Themed collection Lab on a Chip HOT Articles 2022

52 items
Perspective

Inertial microfluidics: current status, challenges, and future opportunities

We present the current status, challenges, and future opportunities of inertial microfluidics.

Graphical abstract: Inertial microfluidics: current status, challenges, and future opportunities
From the themed collection: Lab on a Chip HOT Articles 2022
Open Access Perspective

Engineering a sustainable future for point-of-care diagnostics and single-use microfluidic devices

Single-use, disposable, point-of-care diagnostic devices carry great promise for global health, but present some challenges in terms of environmental sustainability. This perspective covers solutions to embed sustainability at the R&D and product development stages.

Graphical abstract: Engineering a sustainable future for point-of-care diagnostics and single-use microfluidic devices
From the themed collection: Miniaturised Sensors & Diagnostics
Perspective

Radiotherapy on-chip: microfluidics for translational radiation oncology

Current applications of radiotherapy on-a-chip in radiation physics and radiobiology and perspectives in translational radiobiology for cancer treatment.

Graphical abstract: Radiotherapy on-chip: microfluidics for translational radiation oncology
From the themed collection: Lab on a Chip HOT Articles 2022
Perspective

Lab on a chip devices for fertility: from proof-of-concept to clinical impact

This perspective provides an overview of microfluidics for fertility efforts with a particular focus on clinical applications and commercialization.

Graphical abstract: Lab on a chip devices for fertility: from proof-of-concept to clinical impact
From the themed collection: Lab on a Chip HOT Articles 2022
Perspective

Cell-based biocomposite engineering directed by polymers

Polymer chemistry can direct the fusion of biological cells and functional materials. This review introduces the recent progress in polymer-directed engineering of advanced cell-based biocomposites with augmented functionality.

Graphical abstract: Cell-based biocomposite engineering directed by polymers
From the themed collection: Lab on a Chip HOT Articles 2022
Open Access Tutorial Review

Electrically-driven handling of gametes and embryos: taking a step towards the future of ARTs

Electric fields in in vitro processing of gametes and embryos: dielectrophoresis (DEP) and electrowetting on dielectric (EWOD).

Graphical abstract: Electrically-driven handling of gametes and embryos: taking a step towards the future of ARTs
From the themed collection: Lab on a Chip HOT Articles 2022
Tutorial Review

Microscale hydrodynamic confinements: shaping liquids across length scales as a toolbox in life sciences

A review-tutorial focusing on applications and theory behind hydrodynamic confinements (HFCs) across flow regimes and geometries – in closed channels, between parallel plates and in open volume. A further focus on chemical reactions enabled by HFCs.

Graphical abstract: Microscale hydrodynamic confinements: shaping liquids across length scales as a toolbox in life sciences
From the themed collection: Lab on a Chip HOT Articles 2022
Critical Review

Non-invasive biomedical sensors for early detection and monitoring of bacterial biofilm growth at the point of care

This comprehensive review covers current methods used for biofilm detection in clinical and laboratory settings and noninvasive portable technologies for direct and indirect detection of biofilm growth and monitoring at the point of care.

Graphical abstract: Non-invasive biomedical sensors for early detection and monitoring of bacterial biofilm growth at the point of care
From the themed collection: Miniaturised Sensors & Diagnostics
Critical Review

Flow lithography for structured microparticles: fundamentals, methods and applications

This critical review presents flow lithography-based particle fabrication methods, describes fundamental physicochemical concepts, discusses applications of particles and highlights potential future research directions.

Graphical abstract: Flow lithography for structured microparticles: fundamentals, methods and applications
From the themed collection: Lab on a Chip HOT Articles 2022
Critical Review

A review of optoelectrowetting (OEW): from fundamentals to lab-on-a-smartphone (LOS) applications to environmental sensors

This article reviews the fundamentals of the optoelectrowetting (OEW) technology, discusses its research progress, limitations, technological innovations, and finally introduces its emergence as portable smartphone-integrated environmental sensors.

Graphical abstract: A review of optoelectrowetting (OEW): from fundamentals to lab-on-a-smartphone (LOS) applications to environmental sensors
From the themed collection: Lab on a Chip HOT Articles 2022
Critical Review

Blood–brain barrier (BBB)-on-a-chip: a promising breakthrough in brain disease research

This review summarizes recent advances of the integration between BBB-on-a-chip (μBBB) technology and brain disease modeling. It provides a guideline to extend their applications in pathological research, drug development, and personalized medicine.

