Issue 6, 2016

Enhanced user-control of small molecule drug release from a poly(ethylene glycol) hydrogel via azobenzene/cyclodextrin complex tethers

Abstract

We present a versatile and facile method to enhance user-control of small molecule drug release from a poly(ethylene glycol)-based hydrogel using the host/guest complex formed between an azobenzene derivative guest and a β-cyclodextrin host. A model drug is formed from a short peptide containing a fluorophore and an azobenzene functional group on one terminus. Upon irradiation with UV light, azobenzene isomerization leads to decreased complex formation and an on-demand acceleration of the release rate of an entrapped model drug.

Graphical abstract: Enhanced user-control of small molecule drug release from a poly(ethylene glycol) hydrogel via azobenzene/cyclodextrin complex tethers

Supplementary files

Article information

Article type
Communication
Submitted
26 set. 2015
Accepted
11 gen. 2016
First published
12 gen. 2016

J. Mater. Chem. B, 2016,4, 1035-1039

Author version available

Enhanced user-control of small molecule drug release from a poly(ethylene glycol) hydrogel via azobenzene/cyclodextrin complex tethers

E. M. Nehls, A. M. Rosales and K. S. Anseth, J. Mater. Chem. B, 2016, 4, 1035 DOI: 10.1039/C5TB02004B

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