Issue 7, 2019

Copper-catalyzed arene amination in pure aqueous ammonia

Abstract

A simple protocol for copper-catalyzed arene amination using aqueous ammonia without any additional ligands and organic coordinating solvents has been developed. The reaction pathway via a Cu(I)/Cu(III) mechanism is proposed based on the results of control experiments as well as DFT calculations.

Graphical abstract: Copper-catalyzed arene amination in pure aqueous ammonia

Supplementary files

Article information

Article type
Communication
Submitted
31 oct. 2018
Accepted
16 nov. 2018
First published
19 nov. 2018

Org. Biomol. Chem., 2019,17, 1791-1795

Copper-catalyzed arene amination in pure aqueous ammonia

M. Takagi, A. Watanabe, S. Murata and R. Takita, Org. Biomol. Chem., 2019, 17, 1791 DOI: 10.1039/C8OB02708K

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