Multi-omics analysis detected multiple pathways by which pomegranate punicalagin exerts its biological effects in modulating host–microbiota interactions in murine colitis models

Fang Liu, Allen D. Smith, Thomas T. Y. Wang, Quynhchi Pham, Haiyan Yang and Robert W. Li

Food Funct., 2023, 14, 3824
DOI: 10.1039/D3FO00286A

Therapeutic mechanism and clinical application of Chinese herbal medicine against diabetic kidney disease

Dan-Qian Chen, Jun Wu and Ping Li

Front. Pharmacol., 2022, 13
DOI: 10.3389/fphar.2022.1055296

Sesamolin Attenuates Kidney Injury, Intestinal Barrier Dysfunction, and Gut Microbiota Imbalance in High-Fat and High-Fructose Diet-Fed Mice

Yang Yang, Jing Yu, Jiayao Huo and Yaping Yan

J. Agric. Food Chem., 2023, 71, 1562
DOI: 10.1021/acs.jafc.2c07084

Fucoidan Improves Early Stage Diabetic Nephropathy via the Gut Microbiota–Mitochondria Axis in High-Fat Diet-Induced Diabetic Mice

Zhaoyi Zhong, Yangting Zhang, Yuan Wei, Xiaona Li, Lisheng Ren, Yan Li, Xueqian Zhang, Chengyu Chen, Xueru Yin, Run Liu and Qiuzhen Wang

J. Agric. Food Chem., 2024, 72, 9755
DOI: 10.1021/acs.jafc.3c08503

Gut Microbiome-Based Therapeutics in Critically Ill Adult Patients—A Narrative Review

Shiyue He, Fengyu Lin, Xinyue Hu and Pinhua Pan

Nutrients, 2023, 15, 4734
DOI: 10.3390/nu15224734

Gut Microbiota and Their Metabolites as Modulators of Vascular Complications in Diabetes

Meng Duan, Jielu Wen, Anning Chen and Sifan Chen

HM, 2025, 2
DOI: 10.53941/hm.2025.100002

Morroniside alleviates cisplatin-induced renal injury and gut dysbiosis via the gut–kidney axis and ferroptosis

Hangting Li, Ke Xu, Wenhao Mao, Bojian Yu, Zhongliang Liu, Fangfang Huang and Zuisu Yang

International Immunopharmacology, 2025, 153, 114430
DOI: 10.1016/j.intimp.2025.114430

Preclinical Studies of Natural Products Targeting the Gut Microbiota: Beneficial Effects on Diabetes

Xiaofang Jiang, Boyu Sun and Zheng Zhou

J. Agric. Food Chem., 2022, 70, 8569
DOI: 10.1021/acs.jafc.2c02960

Dietary Polyphenols-Gut Microbiota Interactions: Intervention Strategies and Metabolic Regulation for Intestinal Diseases

Huangkun Li, Ji’an Gao, Wenting Peng, Xihan Sun, Wentao Qi and Yong Wang

Biology, 2025, 14, 1705
DOI: 10.3390/biology14121705

Punicalagin attenuates ventricular remodeling after acute myocardial infarction via regulating the NLRP3/caspase-1 pathway

Jian-fei Peng, Xiao-ni Zhao, Meng Zhang, Jing-ya Li, Chun-chun Zhao, Shu-shu Wang, Jia-li Wang, Hui Shi, Peng Zhou and Liang Wang

Pharmaceutical Biology, 2023, 61, 963
DOI: 10.1080/13880209.2023.2224403

Impact of gut microbiota in chronic kidney disease: natural polyphenols as beneficial regulators

Cheng Li, Xulong Chen, Weiwei Zha, Sitian Fang, Jiangwen Shen, Lin Li, Hongli Jiang and PuXun Tian

Renal Failure, 2025, 47
DOI: 10.1080/0886022X.2025.2506810

Fu Brick Tea as a Staple Food Supplement Attenuates High Fat Diet Induced Obesity in Mice

