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Multicomponent metal-organic frameworks: Structural diversity and functional synergy through mixed metals and ligands in biomedical applications
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Progress toward the computational discovery of new metal–organic framework adsorbents for energy applications
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Nat Energy, 2024, 9, 121
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Multiscale Profiling of Nanoscale Metal‐Organic Framework Biocompatibility and Immune Interactions
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Zeolitic Imidazolate Framework-8 (ZIF-8) as a Drug Delivery Vehicle for the Transport and Release of Telomerase Inhibitor BIBR 1532
Shunyu Zhang, Jinxia Li, Liang Yan, Yue You, Feng Zhao, Jixing Cheng, Limin Yang, Yanqi Sun, Qingchao Chang, Ru Liu and Yunhui Li
Nanomaterials, 2023, 13, 1779
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Molecule Engineering Metal–Organic Framework-Based Organic Photoelectrochemical Transistor Sensor for Ultrasensitive Bilirubin Detection
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Lanthanide-Doped Nanoparticles Anchoring on Metal–Organic Frameworks with Thermally Enhanced Upconversion Luminescence for Sensitive Nanothermometers
Wenqian Cao, Zhengluan Liao, Hongxu Chen, Yuanjing Cui, Zhiyu Wang and Guodong Qian
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Defect‐Engineered Metal–Organic Frameworks as Nanocarriers for Pharmacotherapy: Insights into Intracellular Dynamics at The Single Particle Level
Ge Huang, Marcus Winther Dreisler, Jacob Kæstel‐Hansen, Annette Juma Nielsen, Min Zhang and Nikos S. Hatzakis
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Surfactant‐Mediated Crystalline Structure Evolution Enabling the Ultrafast Green Synthesis of Bismuth‐MOF in Aqueous Condition
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Uptake and Intracellular Fate of Fluorophore Labeled Metal–Organic-Framework (MOF) Nanoparticles
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Metal- and covalent-organic framework-based drug delivery systems: Applications to control cell functions
Min-Ji Kang, Yeon-Woo Cho and Tae-Hyung Kim
Coordination Chemistry Reviews, 2025, 527, 216400
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Light‐Responsive Nanoantennas Integrated into Nanoscale Metal–Organic Frameworks for Photothermal Drug Delivery
Manuela Cedrún‐Morales, Manuel Ceballos, Enrica Soprano, Giulia Zampini, Ester Polo, Beatriz Pelaz and Pablo del Pino
Small Science, 2024, 4
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Formulation and characterization of CMPI nanoparticles for enhanced targeting of brain nicotinic receptors by positive allosteric modulator
Rahma Aly, Shoukath Sulthana, Robert Beaudoin, Ayman K. Hamouda and Santosh Aryal
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A Novel “Three‐in‐One” Copper‐Based Metal‐Organic Framework Nanozyme Eradicates Colorectal Cancer and Overcomes Chemoresistance for Tumor Therapy
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Metal-organic framework (MOF)/C-dots and covalent organic framework (COF)/C-dots hybrid nanocomposites: Fabrications and applications in sensing, medical, environmental, and energy sectors
Sina Bazazi, Esmaeil Hashemi, Mahdi Mohammadjavadi, Mohammad Reza Saeb, Yuqian Liu, Yang Huang, Huining Xiao and Farzad Seidi
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Toxicity Challenges and Current Advancement in Metal–Organic Frameworks (MOFs) for Biomedical Applications
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Exploring Helical Peptides and Foldamers for the Design of Metal Helix Frameworks: Current Trends and Future Perspectives
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Angewandte Chemie, 2023, 135
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Blocking Spatiotemporal Crosstalk between Subcellular Organelles for Enhancing Anticancer Therapy with Nanointercepters
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Advanced Materials, 2023, 35
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Metal-Organic Frameworks: Versatile Platforms for Biomedical Innovations
Cătălin Păun, Ludmila Motelică, Denisa Ficai, Anton Ficai and Ecaterina Andronescu
Materials, 2023, 16, 6143
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Preparation of metal-organic framework from in situ self-sacrificial stainless-steel matrix for efficient water oxidation
Li Zhong, Lixiang He, Ni Wang, Yunjian Chen, Xingchen Xie, Baolong Sun, Jinjie Qian, Sridhar Komarneni and Wencheng Hu
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Ultrathin ZIF‐8 Coating‐Reinforced Enzyme Nanoformulation Avoids Lysosomal Degradation for Senile Osteoporosis Therapy
Shiyuan Liang, Liyuan Chen, Cong Liu, Bowen Guo, Yijie Fan, Zhou Li, Yan Liu and Dan Luo
Adv Funct Materials, 2024, 34
