Deterministic cell pairing with simultaneous microfluidic merging and sorting of droplets

Kevin M. Joslin, Sophia Dateshidze, Seung Won Shin, Adam R. Abate and Iain C. Clark

Lab Chip, 2025, 25, 5497
DOI: 10.1039/D5LC00627A

Dynamic sampling from ex vivo adipose tissue using droplet-based microfluidics supports separate mechanisms for glycerol and fatty acid secretion

Md Moniruzzaman, Andresa B. Bezerra, Md Mohibullah, Robert L. Judd, James G. Granneman and Christopher J. Easley

Lab Chip, 2024, 24, 5020
DOI: 10.1039/D4LC00664J

Automated Dynamic Inlet Microfluidics (ADIM) system: cost-effective biaxial nanoliter droplet on demand generation platform and its application in agglutination assays

Abdul Basit Zia and Ian G. Foulds

Lab Chip, 2025, 25, 57
DOI: 10.1039/D4LC00643G

An integrated microfluidic chip for alginate microsphere generation and 3D cell culture

Xiaoxiang Zhou, Libo Zhu, Weihao Li and Quanjun Liu

Anal. Methods, 2022, 14, 1181
DOI: 10.1039/D1AY01820E

Automated dynamic inlet microfluidics system: 3D printer adaptation for cost-effective, low volume, on-demand multi-analyte droplet generator

Abdul Basit Zia, Justin Farrell and Ian G. Foulds

Lab Chip, 2024, 24, 3015
DOI: 10.1039/D4LC00075G

Glass-embedded PDMS microfluidic device for enhanced concentration of nanoparticles using an ultrasonic nanosieve

Bryan Ang, Ankush Sookram, Citsabehsan Devendran, Vincent He, Kellie Tuck, Victor Cadarso and Adrian Neild

Lab Chip, 2023, 23, 525
DOI: 10.1039/D2LC00802E

Development and future of droplet microfluidics

Lang Nan, Huidan Zhang, David A. Weitz and Ho Cheung Shum

Lab Chip, 2024, 24, 1135
DOI: 10.1039/D3LC00729D

Active Flow Control and Dynamic Analysis in Droplet Microfluidics

Nan Shi, Md Mohibullah and Christopher J. Easley

Annual Rev. Anal. Chem., 2021, 14, 133
DOI: 10.1146/annurev-anchem-122120-042627

Microfluidic Printing‐Induced Dynamic Splitting of Conductive MOF to Expose High‐Density Active Sites for Boosted CO2 Electroreduction

Jiao‐Na Yue, Ying Wang, Jie Meng, Li‐Yang Shao, Tian‐Shu He, Bo‐Lin Sun, Lin‐Xi Xie and Quan‐Guo Zhai

Small, 2026
DOI: 10.1002/smll.202600018

Entirely soft valve leveraging snap-through instability for passive flow control

Xinjie Zhang, Ayobami Elisha Oseyemi, Ke Ma and Shouyi Yu

Sensors and Actuators B: Chemical, 2022, 367, 132035
DOI: 10.1016/j.snb.2022.132035

Chemical Analysis of Single Cells and Organelles

Keke Hu, Tho D. K. Nguyen, Stefania Rabasco, Pieter E. Oomen and Andrew G. Ewing

Anal. Chem., 2021, 93, 41
DOI: 10.1021/acs.analchem.0c04361

On-Demand Nanoliter Delivering Platform via Electrical-Activated Microdroplet Assembling

Jianwei Zhong, Yifu Chang, Minhui Liang, Yinning Zhou and Ye Ai

Nano Lett., 2025, 25, 14010
DOI: 10.1021/acs.nanolett.5c02928

Microfluidic Droplet Splitting in T-Junction: State of the Art in Actuation and Flow Manipulation

Xiena M. Salem, Laisha Y. Rincones, Esperanza Moreno, Richard O. Adansi, Sohail M. A. K. Mohammed, Md Mahamudur Rahman and Piyush Kumar

Actuators, 2026, 15, 96
DOI: 10.3390/act15020096

Coupling Droplet Microfluidics with Ion Mobility Spectrometry for Monitoring Chemical Conversions at Nanoliter Scale

Nora T. Hartner, Konstantin Wink, Christian-Robert Raddatz, Christian Thoben, Martin Schirmer, Stefan Zimmermann and Detlev Belder

Anal. Chem., 2021, 93, 13615
DOI: 10.1021/acs.analchem.1c02883

Self-synchronization of reinjected droplets for high-efficiency droplet pairing and merging

Lang Nan, Tianjiao Mao and Ho Cheung Shum

Microsyst Nanoeng, 2023, 9
DOI: 10.1038/s41378-023-00502-6

Probing T-cell activation in nanoliter tumor co-cultures using membrane displacement trap arrays

