Developing new anti-tyrosinase drugs seems crucial for the medical and industrial fields since irregular melanin synthesis is linked to the resurgence of several skin conditions, including melanoma, and the browning of fruits and vegetables.
A set of twenty-three new andrographolide derivatives, bearing a nitrogen-containing moiety, is reported. Several derivatives were found to be promising leads for reversing cancer multidrug resistance.
A new set of imidazo[1,2-a]pyrimidine-thiazole hybrids were developed through a molecular hybridization concept. Three compounds exhibited potent anti-TB activity with MIC of 1.6 μg mL−1.
GSK-3β plays an essential role in cancer progression, making it a promising target for therapeutic intervention with glycogen synthase kinase (GSK-3β) inhibitors.
Two families of binuclear or tetranuclear [MoV2O2S2]2+-based thiosemicarbazone complexes are obtained by varying the rigidity/flexibility of bis-thiosemicarbazone ligands.