Supplementation with soy isoflavones alleviates depression-like behaviour via reshaping the gut microbiota structure

Li Wang, Xuejiao Wu, Yuhao Ma, Xian Li, Jingfeng Zhang and Lichao Zhao

Food Funct., 2021, 12, 4995
DOI: 10.1039/D0FO03254A

Lactobacillus rhamnosus zz-1 exerts preventive effects on chronic unpredictable mild stress-induced depression in mice via regulating the intestinal microenvironment

Jinzhao Xu, Mengqi Tang, Xinyu Wu, Xiangli Kong, Yini Liu and Xiaoxi Xu

Food Funct., 2022, 13, 4331
DOI: 10.1039/D1FO03804D

Gut microbiota in mental health and depression: role of pre/pro/synbiotics in their modulation

Hasnain N. Methiwala, Bhupesh Vaidya, Vamsi Krishna Addanki, Mahendra Bishnoi, Shyam Sunder Sharma and Kanthi Kiran Kondepudi

Food Funct., 2021, 12, 4284
DOI: 10.1039/D0FO02855J

Effect of Lacticaseibacillus paracasei strain Shirota supplementation on clinical responses and gut microbiome in Parkinson's disease

Xiaodong Yang, Xiaoqin He, Shaoqing Xu, Yi Zhang, Chengjun Mo, Yiqiu Lai, Yanyan Song, Zheng Yan, Penghui Ai, Yiwei Qian and Qin Xiao

Food Funct., 2023, 14, 6828
DOI: 10.1039/D3FO00728F

Strategies for circadian rhythm disturbances and related psychiatric disorders: a new cue based on plant polysaccharides and intestinal microbiota

Qiaoyu Sun, Chi-Tang Ho, Xin Zhang, Yanan Liu, Ruilin Zhang and Zufang Wu

Food Funct., 2022, 13, 1048
DOI: 10.1039/D1FO02716F

Study onLactiplantibacillus plantarumR6-3 from Sayram Ketteki to prevent chronic unpredictable mild stress-induced depression in mice through the microbiota–gut–brain axis

Lina Zhao, Dongyao Li, Bimal Chitrakar, Chen Li, Na Zhang, Shaogang Zhang, Xinyu Wang, Miaoshu Wang, Hongtao Tian and Yunbo Luo

Food Funct., 2023, 14, 3304
DOI: 10.1039/D2FO03708D

The Role of Gut Microbiota in Anxiety, Depression, and Other Mental Disorders as Well as the Protective Effects of Dietary Components

Ruo-Gu Xiong, Jiahui Li, Jin Cheng, Dan-Dan Zhou, Si-Xia Wu, Si-Yu Huang, Adila Saimaiti, Zhi-Jun Yang, Ren-You Gan and Hua-Bin Li

Nutrients, 2023, 15, 3258
DOI: 10.3390/nu15143258

Antidepressant and neuroprotective potential of stingless bee honey in a preclinical stress model

Anish Ameera Shaheran, Nurfatihah Azlyna Ahmad Suhaimi, Wan Amir Nizam Wan Ahmad, Shazana Hilda Shamsuddin, Jafri Malin Abdullah and Mohd Zulkifli Mustafa

Journal of Functional Foods, 2025, 130, 106913
DOI: 10.1016/j.jff.2025.106913

Flavonols in Action: Targeting Oxidative Stress and Neuroinflammation in Major Depressive Disorder

Maja Jazvinšćak Jembrek, Nada Oršolić, Dalibor Karlović and Vjekoslav Peitl

IJMS, 2023, 24, 6888
DOI: 10.3390/ijms24086888

Lactobacillus reuteri strain 8008 attenuated the aggravation of depressive-like behavior induced by CUMS in high-fat diet-fed mice through regulating the gut microbiota

Canye Li, Zuanjun Su, Zhicong Chen, Jinming Cao, Xiufeng Liu and Feng Xu

Front. Pharmacol., 2023, 14
DOI: 10.3389/fphar.2023.1149185

The protective effect of S-adenosylmethionine on chronic adolescent stress-induced depression-like behaviors by regulating gut microbiota

