Issue 17, 2018

A rapid and highly sensitive strain-effect graphene-based bio-sensor for the detection of stroke and cancer bio-markers

Abstract

Here, we propose a highly sensitive and rapid bio-sensor for the detection of bio-markers for stroke and cancer-related diseases, based on the utilization of the adsorption properties of ruthenium carbonyl (Ru–CO) clusters on monolayer graphene (MG). A fast rate of decarbonylation of Ru–CO to form ruthenium oxide nanoparticles (RuO2 NPs) on MG was observed. The quantitative detection of matrix metalloproteinase-2 (MMP-2) (bio-marker for stroke and vascular diseases) was demonstrated by tracking the spectral shift of the characteristic G band of graphene caused by the adsorption of RuO2 NPs. A concentration as low as 17 ng mL−1 of MMP-2 was detected in a simulated clinical serum sample. This effective bio-sensor has the potential to revolutionize the biomedical field in the early detection and possible prevention of stroke and cancer diagnosis.

Graphical abstract: A rapid and highly sensitive strain-effect graphene-based bio-sensor for the detection of stroke and cancer bio-markers

Supplementary files

Article information

Article type
Communication
Submitted
09 Cʼhwe. 2018
Accepted
15 Meur. 2018
First published
15 Meur. 2018

J. Mater. Chem. B, 2018,6, 2536-2540

A rapid and highly sensitive strain-effect graphene-based bio-sensor for the detection of stroke and cancer bio-markers

D. Lin, C. Tseng, Q. F. Lim, M. J. Tan and K. V. Kong, J. Mater. Chem. B, 2018, 6, 2536 DOI: 10.1039/C8TB00404H

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