Zheng, Guozhen Cui and Zhangfeng Zhong

Phytomedicine, 2025, 145, 156972
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Traditional Chinese medicine prescription Shenling BaiZhu powder to treat ulcerative colitis: Clinical evidence and potential mechanisms

Jing Chen, Bixin Shen and Zhengli Jiang

Front. Pharmacol., 2022, 13
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Neutral Polysaccharide from Platycodonis Radix-Ameliorated PM2.5-Induced Lung Injury by Inhibiting the TLR4/NF-κB p65 Pathway and Regulating the Lung and Gut Microbiome

Yang Sun, Yanchun Wang, Zaiming Yang, Xianlei Han, Yue Zhang, Liyan Chen, Jinhai Huo, Rina Wu, Weiming Wang and Nan Wang

J. Agric. Food Chem., 2024, 72, 27923
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Renshen Baidu Powder Attenuated Intestinal Inflammation and Apoptosis in Ulcerative Colitis Rats through the Inhibition of PI3K/AKT/NF-κB Signaling Pathway

Peixu Zhang, Xiaobo Zhang, Peiyu Xiong, Chun Zhong, Zhen Zhou, Bo Jia, Xinglong Liu and Abdalbasit Mariod

Evidence-Based Complementary and Alternative Medicine, 2022, 2022, 1
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An evaluation of the qualitative superiority of the Mongolian medicinal herb hurdan-tsagaan (Platycodi Radix) from five different geographic origins based on anti-inflammatory effects

Qin Si, Longga Su, Dong Wang, Bao-Jun De, Risu Na, Nagongbilige He, Tserentsoo Byambaa, Tserendagva Dalkh, Xilinqiqige Bao and Letai Yi

Journal of Ethnopharmacology, 2023, 310, 116331
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Saponins alleviate intestinal inflammation and regulate intestinal metabolic disorders induced by dextran sulfate sodium: TNF-α protein action

Shu Lai, Neng Shen, Chunyan Zhou, Xiangyu Lai, Yiming Wang, Lili Shen and Yimin Jia

International Journal of Biological Macromolecules, 2024, 280, 135728
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TNIP3 Attenuates Colitis by Inhibiting the TAB1/NF-κB/NLRP3 Signaling Pathway in Macrophages

Shijun Li, Jiasheng Liu, Hui Zhou and Yongbin Zheng

Dig Dis Sci, 2025
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Macrophage polarization in inflammatory bowel disease

Kun Zhang, Jing Guo, Wenlong Yan and Lingfen Xu

Cell Commun Signal, 2023, 21
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Deciphering the indigenous microbiome enables rational design of functional starter cultures to enhance platycodins in fermented Platycodon grandiflorus

Yulian Zhao, Haisu Shi, Junrui Wu, Lin Shi, Weiming Wang, Lin Yao, Meijun Song, Tenghe Ma, Lin Ye and Rina Wu

Food Bioscience, 2026, 79, 108643
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Platycodon D reduces obesity and non-alcoholic fatty liver disease induced by a high-fat diet through inhibiting intestinal fat absorption

Xingkui Tang, Yi Yang, Wenxu Peng, Mengping Xu, Qitong Fan, Feng Li, Guorong Zou and Jianlin Zhu

Front. Pharmacol., 2024, 15
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Phytosphingosine alleviates DSS-induced colitis by regulating the gut microbiota and inflammatory responses

Ruping Shan, Kexin Wang, Qiujie Chen, Lijuan Bao, Keyi Wu, Yihong Zhao, Yu Han, Yating Gao, Naisheng Zhang, Xiaoyu Hu, Yunhe Fu, Caijun Zhao and Wenchao Bian

International Immunopharmacology, 2025, 166, 115610
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The Role of AMPK Signaling in Ulcerative Colitis

Yuyi Yuan, Fang Wang, Xingxing Liu, Bo Shuai and Heng Fan

DDDT, 2023, Volume 17, 3855
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Platycodon grandiflorum Attenuates Non‐Alcoholic Fatty Liver Disease in Rats Through Regulating Inflammatory Response via PPARγ and TLR4/NF‐κB Signaling Pathway

