Codonopsis pilosula oligosaccharides modulate the gut microbiota and change serum metabolomic profiles in high-fat diet-induced obese mice

Ruibin Bai, Fang Cui, Wen Li, Yanping Wang, Zixia Wang, Yingrui Gao, Nan Wang, Qiaohong Xu, Fangdi Hu and Yan Zhang

Food Funct., 2022, 13, 8143
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Codonopsis pilosula water extract delays D-galactose-induced aging of the brain in mice by activating autophagy and regulating metabolism

Xuewen Wang, Jiachao Kang, Xuechan Li, Pingmin Wu, Yong Huang, Yongqiang Duan, Juan Feng and Jing Wang

Journal of Ethnopharmacology, 2024, 327, 118016
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Characterization of chemical composition variations in raw and processed Codonopsis Radix by integrating metabolomics and glycomics based on multiple chromatography‐mass spectrometry technology

Yan Wang, Jing‐jing Zhang, Zi‐xia Wang, Fang Cui, Qian‐Nian Zhang, Ping‐ping Song, Bing Li, Zhuo‐shi Tang, Fang‐di Hu and Xiao‐feng Shi

J of Separation Science, 2022, 45, 2375
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Astragali Radix–Codonopsis Radix–Jujubae Fructus water extracts ameliorate exercise‐induced fatigue in mice via modulating gut microbiota and its metabolites

Pan He, Lei Chen, Xuemei Qin, Guanhua Du and Zhenyu Li

J Sci Food Agric, 2022, 102, 5141
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Effect of medicinal and food homologous plants polysaccharides on animal nutrition and health: A review

Zichao Wang, Yi Zheng, Changxing Liu, Danye Zhu, Yingjie Feng, Hongtao Zhang, Qi Wang, Qinggong Chen and Xueyi Qiao

Food Biomacromolecules, 2026, 3, 5
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Bioguided isolation, identification and bioactivity evaluation of anti-fatigue constituents from Schizophyllum commune

Hao Chen, Qianzhen Wu, Kaili Xuan, Wenqiang Guo, Kunfeng Zhang, Yuanyuan Wang, Zhenzhen Dai, Rong Sheng, Huaqi He, Yuzhe Huang and Yan Chen

Fitoterapia, 2024, 175, 105940
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The effect and mechanism of Codonopsis Radix and its active components tangshenoside I and lobetyolin on preventing gastric ulcer based on spectrum-effect relationship

Qianping Chen, Yuting Sun, Xianrun Hu, Qi Xie, Wenkang Liu, Jinchun Lei, Xuemei Cheng, Wenyan Li and Changhong Wang

Journal of Ethnopharmacology, 2025, 353, 120281
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Effect of dietary L-theanine supplementation on skeletal muscle fiber type transformation in vivo

Xiaoling Chen, Man Zhang, Yonghong Xue, Dahui Liang, Wenting An, Gang Jia, Hua Zhao, Guangmang Liu and Zhiqing Huang

The Journal of Nutritional Biochemistry, 2022, 99, 108859
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Quality formation in Codonopsis roots during post-ripening revealed by untargeted metabolomics

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Industrial Crops and Products, 2026, 243, 123062
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Cooperative effects of three preservatives on physiological quality, endophytic bacterial community and volatile organic compounds of postharvest Codonopsis pilosula var. modesta roots

Yanping Wang, Longxia Wen, Zexin Tao, Pingping Song, Fang Cui, Yanjun Jia, Zixia Wang, Guolin Chai and Fangdi Hu

J Sci Food Agric, 2024, 104, 8670
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Effect of Yeast-Derived Peptides on Skeletal Muscle Function and Exercise-Induced Fatigue in C2C12 Myotube Cells and ICR Mice

Jiaming Cai, Lujuan Xing, Wangang Zhang, Jian Zhang, Lei Zhou and Zixu Wang

J. Agric. Food Chem., 2023, 71, 15522
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The Effect of Whey Peptides and Micronutrients on Improving Exercise Performance in Mice

Yitong Cheng, Chenxuan Wang, Jack Yang, Ziyue Wang, Haoran Xing, Wenbin Wu, Ting Yang, Hanfu Xian, Sitong Wan, Dongyuan Zhang, Na Li, Junjie Luo, Yongting Luo, Wanfeng Yang and Peng An

