Issue 80, 2013

Kinetics and thermodynamics of metal binding to the N-terminus of a human copper transporter, hCTR1

Abstract

The N-terminus of hCTR1 was demonstrated to bind three Cu+ ions tightly (log K = 14.92) and reversibly via its Met-rich motifs. Ag+ binds to the protein with the same stoichiometry but much lower affinities than Cu+. The protein also coordinates two Cu2+ ions through its ATCUN motif and His-rich motif with lower affinity. This study provides an insight into the selectivity of the transporter.

Graphical abstract: Kinetics and thermodynamics of metal binding to the N-terminus of a human copper transporter, hCTR1

Supplementary files

Article information

Article type
Communication
Submitted
16 Goue. 2013
Accepted
05 Eost 2013
First published
07 Eost 2013

Chem. Commun., 2013,49, 9134-9136

Kinetics and thermodynamics of metal binding to the N-terminus of a human copper transporter, hCTR1

X. Du, H. Li, X. Wang, Q. Liu, J. Ni and H. Sun, Chem. Commun., 2013, 49, 9134 DOI: 10.1039/C3CC45360J

To request permission to reproduce material from this article, please go to the Copyright Clearance Center request page.

If you are an author contributing to an RSC publication, you do not need to request permission provided correct acknowledgement is given.

If you are the author of this article, you do not need to request permission to reproduce figures and diagrams provided correct acknowledgement is given. If you want to reproduce the whole article in a third-party publication (excluding your thesis/dissertation for which permission is not required) please go to the Copyright Clearance Center request page.

Read more about how to correctly acknowledge RSC content.

Social activity

Spotlight

Advertisements