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Advances in AI-driven applications of metal-organic frameworks for the diagnosis and treatment of pancreatic cancer
Chunyue Shi, Geqi Chen, Min Ye, Ziqi Xia, Yanna Ye, Aparna Kushwaha, Jun Wang, Abhinav Kumar and Ying Pan
Dyes and Pigments, 2025, 242, 112957
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Enhancing Drug Delivery Efficacy Through Bilayer Coating of Zirconium-Based Metal–Organic Frameworks: Sustained Release and Improved Chemical Stability and Cellular Uptake for Cancer Therapy
Xiewen Liu, Joanna Obacz, Giulia Emanuelli, Joseph E. Chambers, Susana Abreu, Xu Chen, Emily Linnane, Joshua P. Mehta, Andrew E. H. Wheatley, Stefan J. Marciniak and David Fairen-Jimenez
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Iron‐MOFs for Biomedical Applications
Zhihao Yu, Mathilde Lepoitevin and Christian Serre
Adv Healthcare Materials, 2025, 14
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Review: synthesis, characterization, and cutting-edge biomedical applications of metal–organic framework-based nanomaterials
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A self-supported aZIF-UC-4 glass membrane for gas separation
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Journal of Membrane Science, 2023, 683, 121873
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Multifunctional metal–organic frameworks as promising nanomaterials for antimicrobial strategies
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P53 Gene Therapy with ZIF-8 Metal–Organic Framework: A Platform in Cancer Gene Therapy
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ACS Omega, 2025, 10, 10891
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A thermosensitive hydrogel-copper meta-organic framework composite improves hindlimb ischemia therapy through synergistically enhancing HIF-1α production and inhibiting HIF-1α degradation
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Precision Cuproptosis Activation via HER2‐Targeted Bimetallic MOF Nanoreactors Breaks Metabolic Adaptation in Aggressive Breast Cancers
Mingjiang Liu, Hongkun Miao, Tong Ye, Jingchao Gao, Lian Tan, Yi Tian, Zhiguang Fu, Li Wen, Maohui Yan, Weijie Gu, Guoli Gu, Yingjie Wang and Yu Wang
Adv Funct Materials, 2026, 36
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Folic acid functionalized exopolysaccharide integrated into a coordination polymer for targeted and controlled drug release
Jose Paul, Rajapriya Govindaraju and Jongsung Kim
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M2 Macrophage‐Derived Migrasomes Mediate Ischaemia‐Induced Retinal Neovascularization by Targeting TREM2
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J of Extracellular Vesicle, 2025, 14
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Delivery of miRNAs through Metal–Organic Framework Nanoparticles for Assisting Neural Stem Cell Therapy for Ischemic Stroke
Hongru Yang, Min Han, Jian Li, Hongfei Ke, Ying Kong, Wenhan Wang, Liang Wang, Wenjun Ma, Jichuan Qiu, Xiwei Wang, Tao Xin and Hong Liu
ACS Nano, 2022, 16, 14503
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Analysis of the Pathogenesis of Gram-Negative Bacterial Sepsis in Rats Under Nano-Body
Xiaoli Li, Xiaogang Wang, Weiye Liu, Wenqiang Li and Meifeng Li
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Partially converted metal-organic frameworks
Yingying Zou, Chaoqi Zhang, Chengzhong Yu and Chao Liu
Coordination Chemistry Reviews, 2024, 510, 215815
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Engineering nanoscale glyco-zeolitic-imidazolate frameworks: Insights into the mechanism of formation
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Hyperthermia as a potential factor in enhancing the effect of antibiotics
Aleksandr L. Urakov and Petr D. Shabanov
Rev Clin Pharm Drug Ther, 2025, 23, 243
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On the Importance of Squaramide and Squarate Derivatives as Metal–Organic Framework Building Blocks
Catalina Nicolau, María de las Nieves Piña, Jeroni Morey and Antonio Bauzá
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Curcuma Longa: Nutraceutical Use and Association With Nanotechnology
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Adv Healthcare Materials, 2024, 13
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Exploring Helical Peptides and Foldamers for the Design of Metal Helix Frameworks: Current Trends and Future Perspectives
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Angew Chem Int Ed, 2023, 62
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Quantitatively Visualizing the Thermal Dehydration Process and Isotope Effect in Single HKUST-1 Metal–Organic Framework Particles
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Gas sorption properties of a new Zn‐BTB metal–organic framework with permanent porosity
In‐Hwan Choi, Ja‐Min Gu, Hyun‐Chul Kim, Youngmee Kim and Seong Huh
Bulletin Korean Chem Soc, 2023, 44, 780
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How safe are nanoscale metal-organic frameworks?