Daying Wu, Haoan Zhao, Lei Guo, Xiukun Liu, Yan Liang, Qian Liu, Wei Cao, Xueyan Chen and Xin Gao

Foods, 2023, 12, 4488
DOI: 10.3390/foods12244488

Apple polyphenols alleviate hyperuricemia by inhibiting xanthine oxidase and promoting uric acid excretion

Ying Chen, Shuhui Hu, Yanjun Guo, Yan Wang, Lei Chen, Xin He, Yajie Yu, Andong Ji, Shengjie Pei, Kelei Li, Xiaofei Guo and Duo Li

Journal of Functional Foods, 2025, 134, 107052
DOI: 10.1016/j.jff.2025.107052

Regulatory mechanisms of Traditional Chinese Medicine on gut microbiota in diabetic microvascular complications

Yiyang Peng, Chenyao Sun, Zheng Wang and Xiaohui Fan

Chin Med, 2026, 21
DOI: 10.1186/s13020-026-01374-4

Protective Role of Dietary Polyphenols in the Management and Treatment of Type 2 Diabetes Mellitus

Monika Martiniakova, Anna Sarocka, Noemi Penzes, Roman Biro, Veronika Kovacova, Vladimira Mondockova, Aneta Sevcikova, Sona Ciernikova and Radoslav Omelka

Nutrients, 2025, 17, 275
DOI: 10.3390/nu17020275

The Potential and Underlying Mechanisms of Punicalagin in Mitigating Enterotoxigenic Escherichia coli-Induced Diarrhea

Xiang-Guang Li, Xiaowen Zhao, Jie Zheng, Changxiu Xian, Zhizhong Liu and Hanwei Chen

The Journal of Nutrition, 2025, 155, 3168
DOI: 10.1016/j.tjnut.2025.08.002

Tuberculosis Prognosis and Clinical Synergistic Activity with gut Microbiome

Karthikeyan Sundaram and Leela Kagithakara Vajravelu

Indian J Microbiol, 2026, 66, 84
DOI: 10.1007/s12088-024-01433-0

Ootheca mantidis mitigates renal fibrosis in mice by the suppression of apoptosis via increasing the gut microbe Akkermansia muciniphila and modulating glutamine metabolism

Jue Wang, Xiaozhen Guo, Ziyuan Zou, Minjun Yu, Xueling Li, Hualing Xu, Yiping Chen, Tingying Jiao, Kanglong Wang, Yuandi Ma, Jie Jiang, Xinyu Liang, Jiawen Wang, Cen Xie and Yifei Zhong

Biomedicine & Pharmacotherapy, 2023, 166, 115434
DOI: 10.1016/j.biopha.2023.115434

Pomegranate polyphenol punicalagin as a nutraceutical for mitigating mild cognitive impairment: An overview of beneficial properties

Wenjun Wang, Pan Long, Mengshan He, Tao Luo, Yubo Li, Ling Yang, Yi Zhang and Xudong Wen

European Journal of Pharmacology, 2024, 977, 176750
DOI: 10.1016/j.ejphar.2024.176750

Dietary Polyphenols in Metabolic Diseases: Roles of Gut Microbiota‐Derived Metabolites

Pengzhao Tang, Hui Feng, Dandan Zhang, Jinlu Wu, Yaochuan Zhou, Wuwen Feng and Cheng Peng

Phytotherapy Research, 2026, 40, 1408
DOI: 10.1002/ptr.70180

Regulatory effects of marine polysaccharides on gut microbiota dysbiosis: A review

Jieying Ou, Zhuo Wang, Xiaofei Liu, Bingbing Song, Jianping Chen, Rui Li, Xuejing Jia, Riming Huang, Wenzhou Xiang and Saiyi Zhong

Food Chemistry: X, 2022, 15, 100444
DOI: 10.1016/j.fochx.2022.100444

Inonotus obliquus (Chaga) against HFD/STZ-induced glucolipid metabolism disorders and abnormal renal functions by regulating NOS-cGMP-PDE5 signaling pathway

