Issue 36, 2017

Synthetic approach to tailored physical associations in peptide-polyurea/polyurethane hybrids

Abstract

Nature has achieved diverse functionality via hierarchical organization driven by physical interactions such as hydrogen bonding. Synthetically, polymer–peptide hybrids have been utilized to achieve these architectural arrangements and obtain diverse mechanical properties, stimuli responsiveness, and bioactivity. Here, we explore the impact of peptide ordering and soft/hard phase interactions in PEG-based non-chain extended and chain extended peptidic polyurea (PU) and polyurea/polyurethane (PUU) hybrids towards tunable mechanics. Increasing the peptide content of poly(ε-carbobenzyloxy-L-lysine) (PZLY) revealed an increase in α-helical formation and modulation in amine/ether hydrogen bonding, suggesting enhanced intermolecular hydrogen bonding between peptide segments and soft/hard blocks. A balance of phase mixing and microphase segregation was observed depending on competitive hydrogen bonding and the hybrid architecture. This phase behaviour strongly modulated the mechanical response, particularly modulus and extensibility. We anticipate that this solid-state, synthetic framework will expand the reach of our peptide hybrids into biointerfacing materials, including scaffolds and responsive actuators via peptide selection.

Graphical abstract: Synthetic approach to tailored physical associations in peptide-polyurea/polyurethane hybrids

Supplementary files

Article information

Article type
Paper
Submitted
03 Mezh. 2017
Accepted
18 Eost 2017
First published
01 Gwen. 2017

Org. Biomol. Chem., 2017,15, 7607-7617

Synthetic approach to tailored physical associations in peptide-polyurea/polyurethane hybrids

L. E. Matolyak, J. K. Keum, K. M. Van de Voorde and L. T. J. Korley, Org. Biomol. Chem., 2017, 15, 7607 DOI: 10.1039/C7OB01352C

To request permission to reproduce material from this article, please go to the Copyright Clearance Center request page.

If you are an author contributing to an RSC publication, you do not need to request permission provided correct acknowledgement is given.

If you are the author of this article, you do not need to request permission to reproduce figures and diagrams provided correct acknowledgement is given. If you want to reproduce the whole article in a third-party publication (excluding your thesis/dissertation for which permission is not required) please go to the Copyright Clearance Center request page.

Read more about how to correctly acknowledge RSC content.

Social activity

Spotlight

Advertisements