Synthesis and characterization of a biocompatible 13C1 isotopologue of trityl radical OX071 for in vivo EPR viscometry†
Martin
Poncelet, 
ab
Thacien
Ngendahimana,
c
Teresa D.
Gluth,
ab
Timothy D.
Eubank,
bd
Gareth R.
Eaton,
c
Sandra S.
Eaton
c
and
Benoit
Driesschaert
*abe
ab
Thacien
Ngendahimana,
c
Teresa D.
Gluth,
ab
Timothy D.
Eubank,
bd
Gareth R.
Eaton,
c
Sandra S.
Eaton
c
and
Benoit
Driesschaert
*abe
Abstract
We describe the synthesis, characterization, and application of an isotopologue of the trityl radical OX071, labeled with 13C at the central carbon (13C1). This spin probe features large anisotropy of the hyperfine coupling with the 13C1 (I = 1/2), leading to an EPR spectrum highly sensitive to molecular tumbling. The high biocompatibility and lack of interaction with blood albumin allow for systemic delivery and in vivo measurement of tissue microviscosity by EPR.
- This article is part of the themed collection: Analyst HOT Articles 2022
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