Issue 44, 2022

Chondroitin sulfate-based composites: a tour d’horizon of their biomedical applications

Abstract

Chondroitin sulfate (CS), a natural anionic mucopolysaccharide, belonging to the glycosaminoglycan family, acts as the primary element of the extracellular matrix (ECM) of diverse organisms. It comprises repeating units of disaccharides possessing β-1,3-linked N-acetyl galactosamine (GalNAc), and β-1,4-linked D-glucuronic acid (GlcA), and exhibits antitumor, anti-inflammatory, anti-coagulant, anti-oxidant, and anti-thrombogenic activities. It is a naturally acquired bio-macromolecule with beneficial properties, such as biocompatibility, biodegradability, and immensely low toxicity, making it the center of attention in developing biomaterials for various biomedical applications. The authors have discussed the structure, unique properties, and extraction source of CS in the initial section of this review. Further, the current investigations on applications of CS-based composites in various biomedical fields, focusing on delivering active pharmaceutical compounds, tissue engineering, and wound healing, are discussed critically. In addition, the manuscript throws light on preclinical and clinical studies associated with CS composites. A short section on Chondroitinase ABC has also been canvassed. Finally, this review emphasizes the current challenges and prospects of CS in various biomedical fields.

Graphical abstract: Chondroitin sulfate-based composites: a tour d’horizon of their biomedical applications

Article information

Article type
Review Article
Submitted
18 Goue. 2022
Accepted
17 Here 2022
First published
18 Here 2022

J. Mater. Chem. B, 2022,10, 9125-9178

Chondroitin sulfate-based composites: a tour d’horizon of their biomedical applications

M. A. S. Abourehab, S. Baisakhiya, A. Aggarwal, A. Singh, M. A. Abdelgawad, A. Deepak, M. J. Ansari and S. Pramanik, J. Mater. Chem. B, 2022, 10, 9125 DOI: 10.1039/D2TB01514E

To request permission to reproduce material from this article, please go to the Copyright Clearance Center request page.

If you are an author contributing to an RSC publication, you do not need to request permission provided correct acknowledgement is given.

If you are the author of this article, you do not need to request permission to reproduce figures and diagrams provided correct acknowledgement is given. If you want to reproduce the whole article in a third-party publication (excluding your thesis/dissertation for which permission is not required) please go to the Copyright Clearance Center request page.

Read more about how to correctly acknowledge RSC content.

Social activity

Spotlight

Advertisements