Jingjing Xu, Xinqi Wang, Wangwang Xu, Yang Zhang, Liangke Pan and Jin Gao

European Journal of Pharmacology, 2024, 982, 176939
DOI: 10.1016/j.ejphar.2024.176939

Combined probiotics attenuate chronic unpredictable mild stress-induced depressive-like and anxiety-like behaviors in rats

Li Huang, Xia Lv, Xiaolei Ze, Zewei Ma, Xuguang Zhang, Ruikun He, Junting Fan, Meilin Zhang, Boran Sun, Fang Wang and Huan Liu

Front. Psychiatry, 2022, 13
DOI: 10.3389/fpsyt.2022.990465

Bifidobacterium breve BB05 alleviates depressive symptoms in mice via the AKT/mTOR pathway

Yanni Pan, Qingling Huang, Yuan Liang, Yuwuqi Xie, Fang Tan and Xingyao Long

Front. Nutr., 2025, 12
DOI: 10.3389/fnut.2025.1529566

The Effects of Stress and Diet on the “Brain–Gut” and “Gut–Brain” Pathways in Animal Models of Stress and Depression

Mauritz F. Herselman, Sheree Bailey and Larisa Bobrovskaya

IJMS, 2022, 23, 2013
DOI: 10.3390/ijms23042013

Exploring role of Bacillus coagulans BCP92™ (MTCC 25460) in modulation of depressive-like behavior: Unraveling microbiome gut-brain axis

Sohel S. Shaikh, Kuldip Vyas, Ayush Sharma, Snehal S. Patel, Farhana Malek and Anis Malik

Behavioural Brain Research, 2025, 495, 115776
DOI: 10.1016/j.bbr.2025.115776

The role of the gut microbiota in neuropsychiatric disorders and therapy

Fan Zhang, Kang Ding, Lin-Mei Zhang, Dong-Yao Liu, Xin Dong, Man-Ni Wang, Fu-Lin Zhou, Yi-Wei Sun, Wei-Ku Zhang, Yu Yan, Jun He and Jie-Kun Xu

Ageing Research Reviews, 2025, 112, 102894
DOI: 10.1016/j.arr.2025.102894

Exertional heat stroke-induced changes in gut microbiota cause cognitive impairment in mice

Jiangang Xie, Linxiao Wang, Yunyun Xu, Yuexiang Ma, Lingqin Zhang, Wen Yin and Yang Huang

BMC Microbiol, 2024, 24
DOI: 10.1186/s12866-024-03276-7

Suppressive Effects of Lactobacillus on Depression through Regulating the Gut Microbiota and Metabolites in C57BL/6J Mice Induced by Ampicillin

Wan-Hua Tsai, Wen-Ling Yeh, Chia-Hsuan Chou, Chia-Lin Wu, Chih-Ho Lai, Yao-Tsung Yeh, Chorng-An Liao and Chih-Chung Wu

Biomedicines, 2023, 11, 1068
DOI: 10.3390/biomedicines11041068

Antidepressant‐Like Effect of Saffron (Crocus sativus L.) in Mice Exposed to Chronic Unpredictable Mild Stress via Attenuating Neuroinflammation and Recovering Neuroplasticity

Jiexin Zhou, Yuemei Hu and Pu Jing

Molecular Nutrition Food Res, 2025, 69
DOI: 10.1002/mnfr.70201

Microbiota-gut-brain axis in perioperative neurocognitive and depressive disorders: Pathogenesis to treatment

Mengxin Que, Shiyong Li, Qian Xia, Xing Li, Xiaoxiao Luo, Gaofeng Zhan and Ailin Luo

Neurobiology of Disease, 2024, 200, 106627
DOI: 10.1016/j.nbd.2024.106627

Contribution of hippocampal BDNF/CREB signaling pathway and gut microbiota to emotional behavior impairment induced by chronic unpredictable mild stress during pregnancy in rats offspring

Feng Zhao, Kai Wang, Yujun Wen, Xiaohui Chen, Hongya Liu, Faqiu Qi, Youjuan Fu, Jiashu Zhu, Suzhen Guan and Zhihong Liu

