Issue 57, 2023

Calcium-triggered DNA-mediated membrane fusion in synthetic cells

Abstract

In cells, membrane fusion is mediated by SNARE proteins, whose activities are calcium-dependent. While several non-native membrane fusion mechanisms have been demonstrated, few can respond to external stimuli. Here, we develop a calcium-triggered DNA-mediated membrane fusion strategy where fusion is regulated using surface-bound PEG chains that are cleavable by the calcium-activated protease calpain-1.

Graphical abstract: Calcium-triggered DNA-mediated membrane fusion in synthetic cells

Supplementary files

Article information

Article type
Communication
Submitted
05 Mae 2023
Accepted
05 Mezh. 2023
First published
07 Mezh. 2023

Chem. Commun., 2023,59, 8806-8809

Author version available

Calcium-triggered DNA-mediated membrane fusion in synthetic cells

Y. Hsu, S. J. Chen, J. Bernal-Chanchavac, B. Sharma, H. Moghimianavval, N. Stephanopoulos and A. P. Liu, Chem. Commun., 2023, 59, 8806 DOI: 10.1039/D3CC02204H

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