Issue 1, 2016

Protein-modified hollow copper sulfide nanoparticles carrying indocyanine green for photothermal and photodynamic therapy

Abstract

A novel phototherapy nanoplatform is prepared by coating hollow CuS nanoparticles with a bovine serum albumin–folic acid (BSA–FA) complex. The obtained CuS–BSA–FA nanoparticles are used as drug-delivery vehicles to transport a near-infrared-absorbing phototherapeutic agent (indocyanine green, ICG) into HeLa cells, after loading ICG onto CuS–BSA–FA. In this manner, a combined therapy approach is established consisting of photothermal therapy (by CuS–BSA–FA nanocarriers) and cytotoxic effects of photodynamic and photothermal therapy (by ICG upon 808 nm laser irradiation). The encapsulation of ICG onto CuS–BSA–FA significantly improves the stability and reduces the dark toxicity of free ICG. This therapeutic system exhibits an obviously higher photothermal heating effect and capability of 1O2 generation under laser irradiation compared with bare nanocarriers. In addition, the grafted FA segments on the surface of CuS–BSA–FA are proved to enhance the internalization of nanoparticles by FA-receptor-mediated endocytosis.

Graphical abstract: Protein-modified hollow copper sulfide nanoparticles carrying indocyanine green for photothermal and photodynamic therapy

Supplementary files

Article information

Article type
Paper
Submitted
26 Gwen. 2015
Accepted
17 Du 2015
First published
17 Du 2015

J. Mater. Chem. B, 2016,4, 105-112

Protein-modified hollow copper sulfide nanoparticles carrying indocyanine green for photothermal and photodynamic therapy

L. Han, Y. Zhang, X. Chen, Y. Shu and J. Wang, J. Mater. Chem. B, 2016, 4, 105 DOI: 10.1039/C5TB02002F

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