Issue 19, 2016

Diblock- and triblock-copolymer based mixed micelles with high tumor penetration in vitro and in vivo

Abstract

A series of self-assembled mixed micelles composed of TPGS and Pluronics were fabricated and their cellular uptake and exocytosis behaviors were studied in 2D cell and 3D tumor spheroid models. Together with in vivo efficacy studies, our results demonstrate that TPGS is not only critical to stabilize the mixed micelle structure but also to improve drug loading and facilitate cell penetration and accumulation.

Graphical abstract: Diblock- and triblock-copolymer based mixed micelles with high tumor penetration in vitro and in vivo

Supplementary files

Article information

Article type
Paper
Submitted
27 Cʼhwe. 2016
Accepted
17 Meur. 2016
First published
17 Meur. 2016

J. Mater. Chem. B, 2016,4, 3216-3224

Diblock- and triblock-copolymer based mixed micelles with high tumor penetration in vitro and in vivo

X. Cao, X. Zhou, Y. Wang, T. Gong, Z. Zhang, R. Liu and Y. Fu, J. Mater. Chem. B, 2016, 4, 3216 DOI: 10.1039/C6TB00508J

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