PeerJ, 2022, 10, e13605
DOI: 10.7717/peerj.13605

Next-Generation Probiotics as Novel Therapeutics for Improving Human Health: Current Trends and Future Perspectives

Mohamed E. Abouelela and Yosra A. Helmy

Microorganisms, 2024, 12, 430
DOI: 10.3390/microorganisms12030430

A systematic review on gut microbiota consortium in the management of depression: Preclinical and clinical evidence

Simranjit Kaur, Aditi Jangli, Vijayasree V. Giridharan and Manoj P. Dandekar

Psychoneuroendocrinology, 2025, 181, 107615
DOI: 10.1016/j.psyneuen.2025.107615

Role of the gut-brain axis in neurological diseases: Molecular connections and therapeutic implications (Review)

Hongjuan Zhang, Jia Luan, Ling He, Xianfang Pan, Hujun Zhang, Yujie Li and Haiyan Li

Int J Mol Med, 2025, 56, 1
DOI: 10.3892/ijmm.2025.5633

Bacopaside I alleviates depressive-like behaviors by modulating the gut microbiome and host metabolism in CUMS-induced mice

Jie Wang, Jiayun Xin, Xike Xu, Wei Chen, Yanhui Lv, Yanping Wei, Xintong Wei, Zhanhong Li, Qianqian Ding, Houyu Zhao, Yukun Wen, Xiuyun Zhang, Yiqun Fang and Xianpeng Zu

Biomedicine & Pharmacotherapy, 2024, 170, 115679
DOI: 10.1016/j.biopha.2023.115679

Exploring the Connection Between BDNF/TrkB and AC/cAMP/PKA/CREB Signaling Pathways: Potential for Neuroprotection and Therapeutic Targets for Neurological Disorders

Abhishek Kumar Gupta, Sumedha Gupta, Sidharth Mehan, Zuber Khan, Ghanshyam Das Gupta and Acharan S. Narula

Mol Neurobiol, 2025, 62, 14627
DOI: 10.1007/s12035-025-05001-5

The Potential Role of Polyphenol Supplementation in Preventing and Managing Depression: A Review of Current Research

Mohd Farhan and Mohd Faisal

Life, 2024, 14, 1342
DOI: 10.3390/life14101342

Antidepressant Shugan Jieyu Capsule Alters Gut Microbiota and Intestinal Microbiome Function in Rats With Chronic Unpredictable Mild Stress -Induced Depression

Jingxuan Tan, Xixuan Li, Ying Zhu, Mitchell A. Sullivan, Bin Deng, Xuejia Zhai and Yongning Lu

Front. Pharmacol., 2022, 13
DOI: 10.3389/fphar.2022.828595

Clostridium butyricum RH2 Alleviates Chronic Foot Shock Stress-Induced Behavioral Deficits in Rats via PAI-1

Wenying Zhang, Tingyu Ding, Hong Zhang, Yuping Chen, Liping Liu, Jinjin Jiang, Siyuan Song, Hao Cheng, Changhao Wu, Jihu Sun and Qin Wu

Front. Pharmacol., 2022, 13
DOI: 10.3389/fphar.2022.845221

The Role of Psychobiotics in Supporting the Treatment of Disturbances in the Functioning of the Nervous System—A Systematic Review

Krzysztof Skowron, Anna Budzyńska, Natalia Wiktorczyk-Kapischke, Karolina Chomacka, Katarzyna Grudlewska-Buda, Monika Wilk, Ewa Wałecka-Zacharska, Małgorzata Andrzejewska and Eugenia Gospodarek-Komkowska

IJMS, 2022, 23, 7820
DOI: 10.3390/ijms23147820

The antidepressant effects and serum metabonomics of bifid triple viable capsule in a rat model of chronic unpredictable mild stress

Qinpeng Bu, Jingkai Zhang, Xiang Guo, Yifei Feng, Huan Yan, Weimin Cheng, Zhitao Feng and Meiqun Cao