Graphical abstract: Blood–brain barrier (BBB)-on-a-chip: a promising breakthrough in brain disease research
From the themed collection: Lab on a Chip HOT Articles 2022
Critical Review

Emerging micro-nanotechnologies for extracellular vesicles in immuno-oncology: from target specific isolations to immunomodulation

In this paper, we summarized the recent advances in cell specific EV isolation, engineering and their potential applications in immune-oncology along with suggested areas of study necessary to bring EVs into clinical practice.

Graphical abstract: Emerging micro-nanotechnologies for extracellular vesicles in immuno-oncology: from target specific isolations to immunomodulation
From the themed collection: Lab on a Chip HOT Articles 2022
Open Access Critical Review

Machine learning for microfluidic design and control

In this review article, we surveyed the applications of machine learning in microfluidic design and microfluidic control.

Graphical abstract: Machine learning for microfluidic design and control
Critical Review

Liver organ-on-chip models for toxicity studies and risk assessment

This review provides an overview of liver organ-on-chip (OoC) technology, including the general concept, different approaches and recent advances. A particular focus is given to the use of liver OoC in toxicity studies and risk assessment.

Graphical abstract: Liver organ-on-chip models for toxicity studies and risk assessment
From the themed collection: Lab on a Chip HOT Articles 2022
Critical Review

Microfluidics and surface-enhanced Raman spectroscopy, a win–win combination?

With the continuous development in nanoscience and nanotechnology, analytical techniques like surface-enhanced Raman spectroscopy (SERS) render structural and chemical information of a variety of analyte molecules in ultra-low concentration.

Graphical abstract: Microfluidics and surface-enhanced Raman spectroscopy, a win–win combination?
From the themed collection: Lab on a Chip HOT Articles 2022
Paper

Microfluidic quantum sensing platform for lab-on-a-chip applications

A microfluidic platform for solid-state quantum sensing, enabling the measurement of various physical quantities for lab-on-a-chip applications.

Graphical abstract: Microfluidic quantum sensing platform for lab-on-a-chip applications
From the themed collection: Miniaturised Sensors & Diagnostics
Paper

Computer vision enabled funnel adapted sensing tube (FAST) for power-free and pipette-free nucleic acid detection

A simple, portable, and low-cost microfluidic system-funnel adapted sensing tube (FAST) is developed as an integrated, power-free, and pipette-free biosensor for viral nucleic acids.

Graphical abstract: Computer vision enabled funnel adapted sensing tube (FAST) for power-free and pipette-free nucleic acid detection
From the themed collection: Miniaturised Sensors & Diagnostics
Paper

Dual-function microneedle array for efficient photodynamic therapy with transdermal co-delivered light and photosensitizers

A dual-function microneedle array was developed to co-delivery photosensitizers and light for photodynamic therapy.

Graphical abstract: Dual-function microneedle array for efficient photodynamic therapy with transdermal co-delivered light and photosensitizers
From the themed collection: Lab on a Chip HOT Articles 2022
Paper

Automated device for multi-stage paper-based assays enabled by an electroosmotic pumping valve

Valving mechanism based on electroosmotic-flow bursting of a hydrophobic barrier to enable the performance of multi-step assays on paper-based devices.

Graphical abstract: Automated device for multi-stage paper-based assays enabled by an electroosmotic pumping valve
From the themed collection: Lab on a Chip HOT Articles 2022
Paper

Rapid prototyping of functional acoustic devices using laser manufacturing

We present a simple method for manufacturing a functional acoustic device for biomanipulation. This method utilizes laser cutting to achieve high efficiency for rapid prototyping.

Graphical abstract: Rapid prototyping of functional acoustic devices using laser manufacturing
From the themed collection: Lab on a Chip HOT Articles 2022
Open Access Paper

You will know by its tail: a method for quantification of heterogeneity of bacterial populations using single-cell MIC profiling

Severe non-healing infections are often caused by multiple pathogens or by genetic variants of the same pathogen exhibiting different levels of antibiotic resistance.

Graphical abstract: You will know by its tail: a method for quantification of heterogeneity of bacterial populations using single-cell MIC profiling
From the themed collection: Lab on a Chip HOT Articles 2022
Paper

Non-adhesive contrast substrate for single-cell trapping and Raman spectroscopic analysis

Droplet splitting by exploiting tailored surface wettability is emerging as an important pathway to creating ultralow volumes of samples that can have applications in bioassays, tissue engineering, protein chips, and material synthesis.