Michael Yeh, Emanuel Salazar-Cavazos, Anagha Krishnan, Grégoire Altan-Bonnet and Don L DeVoe

Integrative Biology, 2024, 16
DOI: 10.1093/intbio/zyae014

Single cell transfection of human-induced pluripotent stem cells using a droplet-based microfluidic system

Camilo Pérez-Sosa, Anahí Sanluis-Verdes, Ariel Waisman, Antonella Lombardi, Gustavo Rosero, Alejandro La Greca, Shekhar Bhansali, Natalia Bourguignon, Carlos Luzzani, Maximiliano. S. Pérez, Santiago Miriuka and Betiana Lerner

R. Soc. open sci., 2022, 9
DOI: 10.1098/rsos.211510

Harnessing the Manipulation of Single Cells to Construct Biological Structures: Tools and Applications

Congying Liu, Yuhe Chen, Rui Tong, Ziyang Wang, Deyuan Zhang, Huawei Chen and Pengfei Zhang

Adv Funct Materials, 2024, 34
DOI: 10.1002/adfm.202316357

Passive microfluidic-based core-shell drug delivery: a fluid mechanics-centric review

Yasaman Mozhdehbakhsh Mofrad and Sasan Asiaei

European Journal of Pharmaceutical Sciences, 2026, 216, 107366
DOI: 10.1016/j.ejps.2025.107366

Microfluidic technology for multiple single-cell capture

Cheng-Kun He and Chia-Hsien Hsu

Biomicrofluidics, 2021, 15
DOI: 10.1063/5.0057685

Simple Method for On-Demand Droplet Trapping in a Microfluidic Device Based on the Concept of Hydrodynamic Resistance

Mohsen Besanjideh, Masoud Rezaeian, Amir Shamloo and Siamak Kazemzadeh Hannani

Langmuir, 2024, 40, 9406
DOI: 10.1021/acs.langmuir.3c03452

Electrocoalescence of unequal-sized aqueous droplet pair in non-conductive medium

Seongsu Cho and Jinkee Lee

Microfluid Nanofluid, 2024, 28
DOI: 10.1007/s10404-024-02763-7

A programmable microfluidic platform for multisample injection, discretization, and droplet manipulation

Hesam Babahosseini, Supriya Padmanabhan, Tom Misteli and Don L. DeVoe

Biomicrofluidics, 2020, 14
DOI: 10.1063/1.5143434

Microfluidics for Biosynthesizing: from Droplets and Vesicles to Artificial Cells

Yongjian Ai, Ruoxiao Xie, Jialiang Xiong and Qionglin Liang

Small, 2020, 16
DOI: 10.1002/smll.201903940

Microfluidic chip for precise trapping of single cells and temporal analysis of signaling dynamics

Nidhi Sinha, Haowen Yang, David Janse, Luc Hendriks, Ulfert Rand, Hansjörg Hauser, Mario Köster, Frans N. van de Vosse, Tom F. A. de Greef and Jurjen Tel

Commun Eng, 2022, 1
DOI: 10.1038/s44172-022-00019-2

Recent advances in microfluidic platforms for single-cell analysis in cancer biology, diagnosis and therapy

Hamed Tavakoli, Wan Zhou, Lei Ma, Stefani Perez, Andrea Ibarra, Feng Xu, Sihui Zhan and XiuJun Li

TrAC Trends in Analytical Chemistry, 2019, 117, 13
DOI: 10.1016/j.trac.2019.05.010

Investigation of viscous effects on droplet generation in a co-flowing step emulsification device

Jiaoyuan Lian, Jiayi Wu, Shiying Wu, Wen Yu, Pengfei Wang, Li Liu and Qiang Zuo

Colloids and Surfaces A: Physicochemical and Engineering Aspects, 2021, 629, 127468
DOI: 10.1016/j.colsurfa.2021.127468

High-throughput deterministic pairing and coculturing of single cells in a microwell array using combined hydrodynamic and recirculation flow captures

Lei Fan, Zhangyan Guan, Tao Luo, Jifeng Ren, Raymond H. W. Lam and Dong Sun

Biomicrofluidics, 2021, 15
DOI: 10.1063/5.0066668

Multiple interactions between microfluidic droplets and on-chip pneumatic valves

Tristan Gilet and Stéphanie van Loo

Microfluid Nanofluid, 2022, 26
DOI: 10.1007/s10404-022-02524-4

Latest Updates on the Advancement of Polymer-Based Biomicroelectromechanical Systems for Animal Cell Studies

Ricardo Garcia-Ramirez, Ana S. Cerda-Kipper, Damaris Alvarez, Sofia Reveles-Huizar, Jorge A. Garza-Abdala, Samira Hosseini and Kinga Pielichowska