Front. Nutr., 2022, 9
DOI: 10.3389/fnut.2022.947697

Microbiome‐gut‐brain axis as a novel hotspot in depression

Yue Ma, Peng Xu, ZhenJun Bai and JiLiang Fang

Brain-X, 2024, 2
DOI: 10.1002/brx2.43

Nutrition and the gut microbiome: a symbiotic dialogue influencing health and disease

Sayantanee Ray and Prakash Shankaran

Front. Nutr., 2026, 13
DOI: 10.3389/fnut.2026.1761992

Semen Sojae Praeparatum alters depression-like behaviors in chronic unpredictable mild stress rats via intestinal microbiota

Yanlan Chen, Nan Xiao, Yuxin Chen, Xinye Chen, Chunfei Zhong, Yuying Cheng, Bing Du and Pan Li

Food Research International, 2021, 150, 110808
DOI: 10.1016/j.foodres.2021.110808

Molecular pathways of major depressive disorder converge on the synapse

Gabriel R. Fries, Valeria A. Saldana, Johannes Finnstein and Theo Rein

Mol Psychiatry, 2023, 28, 284
DOI: 10.1038/s41380-022-01806-1

Anxiety disorders and the gut microbiota: a bibliometric and visual analysis

Linli Guo, Qin Ding, Qing Li, Danping Zheng, Linglin Guo, Xiaotao Cao and Qianqian Mou

Front. Psychiatry, 2025, 15
DOI: 10.3389/fpsyt.2024.1517508

Effect of prebiotics, probiotics, synbiotics on depression: results from a meta-analysis

Qin Zhang, Bing Chen, Jinghui Zhang, Jingyi Dong, Jianglin Ma, Yuyan Zhang, Kangyu Jin and Jing Lu

BMC Psychiatry, 2023, 23
DOI: 10.1186/s12888-023-04963-x

Lacticaseibacillus rhamnosus KY16 Improves Depression by Promoting Intestinal Secretion of 5-HTP and Altering the Gut Microbiota

Shicai Xie, Chen Wang, Jiajia Song, Yu Zhang, Hongwei Wang, Xiaoyong Chen and Huayi Suo

J. Agric. Food Chem., 2024, 72, 21560
DOI: 10.1021/acs.jafc.4c03870

Abnormal gut microbiota and bile acids in patients with first‐episode major depressive disorder and correlation analysis

Ning Sun, Jie Zhang, Jizhi Wang, Zhifen Liu, Xin Wang, Pengli Kang, Chunxia Yang, Penghong Liu and Kerang Zhang

Psychiatry Clin Neurosci, 2022, 76, 321
DOI: 10.1111/pcn.13368

The Roles of Periaqueductal Gray and Dorsal Raphe Nucleus Dopaminergic Systems in the Mechanisms of Thermal Hypersensitivity and Depression in Mice

Xingfeng Liu, Jingxin He, Wei Jiang, Song Wen and Zhi Xiao

The Journal of Pain, 2023, 24, 1213
DOI: 10.1016/j.jpain.2023.02.004

Cuscutae semen alleviates CUS-induced depression-like behaviors in mice via the gut microbiota-neuroinflammation axis

Lanwei Hou, Liu Yang, Caiting Zhu, Jingyu Miao, Wenjuan Zhou, Yuchun Tang, Haiwei Meng and Shuwei Liu

Front. Pharmacol., 2023, 14
DOI: 10.3389/fphar.2023.1107781

Ginsenoside Rg1: A Neuroprotective Natural Dammarane‐Type Triterpenoid Saponin With Anti‐Depressive Properties

Dong Han, Zheng Zhao, Tinghui Mao, Man Gao, Xue Yang and Yan Gao

CNS Neurosci Ther, 2024, 30
DOI: 10.1111/cns.70150

Beslenme ve Mikrobiyotanın Depresyon Üzerine Olası Etkileri

Elif Nida KOÇ and Emre DUMAN

Bandırma Onyedi Eylül Üniversitesi Sağlık Bilimleri ve Araştırmaları Dergisi, 2022, 4, 156
DOI: 10.46413/boneyusbad.1105519

How Microbes Affect Depression: Underlying Mechanisms via the Gut–Brain Axis and the Modulating Role of Probiotics

