Issue 6, 2023

Toxicological data bank bridges the gap between environmental risk assessment and green organic chemical design in One Health world

Abstract

In the conceptual frame of “One Health”, the safety crisis caused by various toxicological issues due to chemical exposure is of great concern. The urgent demand for environmentally safe chemicals is increasing the awareness of the importance of designing non-toxic chemical molecules. The expanding toxicological data can provide a foundation for studying interactions between the living organisms and environment. However, a large amount of toxicological data is fragmented and scattered in the literature and online resources. Thus, to promote the more efficient use of toxicological information, further collection and collation of the current toxicity data is urgent. In the present review, we discuss the application of existing toxicological data to support environmental risk assessment and guide green chemical design. The importance of chemical toxicity data for human health and ecological risk assessment, trends of available chemical toxicity data, details of the common structural features associated with different toxicity endpoints, and applications of toxicological big data in toxicity prediction combined with artificial intelligence are described and discussed. Additionally, based on the systematic collection and analysis of the current toxicity data, a reorganized toxicological databank is provided to cover a wider range of organic chemicals and tested species. It is expected that this work can contribute to the study of organic structural toxicity, chemical toxicity prediction, environmental risk assessment, and safer chemical design.

Graphical abstract: Toxicological data bank bridges the gap between environmental risk assessment and green organic chemical design in One Health world

Article information

Article type
Tutorial Review
Submitted
24 Here 2022
Accepted
09 Gen. 2023
First published
25 Gen. 2023

Green Chem., 2023,25, 2170-2219

Toxicological data bank bridges the gap between environmental risk assessment and green organic chemical design in One Health world

X. Shi, Z. Wang, X. Sun, Y. Wang, H. Liu, F. Wang, G. Hao and G. Yang, Green Chem., 2023, 25, 2170 DOI: 10.1039/D2GC03973G

To request permission to reproduce material from this article, please go to the Copyright Clearance Center request page.

If you are an author contributing to an RSC publication, you do not need to request permission provided correct acknowledgement is given.

If you are the author of this article, you do not need to request permission to reproduce figures and diagrams provided correct acknowledgement is given. If you want to reproduce the whole article in a third-party publication (excluding your thesis/dissertation for which permission is not required) please go to the Copyright Clearance Center request page.

Read more about how to correctly acknowledge RSC content.

Social activity

Spotlight

Advertisements