Dhruv Menon and Swaroop Chakraborty
Front. Toxicol., 2023, 5
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Screening of transcytosable iron oxide nanoparticles (TIONs) for deep tissue-penetrating imaging
Yongzhao Su, Zhehao Wang, Qiuhui Hu, Yuji Sun, Qiuyang Dong, Ying Piao, Zheng Hua, Chengyuan Dong, Hongjie Hu, Youqing Shen and Zhuxian Zhou
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Mn and Zn‐Doped Multivariate Metal–Organic Framework as a Metalloimmunological Adjuvant to Promote Protection Against Tuberculosis Infection
Thomas S. Howlett, Sneha Kumari, Ryanne N. Ehrman, Jesse Masson, Linda Izzo, Trixie Wang, Humera Gull, Ikeda Trashi, Wendy Tang, Orikeda Trashi, Neha Satish, Yalini H. Wijesundara, Fabian C. Herbert, Angelo A. Izzo and Jeremiah J. Gassensmith
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Hydrogel-based 3D printing technology: From interfacial engineering to precision medicine
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Recent Advances in Sensing Materials Targeting Clinical Volatile Organic Compound (VOC) Biomarkers: A Review
Akhilesh Pathak, Kankan Swargiary, Nuntaporn Kongsawang, Pannathorn Jitpratak, Noppasin Ajchareeyasoontorn, Jade Udomkittivorakul and Charusluk Viphavakit
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Oral Delivery Systems of Dietary Bioactive Compounds Based on Metal–Organic Frameworks: A Review
Huanhuan Yang, Qian Luan, Weiliang Guan and Wenqian Nong
Comp Rev Food Sci Food Safe, 2025, 24
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Sustainable metal-organic framework (MOF) bio-films for biomedical applications
Amir Reza Shojaei, Ali Soleimany Zefreh, Moein Malekli, Bahram Ramezanzadeh and Hossein Eivaz Mohammadloo
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On-target site enriching fluorescent bioprobe for imaging of receptor tyrosine kinase in tumor
Meng Gao, Jiqiu Yin, XianChao Jia, Ye Gao and Yang Jiao
Chinese Chemical Letters, 2025, 36, 110297
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A Decade‐Long Journey in Design Strategies and Structure–Property Relationships of Covalent Organic Framework Nanocarriers for Anticancer Drug Delivery
Preeti Rathi, Sumanta Chowdhury and Prem Felix Siril
Small, 2025, 21
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From construction strategies to applications: Multifunctional defective metal-organic frameworks
Xiaoyu Qiu and Rui Wang
Coordination Chemistry Reviews, 2025, 526, 216356
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Advances in surface functionalization of next-generation metal-organic frameworks for biomedical applications: Design, strategies, and prospects
Xu Chen, Sergio Mercado Argandona, Francesca Melle, Nakul Rampal and David Fairen-Jimenez
Chem, 2024, 10, 504
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Metal-organic frameworks as therapeutic chameleons: revolutionizing the cancer therapy employing novel nanoarchitectonics
Sajja Bhanu Prasad, Akshay Shinde, Dadi A. Srinivasrao, Paras Famta, Saurabh Shah, Tejaswini Kolipaka, Giriraj Pandey, Deelip Gaonker, Ganesh Vambhurkar, Pooja Khairnar, Rahul Kumar, Amol G. Dikundwar, Vinaykumar Kanchupalli and Saurabh Srivastava
Asian Journal of Pharmaceutical Sciences, 2025, 20, 101054
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Beyond the magic bullet: Programming delivery systems to overcome the antibody specificity paradox
Yaowei Ma, Yangyihua Zhou, Can Xu, Peixun Gao, Huile Gao, Longlong Luo and Xiang Gao
Journal of Controlled Release, 2026, 392, 114744
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Nanoencapsulation of Tomentosin-Rich Pulicaria crispa Fraction in MIL-53(Fe) Improves the Release Profile and In Vitro Anti-Colorectal Cancer Activity
