Issue 3, 2015

Designing compartmentalized hydrogel microparticles for cell encapsulation and scalable 3D cell culture

Abstract

We describe here designs of compartmentalized hydrogel microparticles with a tunable extracellular matrix (ECM) support for cell encapsulation and scalable 3D cell culture. The microparticles, rapidly formed by a one-step, multi-fluidic electrostatic spraying technique (>10 000 min−1), have a uniform spherical shape, a nearly monodisperse size distribution and controlled compartmentalization. They not only have a high surface area for mass transfer but also offer defined space and essential ECM support for various scalable and efficient 3D cell culture, co-culture and microtissue production applications.

Graphical abstract: Designing compartmentalized hydrogel microparticles for cell encapsulation and scalable 3D cell culture

Supplementary files

Article information

Article type
Communication
Submitted
20 oct. 2014
Accepted
24 nov. 2014
First published
27 nov. 2014

J. Mater. Chem. B, 2015,3, 353-360

Author version available

Designing compartmentalized hydrogel microparticles for cell encapsulation and scalable 3D cell culture

Y. Lu, W. Song, D. An, B. J. Kim, R. Schwartz, M. Wu and M. Ma, J. Mater. Chem. B, 2015, 3, 353 DOI: 10.1039/C4TB01735H

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