Graphical abstract: Non-adhesive contrast substrate for single-cell trapping and Raman spectroscopic analysis
From the themed collection: Lab on a Chip HOT Articles 2022
Paper

Cell marathon: long-distance cell migration and metastasis-associated gene analysis using a folding paper system

A folding paper system was developed to mimic a tumor–vascular interface for the study of long-distance cell migration.

Graphical abstract: Cell marathon: long-distance cell migration and metastasis-associated gene analysis using a folding paper system
From the themed collection: Lab on a Chip HOT Articles 2022
Paper

Size-selective filtration of extracellular vesicles with a movable-layer device

This paper presents a microfluidic device that can isolate extracellular vesicles (EVs) with multiple size intervals in a simple, effective, and automated manner.

Graphical abstract: Size-selective filtration of extracellular vesicles with a movable-layer device
From the themed collection: Lab on a Chip HOT Articles 2022
Paper

Ultra-rapid real-time microfluidic RT-PCR instrument for nucleic acid analysis

The described microfluidic instrument performs real-time PCR (40 cycles) with comparable sensitivity to commercial instrumentation in under 10 minutes.

Graphical abstract: Ultra-rapid real-time microfluidic RT-PCR instrument for nucleic acid analysis
From the themed collection: Miniaturised Sensors & Diagnostics
Paper

A sample-to-answer, quantitative real-time PCR system with low-cost, gravity-driven microfluidic cartridge for rapid detection of SARS-CoV-2, influenza A/B, and human papillomavirus 16/18

We present a low-cost microfluidic cartridge design scheme that combines gravity-driven passive microfluidic pumping with extraction-free amplification to achieve “sample-in, answer-out” point-of-care nucleic acid detection within 30 minutes.

Graphical abstract: A sample-to-answer, quantitative real-time PCR system with low-cost, gravity-driven microfluidic cartridge for rapid detection of SARS-CoV-2, influenza A/B, and human papillomavirus 16/18
From the themed collection: Lab on a Chip HOT Articles 2022
Open Access Paper

Adipose microtissue-on-chip: a 3D cell culture platform for differentiation, stimulation, and proteomic analysis of human adipocytes

In this study, we developed a microfluidic large-scale integration chip platform to automate longitudinal 3D cell culture studies. Proteome analysis of on chip cultured adipocytes under changing glucose conditions revealed metabolic stress profiles.

Graphical abstract: Adipose microtissue-on-chip: a 3D cell culture platform for differentiation, stimulation, and proteomic analysis of human adipocytes
From the themed collection: Lab on a Chip HOT Articles 2022
Paper

Parallel multistep digital analysis SlipChip demonstrated with the quantification of nucleic acid by digital LAMP-CRISPR

A parallel multistep digital analysis SlipChip for the parallel manipulation of a large number of droplets for digital biological analysis.

Graphical abstract: Parallel multistep digital analysis SlipChip demonstrated with the quantification of nucleic acid by digital LAMP-CRISPR
From the themed collection: Miniaturised Sensors & Diagnostics
Paper

Intelligent nanoscope for rapid nanomaterial identification and classification

Microspheres array based intelligent nanoscope processed data collection for deep learning training. The trained convolutional neural network model classified the different sizes of nanoparticle samples.

Graphical abstract: Intelligent nanoscope for rapid nanomaterial identification and classification
From the themed collection: AI in Microfluidics
Paper

High-throughput digital pathology via a handheld, multiplexed, and AI-powered ptychographic whole slide scanner

The handheld, do-it-yourself ptychographic whole slide scanner for high-throughput digital pathology applications.

Graphical abstract: High-throughput digital pathology via a handheld, multiplexed, and AI-powered ptychographic whole slide scanner
From the themed collection: AI in Microfluidics
Paper

Micro-PCR chip-based multifunctional ultrafast SARS-CoV-2 detection platform

By using different customized microfluidic chips, a multifunctional rapid PCR platform allows fast screening of suspected cases within 15 min, followed by rapidly providing precise quantification of the SARS-CoV-2 virus.

Graphical abstract: Micro-PCR chip-based multifunctional ultrafast SARS-CoV-2 detection platform
From the themed collection: Miniaturised Sensors & Diagnostics
Paper

A reconfigurable microfluidic building block platform for high-throughput nonhormonal contraceptive screening

A reconfigurable microfluidic building block platform for high throughput drug screening.

