Issue 7, 2019

Vinylogous acyl triflates as an entry point to α,β-disubstituted cyclic enones via Suzuki–Miyaura cross-coupling

Abstract

An alternative protocol for the B-alkyl Suzuki–Miyaura reaction to produce cyclic α,β-disubstituted enones is reported. The use of β-triflyl enones as coupling partners in lieu of their halogenated analogs provides enhanced substrate stability to light and chromatography without adversely affecting reactivity. This protocol allows efficient access to the synthetically challenging α,β-disubstituted enone motif under mild conditions.

Graphical abstract: Vinylogous acyl triflates as an entry point to α,β-disubstituted cyclic enones via Suzuki–Miyaura cross-coupling

Supplementary files

Article information

Article type
Communication
Submitted
16 oct. 2018
Accepted
14 nov. 2018
First published
30 nov. 2018

Org. Biomol. Chem., 2019,17, 1796-1799

Vinylogous acyl triflates as an entry point to α,β-disubstituted cyclic enones via Suzuki–Miyaura cross-coupling

D. E. Kim, Y. Zhu and T. R. Newhouse, Org. Biomol. Chem., 2019, 17, 1796 DOI: 10.1039/C8OB02573H

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