An efficient environmentally friendly microwave-assisted approach under catalyst, additive and solvent-free conditions for the N-Boc-activated secondary amide transamidation via tetrahedral intermediate was developed.
Transamidation of planar and resonance stabilized N-pivaloyl activated amides with non-nucleophilic aromatic amines is demonstrated in absence of catalyst, base and additives.
N-Pivaloylation enables amides as reactive substrates for transamidation with a wide array of alkyl amines in the absence of a catalyst, base and additive at room temperature in a short reaction time.
Here, we developed a novel Lewis acid BF3·OEt2-promoted transamidation method. In this work, both primary and secondary amines can undergo transamidation, and achieve excellent chemoselectivity and atom economy.
A mild and efficient visible-light promoted FeCl3-catalyzed reductive transamidation of N-acyl benzotriazoles with nitro compounds by PhSiH3 was developed.