Fatma Abo-Elghiet, George M. Hakeem, Rehab Mahmoud, Mona H. Ibrahim, Hamies B. Nabil, Zienab E. Eldin, Maha B. Abd Elhaleem, Sarah I. Othman, Nourhan Hassan and Emad M. Elzayat
Pharmaceutics, 2026, 18, 227
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A stable cd(II) metal-organic framework as a fluorescence sensor for nitrofuran antibiotics and vitamin B1/B9 in living cells
Fang-Sen Zhong, Man-Lian Zhang, Qinglin Chen, Chen Cao, Zhi-Yuan Li, Teng-Fei Zheng, Jing-Lin Chen, Yongquan Wu, He-Rui Wen and Sui-Jun Liu
Spectrochimica Acta Part A: Molecular and Biomolecular Spectroscopy, 2026, 127834
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CPP10-targeted photoactivatable MOF nanosystem for combined photodynamic Therapy−Chemotherapy of cancer
Jiahui Kong, Mengru Cai, Rongyue Zhu, Yongqiang Zhang, Yuji Du, Xiaohong Jing, Yufei Sun, Rongrong Chang, Changhai Qu, Xiaoxv Dong, Jian Ni and Xingbin Yin
Journal of Science: Advanced Materials and Devices, 2024, 9, 100761
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Bioempowerment of Therapeutic Living Cells by Single‐Cell Surface Engineering
Seoin Yang, Hyunwoo Choi, Duc Tai Nguyen, Nayoung Kim, Su Yeon Rhee, Sang Yeong Han, Hojae Lee and Insung S. Choi
Advanced Therapeutics, 2023, 6
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Guiding the rational design of biocompatible metal-organic frameworks for drug delivery
Dhruv Menon and David Fairen-Jimenez
Matter, 2025, 8, 101958
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Metal organic frameworks in biomedicine: Innovations in drug delivery
Alan Benny, Sunaja Devi Kalathiparambil Rajendra Pai, Dephan Pinheiro and Sony J. Chundattu
Results in Chemistry, 2024, 7, 101414
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Oligonucleotide-mediated assembly of temperature-responsive gelatin hydrogels to enhance the pharmacodynamic efficacy of antibiotics
Xueping Ning, Meng Liu, Yanlin Chen, Zhao Li, Jian Sun, Lanyu Cui and Shengbin He
International Journal of Biological Macromolecules, 2025, 333, 148927
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Environmental Carriers for Metal Nanoparticles: Transport, Fate, and Eco-risks
Ziyi Liu, Siying Ying, Yuelu Jiang, Haruka Takeuchi and Yuxiong Huang
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Strategies for the construction of new fluorescent nanomaterials in the detection and degradation of pesticide residues in food: From sensing to degradation applications prospects
Hanyao Hua and Liyi Zhou
Current Research in Food Science, 2025, 11, 101140
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Single-file diffusion and its influence on membrane gas separation: A case study on UTSA-280
Cheng-Hsun Hsu, Chia-Yi Lin, Hsiang-Yu Wang, Pei-Ying Lin, Chia-Hui Chuang, Li-Wei Hsiao, Cheng-chau Chiu and Dun-Yen Kang
Journal of Membrane Science, 2024, 706, 122920
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Two new anionic metal-organic frameworks based on scandium(III) and 2,5-thiophenedicarboxylate ligands: synthesis, structure and application
Matvei A. Tomas, Anna A. Lysova, Evgeniya V. Polyakova, Denis G. Samsonenko, Danil N. Dybtsev and Vladimir P. Fedin
Struct Chem, 2026
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High Throughput and Noninvasive Exosomal PD-L1 Detection for Accurate Immunotherapy Response Prediction via Tim4-Functionalized Magnetic Core–Shell Metal–Organic Frameworks
Haiyan Wang, Yanli Liu, Liyuan Zhang, Xinran Li, Guofa Zhao, Zizheng Song, Youchao Jia and Xiaoqiang Qiao
Anal. Chem., 2023, 95, 18268
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Polydopamine‐Mediated Metal–Organic Frameworks Modification for Improved Biocompatibility
Jiayu Feng, Liwang Xu, Lulu Qi, Zhengwei Fu and Qinglian Hu
Macromolecular Bioscience, 2024, 24
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Make metal–organic frameworks safe and sustainable by design for industrial translation