Kazunori Suda and Kazunori Matsuda

IJMS, 2022, 23, 1172
DOI: 10.3390/ijms23031172

Traditional Chinese herbal formula, Fuzi-Lizhong pill, produces antidepressant-like effects in chronic restraint stress mice through systemic pharmacology

Fangyi Zhao, Jingjing Piao, Jinfang Song, Zihui Geng, Hongyu Chen, Ziqian Cheng, Ranji Cui and Bingjin Li

Journal of Ethnopharmacology, 2025, 338, 119011
DOI: 10.1016/j.jep.2024.119011

Multiple stressors, including cold exposure, disrupt growth and intestinal homeostasis via TLR4/p38MAPK/NF-κB and AMPK/SIRT1/PGC-1α pathways in layer chicks

Qingqing Chang, Haiyue Gong, Liying Pan, Zhaohong Pu, Jiaqi Zhang, Jianhong Li, Jun Bao and Runxiang Zhang

Journal of Thermal Biology, 2026, 136, 104431
DOI: 10.1016/j.jtherbio.2026.104431

Antidepressive Effect of Natural Products and Their Derivatives Targeting BDNF-TrkB in Gut–Brain Axis

Humna Liaqat, Amna Parveen and Sun-Yeou Kim

IJMS, 2022, 23, 14968
DOI: 10.3390/ijms232314968

Lactobacillus salivarius and Lactobacillus gasseri supplementation reduces stress‐induced sugar craving in mice

Marion Nicol, Emilie Lahaye, Mouna El Mehdi, Jean‐Luc do Rego, Jean‐Claude do Rego and Serguei O. Fetissov

Euro Eating Disorders Rev, 2024, 32, 1041
DOI: 10.1002/erv.3004

Lacticaseibacillus rhamnosus TF318 prevents depressive behavior in rats by inhibiting HPA-axis hyperactivity and upregulating BDNF expression

Yujuan Zhao, You Kang, Zijian Zhao, Ge Yang, Yansong Gao, Lei Gao, Chao Wang and Shengyu Li

Neuroscience Letters, 2023, 814, 137460
DOI: 10.1016/j.neulet.2023.137460

Contribution of Lactobacilli on Intestinal Mucosal Barrier and Diseases: Perspectives and Challenges of Lactobacillus casei

Da Qin, Yixuan Ma, Yanhong Wang, Xilin Hou and Liyun Yu

Life, 2022, 12, 1910
DOI: 10.3390/life12111910

Estrogenic Effect of Probiotics on Anxiety and Depression: A Narrative Review

Gilberto Uriel Rosas-Sánchez, León Jesús Germán-Ponciano, Juan Francisco Rodríguez-Landa, Herlinda Bonilla-Jaime, Ofelia Limón-Morales, Rosa Isela García-Ríos, José Luis Muñoz-Carrillo, Oscar Gutiérrez-Coronado, Paola Trinidad Villalobos-Gutiérrez and César Soria-Fregozo

IJMS, 2025, 26, 9948
DOI: 10.3390/ijms26209948

Gut Microbiota and Neuroinflammation: An Interconnected Nexus of Health and Neurodegenerative Disease

Mega Obukohwo Oyovwi, Gregory Joseph Uchechukwu, Bolape Adeola Oyekanmi, Emmanuel Igho Odokuma and Ugushida Thankgod Ogenma

OBM Neurobiol, 2024, 08, 1
DOI: 10.21926/obm.neurobiol.2404254

Gut Microbiota and Pathophysiology of Depressive Disorder

Hiroshi Kunugi

Ann Nutr Metab, 2021, 77, 11
DOI: 10.1159/000518274

Electroacupuncture Improves Depression-Like Behavior by Regulating the Abundance of Lactobacillus and Staphylococci in Mice

Xiaoke Qiu, Zheng Li, Shengtao Huang, Xiaowen Cai, Shanshan Qu, Zhong Zheng, Jiping Zhang, Feng Wen, Zhiyi Fu, Yong Huang and Zhinan Zhang

