Issue 52, 2023

An ambient pressure, direct hydrogenation of ketones

Abstract

We report two bifunctional (pyridyl)carbene-iridium(I) complexes that catalyze ketone and aldehyde hydrogenation at ambient pressure. Aryl, heteroaryl, and alkyl groups are demonstrated, and mechanistic studies reveal an unusual polarization effect in which the rate is dependant of proton, rather than hydride, transfer. This method introduces a convenient, waste-free alternative to traditional borohydride and aluminum hydride reagents.

Graphical abstract: An ambient pressure, direct hydrogenation of ketones

Supplementary files

Article information

Article type
Communication
Submitted
28 Cʼhwe. 2023
Accepted
25 Mae 2023
First published
09 Mezh. 2023

Chem. Commun., 2023,59, 8107-8110

Author version available

An ambient pressure, direct hydrogenation of ketones

L. Zhang, Z. Lu, A. R. Rander and T. J. Williams, Chem. Commun., 2023, 59, 8107 DOI: 10.1039/D3CC01014G

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