A base-mediated (3+3)-annulation of diaziridines with in situ generated azaoxyallyl cations is described to produce 1,2,4-triazines under mild reaction conditions.
Unprecedented migration reactivity; new convenient access to chiral azaheterocycles & chiral center is on the side chain.
The mechanism and stereoselectivity of the Ni-catalyzed [3 + 3] annulation between donor–acceptor cyclopropanes (DACs) and diaziridines were rationalized by DFT calculations.
High-level ab initio calculations of gas phase enthalpies of formation combined with enthalpies of sublimations estimated using descriptors of electrostatic potential allow predicting the enthalpies of formation of diaziridines in the solid phase.
A novel, divergent radical cyclization of homoallylic diazirines for the synthesis of pyrrolines and fused diaziridines is described.