J. Integr. Neurosci., 2023, 22
DOI: 10.31083/j.jin2202028

3,3′-Diindolylmethane and 1,4-dihydroxy-2-naphthoic acid prevent chronic mild stress induced depressive-like behaviors in female mice

Caitlin A. Madison, Jacob Kuempel, Georgia Lee Albrecht, Lauren Hillbrick, Arul Jayaraman, Stephen Safe, Robert S. Chapkin and Shoshana Eitan

Journal of Affective Disorders, 2022, 309, 201
DOI: 10.1016/j.jad.2022.04.106

Molecular mechanisms of Baihedihuang decoction as a treatment for breast cancer related anxiety: A network pharmacology and molecular docking study

Zhong-Hui Li, Guo-Hua Yang and Fang Wang

World J Clin Cases, 2022, 10, 12104
DOI: 10.12998/wjcc.v10.i33.12104

Progress in Molecular Mechanisms of Depression Induced by Mother-Infant Separation and Intervention of Traditional Chinese Medicine

Ling-hui Kong, Min Liu, Hui Li, Rui-rui Shang, Shi-Meng Lv, Zhong-lin Wang and Qiang Ren

Alpha Psychiatry, 2025, 26
DOI: 10.31083/AP45684

Deciphering relationship between depression and microbial molecules based on multi-omics: A case study of Chaigui Granules

Qi Wang, Yingxia Zhao, Xuemei Qin and Junsheng Tian

Chinese Herbal Medicines, 2024, 16, 612
DOI: 10.1016/j.chmed.2023.12.003

Baihe Jizihuang Tang Ameliorates Chronic Unpredictable Mild Stress-Induced Depression-Like Behavior: Integrating Network Pharmacology and Brain-Gut Axis Evaluation

Jian-ping Zhu, Hua-ying Wu, Yuan Zi, Xin-bin Xia, Meng-zhou Xie, Zhi-ying Yuan and Smail Aazza

Evidence-Based Complementary and Alternative Medicine, 2021, 2021, 1
DOI: 10.1155/2021/5554363

Beneficial effects of Lactococcus lactis subsp. cremoris LL95 treatment in an LPS-induced depression-like model in mice

Juliana Bernera Ramalho, Cristiano Chiapinotto Spiazzi, Diogo Ferreira Bicca, Jéssica Ferreira Rodrigues, Carla Pohl Sehn, Wladimir Padilha da Silva and Francielli Weber Santos Cibin

Behavioural Brain Research, 2022, 426, 113847
DOI: 10.1016/j.bbr.2022.113847

Short-chain fatty acids-producing probiotics: A novel source of psychobiotics

Yiwen Cheng, Jiaming Liu and Zongxin Ling

Critical Reviews in Food Science and Nutrition, 2022, 62, 7929
DOI: 10.1080/10408398.2021.1920884

The pharmacological mechanism of Xiaoyaosan polysaccharide reveals improvement of CUMS-induced depression-like behavior by carbon source-triggered butyrate-producing bacteria

Linlin Xiong, Yanning Wu, Qinglong Shu and Wei Xiong

Journal of Applied Microbiology, 2023, 134
DOI: 10.1093/jambio/lxad052

Dendrobium officinale polysaccharides alleviate depression-like symptoms via regulating gut microbiota-neuroinflammation in perimenopausal mice

Qiu-Ping Zhang, Jie Cheng, Qing Liu, Guang-Hui Xu, Cheng-Fu Li and Li-Tao Yi

Journal of Functional Foods, 2022, 88, 104912
DOI: 10.1016/j.jff.2021.104912

Lactobacillus pentosus LPQ1 attenuates depressive-like behavior in BALB/C mice induced by chronic unpredictable mild stress (CUMS)

Yixiu Zeng, Zhen Wei, Yuhong Zhang, Feng Zhang, Jiajia Song and Huayi Suo

Food Bioscience, 2024, 62, 105240
DOI: 10.1016/j.fbio.2024.105240

Extracellular Vesicles from Gram-positive and Gram-negative Probiotics Remediate Stress-Induced Depressive Behavior in Mice