Ming Dang, Jie Zhang, Run‐Xin Ren, Mao‐Mao Fu, Kang‐Jie Li, Huan‐Qing Gao, Qiao Zhang, Jing Wang, Jing Sun, Xiao‐Fei Zhang, Chang‐Li Wang, Meng‐Meng Zhang and Chong‐Bo Zhao

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Comprehensive Advances on Probiotic-Fermented Medicine and Food Homology

Huijun Dong, Derui Bu, Yutong Cheng, Wen Gao and Fubo Han

Fermentation, 2025, 11, 682
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Development of a Functional Food Based on the Fermentation Broth of Jiegeng for the Treatment of Inflammatory Bowel Disease

Jiahui Peng, Chunhai Li, Zhe Wang, Songsen Sui, Chuanzhuang Guo, Ruiting Zhao, Haoran Liu, Ting Wang, Zhenshang Xu and Rotimi Aluko

Journal of Food Biochemistry, 2023, 2023, 1
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Network pharmacology and experimental verification revealing valnemulin alleviates DSS-induced ulcerative colitis by inhibiting intestinal senescence

Zhiwei Wang, Wei Lian, Cui Chen, Qianlong Dai, Zhenlin Liu, Jiayu Liu, Yuanyuan Zhang, Min Zhou and Xiaobo Wang

International Immunopharmacology, 2024, 141, 112810
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Recent advances in Platycodon grandiflorum polysaccharides: Preparation techniques, structural features, and bioactivities

Lile Feng, Yajun Shi, Junbo Zou, Xiaofei Zhang, Bingtao Zhai, Dongyan Guo, Jing Sun, Mei Wang and Fei Luan

International Journal of Biological Macromolecules, 2024, 259, 129047
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Static Magnetic Field–Assisted Co-fermentation of Lactic Acid Bacteria Consortium in Platycodon grandiflorum Roots Powder for Process Optimization and Antioxidant Property Enhancement

Yulian Zhao, Rina Wu, Junrui Wu, Lin Shi, Jingwen Xu, Xinyu Hu, Lin Yao, Ke Qiao, Haisu Shi and Weiming Wang

Food Bioprocess Technol, 2025, 18, 7561
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Whipworm infection remodels the gut microbiome ecosystem and compromises intestinal homeostasis in elderly patients revealed by multi-omics analyses

Benguang Zhang, Zhaoan Sheng, Cancan Bu, Longjiang Wang, Wenxiang Lv, Yongbin Wang, Yan Xu, Ge Yan, Maoqing Gong, Lijuan Liu and Wei Hu

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Vanillic acid protects against ulcerative colitis by modulating oxidative stress, inflammatory response, macrophage polarization and AMPK signaling pathways

Xiaojing Ma, Changlong Ouyang, Ping Tang, Haoxi Ma, Zijun Wang, Yiyang Hou, Lijuan Zhu and Haibo Huang

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Characterization of a β-glucosidase of Bacillus velezensis SK-P1 and its application in platycodin D and deapio-platycodin D production

Xiao Yang, Lingyue Tang, Qi An, Ling Zeng, Shuang Zhu, Mohan Zhang, Yanbing Zou, Hongjie Piao, Yuping Wen, Hushan Cui and Qing Jin

International Journal of Biological Macromolecules, 2026, 340, 150113
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Sericic Acid Ameliorates DSS-induced Ulcerative Colitis in Mice by Modulating the NF-κB and Nrf2 Pathways

Lifei-Luo, Jingze Zhang, Xinyu Li, Yanru Zhu, Yansheng Wang and Dailin Liu

CMP, 2023, 16
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A Hepatic Oxidative Metabolite of Palmatine Ameliorates DSS-Induced Ulcerative Colitis by Regulating Macrophage Polarization Through AMPK/NF-κB Pathway

Qi-Ting Huang, Xing-Dong Ma, Jia-Na Zhang, Wei-Xiong Lin, Xue-Xia Shen, Zhuo-Wen Huang, Xia Zhang, Xiao-Yan Wu, Yao-Xing Dou, Zi-Ren Su, Ji-Yan Su, Yu-Cui Li, Yu-Hong Liu, You-Liang Xie, Rong-Feng Lin, Hai-Yang Huang, Qi-Hui Zhang and Xiao-Qi Huang

