Issue 3, 2024

H2O2-stimulated Janus-shaped self-propelled nanomotors as an active treatment for acute renal injury

Abstract

As emerging nanosystems, nanomotors have been applied in the active treatment of many diseases. In this paper, Pt@chitosan-loaded melatonin asymmetrical nanomaterials embedded with L-serine (S, kidney injury molecule 1-targeting agent) were constructed to alleviate acute kidney injury (AKI). The Janus nanocarriers arrived at the renal injury site via the bloodstream and exhibited high permeability. Because of melatonin distribution in the kidneys combined with H2O2-stimulated O2 release, the administration of the Janus nanosystem resulted in active treatment through the motion of nanomotors by asymmetrical O2 release.

Graphical abstract: H2O2-stimulated Janus-shaped self-propelled nanomotors as an active treatment for acute renal injury

Supplementary files

Article information

Article type
Paper
Submitted
23 Gwen. 2023
Accepted
07 Du 2023
First published
21 Ker. 2023

Nanoscale, 2024,16, 1282-1290

H2O2-stimulated Janus-shaped self-propelled nanomotors as an active treatment for acute renal injury

J. Xu, Y. Zhong, W. Wang, R. Gao, Y. Wang, F. Tong, J. Sun, M. Hong, L. Qiao, W. Qiao, Q. Mei and J. Wu, Nanoscale, 2024, 16, 1282 DOI: 10.1039/D3NR04808J

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