Juli Choi, Hyejin Kwon, Yoon-Keun Kim and Pyung-Lim Han

Mol Neurobiol, 2022, 59, 2715
DOI: 10.1007/s12035-021-02655-9

Ingestion of Lactobacillus helveticus WHH1889 improves depressive and anxiety symptoms induced by chronic unpredictable mild stress in mice

K. Gao, C.-L. Chen, X.-Q. Ke, Y.-X Yu, S. Chen, G.-C. Liu, H.-F. Wang and Y.-J. Li

BM, 2022, 13, 473
DOI: 10.3920/BM2022.0052

Probiotics for the treatment of depression and its comorbidities: A systemic review

Jie Gao, Longyou Zhao, Yiwen Cheng, Wenhui Lei, Yu Wang, Xia Liu, Nengneng Zheng, Li Shao, Xulei Chen, Yilai Sun, Zongxin Ling and Weijie Xu

Front. Cell. Infect. Microbiol., 2023, 13
DOI: 10.3389/fcimb.2023.1167116

Disrupting the Gut–Brain Axis: How Artificial Sweeteners Rewire Microbiota and Reward Pathways

Roberto Coccurello

IJMS, 2025, 26, 10220
DOI: 10.3390/ijms262010220

Comparison of the chronic unpredictable mild stress and the maternal separation in mice postpartum depression modeling

Yan Zhang, Li Zhang, Birui Shi, Fulong Huang, Yinhuang Gao, Zhishuo Miao, Ke Ma, Ziyao Zhan, Wei Zou and Menghua Liu

Biochemical and Biophysical Research Communications, 2022, 632, 24
DOI: 10.1016/j.bbrc.2022.09.063

A review on probiotics and mental health: exploring the gut-brain axis and its therapeutic potential

Yogish R. Srinivas, Tejashree M. Ramesh, Mahendra K. B. Jayappa and Pavan K. C. Muddanna

Int J Res Med Sci, 2025, 13, 3921
DOI: 10.18203/2320-6012.ijrms20252821

Gut microbiota as a novel target for treating anxiety and depression: from mechanisms to multimodal interventions

Zhang Ruohan, Wang Ruting, Wu Hongxi, Huang Zhenjin, Liang Jiale, Zhang Rongxin, Jiang Feng and Song Yuanbo

Front. Microbiol., 2025, 16
DOI: 10.3389/fmicb.2025.1664800

The correlation between gut microbiota and both neurotransmitters and mental disorders: A narrative review

Amjad Mhanna, Nafiza Martini, Ghefar Hmaydoosh, George Hamwi, Mulham Jarjanazi, Ghaith Zaifah, Reem Kazzazo, Aya Haji Mohamad and Zuheir Alshehabi

Medicine, 2024, 103, e37114
DOI: 10.1097/MD.0000000000037114

Isoalantolactone relieves depression-like behaviors in mice after chronic social defeat stress via the gut-brain axis

Siming Wang, Qihan Cai, Lu Xu, Yanan Sun, Mengmeng Wang, Yu Wang, Lili Zhang, Keqing Li and Zhiyu Ni

Psychopharmacology, 2023, 240, 1775
DOI: 10.1007/s00213-023-06413-8

The antidepressant potential of lactobacillus casei in the postpartum depression rat model mediated by the microbiota-gut-brain axis

Yiquan Yang, Shuzhen Zhao, Xiaoping Yang, Wei Li, Junying Si and Xiying Yang

Neuroscience Letters, 2022, 774, 136474
DOI: 10.1016/j.neulet.2022.136474

Lactobacillus plantarum-derived postbiotics prevent Salmonella-induced neurological dysfunctions by modulating gut–brain axis in mice

Yanping Wu, Yan Wang, Aixin Hu, Xin Shu, Wenxia Huang, Jinsong Liu, Baikui Wang, Ruiqiang Zhang, Min Yue and Caimei Yang

Front. Nutr., 2022, 9
DOI: 10.3389/fnut.2022.946096

Chaihu Guizhi decoction ameliorates depression symptoms in chronic restraint stress‐induced depressive rats by regulating gut microbiota and short‐chain fatty acids