Yating FENG, Jing LIU, Le GONG, Zhaodi HAN, Yan ZHANG, Rongshan LI and Hui LIAO

Chinese Journal of Natural Medicines, 2024, 22, 619
DOI: 10.1016/S1875-5364(24)60616-3

Pomegranate Punicalagin: A Comprehensive Review of Various In Vitro and In Vivo Biological Studies

Maria Maqsood, Raakia Anam Saeed, Hafiz Ubaid Ur Rahman, Muhammad Issa Khan and Nauman Khalid

ACS Food Sci. Technol., 2025, 5, 2064
DOI: 10.1021/acsfoodscitech.5c00117

Exploration of the pathogenesis of nephrotic syndrome and traditional Chinese medicine intervention based on gut microbiota

Jing Li, Yupei Xu, Tianhao Sun, Xiaotian Zhang, Huimin Liang, Wei Lin, Hangxing Yu, Bo Yang and Hongtao Yang

Front. Immunol., 2024, 15
DOI: 10.3389/fimmu.2024.1430356

Gut microbiota and its metabolites – molecular mechanisms and management strategies in diabetic kidney disease

Zi-Hui Mao, Zhong-Xiuzi Gao, Dong-Wei Liu, Zhang-Suo Liu and Peng Wu

Front. Immunol., 2023, 14
DOI: 10.3389/fimmu.2023.1124704

Fucoxanthin Ameliorates Kidney Injury by CCl4-Induced via Inhibiting Oxidative Stress, Suppressing Ferroptosis, and Modulating Gut Microbiota

Yaping Ding, Jiena Ye, Ying Liu, Shaohua Zhang, Yan Xu, Zuisu Yang and Zhongliang Liu

ACS Omega, 2025, 10, 7407
DOI: 10.1021/acsomega.4c11437

Feasibility of vinegar processing of toxic herbs in Shi–Zao–Tang: toxicity reduction, efficacy preservation in malignant ascites rats and underlying pharmacodynamic mechanisms

Jin-Di Xu, Xiao-Qin Gao, Rong-Ling Zhong, Jing Zhou, Ting Wang, Can Chen, Wei-Feng Yao, Ting Geng, Yi Zhang, Song-Lin Li and Li Zhang

Chin Med, 2025, 20
DOI: 10.1186/s13020-025-01224-9

The modulation of gut microbiota by herbal medicine to alleviate diabetic kidney disease – A review

Jinxin Du, Meina Yang, Zhongwen Zhang, Baorui Cao, Zhiying Wang and Jinxiang Han

Front. Pharmacol., 2022, 13
DOI: 10.3389/fphar.2022.1032208

Gut microbiota regulates oxidative stress and inflammation: a double-edged sword in renal fibrosis

Xiao-Jun Li, Qi-Yuan Shan, Xin Wu, Hua Miao and Ying-Yong Zhao

Cell. Mol. Life Sci., 2024, 81
DOI: 10.1007/s00018-024-05532-5

Crosstalk between dietary pomegranate and gut microbiota: evidence of health benefits

Yantao Yin, Remigio Martínez, Wangang Zhang and Mario Estévez

Critical Reviews in Food Science and Nutrition, 2024, 64, 10009
DOI: 10.1080/10408398.2023.2219763

Intestinal Akkermansia muciniphila is Beneficial to Functional Recovery Following Ischemic Stroke

Kemin Li, Wancong Ding, Xinrui Li, Hao Gao, Shuang Wang, Ting Li, Haiyu Zhao and Shengxiang Zhang

J Neuroimmune Pharmacol, 2024, 19
DOI: 10.1007/s11481-024-10146-6

Fucoxanthin ameliorates high-fat diet-induced kidney injury in mice

Zhongliang Liu, Baogui Xu, Jiawen Zheng, Yizhou Tian, Zuisu Yang and Huiyang Shi

Br J Nutr, 2025, 134, 441
DOI: 10.1017/S0007114525105023

Punicalagin prevents the bone loss of diabetic mice induced by high‐fat diet via the metabolism of gut microbiota