Nutrients, 2026, 18, 237
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Quality evaluation of Codonopsis Radix and processed products based on the analysis of monosaccharides and oligosaccharides by liquid chromatography coupled with charged aerosol detector

Qi Xie, Hemiao Tian, Xiaohan Huan, Lanlan Cao, Yan Wang, Xuemei Cheng, Chuguang Ning, Fangdi Hu and Changhong Wang

Phytochemical Analysis, 2022, 33, 262
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Extraction, purification, structural characteristics and biological properties of the polysaccharides from Codonopsis pilosula: A review

Fei Luan, Yafei Ji, Lixia Peng, Qi Liu, Haijuan Cao, Yan Yang, Xirui He and Nan Zeng

Carbohydrate Polymers, 2021, 261, 117863
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From environment to environmental adaptation: Environmental perspectives on the study of food and medicine homology

Ke-Ke Suo, Xue Li, Xin Liu, Jia-Qing Zhu, Yan-Ling Shi, Juan-Juan Yi and Ji-Ke Lu

Food & Medicine Homology, 2026, 3, 9420082
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An inulin-type fructan CP-A from Codonopsis pilosula alleviates TNBS-induced ulcerative colitis based on serum-untargeted metabolomics

Jiangtao Zhou, Jiajing Wang, Deyun Li, Zhijia Zhang, Changjian Wang, Xuepeng Zhang, Xiexin Xu and Jianping Gao

American Journal of Physiology-Gastrointestinal and Liver Physiology, 2024, 326, G216
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Anti-fatigue and anti-oxidant effects of curcumin supplementation in exhaustive swimming mice via Nrf2/Keap1 signal pathway

Yong Chen, Jiajun Wang, Ziheng Jing, Jose M. Ordovas, Jing Wang and Lirong Shen

Current Research in Food Science, 2022, 5, 1148
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Plant polysaccharides and antioxidant benefits for exercise performance and gut health: from molecular pathways to clinic

Di Lin and Mohammad J. Rezaei

Mol Cell Biochem, 2025, 480, 2827
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Multiple-Fingerprint and Spectrum-Effect Relationship of Bioactivity from Codonopsis Pilosula Polysaccharide

Jingmin Fan, Fang Cui, Ruibin Bai, Yingrui Gao, Qiaohong Xu, Wenbo Shi, Wen Li and Fangdi Hu

SSRN Journal, 2021
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Optimized new Shengmai powder ameliorates myocardial fibrosis in rats with heart failure by inhibition of the MAPK signaling pathway

Zeyu Zhang, Yuwei Song, Xuan Zhang, Shuai Wang, Zhuangzhuang Jia, Lin Wang, Ci Wang, Xianliang Wang and Jingyuan Mao

Journal of Ethnopharmacology, 2024, 319, 117210
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Natural polysaccharides from Panax notoginseng alleviate fatigue via the energy metabolism pathway mediated by p-AMPK/PGC-1α

Panpan Wei, Mengyue Deng, Xiaoping Wu, Yuzhen Ding, Die Xia, Renjie Li, Keqin Fan, Fangyu Song, Zijun Yan and Tong Chen

International Journal of Biological Macromolecules, 2026, 348, 150764
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Influence of the pKa value on the antioxidant activity of licorice flavonoids under solvent‐mediated effects

Yi Hu, Zhuxian Wang, Chunyan Shen, CuiPing Jiang, Zhaoming Zhu, Peiyi Liang, Hui Li, Quanfu Zeng, Yaqi Xue, Yufan Wu, Yuan Wang, Li Liu, Hongxia Zhu, Yankui Yi and Qiang Liu

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The Effect and Mechanism of New Processing Method of Codonopsis pilosula on Endocrine Physique Index in Rats

Xiaomeng Gong, Changjiang Hu and Min Tang

Computational and Mathematical Methods in Medicine, 2022, 2022, 1
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Multi-omics revealed the mechanisms of Codonopsis pilosula aqueous extract in improving UC through blocking abnormal activation of PI3K/Akt signaling pathway

