Issue 6, 2023

Isothermal nucleic acid amplification technology in HIV detection

Abstract

Nucleic acid testing for HIV plays an important role in the early diagnosis and monitoring of antiretroviral therapy outcomes in HIV patients and HIV-infected infants. Currently, the main molecular diagnostic methods employed are complex, time-consuming, and expensive to operate in resource-limited areas. Isothermal nucleic acid amplification technology overcomes some of the shortcomings of traditional assays and makes it possible to use point-of-care tests for molecular HIV detection. Here, we summarize and discuss the latest technological advances in isothermal nucleic acid amplification for HIV detection, with the intent of providing guidance for the development of subsequent HIV assays with high sensitivity and specificity.

Graphical abstract: Isothermal nucleic acid amplification technology in HIV detection

Article information

Article type
Tutorial Review
Submitted
03 Du 2022
Accepted
01 Cʼhwe. 2023
First published
09 Cʼhwe. 2023

Analyst, 2023,148, 1189-1208

Isothermal nucleic acid amplification technology in HIV detection

A. Gulinaizhaer, M. Zou, S. Ma, Y. Yao, X. Fan and G. Wu, Analyst, 2023, 148, 1189 DOI: 10.1039/D2AN01813F

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