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Regulation of pyroptosis by natural products in ulcerative colitis: mechanisms and therapeutic potential

Xiaobei Lu, Yapeng Sun, Zhaoyi Zhang, Zhigang Sun, Shaohui Wang and Erping Xu

Front. Pharmacol., 2025, 16
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Application of fermented Chinese herbal medicines in food and medicine field: From an antioxidant perspective

Yuzhu Zhang, Jing Zhang, Jingwen Yan, Xinrui Qi, Yuehan Wang, Zitong Zheng, Jianqi Liang, Jitao Ling, Yixuan Chen, Xiaoyi Tang, Xinxing Zeng, Peng Yu and Deju Zhang

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Network pharmacology and metabolomics reveal Jingfang Granules alleviates DSS-induced colitis via the NF-κB/NLRP3/IL-6/STAT3 pathway

Shen Cao, Yi Tai, Shirong Li, Xinzhe Liu, Yanjin Zheng, Jing Han, Weikang Chen, Jingxu Han, Hong Xiang Zuo, Ming Yue Li, Yue Xing, Guimin Zhang, Xuejun Jin and Juan Ma

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Platycodon D protects human nasal epithelial cells from pyroptosis through the Nrf2/HO-1/ROS signaling cascade in chronic rhinosinusitis

Ruizhi Wang, Yongchun Wang, He Liu, Jinxiang Zhu, Caishan Fang, Weizhen Xu, Zesheng Lu, Yajie Yan, Weiping He, Yan Ruan and Min Zhou

Chin Med, 2024, 19
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A postbiotic exopolysaccharide synergizes with Lactobacillus acidophilus to reduce intestinal inflammation in a mouse model of colitis

Chong Ma, Xiaobin Zheng, Qian Zhang, Stephen James Renaud, Hansheng Yu, Yaning Xu, Yuchun Chen, Jing Gong, Yonghua Cai, Yanjun Hong, Hao Li, Qiongfeng Liao, Ying Guo, Liang Kang and Zhiyong Xie

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Natural products modulate NLRP3 in ulcerative colitis

Jia-Chen Xue, Shuo Yuan, Xiao-Ting Hou, Huan Meng, Bao-Hong Liu, Wen-Wen Cheng, Ming Zhao, Hong-Ben Li, Xue-Fen Guo, Chang Di, Min-Jie Li and Qing-Gao Zhang

Front. Pharmacol., 2023, 14
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NOD-like receptors mediate homeostatic intestinal epithelial barrier function: promising therapeutic targets for inflammatory bowel disease

Feng Zhou, Guo Dong Zhang, Yang Tan, Shi An Hu, Qun Tang and Gang Pei

Therap Adv Gastroenterol, 2023, 16
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Optimization of Solid-State Fermentation Process of Radix Ranunculi ternate Using Response Surface Method and Addressing Its Antioxidant and Hypoglycemic Activity

Dingxuan He, Dingyu Duan, Xueyan Lv, Baihui Xiong, Zhuojia Li, Shaojun Zhang, Jing Cai, Xinrong Qiao and Qiong Chen

Fermentation, 2024, 10, 153
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Targeting pyroptosis in inflammatory bowel disease: A potentially effective therapeutic approach

Wei-Wei Dong, Tao Liu, Li-Xia He and Wen-Ting He

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Fermentation: improvement of pharmacological effects and applications of botanical drugs

Xinxin Luo, Mosi Dong, Juntong Liu, Naifei Guo, Jing Li, Yan Shi and Yufeng Yang

Front. Pharmacol., 2024, 15
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Sophocarpine prevents LPS and IFN-γ-stimulated oxidative stress and neuroinflammation of BV-2 microglia by regulating the AMPK/NF-κB signaling pathway

Shupeng Guo, Ti Li, Lili Luan, Jialin Deng and Yuntao Luo

Neurological Research, 2025, 1
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Antioxidant and Anti-Inflammatory Activities of Root Vegetable Mixture Extract

Hyunna Kim, Seungman Park, Gyoyoung Lee, Dong-Sung Lee and Joomin Lee

kjcls, 2024, 35, 265
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