Fang Li, Yanping Yang, Junli Ge, Chunxia Wang, Zhengjun Chen, Qin Li and Fude Yang

Journal of Ethnopharmacology, 2024, 319, 117220
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Oligosaccharides as Potential Regulators of Gut Microbiota and Intestinal Health in Post-COVID-19 Management

Kit-Leong Cheong, Shutong Chen, Bo Teng, Suresh Veeraperumal, Saiyi Zhong and Karsoon Tan

Pharmaceuticals, 2023, 16, 860
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A Multimodal Strategy for Quality Control and Botanical Origin Traceability of Codonopsis Radix based on HPLC Fingerprints With Chemometric Analysis

Yalan Li, Piaopiao Yang, Huixian Qing, Zhiyan Xie, Kexin Zhou, Lili Sun, Meiling Chen, Meng Wang and Xiaoliang Ren

Biomedical Chromatography, 2025, 39
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Fermentation-assisted extraction of polysaccharides from the roots of Codonopsis pilosula using a selected Rhizopus arrhizus strain

Jianfeng Mei, Shiyan Shen, Yang Wang, Yipeng Wang, Yu Yi and Guoqing Ying

Food and Bioproducts Processing, 2024, 147, 27
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Structural Characterization and Bioactivity Analysis of Ultrasound‐Assisted Polysaccharides From Codonopsis pilosula: Insights Into Antioxidant and Hypoglycemic Potentials

Anxiang Wang, Hong Zhang, Mingjun Yang, Xinjian Wang, Fang Wang and Yonggang Wang

Chemistry & Biodiversity, 2025, 22
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Tibetan Medicine Duoxuekang Capsule Ameliorates High-Altitude Polycythemia Accompanied by Brain Injury

Ke Chen, Ning Li, Fangfang Fan, ZangJia Geng, Kehui Zhao, Jing Wang, Yi Zhang, Ce Tang, Xiaobo Wang and Xianli Meng

Front. Pharmacol., 2021, 12
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Anti‐oxidant and anti‐fatigue properties of apple pomace polysaccharides by acid or alkali extraction

Xiangna Chang, Xuefeng Chen, Pin Gong, Wenjuan Yang, Lan Wang, Ning Liu, Yao Su and Yuanyuan Zhao

Int J of Food Sci Tech, 2022, 57, 78
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Differences of gut microbiota composition in mice supplied with polysaccharides from γ-irradiated and non-irradiated Schizophyllum commune

Chaomin Yin, Xin Qiao, Xiuzhi Fan, Zheya Chen, Fen Yao, Defang Shi, Yuhong Li and Hong Gao

Food Research International, 2022, 151, 110855
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Review of biological activities: A plant of traditional Chinese tonic

Qi Shi, Zhengjun Chen, Jie Yang, Xuxia Liu, Yuanjin Su, Miao Wang, Jiayu Xi, Fude Yang and Fang Li

Journal of Ethnopharmacology, 2024, 332, 118334
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Polysaccharides from Polygonatum kingianum Collett & Hemsl ameliorated fatigue by regulating NRF2/HO-1/NQO1 and AMPK/PGC-1α/TFAM signaling pathways, and gut microbiota

Xingrui Xu, Meimei Shan, Chuanqi Chu, Shenke Bie, He Wang and Shengbao Cai

International Journal of Biological Macromolecules, 2024, 266, 131440
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A review of the polysaccharides against fatigue and the underlying mechanism

Ziwen Lei, Yajun Shi, Junbo Zou, Xiaofei Zhang, Bao Xin, Dongyan Guo, Jing Sun and Fei Luan

International Journal of Biological Macromolecules, 2024, 275, 133601
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Prediction of saccharides concentration in intact and ground Codonopsis root using near-infrared reflectance spectroscopy

Zheng Jiang, Thomas Rodemann, Alieta Eyles, Qinan Wu and Dugald C. Close

Microchemical Journal, 2024, 205, 111333
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Preparation, structural characterization, biological activity, and nutritional applications of oligosaccharides

Ya-jing Chen, Xin Sui, Yue Wang, Zhi-hui Zhao, Tao-hong Han, Yi-jun Liu, Jia-ning Zhang, Ping Zhou, Ke Yang and Zhi-hong Ye