Advances in Polymer Technology, 2021, 2021, 1
DOI: 10.1155/2021/8816564

Droplet Microfluidics for Current Cancer Research: From Single-Cell Analysis to 3D Cell Culture

Lin Jiang, Kefan Guo, Yao Chen and Nan Xiang

ACS Biomater. Sci. Eng., 2024, 10, 1335
DOI: 10.1021/acsbiomaterials.3c01866

Concentration on demand – A microfluidic system for precise adjustment of the content of single droplets

Damian Zaremba, Slawomir Blonski and Piotr M. Korczyk

Chemical Engineering Journal, 2022, 430, 132935
DOI: 10.1016/j.cej.2021.132935

Droplet-Based Microfluidics in Single-Bacterium Analysis: Advancements in Cultivation, Detection, and Application

Haiyan Ma, Yuewen Zhang, Ren Shen and Yanwei Jia

Biosensors, 2025, 15, 535
DOI: 10.3390/bios15080535

Generation of microdroplets in T-junction devices by pulsed fluid flow: Simulation studies

K. Sripadaraja, M. N. Satyanarayan and G. Umesh

ISSS J Micro Smart Syst, 2021, 10, 103
DOI: 10.1007/s41683-021-00073-6

A review of electrochemical sensing in droplet systems: Droplet and digital microfluidics

Kathy Ly, Aaliya Pathan and Darius G. Rackus

Analytica Chimica Acta, 2025, 1347, 343744
DOI: 10.1016/j.aca.2025.343744

3D-Printed Microfluidic Droplet Generator with Hydrophilic and Hydrophobic Polymers

Chandler A. Warr, Hunter S. Hinnen, Saroya Avery, Rebecca J. Cate, Gregory P. Nordin and William G. Pitt

Micromachines, 2021, 12, 91
DOI: 10.3390/mi12010091

Off-Chip-Controlled Droplet-on-Demand Method for Precise Sample Handling

Medina Hamidović, Uli Marta, Helen Bridle, Damir Hamidović, Gerold Fink, Robert Wille, Andreas Springer and Werner Haselmayr

ACS Omega, 2020, 5, 9684
DOI: 10.1021/acsomega.9b03883

One Cell, One Drop, One Click: Hybrid Microfluidics for Mammalian Single Cell Isolation

Kenza Samlali, Fatemeh Ahmadi, Angela B. V. Quach, Guy Soffer and Steve C. C. Shih

Small, 2020, 16
DOI: 10.1002/smll.202002400

Programmable Control of Nanoliter Droplet Arrays Using Membrane Displacement Traps

Jason Harriot, Michael Yeh, Mani Pabba and Don L. DeVoe

Adv Materials Technologies, 2023, 8
DOI: 10.1002/admt.202300963

Design and realization of flexible droplet-based lab-on-a-chip devices

Gerold Fink, Medina Hamidović, Andreas Springer, Robert Wille and Werner Haselmayr

Elektrotech. Inftech., 2020, 137, 113
DOI: 10.1007/s00502-020-00790-0

Adjustable behaviors and dynamic mechanisms of droplets in the cross junction

Zhaomiao Liu, Zhaocheng Wang, Yan Pang, Peng Su and Xiang Wang

Physics of Fluids, 2023, 35
DOI: 10.1063/5.0175114

Multiphase flow in microfluidics: From droplets and bubbles to the encapsulated structures

Amirmohammad Sattari, Pedram Hanafizadeh and Mina Hoorfar

Advances in Colloid and Interface Science, 2020, 282, 102208
DOI: 10.1016/j.cis.2020.102208

A Review of Advanced Impedance Biosensors with Microfluidic Chips for Single-Cell Analysis

Soojung Kim, Hyerin Song, Heesang Ahn, Taeyeon Kim, Jihyun Jung, Soo Kyung Cho, Dong-Myeong Shin, Jong-ryul Choi, Yoon-Hwae Hwang and Kyujung Kim

Biosensors, 2021, 11, 412
DOI: 10.3390/bios11110412

Microdroplet event recognition and volume detection system based on flexible printed circuit electrode

Xiaoming Han, Zhen Su, Ying Xu and Quanjun Liu

J. Phys.: Conf. Ser., 2020, 1520, 012004
DOI: 10.1088/1742-6596/1520/1/012004

Magnetophoretic Micro‐Distributor for Controlled Clustering of Cells

Jonghwan Yoon, Yumin Kang, Hyeonseol Kim, Sri Ramulu Torati, Keonmok Kim, Byeonghwa Lim and CheolGi Kim

Advanced Science, 2022, 9
DOI: 10.1002/advs.202103579