Dong Peng, Yuying Cheng, Yanlan Chen, Xin Cai, Hanxiao Bao, Xiangmin Pan, Wanyue Ding, Jianping Chen and Pan Li

Food Safety and Health, 2024, 2, 276
DOI: 10.1002/fsh3.12038

Purinergic modulation of major depressive disorder: Experimental findings, pathogenesis and therapeutic opportunities

Xing-Ying Ren, Patrizia Rubini, Tobias Engel, Yong Tang and Peter Illes

Pharmacological Research, 2025, 221, 107989
DOI: 10.1016/j.phrs.2025.107989

Luana M. Manosso, Jaime Lin, Anelise S. Carlessi, Kelen C.C. Recco, João Quevedo, Cinara L. Gonçalves and Gislaine Z. Réus

Brain Research Bulletin, 2021, 171, 196
DOI: 10.1016/j.brainresbull.2021.04.001

A combination of cecum microbiome and metabolome in CUMS depressed rats reveals the antidepressant mechanism of traditional Chinese medicines: A case study of Xiaoyaosan

Meng Lv, Yaze Wang, Ping Qu, Shunyong Li, Zhiyi Yu, Xuemei Qin and Xiaojie Liu

Journal of Ethnopharmacology, 2021, 276, 114167
DOI: 10.1016/j.jep.2021.114167

Exercise, Diet, and Brain Health: From the Perspective of Gut Microbiota Regulation

Li Zhang, Renhe Liu, Zheyi Song and Xin Zhang

Nutrients, 2025, 17, 1686
DOI: 10.3390/nu17101686

Association of gut microbiota with cerebral cortical thickness: A Mendelian randomization study

Lubo Shi, Xiaoduo Liu, Shutian Zhang and Anni Zhou

Journal of Affective Disorders, 2024, 352, 312
DOI: 10.1016/j.jad.2024.02.063

Mechanism of Microbiota-Gut-Brain in Perimenopausal Depression: An Inflammatory Perspective

Xia Yu, Yi Zuo, Yang Yang, Wei Cheng, Mingxiu Shi, Luona Cheng, Qixiang Shao, Yongjun Xu and Li Chen

Expert Rev. Mol. Med., 2025, 27
DOI: 10.1017/erm.2025.10011

The effect of familact probiotic on seizure acquisition, cognitive function, and memory in an electrical kindling model of epilepsy in rats

Siamak Beheshti, Maedeh Feghhi, Mohammad Rabbani Khorasgani and Nasrin Farjad

Epilepsy & Behavior, 2026, 176, 110905
DOI: 10.1016/j.yebeh.2026.110905

Gut microbiota in anxiety and depression: mechanisms, drug interactions, and therapeutic implications

Hanane El Fatimi, Bilal El-Mansoury, Anass Tinakoua, Martin Ndayambaje, Younes Zaid, Hanane Khalki and Loubna Khalki

Pharmacol. Rep, 2025, 77, 1446
DOI: 10.1007/s43440-025-00759-w

Possible Effects and Mechanisms of Dietary Natural Products and Nutrients on Depression and Anxiety: A Narrative Review

Si-Xia Wu, Jiahui Li, Dan-Dan Zhou, Ruo-Gu Xiong, Si-Yu Huang, Adila Saimaiti, Ao Shang and Hua-Bin Li

Antioxidants, 2022, 11, 2132
DOI: 10.3390/antiox11112132

Synergistic effects of plant polysaccharides and exercise on depression alleviation from the microbiota-gut-brain axis

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DOI: 10.1016/j.fbio.2025.105967

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DOI: 10.1021/acschemneuro.2c00143

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DOI: 10.1093/abbs/gmab100

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DOI: 10.3748/wjg.v27.i39.6715

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DOI: 10.1021/acschemneuro.2c00580

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DOI: 10.1007/s12602-024-10332-1

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DOI: 10.1016/j.jnutbio.2023.109326

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DOI: 10.1016/j.afres.2025.101383

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DOI: 10.1016/j.bbi.2024.09.014

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DOI: 10.7717/peerj.15113

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DOI: 10.1016/j.crfs.2025.101020