Food Chemistry: X, 2024, 22, 101289
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Therapeutic effects of Huangqi formula (Eefooton) in chronic kidney disease: clinical research and narrative literature review

Kuo-Cheng Lu, San-Chiang Wu, Tsuo-Cheng Lu, I-Shang Tzeng, Chun-En Kuo, Yu-Chiang Hung, Szu-Ying Wu, Te-Chuan Chen, Ming-Kai Tsai, Chih-Kuang Chuang and Wen-Long Hu

Aging, 2024, 16, 13627
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Energy preservation for skeletal muscles: Shenqi Fuzheng injection prevents tissue wasting and restores bioenergetic profiles in a mouse model of chemotherapy-induced cachexia

Wei Li, Zijia Zhang, Entezar Berik, Yawen Liu, Wenqiang Pei, Sihan Chen, Wenyong Wu, Zhaojun Wang, Xinqin Kong, Huali Long, Min Lei, Jennifer Yiyang Wang, Zhaoxia Li, Liangfeng Liu, Jinjun Hou, Wanying Wu and De-an Guo

Phytomedicine, 2024, 125, 155269
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Potential of Dendrobium officinale oligosaccharides to alleviate chronic colitis by modulating inflammation and gut microbiota

Dong-Cheng Shi, Pei-Yi Wang, Lei Xu, Hua Zhu, Wang-Yue Zhang, Qi-Yong Wu, Ting-Ting Bu, Bao-Ming Tian, Pei-Long Sun and Ming Cai

Food & Medicine Homology, 2025, 2, 9420077
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Deciphering the potential role of Maca compounds prescription influencing gut microbiota in the management of exercise-induced fatigue by integrative genomic analysis

Hongkang Zhu, Ruoyong Wang, Hanyi Hua, He Qian and Peng Du

Front. Nutr., 2022, 9
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Screening prolyl hydroxylase domain 2 inhibitory activity of traditional Chinese medicine by CZE‐UV

Ying Zhang, Ming Zhao, Cheng‐Bo Wang, Yu Wang, Stanislas Nsanzamahoro, Ling‐Ling Zhu, Wei‐Feng Wang and Jun‐Li Yang

Electrophoresis, 2022, 43, 1601
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Extraction, purification, structural features, biological activities, modifications, and applications from Taraxacum mongolicum polysaccharides: A review

Ying Liu, Yajun Shi, Junbo Zou, Xiaofei Zhang, Bingtao Zhai, Dongyan Guo, Jing Sun and Fei Luan

International Journal of Biological Macromolecules, 2024, 259, 129193
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Characterization of emulsions stabilized by aqueous and alkaline extraction of polysaccharide conjugates from bamboo leaves

Ruixiang Shao, Wendan Cao, Xuejun Huang, Na Zhang, Lixin Ma, Yang Huang, Yi Huang, Jianwei Mao, Yonggang Qi, Shuiyuan Cheng and Xiaoqiang Chen

Industrial Crops and Products, 2024, 219, 119016
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Structural characterization and immunomodulatory activity of a glucan from Radix Codonopsis

Jiankuan Li, Yan Wang, Jiaojiao Ji, Lingya Cao, Yune Bai and Jianping Gao

Journal of Functional Foods, 2021, 83, 104537
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Discrimination of the species and origins of Codonopsis Radix by UPLC–Q-TOF-MS and UPLC–ELSD-based metabolomics combined with chemometrics

Xiaoyan Lan, Xiaoyan Hou, Li Zhou, Zidong Qiu, Xiang Li, Jian Yang, Zhilai Zhan, Tiegui Nan, Qingxiu Hao, Yi Yu, Xiaoliang Lin, Meilan Chen, Liping Kang and Luqi Huang

Journal of Food Composition and Analysis, 2025, 139, 107142
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Codonopsis Radix: A comprehensive review for its ethnopharmacology, phytochemistry, pharmacodynamics, pharmacokinetics, toxicity and potential clinical applications

Jinrong Bai, Na Xie, Ya Hou, Chenghua Li, Peiyang Gao, Luming Qi, Xiaoyun Nie, Jierui Yan, Yong Zeng, Yi Zhang, Xianli Meng and Xiaobo Wang