Swaroop Chakraborty, Dhruv Menon, Iuliia Mikulska, Christian Pfrang, David Fairen-Jimenez, Superb K. Misra and Iseult Lynch
Nat Rev Mater, 2025, 10, 167
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Multidimensional Applications and Challenges of Metal–Organic Frameworks (MOFs) in Biomedicine: From Drug Safety Evaluation to Drug Delivery
Zhe Liu, Yuanye Gao, Wenyuan Shao, Xuhui Guo, Danqing Zhao, Rui Yang and Siwei Li
J Biomedical Materials Res, 2025, 113
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Regulatory effect of Antarctic krill protein-pectin calcium-loaded complex on calcium absorption
Lei Chen, Songyi Lin, Xueqing He, Jiaqi Ye, Yihan Huang and Na Sun
Food Bioscience, 2025, 68, 106692
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A Fluorescent In (III) Metal-Organic Framework for Explosives Detection
Wen Li, Xinyao Liu, Guanghua Li and Yunling Liu
Chem. Res. Chin. Univ., 2023, 39, 1005
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Rational design of metal organic frameworks as the carriers for improving the efficiency of cancer drug delivery
Dongyu Gu, Yunxiao Wang and Yi Yang
Journal of Drug Delivery Science and Technology, 2024, 102, 106378
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Engineered Metal–Organic Frameworks for Targeted CRISPR/Cas9 Gene Editing
Navid Rabiee and Mohammad Rabiee
ACS Pharmacol. Transl. Sci., 2025, 8, 1028
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MOF‐Based Electromagnetic Shields Multiscale Design: Nanoscale Chemistry, Microscale Assembly, and Macroscale Manufacturing
Mahyar Panahi‐Sarmad, Shakiba Samsami, Ahmadreza Ghaffarkhah, Seyyed Alireza Hashemi, Shayan Ghasemi, Majed Amini, Stefan Wuttke, Orlando Rojas, Kam Chiu Tam, Feng Jiang, Mohammad Arjmand, Farhad Ahmadijokani and Milad Kamkar
Adv Funct Materials, 2024, 34
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Synthesis and evaluation of CuNi-MOF as a corrosion inhibitor of AISI 304 and 316 stainless steel in 1N HCl solution
Alireza Veysi, Mahmoud Roushani and Hossein Najafi
Heliyon, 2025, 11, e41296
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Magnetic Field-Responsive Smart bioMOF Composites Based on Bi(III)-Ellagate SU-101
Darina Francesca Picchi, Catalina Biglione, Julie Charlotte Pauline Mellerin, Doha Zorkot, Pascal Clerc, Manon Boulet, Safiyye Kavak, Pablo Cristóbal-Cueto, Ana Maria Panaite, Erik Svensson Grape, A. Ken Inge, Sara Bals, Julian Carrey, Teresa Pellegrino, Véronique Gigoux and Patricia Horcajada
ACS Appl. Mater. Interfaces, 2026, 18, 17631
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Facile manufacturing of carbon nanotube/ZIF-67-derived cobalt composite aerogel with high-efficiency electromagnetic wave absorption
Chang Liu, Na Wu, Bin Li, Zhou Wang, Lili Wu, Zhihui Zeng and Jiurong Liu
Journal of Materials Science & Technology, 2025, 220, 129
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Second near-infrared fluorescent Metal–Organic framework sensors for in vivo extracellular adenosine triphosphate monitoring
Qiming Qiu, Shengchun Sun, Hao Yuan, Shiyi Zhang, Yuyan Feng, Fanghao Wang, Yihang Zhu, Mingchuan Zhou and Yixian Wang
Biosensors and Bioelectronics, 2024, 251, 116114
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Receptor-targeted metal-organic frameworks: Recent progress in synthesis, modifications, and applications in targeted drug delivery
Hossein Poursadegh, Siamak Javanbakht, Jeremiah J. Gassensmith, Shengqian Ma and Seyed Mohammad Davachi
Advances in Colloid and Interface Science, 2026, 348, 103744
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Low-dose of zeolitic imidazolate framework-8 nanoparticle cause energy metabolism disorder through lysosome-mitochondria dysfunction
Dan Luo, Xiaojiao Wang, Xin Luo and Sisi Wu
Toxicology, 2023, 489, 153473
