Perspective
Perspectives in growth production trade-off in microbial bioproduction
Strain engineering has advanced in the past decade. Herein, we review the importance of growth coupling, growth decoupling, regulatory control and medium optimization for microbial bioproduction to provide stable conversion over a longer period.
Review Article
Genetically encodable biosensors for Ras activity
Genetically encoded Ras biosensors have illuminated the spatiotemporal dynamics of Ras activity since the start of the imaging revolution of the early 21st century, helping elucidate Ras signalling at various subcellular compartments.
Review Article
Matrix metalloproteinase profiling and their roles in disease
Dysregulation of MMPs and/or ADAMs occurs in DFUs, PUs, IPF, pterygium, and GBM. The batimastat affinity resin binds only to active MMPs/ADAMs, which are identified by proteomics. Selective inhibitors are used to determine the role of the MMP/ADAM.
Cavity-containing aromatic oligoamide foldamers and macrocycles: progress and future perspectives
This review summarizes new progress made in the construction and study of cavity-containing aromatic oligoamide foldamers and macrocycles.
Localized and regulated peptide pigment formation inside liquid droplets through confined enzymatic oxidation
We demonstrate multi-component liquid peptide droplets that upon enzymatic oxidation, give rise to the formation of soluble polyphenolic pigments as simple mimics of the biological pigment, melanin.
Edge Article
High-affinity single and double helical pseudofoldaxanes with cationic guests
Helical aromatic oligoamide foldamers provide negative cavities that strongly bind dicationic guests, giving complexes as stable pseudofoldaxanes with few precedents.
Edge Article
Selection of diverse polymorphic structures from a small dynamic molecular network controlled by the environment
The solvent environment dictates assembly morphology and molecular constitution allowing access to a remarkable variety of self-assembled structures.
Edge Article
Short peptide-based cross-β amyloids exploit dual residues for phosphoesterase like activity
Amyloid based short peptide assemblies use antiparallel registry to expose multiple catalytic residues to bind and cleave kinetically stable phosphoester bonds of nucleic acid congeners, foreshadowing interactions of protein folds with nucleic acids.
Enhanced microbial production of protocatechuate from engineered sorghum using an integrated feedstock-to-product conversion technology
Building a stronger bioeconomy requires production capabilities that can be generated through microbial genetic engineering. Engineered microbes can be paired with engineered feedstocks and compatible deconstruction methods to improve production.
A NanoCurvS platform for quantitative and multiplex analysis of curvature-sensing proteins
The NanoCurvS platform provides a robust, multiplex, and easy-to-use tool for quantitative analysis of both positive and negative curvature-sensing proteins.
Dynamic exchange controls the assembly structure of nucleic-acid-peptide chimeras
Reversible self-assembly reactions are used to tune the formation of nucleic-acid-peptide materials. Investigation of the co-assembly structure and dynamics yields new insight into prebiotic hybrid complexes.
Confinement dependence of protein-associated solvent dynamics around different classes of proteins, from the EPR spin probe perspective
Confinement uniformly impacts the protein-associated solvent domain dynamics of soluble proteins.
About this collection
David Lynn has helped nurture his students to make significant and insightful contributions to the fields of natural products and chemical communication, parasitic plant life strategies, signal transduction in cellular development and pathogenesis, and evolution of self-replicating and dynamic chemical networks. These papers from his network of colleagues and collaborators over the years illustrate and celebrate the diversity and creativity of David's scientific vision, pedagogical innovations, and public engagement.