Graphical abstract: A reconfigurable microfluidic building block platform for high-throughput nonhormonal contraceptive screening
From the themed collection: Lab on a Chip HOT Articles 2022
Paper

Microfluidic harvesting of breast cancer tumor spheroid-derived extracellular vesicles from immobilized microgels for single-vesicle analysis

A novel microfluidic system for the low-volume harvesting of extracellular vesicles from breast cancer tumor spheroids encapsulated within immobilized hydrogel microbioreactors for downstream single-vesicle analyses.

Graphical abstract: Microfluidic harvesting of breast cancer tumor spheroid-derived extracellular vesicles from immobilized microgels for single-vesicle analysis
From the themed collection: Lab on a Chip HOT Articles 2022
Paper

Glass-patternable notch-shaped microwave architecture for on-chip spin detection in biological samples

This on-chip device realizes large-area and predictable spin detection of fluorescent nanodiamonds, providing a scalable platform for quantum-sensor-based bioassay.

Graphical abstract: Glass-patternable notch-shaped microwave architecture for on-chip spin detection in biological samples
From the themed collection: Lab on a Chip HOT Articles 2022
Open Access Paper

Laser particle activated cell sorting in microfluidics

A microfluidic device is developed that uses the narrowband optical radiation of laser particle barcodes to sort tagged cells.

Graphical abstract: Laser particle activated cell sorting in microfluidics
From the themed collection: Lab on a Chip HOT Articles 2022
Paper

Immunomagnetic leukocyte differential in whole blood on an electronic microdevice

A cartridge-based, disposable magnetophoretic cytometer testing 3-part leukocyte differentials for point-of-care or self-testing applications.

Graphical abstract: Immunomagnetic leukocyte differential in whole blood on an electronic microdevice
From the themed collection: Lab on a Chip HOT Articles 2022
Open Access Paper

Systematic characterization of effect of flow rates and buffer compositions on double emulsion droplet volumes and stability

Measured double emulsion droplet sizes across hundreds of flow rate and surfactant conditions parameterize core/shell volumes and droplet stability.

Graphical abstract: Systematic characterization of effect of flow rates and buffer compositions on double emulsion droplet volumes and stability
From the themed collection: Lab on a Chip HOT Articles 2022
Paper

From saliva to SNP: non-invasive, point-of-care genotyping for precision medicine applications using recombinase polymerase amplification and giant magnetoresistive nanosensors

We present a portable, highly integrated platform that employs isothermal recombinase polymerase amplification and giant magnetoresistive nanosensors to perform multiplex SNP genotyping at the point-of-care.

Graphical abstract: From saliva to SNP: non-invasive, point-of-care genotyping for precision medicine applications using recombinase polymerase amplification and giant magnetoresistive nanosensors
From the themed collection: Miniaturised Sensors & Diagnostics
Paper

A tripodal wheeled mobile robot driven by a liquid metal motor

An 8-shaped tripodal wheeled mobile robot utilizing liquid metal motors as the core driving part is proposed herein. This robot can achieve three types of driving functions on a two-dimensional plane via wireless control.

Graphical abstract: A tripodal wheeled mobile robot driven by a liquid metal motor
From the themed collection: Lab on a Chip HOT Articles 2022
Paper

Controllable high-performance liquid marble micromixer

A high-performance micromixer based on rolling liquid marble.

Graphical abstract: Controllable high-performance liquid marble micromixer
From the themed collection: Lab on a Chip HOT Articles 2022
Paper

Rheotaxis quality index: a new parameter that reveals male mammalian in vivo fertility and low sperm DNA fragmentation

Rheotaxis plays a crucial role in sperm navigation through the female reproductive tract. By mimicking the structure of the uterotubal junction, we provide a new method of sperm quality assessment.

Graphical abstract: Rheotaxis quality index: a new parameter that reveals male mammalian in vivo fertility and low sperm DNA fragmentation
From the themed collection: Lab on a Chip HOT Articles 2022
Paper

Antibody mediated cotton-archetypal substrate for enumeration of circulating tumor cells and chemotherapy outcome in 3D tumors

A surface modified cotton-based biomedical matrix has been designed for the controlled in vitro 3D tumor expansion of captured cancer cells to investigate anti-cancer drug efficacy and multi-drug resistance (MDR) mechanisms.

Graphical abstract: Antibody mediated cotton-archetypal substrate for enumeration of circulating tumor cells and chemotherapy outcome in 3D tumors
From the themed collection: Lab on a Chip HOT Articles 2022
Open Access Paper

Multi-parametric functional imaging of cell cultures and tissues with a CMOS microelectrode array

A CMOS-MEA device combined with new impedance and electrochemical techniques measures cell attachment, growth/wound healing, cell–cell adhesion, metabolic state, and redox properties with single-cell spatial resolution for cell-biology applications.

