Issue 24, 2013
From the journal:

Chemical Communications

Design of a platinum–acridine–endoxifen conjugate targeted at hormone-dependent breast cancer†

Song Ding,a   Xin Qiao,ab   Gregory L. Kucerac  and  Ulrich Bierbach*a  

* Corresponding authors

a Department of Chemistry, Wake Forest University, Winston-Salem, North Carolina 27109, USA
E-mail: bierbau@wfu.edu
Fax: +1 336-758-4656
Tel: +1 336-758-3507

b School of Pharmaceutical Sciences, Tianjin Medical University, Tianjin 300070, PR China

c Department of Internal Medicine, Section on Hematology and Oncology, Wake Forest University Health Sciences, Winston-Salem, North Carolina 27157, USA

Abstract

The synthesis of a novel pharmacophore comprising a DNA-targeted platinum–acridine hybrid agent and estrogen receptor-targeted 4-hydroxy-N-desmethyltamoxifen (endoxifen) using carbamate coupling chemistry and its evaluation in breast cancer cell lines are described.

Graphical abstract: Design of a platinum–acridine–endoxifen conjugate targeted at hormone-dependent breast cancer

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Article information

DOI
https://doi.org/10.1039/C3CC38957J
Article type
Communication
Submitted
14 Ker. 2012
Accepted
06 Cʼhwe. 2013
First published
07 Cʼhwe. 2013

Chem. Commun., 2013,49, 2415-2417

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Design of a platinum–acridine–endoxifen conjugate targeted at hormone-dependent breast cancer

S. Ding, X. Qiao, G. L. Kucera and U. Bierbach, Chem. Commun., 2013, 49, 2415 DOI: 10.1039/C3CC38957J

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