Issue 40, 2014

Catalytic intermolecular β-C–H alkenylation of α-enamino-ketones with simple alkynes

Abstract

A unique strategy to synthesize β-alkenylated α-enamino-ketones via catalytic C–H/alkyne coupling is described. The slow addition of alkyne substrates and the use of NaI as an additive play key roles in controlling the alkyne insertion. Replacement of the pyridyl group with carbamates was also developed. This method allows for rapid synthesis of highly functionalized vinyl-substituted enamino-ketones.

Graphical abstract: Catalytic intermolecular β-C–H alkenylation of α-enamino-ketones with simple alkynes

Supplementary files

Article information

Article type
Communication
Submitted
02 Here 2013
Accepted
04 Du 2013
First published
05 Du 2013

Chem. Commun., 2014,50, 5230-5232

Catalytic intermolecular β-C–H alkenylation of α-enamino-ketones with simple alkynes

Z. Wang, B. J. Reinus and G. Dong, Chem. Commun., 2014, 50, 5230 DOI: 10.1039/C3CC47556E

To request permission to reproduce material from this article, please go to the Copyright Clearance Center request page.

If you are an author contributing to an RSC publication, you do not need to request permission provided correct acknowledgement is given.

If you are the author of this article, you do not need to request permission to reproduce figures and diagrams provided correct acknowledgement is given. If you want to reproduce the whole article in a third-party publication (excluding your thesis/dissertation for which permission is not required) please go to the Copyright Clearance Center request page.

Read more about how to correctly acknowledge RSC content.

Social activity

Spotlight

Advertisements