Phytomedicine, 2025, 149, 157540
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Modulation of Human Gut Microbiota In Vitro by Inulin-Type Fructan from Codonopsis pilosula Roots

Jiankuan Li, Lingya Cao, Jiaojiao Ji, Mingyue Shen and Jianping Gao

Indian J Microbiol, 2024, 64, 520
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Dietary Polysaccharides Exert Anti-Fatigue Functions via the Gut-Muscle Axis: Advances and Prospectives

Yaping Zhou, Zhongxing Chu, Yi Luo, Feiyan Yang, Fuliang Cao, Feijun Luo and Qinlu Lin

Foods, 2023, 12, 3083
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Regulation of optimized new Shengmai powder on cardiomyocyte apoptosis and ferroptosis in ischemic heart failure rats: The mediating role of phosphatidylinositol-3-kinase/protein kinase B/tumor protein 53 signaling pathway

Ze-Yu Zhang, Zhi-Hua Yang, Shuai Wang, Shao-Ling Feng, Xian-Liang Wang and Jing-Yuan Mao

Journal of Ethnopharmacology, 2024, 330, 118264
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Lactobacillus fermentum CQPC08 Attenuates Exercise-Induced Fatigue in Mice Through Its Antioxidant Effects and Effective Intervention of Galactooligosaccharide

Dong Liu, Da Chuan Liu, Hao Fan and Yu Wang

DDDT, 2021, Volume 15, 5151
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Polysaccharides derived from natural edible and medicinal sources as agents targeting exercise-induced fatigue: A review

Yuzhou Liu, Zige Feng, Yao Hu, Xinmei Xu, Tingting Kuang and Yue Liu

International Journal of Biological Macromolecules, 2024, 256, 128280
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Millettia speciosa Champ. root extracts relieve exhaustive fatigue by regulating gut microbiota in mice

Xinru Hu, Zhen Zhong, Longhui Yu, Qinru Yang, Jinfeng Zhang, Wenjing Wang, Peiqin Chen, Jingen Li and Guodong Zheng

Food and Chemical Toxicology, 2025, 203, 115557
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Exploring apple pectic polysaccharides: Extraction, characterization, and biological activities - A comprehensive review

Neeraj Kumari, Manoj Kumar, Radha, Nadeem Rais, Sunil Puri, Kanika Sharma, Suman Natta, Sangram Dhumal, Rahul D. Damale, Sunil Kumar, Marisennayya Senapathy, Sheetal Vishal Deshmukh, T. Anitha, T. Prabhu, S. Shenbagavalli, V. Balamurugan, Jose M. Lorenzo and John F. Kennedy

International Journal of Biological Macromolecules, 2024, 255, 128011
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Exploration of Postharvest Conditions for Codonopsis pilosula Nannf. var. modesta (Nannf.) L. T. Shen Roots Based on Sensory Quality, Active Components, Antioxidant Capacity and Physiological Changes at Different Storage Temperatures

Longxia Wen, Yanping Wang, Pingping Song, Zixia Wang, Zhuoshi Tang, Yina Guo, Huaqiao Yu and Fangdi Hu

Foods, 2023, 12, 4418
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Structural Characterization and Antifatigue Activity of a Novel Exopolysaccharide Isolated from Marasmius androsaceus

Peng Du, Nan Li, Junqing Wang, Piwu Li, Jia Song, Xiaoqi Geng, Ziyang Zhang, Shuai Yang, Ruiming Wang and Seyed Mohammad Taghi Gharibzahedi

Journal of Food Biochemistry, 2023, 2023, 1
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The in vitro/in vivo metabolic pathways analysis of lobetyol, lobetyolin, and lobetyolinin, three polyacetylenes from Codonopsis Radix, by UHPLC-Q/TOF-MS and UHPLC-MS/MS

Qi Xie, Hanxue Wang, Huida Guan, Nan Xu, Xiang Zhao, Xuemei Cheng and Changhong Wang

Journal of Pharmaceutical and Biomedical Analysis, 2023, 223, 115140
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Bioactives in Food-As-Medicine for Special Medical Purposes