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Reproducibility in research into metal-organic frameworks in nanomedicine
Ross S. Forgan
Commun Mater, 2024, 5
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An investigation of IRMOF-16 as a pH-responsive drug delivery carrier of curcumin
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Different Size Formulations of Fluopyram: Preparation, Antifungal Activity, and Accumulation in the Fungal Pathogen Botrytis cinerea
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Advances in the Functionalization of Vaccine Delivery Systems: Innovative Strategies and Translational Perspectives
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Amorphous metal–organic frameworks: Pioneering frontiers in cancer diagnostics and therapeutics
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Experimental and Computational Investigations of the Effects of Bridging Linkers on the Protein Corona of Nanoscale Metal–Organic Frameworks
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Perturbative spin–orbit couplings for the simulation of extended framework materials
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Fullerenols hijack lysosomes to disrupt inter-organellar crosstalk and block autophagy pre-activated by mTOR inhibitors for cancer cell PANoptosis
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Challenges and strategies for hydrogen storage and carbon dioxide capture using metal-organic framework: Synergizing experimental and machine learning approach
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Enalaprilat reverses neutrophil polarization imbalance via targeting taurine-STING axis for treatment of diabetic wounds
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Metal–organic frameworks for biological applications
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Recent advances in nanoscale metal–organic frameworks (nanoMOFs) for electrochemical pharmaceutical sensing: a review
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MicroRNA functional metal-organic framework nanocomposite for efficient inhibition of drug-resistant breast cancer cells
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Metal-organic frameworks (MOFs): Redefining antiparasitic drug delivery
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Brain-specific targeted delivery of therapeutic agents using metal–organic framework-based nanomedicine
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A computational study of metal–organic frameworks (MOFs) as potential nanostructures to combat SARS-CoV-2
Mohammad Dahri, Mohammad Moein Sadeghi and Samira Sadat Abolmaali
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Multifunctional DNA nanoplatform based on near-infrared AgInS2 QDs and rolling circle amplification for fluorescence imaging and therapy of breast cancer cells
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Nanocomposites Based on Magnetic Nanoparticles and Metal–Organic Frameworks for Therapy, Diagnosis, and Theragnostics
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Engineered transferrin-conjugated PEGylated multifunctional MOF-74 as precision nanotheranostics for triple-negative breast cancer
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Editorial: Metal organic frameworks for antimicrobial prevention and treatments
Maria Cristina Cassani, Raymond J. Turner, Francesca Bonvicini and Silvia Panzavolta
Front. Chem., 2025, 13
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MIL-100(Fe)-Enabled Oral Delivery of Syringic Acid with Enhanced Pharmacokinetics
Joshua H. Santos, Hannah Jean Victoriano, Mary Sepulveda, Hung-En Liu, Shierrie Mae N. Valencia, Rikkamae Zinca Marie L. Walde, Emelda A. Ongo and Chia-Her Lin
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