Jie Gao, Qinglian Hua, Lingling Chen, Junwei Zhang, Haifeng Zhao, Xiangyuan Meng, Feng Zhong and Tianlin Gao

eFood, 2024, 5
DOI: 10.1002/efd2.186

Tea Polyphenol Epigallocatechin Gallate and the Gut–Health Axis: Unraveling Structural Characteristics, Metabolic Pathways, and Systemic Benefits

Jiaying Yang, Wei Chen, Jiayi Chen, Dengchao Xie, Yuefei Wang and Jihong Zhou

Advances in Nutrition, 2025, 16, 100545
DOI: 10.1016/j.advnut.2025.100545

The gut microbiota and diabetic nephropathy: an observational study review and bidirectional Mendelian randomization study

Yi Zhen Han, Yang Zhi Yuan Wang, Xing Yu Zhu, Bo Xuan Du, Yao Xian Wang, Xue Qin Zhang, Jia Meng Jia, Wei Jing Liu and Hui Juan Zheng

Trials, 2025, 26
DOI: 10.1186/s13063-025-08755-4

Sesamolin Alleviates Nonalcoholic Fatty Liver Disease through Modulating Gut Microbiota and Metabolites in High-Fat and High-Fructose Diet-Fed Mice

Jing Yu, Hao Sun, Yang Yang and Yaping Yan

IJMS, 2022, 23, 13853
DOI: 10.3390/ijms232213853

Unraveling the mysteries of the gut-kidney axis: the protective role of traditional Chinese medicine in chronic kidney disease

Jiahui Li, Lijia Diao, Menglin Li, Fugang Huang and Ke Sun

Front. Microbiol., 2025, 16
DOI: 10.3389/fmicb.2025.1642377

Car@PLGA-NPs target gut microbiota-ER stress axis to combat diabetes

Wei Zhao, Li Chen, Jing Qing, Zhujia Zhao, Lijuan Xiong, Pingzhen Tong, Ziruo Huang and Yunzhi Chen

Front. Cell. Infect. Microbiol., 2026, 15
DOI: 10.3389/fcimb.2025.1667023

Fucoidan prevents diabetic cognitive dysfunction via promoting TET2-mediated active DNA demethylation in high-fat diet induced diabetic mice

Lei Chen, Yan Li, Xueqian Zhang, Xiuping Du, Yangting Zhang, Xiaona Li, Zhaoyi Zhong, Chengfeng Zhou, Xiaohong Liu, Jun Wang and Qiuzhen Wang

International Journal of Biological Macromolecules, 2024, 278, 134186
DOI: 10.1016/j.ijbiomac.2024.134186

Sanziguben polysaccharides improve diabetic nephropathy in mice by regulating gut microbiota to inhibit the TLR4/NF-κB/NLRP3 signalling pathway

Fan Wang, Chang Liu, LingZhi Ren, YanYang Li, HongMei Yang, Yang Yu and WeiPing Xu

Pharmaceutical Biology, 2023, 61, 427
DOI: 10.1080/13880209.2023.2174145

Regulation of Gut Microflora by Lactobacillus casei Zhang Attenuates Liver Injury in Mice Caused by Anti-Tuberculosis Drugs

Yue Li, Liangjie Zhao, Changyu Sun, Jingyi Yang, Xinyue Zhang, Sheng Dou, Qinglian Hua, Aiguo Ma and Jing Cai

IJMS, 2023, 24, 9444
DOI: 10.3390/ijms24119444

Lacticaseibacillus casei ATCC334 Ameliorates Radiation‐Induced Intestinal Injury in Rats by Targeting Microbes and Metabolites

Qinglian Hua, Haowen Zhang, Rui Xu, Chunxiang Tian, Tianlin Gao, Yanlei Yuan, Yaling Han, Yue Li, Ce Qi, Feng Zhong and Aiguo Ma

Molecular Nutrition Food Res, 2023, 67
DOI: 10.1002/mnfr.202200337