Xueyao Xi, Senyang Hu, Xunuo Zhang, Peng An, Yongting Luo, Junjie Luo and Yinhua Zhu

Advances in Nutrition, 2025, 16, 100546
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Discrimination of three varieties of Codonopsis Radix based on fingerprint profiles of oligosaccharides by high performance liquid chromatography- evaporative light scattering detector combined with multivariate analysis

Ruibin Bai, Yanping Wang, Yangyang Cao, Huaqiao Yu, Pengpeng Li, Guolin Chai, Xiaodong Li, Wen Li, Fang Cui and Fangdi Hu

Journal of Chromatography A, 2022, 1685, 463642
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Combining stable C, N, O, H isotope and multi-element with chemometrics for identifying the geographical origins of Codonopsis pilosula

Ruibin Bai, Feng Xiong, Zhiqiang Luo, Xiaoyan Lan, Xiufu Wan, Liping Kang and Jian Yang

Journal of Food Composition and Analysis, 2023, 123, 105560
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Tracking the infection dynamics of Fusarium oxysporum in Codonopsis pilosula based on GFP labelling

Mingming Shi, Huixia Li, Wei Guo, Ning Luo, Jinghuan Chen, Yonggang Liu, Rui Liu and Zhenchuan Mao

Front. Plant Sci., 2025, 16
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Ganoderic Acid A Enhances Glycometabolism in Mouse Gastrocnemius Muscle During Exercise‐Induced Fatigue via AMPK/PGC‐1α Pathway Activation

Jialin Zhu, Fenglin Peng, Lin Zhang, Yanju Guo, Weiguo Liu, Jingrong Li, Shuju Shang, Bohan Zhang and Taotao Qiu

Food Science & Nutrition, 2026, 14
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A review of the botany, ethnopharmacology, phytochemistry, analysis method and quality control, processing methods, pharmacological effects, pharmacokinetics and toxicity of codonopsis radix

Jiaojiao Dong, Yexin Na, Ajiao Hou, Shihao Zhang, Huan Yu, Senwang Zheng, Wei Lan and Liu Yang

Front. Pharmacol., 2023, 14
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Multi-level characterization and comparison of polysaccharides and small-molecule metabolites enabling the differentiation of three Codonopsis species

Yu-ying Zhao, Rui Wei, Wei Wang, Yi-qing Yao, Ya-dan Zou, Min Zhang, Dian-xin Cui, Qi-long Wang, Xue Li, Jun-hua Zhang and Wen-zhi Yang

Journal of Food Composition and Analysis, 2025, 148, 108259
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Effects and mechanisms of polysaccharides from natural medicinal plants on improving aerobic exercise capacity

Mingxin Xu, Weiyu Chen and Wenjian Liang

Front. Nutr., 2025, 12
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Anti-hypoxia polyacetylenes and sesquiterpenoids from Codonopsis pilosula (Franch.) Nannf

Zhuo-Yang Cheng, Jun-Ge Jin, Meng Yan, Xin-Yue Chen, Jian-Kuan Li, Jian-Ping Gao and Jiang-Tao Zhou

Natural Product Research, 2025, 1
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Effects and mechanism of extracts rich in phenylpropanoids-polyacetylenes and polysaccharides from Codonopsis Radix on improving scopolamine-induced memory impairment of mice

Qi Xie, Xianrun Hu, Xiang Zhao, Zedong Xiang, Qianping Chen, Zhejun Xie, Hanxue Wang, Yonglin Zhao, Xuemei Cheng and Changhong Wang

Journal of Ethnopharmacology, 2024, 319, 117106
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Pharmacokinetics and related gender difference studies of four active components of Codonopsis Pilosula by LC-MS/MS determination

Hongfei Mu, Qiong Jin, Jia Tang, Lisha Ye and Baolian Wang

Journal of Ethnopharmacology, 2025, 337, 118899
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Cornus officinalis polysaccharides nano-selenium exhibits anti-fatigue effects by regulating gut microbiota in mice

Jianrui Sun, Ruirui Ren, Jinglan Li, Jiaqi Fan, Linlin Yao, Shanshan Tie, Jie Zhang, Dahong Wang and Shaobin Gu

Food Bioscience, 2025, 73, 107728
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