Issue 67, 2020

The oxazolomycin family: a review of current knowledge

Abstract

Oxazolomycin A and neooxazolomycin were firstly isolated in 1985 by the group of Uemura et al. from the Streptomyces sp. bacteria. To date, there have been reported 15 different natural compounds commonly classified as part of the oxazolomycin family. All oxazolomycin compounds possess extraordinary structures and they represent a synthetic challenge. Such molecules are additionally known for their wide range of biological activity including antibacterial, antiviral and cytotoxic effects. The present review summarizes the structural elucidation and classification of oxazolomycin compounds, their biosynthesis and biological activity. It is further focused on the total syntheses of oxazolomycins and one formal synthesis reported to date.

Graphical abstract: The oxazolomycin family: a review of current knowledge

Article information

Article type
Review Article
Submitted
01 oct. 2020
Accepted
25 oct. 2020
First published
09 nov. 2020
This article is Open Access
Creative Commons BY-NC license

RSC Adv., 2020,10, 40745-40794

The oxazolomycin family: a review of current knowledge

P. Oleksak, J. Gonda, E. Nepovimova, K. Kuca and K. Musilek, RSC Adv., 2020, 10, 40745 DOI: 10.1039/D0RA08396H

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