Issue 7, 2019

An enantioselective synthesis of α-alkylated pyrroles via cooperative isothiourea/palladium catalysis

Abstract

Herein we describe the direct enantioselective Lewis base/Pd catalysed α-allylation of pyrrole acetic acid esters. This provides high isolated yields of highly enantioenriched products and exhibits broad reaction scope with respect to both reaction partners. The products can be readily elaborated in a manner which points towards potential applications in target directed synthesis.

Graphical abstract: An enantioselective synthesis of α-alkylated pyrroles via cooperative isothiourea/palladium catalysis

Supplementary files

Article information

Article type
Communication
Submitted
20 oct. 2018
Accepted
20 nov. 2018
First published
28 nov. 2018

Org. Biomol. Chem., 2019,17, 1787-1790

An enantioselective synthesis of α-alkylated pyrroles via cooperative isothiourea/palladium catalysis

W. Rush Scaggs, T. D. Scaggs and T. N. Snaddon, Org. Biomol. Chem., 2019, 17, 1787 DOI: 10.1039/C8OB02600A

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