Graphical abstract: Multi-parametric functional imaging of cell cultures and tissues with a CMOS microelectrode array
From the themed collection: Lab on a Chip HOT Articles 2022
Paper

Vasculature-on-a-chip platform with innate immunity enables identification of angiopoietin-1 derived peptide as a therapeutic for SARS-CoV-2 induced inflammation

Microfluidic polymeric blood vessel captures the adverse effects of SARS-CoV-2 on vasculature and enables identification of a therapeutic peptide that abolished virus induced cytokine storm orchestrated by the immune cells.

Graphical abstract: Vasculature-on-a-chip platform with innate immunity enables identification of angiopoietin-1 derived peptide as a therapeutic for SARS-CoV-2 induced inflammation
Paper

Accelerated protein digestion and separation with picoliter volume utilizing nanofluidics

Integrated device for protein digestion, peptide separation and UV-detection on a femtoliter to picoliter volume based on micro/nanofluidics.

Graphical abstract: Accelerated protein digestion and separation with picoliter volume utilizing nanofluidics
From the themed collection: Lab on a Chip HOT Articles 2022
Paper

Rapid cell pairing and fusion based on oscillating bubbles within an acoustofluidic device

An acoustofluidic device based on oscillating bubbles was designed to rapidly pair and fuse cells with no limitation of cell size. The cell pairing rate reached 90% within 40 ms and fused cells kept biological functions.

Graphical abstract: Rapid cell pairing and fusion based on oscillating bubbles within an acoustofluidic device
From the themed collection: Lab on a Chip HOT Articles 2022
Open Access Paper

Pairing cells of different sizes in a microfluidic device for immunological synapse monitoring

A cell pairing method is developed to monitor immunological synapses formed by single cells with different sizes.

Graphical abstract: Pairing cells of different sizes in a microfluidic device for immunological synapse monitoring
From the themed collection: Lab on a Chip HOT Articles 2022
Paper

Traffic light type paper-based analytical device for intuitive and semi-quantitative naked-eye signal readout

By simply applying a sample, the traffic light type μPAD enables highly intuitive equipment-free naked-eye readout with no need for calibration, subjective interpretation or calculation.

Graphical abstract: Traffic light type paper-based analytical device for intuitive and semi-quantitative naked-eye signal readout
From the themed collection: Miniaturised Sensors & Diagnostics
Paper

Point-of-care blood coagulation assay enabled by printed circuit board-based digital microfluidics

Using printed circuit board-based digital microfluidics, a point-of-care blood coagulation assay was developed to simultaneously assess the clotting tendency and the stiffness of the resultant blood clot.

Graphical abstract: Point-of-care blood coagulation assay enabled by printed circuit board-based digital microfluidics
From the themed collection: Lab on a Chip HOT Articles 2022
Paper

Bubble-enhanced ultrasonic microfluidic chip for rapid DNA fragmentation

We present a new bubble-enhanced microfluidic approach for highly efficient DNA fragmentation, suitable for next generation sequencing platforms. Improved on-chip performance arises from acoustic streaming generated by oscillating bubble interfaces.

Graphical abstract: Bubble-enhanced ultrasonic microfluidic chip for rapid DNA fragmentation
From the themed collection: Lab on a Chip HOT Articles 2022
Paper

Investigating the mechanotransduction of transient shear stress mediated by Piezo1 ion channel using a 3D printed dynamic gravity pump

This work describes a 3D printed dynamic gravity pump for studying the response of mechanoresponsive cells expressing Piezo1 ion channels under transient flows.

Graphical abstract: Investigating the mechanotransduction of transient shear stress mediated by Piezo1 ion channel using a 3D printed dynamic gravity pump
From the themed collection: Lab on a Chip HOT Articles 2022
Open Access Paper

Engineering a deformation-free plastic spiral inertial microfluidic system for CHO cell clarification in biomanufacturing

A deformation-free and mass-producible plastic spiral inertial microfluidic device was developed, which provides continuous, clogging-free, and industry-level-throughput cell manipulation.

Graphical abstract: Engineering a deformation-free plastic spiral inertial microfluidic system for CHO cell clarification in biomanufacturing
From the themed collection: Lab on a Chip HOT Articles 2022
52 items

About this collection

This themed collection features articles published in Lab on a Chip marked as HOT by the handling editor or as recommended by referees. Congratulations to all the authors whose articles are featured.


Spotlight

Advertisements