Issue 31, 2019

Rationally designed curcumin based ruthenium(ii) antimicrobials effective against drug-resistant Staphylococcus aureus

Abstract

Two new curcumin containing octahedral ruthenium(II) polypyridyl complexes, viz. [Ru(NN)2(cur)](PF6) [NN = bpy (1), phen (2)], were designed to explore the antimicrobial activity against ESKAPE pathogens, especially with the Gram-positive drug resistant S. aureus. Solid-state structural characterization by single-crystal X-ray crystallography shows the RuII-center in a distorted octahedral {RuN4O2} geometry. The tested compounds showed significant inhibitory activity and high selectivity (MIC = 1 μg mL−1, SI = 80) against a wide variety of methicillin and vancomycin-resistant S. aureus strains. Compound 1 exhibited strong anti-biofilm activity (48% reduction of biofilm) at 10× MIC compared to the other approved drugs. The murine model of Staphylococcus infection significantly reduced the mean bacterial counts when treated with complex 1 compared to vancomycin, demonstrating its antimicrobial potential in vivo.

Graphical abstract: Rationally designed curcumin based ruthenium(ii) antimicrobials effective against drug-resistant Staphylococcus aureus

Supplementary files

Article information

Article type
Paper
Submitted
18 Ebr. 2019
Accepted
05 Mezh. 2019
First published
19 Mezh. 2019

Dalton Trans., 2019,48, 11822-11828

Rationally designed curcumin based ruthenium(II) antimicrobials effective against drug-resistant Staphylococcus aureus

P. Srivastava, M. Shukla, G. Kaul, S. Chopra and A. K. Patra, Dalton Trans., 2019, 48, 11822 DOI: 10.1039/C9DT01650C

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