Issue 14, 2016

A novel multifunctional biomimetic Au@BSA nanocarrier as a potential siRNA theranostic nanoplatform

Abstract

Pancreatic cancer severely affects people's wellbeing and has been one of the most malignant digestive diseases with regard to its tough diagnosis and treatment. Recently many papers have focused on the utility of siRNA as potential therapeutics to cure tumors. Herein, we developed a novel siRNA nanocarrier based on biomimetic Au@BSA nanoflowers that might be applied as a potential theranostic nanoplatform. As gold has a much larger atomic number and X-ray absorption coefficient in comparison with traditional iodine agents, it is suitable to utilize the nanoprobe for computed tomography (CT) as well as optical multimodal imaging when combined with fluorescence markers. Firstly, Au@BSA nanoflowers were obtained utilizing bovine serum albumin (BSA) as a biotemplate. Then the synthesized Au@BSA nanocomposites were conjugated with siRNA-FAM to form Au@BSA–siRNA-FAM through electrostatic layer-by-layer assembling interactions. The constructed delivery system showed good biocompatibility due to the BSA coating. Furthermore, the in vitro experiments demonstrated that the delivered siRNA could efficiently suppress the growth of BXPC-3 cells through gene silencing. In general, the biomimetic Au@BSA nanocarrier may provide a new method for cancer therapy.

Graphical abstract: A novel multifunctional biomimetic Au@BSA nanocarrier as a potential siRNA theranostic nanoplatform

Article information

Article type
Paper
Submitted
07 nov. 2015
Accepted
12 març 2016
First published
14 març 2016

J. Mater. Chem. B, 2016,4, 2519-2526

A novel multifunctional biomimetic Au@BSA nanocarrier as a potential siRNA theranostic nanoplatform

Z. Wang, H. Wu, H. Shi, M. Wang, C. Huang and N. Jia, J. Mater. Chem. B, 2016, 4, 2519 DOI: 10.1039/C5TB02326B

To request permission to reproduce material from this article, please go to the Copyright Clearance Center request page.

If you are an author contributing to an RSC publication, you do not need to request permission provided correct acknowledgement is given.

If you are the author of this article, you do not need to request permission to reproduce figures and diagrams provided correct acknowledgement is given. If you want to reproduce the whole article in a third-party publication (excluding your thesis/dissertation for which permission is not required) please go to the Copyright Clearance Center request page.

Read more about how to correctly acknowledge RSC content.

Social activity

Spotlight

Advertisements